UA93226C2 - (4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof - Google Patents
(4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereofInfo
- Publication number
- UA93226C2 UA93226C2 UAA200809311A UAA200809311A UA93226C2 UA 93226 C2 UA93226 C2 UA 93226C2 UA A200809311 A UAA200809311 A UA A200809311A UA A200809311 A UAA200809311 A UA A200809311A UA 93226 C2 UA93226 C2 UA 93226C2
- Authority
- UA
- Ukraine
- Prior art keywords
- trione
- imidazolidine
- dichlorophenyl
- spiro
- ene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77111906P | 2006-02-07 | 2006-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93226C2 true UA93226C2 (en) | 2011-01-25 |
Family
ID=38345567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200809311A UA93226C2 (en) | 2006-02-07 | 2007-06-02 | (4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof |
Country Status (21)
Country | Link |
---|---|
US (2) | US20070185179A1 (ru) |
EP (1) | EP2013215A4 (ru) |
JP (1) | JP2009526043A (ru) |
KR (1) | KR20080094906A (ru) |
CN (1) | CN101415711A (ru) |
AR (1) | AR059265A1 (ru) |
AU (1) | AU2007212786B2 (ru) |
BR (1) | BRPI0707423A2 (ru) |
CA (1) | CA2641632A1 (ru) |
CL (1) | CL2009000523A1 (ru) |
IL (1) | IL192890A0 (ru) |
NO (1) | NO20083547L (ru) |
NZ (1) | NZ571070A (ru) |
RU (1) | RU2421457C2 (ru) |
SA (1) | SA07280027B1 (ru) |
SG (1) | SG169387A1 (ru) |
TW (1) | TW200801011A (ru) |
UA (1) | UA93226C2 (ru) |
UY (1) | UY30132A1 (ru) |
WO (1) | WO2007091947A2 (ru) |
ZA (1) | ZA200806407B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013057944A1 (ja) * | 2011-10-19 | 2013-04-25 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
TWI586668B (zh) * | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
CN108409746B (zh) * | 2018-05-15 | 2021-08-24 | 中山大学 | 一种含吡咯或吲哚并氮杂环烷结构的手性氧代螺环吲哚类化合物及其消旋体和制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA806623B (en) * | 1979-11-13 | 1981-12-30 | Ici Ltd | Substituted indoline-2-one derivatives |
AU532110B2 (en) | 1979-11-13 | 1983-09-15 | Ici Ltd. | Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives |
IE52879B1 (en) | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
GB8331194D0 (en) | 1982-12-20 | 1983-12-29 | Ici Plc | Chemical process |
US4611062A (en) * | 1984-03-26 | 1986-09-09 | Imperial Chemical Industries Plc | Process for resolving certain spiro compounds |
WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
US6774132B1 (en) * | 1999-07-21 | 2004-08-10 | Astrazeneca Ab | Spirooxindole derivatives that act as analgesics |
US7248802B2 (en) | 2002-11-27 | 2007-07-24 | Nokia Corporation | Distribution of a synchronization signal in an optical communication system |
TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
JP4400566B2 (ja) | 2003-06-12 | 2010-01-20 | アステラス製薬株式会社 | ベンズアミド誘導体又はその塩 |
GB0326633D0 (en) * | 2003-11-14 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents |
EP1771162B1 (en) | 2004-07-19 | 2013-06-05 | Xenia Pharma | Capsaicin inhibitors for the treatment of obesity-related disorders |
CN101415713A (zh) | 2006-02-07 | 2009-04-22 | 阿斯利康(瑞典)有限公司 | 用于治疗香草素受体1相关病症的新螺[咪唑烷-4,3’-吲哚]-2,2’,5(1’h)-三酮 |
-
2007
- 2007-01-31 AR ARP070100412A patent/AR059265A1/es not_active Application Discontinuation
- 2007-01-31 TW TW096103591A patent/TW200801011A/zh unknown
- 2007-02-05 US US11/671,153 patent/US20070185179A1/en not_active Abandoned
- 2007-02-06 SG SG201100854-7A patent/SG169387A1/en unknown
- 2007-02-06 WO PCT/SE2007/000107 patent/WO2007091947A2/en active Application Filing
- 2007-02-06 NZ NZ571070A patent/NZ571070A/en unknown
- 2007-02-06 CA CA002641632A patent/CA2641632A1/en not_active Abandoned
- 2007-02-06 CN CNA2007800125819A patent/CN101415711A/zh active Pending
- 2007-02-06 BR BRPI0707423-9A patent/BRPI0707423A2/pt not_active IP Right Cessation
- 2007-02-06 KR KR1020087019272A patent/KR20080094906A/ko not_active Application Discontinuation
- 2007-02-06 SA SA07280027A patent/SA07280027B1/ar unknown
- 2007-02-06 RU RU2008131905/04A patent/RU2421457C2/ru not_active IP Right Cessation
- 2007-02-06 JP JP2008554186A patent/JP2009526043A/ja active Pending
- 2007-02-06 EP EP07709323A patent/EP2013215A4/en not_active Withdrawn
- 2007-02-06 AU AU2007212786A patent/AU2007212786B2/en not_active Ceased
- 2007-02-06 UY UY30132A patent/UY30132A1/es not_active Application Discontinuation
- 2007-06-02 UA UAA200809311A patent/UA93226C2/ru unknown
-
2008
- 2008-07-17 IL IL192890A patent/IL192890A0/en unknown
- 2008-07-23 ZA ZA200806407A patent/ZA200806407B/xx unknown
- 2008-08-14 NO NO20083547A patent/NO20083547L/no not_active Application Discontinuation
- 2008-11-20 US US12/274,837 patent/US7868181B2/en not_active Expired - Fee Related
-
2009
- 2009-03-05 CL CL2009000523A patent/CL2009000523A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US7868181B2 (en) | 2011-01-11 |
UY30132A1 (es) | 2009-07-17 |
US20070185179A1 (en) | 2007-08-09 |
BRPI0707423A2 (pt) | 2011-05-03 |
RU2008131905A (ru) | 2010-03-20 |
US20090137650A1 (en) | 2009-05-28 |
AR059265A1 (es) | 2008-03-19 |
SG169387A1 (en) | 2011-03-30 |
KR20080094906A (ko) | 2008-10-27 |
IL192890A0 (en) | 2009-02-11 |
AU2007212786A1 (en) | 2007-08-16 |
EP2013215A2 (en) | 2009-01-14 |
CA2641632A1 (en) | 2007-08-16 |
TW200801011A (en) | 2008-01-01 |
NO20083547L (no) | 2008-11-05 |
RU2421457C2 (ru) | 2011-06-20 |
SA07280027B1 (ar) | 2010-11-22 |
NZ571070A (en) | 2011-07-29 |
AU2007212786B2 (en) | 2011-06-02 |
CN101415711A (zh) | 2009-04-22 |
JP2009526043A (ja) | 2009-07-16 |
WO2007091947A8 (en) | 2008-08-07 |
EP2013215A4 (en) | 2010-09-08 |
WO2007091947A3 (en) | 2007-10-04 |
WO2007091947A2 (en) | 2007-08-16 |
AU2007212786A8 (en) | 2010-05-06 |
ZA200806407B (en) | 2009-04-29 |
CL2009000523A1 (es) | 2009-07-17 |
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UA93226C2 (en) | (4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof |