JP2009525288A5 - - Google Patents

Info

Publication number

JP2009525288A5

JP2009525288A5 JP2008552668A JP2008552668A JP2009525288A5 JP 2009525288 A5 JP2009525288 A5 JP 2009525288A5 JP 2008552668 A JP2008552668 A JP 2008552668A JP 2008552668 A JP2008552668 A JP 2008552668A JP 2009525288 A5 JP2009525288 A5 JP 2009525288A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

growth factor

epidermal growth

microspheres

Prior art date

2007-01-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 239000004005 microsphere Substances 0.000 claims 6
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 5
• 101800003838 Epidermal growth factor Proteins 0.000 claims 5
• 229940116977 epidermal growth factor Drugs 0.000 claims 5
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 3
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
• 229920001610 polycaprolactone Polymers 0.000 claims 2
• 239000004632 polycaprolactone Substances 0.000 claims 2
• 229920001661 Chitosan Polymers 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 208000008960 Diabetic foot Diseases 0.000 claims 1
• 229920006022 Poly(L-lactide-co-glycolide)-b-poly(​ethylene glycol) Polymers 0.000 claims 1
• 229920002732 Polyanhydride Polymers 0.000 claims 1
• 229920001710 Polyorthoester Polymers 0.000 claims 1
• 206010052428 Wound Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 229920001519 homopolymer Polymers 0.000 claims 1
• 239000000017 hydrogel Substances 0.000 claims 1
• 230000008595 infiltration Effects 0.000 claims 1
• 238000001764 infiltration Methods 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 235000014655 lactic acid Nutrition 0.000 claims 1
• 239000004310 lactic acid Substances 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 239000002077 nanosphere Substances 0.000 claims 1
• 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 1
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1