AR059234A1 - Composicion farmaceutica de microesferas para prevenir la amputacion del pie diabetico - Google Patents
Composicion farmaceutica de microesferas para prevenir la amputacion del pie diabeticoInfo
- Publication number
- AR059234A1 AR059234A1 ARP070100377A ARP070100377A AR059234A1 AR 059234 A1 AR059234 A1 AR 059234A1 AR P070100377 A ARP070100377 A AR P070100377A AR P070100377 A ARP070100377 A AR P070100377A AR 059234 A1 AR059234 A1 AR 059234A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- microspheres
- copolymers
- lactic acid
- homopolymers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Una composicion farmacéutica que contiene microesferas cargadas con Factor de Crecimiento Epidérmico para ser administrada por vía parenteral en los miembro inferiores de pacientes diabáticos aquejados de lesiones isquémicas cutáneas cronicas. La composicion de la presente reduce la frecuencia de administracion durante el tratamiento y permite que la cicatrizacion de las lesiones sea más rápida comparada con la administracion de cantidades equivalentes del Factor libre en solucion. Reivindicacion 2: Una composicion farmacéutica segun la reivindicacion 1, donde el factor de crecimiento epidérmico se encuentra encapsulado en microesferas o nanoesferas poliméricas. Reivindicacion 3: Una composicion farmacéutica segun la reivindicacion 2, donde las microesferas se fabrican de un material polimérico del grupo integrado por copolímeros de ácido láctico y ácido glicolico, homopolímeros de ácido láctico, homopolímeros de ácido glicolico, policaprolactona, copolímeros de hidroxibutirato e hidroxivalerato, copolímeros de ácido láctico y caprolactona, poliortoésteres y polianhídridos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060021A CU23388B6 (es) | 2006-01-31 | 2006-01-31 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059234A1 true AR059234A1 (es) | 2008-03-19 |
Family
ID=38185604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100377A AR059234A1 (es) | 2006-01-31 | 2007-01-30 | Composicion farmaceutica de microesferas para prevenir la amputacion del pie diabetico |
Country Status (24)
Country | Link |
---|---|
US (1) | US8741848B2 (es) |
EP (1) | EP1987817B1 (es) |
JP (1) | JP5219841B2 (es) |
KR (1) | KR101401273B1 (es) |
CN (2) | CN101400338A (es) |
AR (1) | AR059234A1 (es) |
AT (1) | ATE437631T1 (es) |
AU (1) | AU2007211753B2 (es) |
BR (1) | BRPI0707395A2 (es) |
CA (1) | CA2640743C (es) |
CU (1) | CU23388B6 (es) |
CY (1) | CY1109513T1 (es) |
DE (1) | DE602007001786D1 (es) |
DK (1) | DK1987817T3 (es) |
ES (1) | ES2330688T3 (es) |
HK (1) | HK1198743A1 (es) |
MY (1) | MY143742A (es) |
PL (1) | PL1987817T3 (es) |
PT (1) | PT1987817E (es) |
RU (1) | RU2426528C2 (es) |
SG (1) | SG169366A1 (es) |
SI (1) | SI1987817T1 (es) |
WO (1) | WO2007087759A2 (es) |
ZA (1) | ZA200806648B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
ES2340902B1 (es) | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
GB0814302D0 (en) | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
KR101156094B1 (ko) * | 2010-02-22 | 2012-06-20 | 경상대학교산학협력단 | 약물송달을 위한 양친성 PHA-mPEG 공중합 나노 컨테이너 |
ES2357601B1 (es) | 2011-01-26 | 2012-03-21 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas. |
EP2737895A1 (en) | 2012-11-30 | 2014-06-04 | Praxis Pharmaceutical, S.A. | Microparticles with EGF, method of preparation and use |
EP2821077A1 (en) | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
EP3097922A1 (fr) | 2015-05-28 | 2016-11-30 | Denis Barritault | Composition pour le traitement des lesions tissulaires |
CN106267163A (zh) * | 2015-06-09 | 2017-01-04 | 济南博创医药科技有限公司 | 一种治疗皮肤创伤的药物组合物及其药物制剂 |
MX2016016339A (es) * | 2016-12-09 | 2018-06-08 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A S De C V | Composicion coadyuvante de un factor de crecimiento y un neuropeptido para acelerar la cicatrizacion de heridas y la repitelizacion de organos. |
KR102218427B1 (ko) * | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
CU20190022A7 (es) * | 2019-03-18 | 2020-10-20 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica para el tratamiento de la úlcera del pie diabético |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5034375A (en) | 1988-08-10 | 1991-07-23 | Institute Of Molecular Biology, Inc. | Process of wound healing using PDGF and EGF |
US4944948A (en) * | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
WO1990011781A1 (en) | 1989-04-04 | 1990-10-18 | Alcon Laboratories, Inc. | The use of liposomes for the delivery of therapeutic agents to wounds, cuts and abrasions |
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
JPH04501123A (ja) | 1989-08-01 | 1992-02-27 | ザ ユニヴァーシティ オブ ミシガン | 脱水/水補給リポソームに被嚢されたペプチド/タンパク質の局所送達 |
AU629316B2 (en) | 1990-04-11 | 1992-10-01 | Flora Inc. | Periodontal disease treatment system |
US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
AU725654B2 (en) * | 1996-05-03 | 2000-10-19 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
US5861149A (en) * | 1997-06-04 | 1999-01-19 | Polyheal Ltd. | Methods for wound treatment |
EP2316490A3 (en) * | 2000-10-31 | 2012-02-01 | PR Pharmaceuticals, Inc. | Methods and compositions for enhanced delivery of bioactive molecules |
HK1077740A1 (en) * | 2001-12-20 | 2006-02-24 | Ct Ingenieria Genetica Biotech | Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation |
WO2003075949A1 (en) | 2002-03-12 | 2003-09-18 | Bio-Click Technologies Ltd. | Method and composition for treating skin wounds with epidermal growth factor |
CN1720989A (zh) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | 一种表皮生长因子缓释微球及其制备方法与应用 |
CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
-
2006
- 2006-01-31 CU CU20060021A patent/CU23388B6/es unknown
-
2007
- 2007-01-29 WO PCT/CU2007/000002 patent/WO2007087759A2/es active Search and Examination
- 2007-01-29 PT PT07702319T patent/PT1987817E/pt unknown
- 2007-01-29 KR KR1020087021210A patent/KR101401273B1/ko active IP Right Grant
- 2007-01-29 SG SG201100715-0A patent/SG169366A1/en unknown
- 2007-01-29 BR BRPI0707395-0A patent/BRPI0707395A2/pt not_active Application Discontinuation
- 2007-01-29 DE DE602007001786T patent/DE602007001786D1/de active Active
- 2007-01-29 ES ES07702319T patent/ES2330688T3/es active Active
- 2007-01-29 JP JP2008552668A patent/JP5219841B2/ja active Active
- 2007-01-29 MY MYPI20082850A patent/MY143742A/en unknown
- 2007-01-29 RU RU2008135354/15A patent/RU2426528C2/ru active
- 2007-01-29 US US12/162,505 patent/US8741848B2/en active Active
- 2007-01-29 EP EP07702319A patent/EP1987817B1/en active Active
- 2007-01-29 CA CA2640743A patent/CA2640743C/en active Active
- 2007-01-29 AU AU2007211753A patent/AU2007211753B2/en active Active
- 2007-01-29 AT AT07702319T patent/ATE437631T1/de active
- 2007-01-29 CN CNA2007800090345A patent/CN101400338A/zh active Pending
- 2007-01-29 DK DK07702319T patent/DK1987817T3/da active
- 2007-01-29 PL PL07702319T patent/PL1987817T3/pl unknown
- 2007-01-29 SI SI200730087T patent/SI1987817T1/sl unknown
- 2007-01-29 CN CN201410189221.8A patent/CN103933552A/zh active Pending
- 2007-01-30 AR ARP070100377A patent/AR059234A1/es unknown
-
2008
- 2008-07-30 ZA ZA200806648A patent/ZA200806648B/xx unknown
-
2009
- 2009-10-23 CY CY20091101105T patent/CY1109513T1/el unknown
-
2014
- 2014-12-04 HK HK14112245.2A patent/HK1198743A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1987817B1 (en) | 2009-07-29 |
US20090220608A1 (en) | 2009-09-03 |
KR20080096804A (ko) | 2008-11-03 |
EP1987817A2 (en) | 2008-11-05 |
KR101401273B1 (ko) | 2014-05-29 |
CA2640743A1 (en) | 2007-08-09 |
JP5219841B2 (ja) | 2013-06-26 |
CN101400338A (zh) | 2009-04-01 |
AU2007211753A1 (en) | 2007-08-09 |
RU2426528C2 (ru) | 2011-08-20 |
WO2007087759A2 (es) | 2007-08-09 |
PL1987817T3 (pl) | 2010-01-29 |
MY143742A (en) | 2011-07-15 |
CA2640743C (en) | 2012-05-15 |
RU2008135354A (ru) | 2010-03-10 |
ES2330688T3 (es) | 2009-12-14 |
CY1109513T1 (el) | 2014-08-13 |
US8741848B2 (en) | 2014-06-03 |
HK1198743A1 (en) | 2015-06-05 |
CN103933552A (zh) | 2014-07-23 |
CU23388B6 (es) | 2009-07-16 |
BRPI0707395A2 (pt) | 2011-05-03 |
WO2007087759A3 (es) | 2007-09-20 |
SG169366A1 (en) | 2011-03-30 |
JP2009525288A (ja) | 2009-07-09 |
ATE437631T1 (de) | 2009-08-15 |
SI1987817T1 (sl) | 2009-12-31 |
PT1987817E (pt) | 2009-10-26 |
DK1987817T3 (da) | 2009-11-30 |
ZA200806648B (en) | 2009-05-27 |
AU2007211753B2 (en) | 2012-03-01 |
DE602007001786D1 (de) | 2009-09-10 |
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