CY1109513T1 - Φαρμακευτικη συνθεση μικροσφαιριδιων για την προληψη του ακρωτηριασμου διαβητικου ποδιου - Google Patents
Φαρμακευτικη συνθεση μικροσφαιριδιων για την προληψη του ακρωτηριασμου διαβητικου ποδιουInfo
- Publication number
- CY1109513T1 CY1109513T1 CY20091101105T CY091101105T CY1109513T1 CY 1109513 T1 CY1109513 T1 CY 1109513T1 CY 20091101105 T CY20091101105 T CY 20091101105T CY 091101105 T CY091101105 T CY 091101105T CY 1109513 T1 CY1109513 T1 CY 1109513T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical composition
- microphyses
- egf
- prevent diabetic
- diabetic health
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 1
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 229940116977 epidermal growth factor Drugs 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 210000003141 lower extremity Anatomy 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060021A CU23388B6 (es) | 2006-01-31 | 2006-01-31 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
| EP07702319A EP1987817B1 (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109513T1 true CY1109513T1 (el) | 2014-08-13 |
Family
ID=38185604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101105T CY1109513T1 (el) | 2006-01-31 | 2009-10-23 | Φαρμακευτικη συνθεση μικροσφαιριδιων για την προληψη του ακρωτηριασμου διαβητικου ποδιου |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8741848B2 (enExample) |
| EP (1) | EP1987817B1 (enExample) |
| JP (1) | JP5219841B2 (enExample) |
| KR (1) | KR101401273B1 (enExample) |
| CN (2) | CN103933552A (enExample) |
| AR (1) | AR059234A1 (enExample) |
| AT (1) | ATE437631T1 (enExample) |
| AU (1) | AU2007211753B2 (enExample) |
| BR (1) | BRPI0707395A2 (enExample) |
| CA (1) | CA2640743C (enExample) |
| CU (1) | CU23388B6 (enExample) |
| CY (1) | CY1109513T1 (enExample) |
| DE (1) | DE602007001786D1 (enExample) |
| DK (1) | DK1987817T3 (enExample) |
| ES (1) | ES2330688T3 (enExample) |
| HK (1) | HK1198743A1 (enExample) |
| MY (1) | MY143742A (enExample) |
| PL (1) | PL1987817T3 (enExample) |
| PT (1) | PT1987817E (enExample) |
| RU (1) | RU2426528C2 (enExample) |
| SG (1) | SG169366A1 (enExample) |
| SI (1) | SI1987817T1 (enExample) |
| WO (1) | WO2007087759A2 (enExample) |
| ZA (1) | ZA200806648B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
| RU2351334C1 (ru) * | 2007-12-04 | 2009-04-10 | Георгий Кимович Золоев | Способ лечения хронической ишемии нижних конечностей ii б - iv степени |
| ES2340902B1 (es) | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
| GB0814302D0 (en) | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
| KR101156094B1 (ko) * | 2010-02-22 | 2012-06-20 | 경상대학교산학협력단 | 약물송달을 위한 양친성 ＰＨＡ－ｍＰＥＧ 공중합 나노 컨테이너 |
| RU2421221C1 (ru) * | 2010-03-22 | 2011-06-20 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Способ лечения критической ишемии нижних конечностей различного генеза |
| RU2425675C1 (ru) * | 2010-05-25 | 2011-08-10 | Федеральное государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии Федерального агентства по высокотехнологичной медицинской помощи" | Способ лечения больных с нейропатической и нейроишемической формами синдрома "диабетическая стопа" |
| ES2357601B1 (es) | 2011-01-26 | 2012-03-21 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas. |
| EP2737895A1 (en) * | 2012-11-30 | 2014-06-04 | Praxis Pharmaceutical, S.A. | Microparticles with EGF, method of preparation and use |
| EP2821077A1 (en) | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
| EP3097922A1 (fr) | 2015-05-28 | 2016-11-30 | Denis Barritault | Composition pour le traitement des lesions tissulaires |
| CN106267163A (zh) * | 2015-06-09 | 2017-01-04 | 济南博创医药科技有限公司 | 一种治疗皮肤创伤的药物组合物及其药物制剂 |
| MX389934B (es) * | 2016-12-09 | 2025-03-20 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A De C V | Composición coadyuvante de un factor de crecimiento y un neuropéptido para acelerar la cicatrización de heridas y la repitelización de órganos. |
| KR102218427B1 (ko) * | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
| CU20190022A7 (es) * | 2019-03-18 | 2020-10-20 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica para el tratamiento de la úlcera del pie diabético |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| US5034375A (en) | 1988-08-10 | 1991-07-23 | Institute Of Molecular Biology, Inc. | Process of wound healing using PDGF and EGF |
| US4944948A (en) * | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
| KR920700691A (ko) | 1989-04-04 | 1992-08-10 | 존.에프.맥인티리 | 상처부위, 절개부위, 찰과상 부위에 치료제의 투여에 대한 리포좀(liposomes)의 용도 |
| US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
| WO1991001719A1 (en) | 1989-08-01 | 1991-02-21 | The University Of Michigan | Topical delivery of peptides/proteins entrapped in dehydration/rehydration liposomes |
| AU629316B2 (en) * | 1990-04-11 | 1992-10-01 | Flora Inc. | Periodontal disease treatment system |
| US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
| CA2251129A1 (en) * | 1996-05-03 | 1997-11-13 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
| CN1126537C (zh) * | 1996-05-23 | 2003-11-05 | 株式会社三养社 | 可局部给药,可生物降解和持续释放的用于治疗牙周炎的药物组合物及其制备方法 |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US5861149A (en) * | 1997-06-04 | 1999-01-19 | Polyheal Ltd. | Methods for wound treatment |
| CN101584867A (zh) * | 2000-10-31 | 2009-11-25 | 瑟莫迪克斯药品公司 | 提高生物活性分子传递的方法和组合物 |
| CU23043A1 (es) * | 2001-12-20 | 2005-05-20 | Ct Ingenieria Genetica Biotech | Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico. |
| AU2003213985A1 (en) | 2002-03-12 | 2003-09-22 | Bio-Click Technologies Ltd. | Method and composition for treating skin wounds with epidermal growth factor |
| CN1720989A (zh) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | 一种表皮生长因子缓释微球及其制备方法与应用 |
| CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
-
2006
- 2006-01-31 CU CU20060021A patent/CU23388B6/es unknown
-
2007
- 2007-01-29 JP JP2008552668A patent/JP5219841B2/ja active Active
- 2007-01-29 CN CN201410189221.8A patent/CN103933552A/zh active Pending
- 2007-01-29 SG SG201100715-0A patent/SG169366A1/en unknown
- 2007-01-29 DE DE602007001786T patent/DE602007001786D1/de active Active
- 2007-01-29 PT PT07702319T patent/PT1987817E/pt unknown
- 2007-01-29 SI SI200730087T patent/SI1987817T1/sl unknown
- 2007-01-29 EP EP07702319A patent/EP1987817B1/en active Active
- 2007-01-29 KR KR1020087021210A patent/KR101401273B1/ko active Active
- 2007-01-29 RU RU2008135354/15A patent/RU2426528C2/ru active
- 2007-01-29 AT AT07702319T patent/ATE437631T1/de active
- 2007-01-29 DK DK07702319T patent/DK1987817T3/da active
- 2007-01-29 BR BRPI0707395-0A patent/BRPI0707395A2/pt not_active Application Discontinuation
- 2007-01-29 ES ES07702319T patent/ES2330688T3/es active Active
- 2007-01-29 WO PCT/CU2007/000002 patent/WO2007087759A2/es not_active Ceased
- 2007-01-29 US US12/162,505 patent/US8741848B2/en active Active
- 2007-01-29 CA CA2640743A patent/CA2640743C/en active Active
- 2007-01-29 PL PL07702319T patent/PL1987817T3/pl unknown
- 2007-01-29 MY MYPI20082850A patent/MY143742A/en unknown
- 2007-01-29 AU AU2007211753A patent/AU2007211753B2/en not_active Ceased
- 2007-01-29 CN CNA2007800090345A patent/CN101400338A/zh active Pending
- 2007-01-30 AR ARP070100377A patent/AR059234A1/es unknown
-
2008
- 2008-07-30 ZA ZA200806648A patent/ZA200806648B/xx unknown
-
2009
- 2009-10-23 CY CY20091101105T patent/CY1109513T1/el unknown
-
2014
- 2014-12-04 HK HK14112245.2A patent/HK1198743A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1987817E (pt) | 2009-10-26 |
| EP1987817B1 (en) | 2009-07-29 |
| CA2640743C (en) | 2012-05-15 |
| BRPI0707395A2 (pt) | 2011-05-03 |
| KR20080096804A (ko) | 2008-11-03 |
| CA2640743A1 (en) | 2007-08-09 |
| US8741848B2 (en) | 2014-06-03 |
| DE602007001786D1 (de) | 2009-09-10 |
| CN101400338A (zh) | 2009-04-01 |
| KR101401273B1 (ko) | 2014-05-29 |
| SG169366A1 (en) | 2011-03-30 |
| WO2007087759A3 (es) | 2007-09-20 |
| CU23388B6 (es) | 2009-07-16 |
| HK1198743A1 (en) | 2015-06-05 |
| AU2007211753A1 (en) | 2007-08-09 |
| DK1987817T3 (da) | 2009-11-30 |
| PL1987817T3 (pl) | 2010-01-29 |
| ES2330688T3 (es) | 2009-12-14 |
| ATE437631T1 (de) | 2009-08-15 |
| AR059234A1 (es) | 2008-03-19 |
| MY143742A (en) | 2011-07-15 |
| RU2426528C2 (ru) | 2011-08-20 |
| AU2007211753B2 (en) | 2012-03-01 |
| CN103933552A (zh) | 2014-07-23 |
| WO2007087759A2 (es) | 2007-08-09 |
| ZA200806648B (en) | 2009-05-27 |
| RU2008135354A (ru) | 2010-03-10 |
| EP1987817A2 (en) | 2008-11-05 |
| SI1987817T1 (sl) | 2009-12-31 |
| US20090220608A1 (en) | 2009-09-03 |
| JP5219841B2 (ja) | 2013-06-26 |
| JP2009525288A (ja) | 2009-07-09 |
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