JP2009524692A - ドライアイのための処方物および方法 - Google Patents

ドライアイのための処方物および方法 Download PDF

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Publication number
JP2009524692A
JP2009524692A JP2008552581A JP2008552581A JP2009524692A JP 2009524692 A JP2009524692 A JP 2009524692A JP 2008552581 A JP2008552581 A JP 2008552581A JP 2008552581 A JP2008552581 A JP 2008552581A JP 2009524692 A JP2009524692 A JP 2009524692A
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eye
registered trademark
subject
ophthalmic formulation
tear
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JP2009524692A5 (enExample
Inventor
ジョージ ダブリュー． ウースラー，
マシュー ジェイ． チャピン，
マーク ビー． アベルソン，
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アーシエックス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
JP2008552581A 2006-01-25 2007-01-25 ドライアイのための処方物および方法 Pending JP2009524692A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76194506P 2006-01-25 2006-01-25
PCT/US2007/061065 WO2007087609A2 (en) 2006-01-25 2007-01-25 Formulations and methods for treating dry eye

Publications (2)

Publication Number Publication Date
JP2009524692A true JP2009524692A (ja) 2009-07-02
JP2009524692A5 JP2009524692A5 (enExample) 2011-03-17

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ID=38309951

Family Applications (1)

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JP2008552581A Pending JP2009524692A (ja) 2006-01-25 2007-01-25 ドライアイのための処方物および方法

Country Status (6)

Country Link
US (1) US20070254841A1 (enExample)
EP (1) EP1981491A4 (enExample)
JP (1) JP2009524692A (enExample)
AU (1) AU2007208054A1 (enExample)
CA (1) CA2636646A1 (enExample)
WO (1) WO2007087609A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513416A (ja) * 2008-03-03 2011-04-28 アラーガン、インコーポレイテッド 眼痛を処置または防止するためのケトロラックトロメタミン組成物
JP2013503873A (ja) * 2009-09-01 2013-02-04 アラーガン インコーポレイテッド 眼痛を処置または予防するためのケトロラクトロメタミン組成物
JP2014510018A (ja) * 2010-12-15 2014-04-24 シェンヤン、シンチ、ファーマシューティカル、カンパニー、リミテッド ブロムフェナク有機塩、ならびにその製造方法、組成物および使用
JP2014513073A (ja) * 2011-04-05 2014-05-29 オプトソルヴ リミテッド ライアビリティー パートナーシップ 眼科治療
JP2014521606A (ja) * 2011-07-22 2014-08-28 インサイト・ビジョン・インコーポレイテッド 眼表面アレルギーの処置のための組成物および方法
JP2020122009A (ja) * 2013-12-25 2020-08-13 株式会社Ｌｔｔバイオファーマ ドライアイ治療用点眼剤

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512717B2 (en) 2003-08-07 2013-08-20 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using same
US8372814B2 (en) * 2004-06-07 2013-02-12 Ista Pharmaceuticals, Inc. Ophthalmic formulations and uses thereof
US8748402B2 (en) 2004-06-07 2014-06-10 Bausch & Lomb Pharma Holdings Corp. Ophthalmic formulations and uses thereof
US8137111B2 (en) * 2007-06-28 2012-03-20 Eye Care And Cure Pte. Ltd Model human eye
AU2009202969B1 (en) * 2009-07-23 2009-11-19 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
US8778999B2 (en) * 2009-03-05 2014-07-15 Insite Vision Incorporated Non-steroidal anti-inflammatory ophthalmic compositions
PT2506831E (pt) 2009-12-03 2014-01-08 Alcon Res Ltd Suspensões de nanopartículas contendo um polímero de carboxivinilo
SI2555770T1 (en) * 2010-04-09 2018-04-30 Allergan, Inc. Ketorolac compositions for corneal wound healing
US8684743B2 (en) 2010-07-23 2014-04-01 Eye Care And Cure Pte. Ltd Model human eye and face manikin for use therewith
EP3013790A1 (en) 2013-06-27 2016-05-04 Mylan Laboratories Ltd. Process for the preparation of nepafenac
US9492474B2 (en) 2013-07-10 2016-11-15 Matrix Biology Institute Compositions of hyaluronan with high elasticity and uses thereof
US9775861B1 (en) * 2014-09-26 2017-10-03 Paul S. Jensen Dry eye composition and method for preparing the composition
PT3842047T (pt) 2015-09-24 2024-09-19 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
JP2024524590A (ja) * 2021-07-09 2024-07-05 コアンチョウ オキュサン オフサルミック バイオテクノロジー カンパニー リミテッド ドライアイを治療する薬物の製造におけるロキソプロフェンナトリウムの使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239745A1 (en) * 2004-03-03 2005-10-27 Ophthalmic Research Associates, Inc. Novel topical ophthalmic formulations
WO2005101982A2 (en) * 2004-03-24 2005-11-03 Sun Pharmaceutical Industries Limited A stable ophthalmic composition

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230724A (en) * 1979-07-16 1980-10-28 Allergan Pharmaceuticals, Inc. Method of treating vascularization of the eye with Flurbiprofen
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
DE3612537C1 (de) * 1986-04-14 1987-07-16 Dispersa Ag Arzneimittel zur Behandlung von Entzuendungen im Auge
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
CA1325382C (en) * 1988-01-27 1993-12-21 Takahiro Ogawa Locally administrable therapeutic composition for inflammatory disease
US4960799A (en) * 1988-09-13 1990-10-02 Ciba-Geigy Corporation Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use
WO1994012900A1 (de) * 1992-11-27 1994-06-09 Siemens Aktiengesellschaft Steckverbindung für einen an einen baugruppenrahmen anschliessbaren lichtleiter
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
CN100408100C (zh) * 1997-07-29 2008-08-06 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
US6552020B1 (en) * 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
CA2477044A1 (en) * 2002-02-22 2003-09-04 Pharmacia Corporation Ophthalmic formulation with gum system
US6828356B2 (en) * 2002-07-29 2004-12-07 Ast Products, Inc. Preparation of ophthalmic compositions
US6806364B2 (en) * 2002-07-29 2004-10-19 Ast Products, Inc. Ophthalmic compositions
US8129431B2 (en) * 2003-01-21 2012-03-06 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
PT1885336E (pt) * 2005-05-10 2009-05-07 Alcon Inc Formulações de suspensão compreendendo um princípio activo, um tensoactivo poloxâmero ou meroxapol e um glicol, sua utilização no fabrico de um medicamento para tratamento de distúrbios oftálmicos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239745A1 (en) * 2004-03-03 2005-10-27 Ophthalmic Research Associates, Inc. Novel topical ophthalmic formulations
WO2005101982A2 (en) * 2004-03-24 2005-11-03 Sun Pharmaceutical Industries Limited A stable ophthalmic composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5010008247; ＬＥＫＨＡＮＯＮＴ　ＫＡＥＶＡＬＩＮ: ＪＯＵＲＮＡＬ　ＯＦ　ＯＣＵＬＡＲ　ＰＨＡＲＭＡＣＯＬＯＧＹ　ＡＮＤ　ＴＨＥＲＡＰＥＵＴＩＣＳ Ｖ２３　Ｎ１, 20070201, Ｐ２７-３４, ＭＡＲＹ　ＡＮＮ　ＬＩＥＢＥＲＴ　ＩＮＣ． *
JPN6012019223; ＧＩＯＲＧＩ，　Ｄ．　ｅｔ　ａｌ．: ＲＥＣＥＮＴＩ　ＰＲＯＧＲＥＳＳＩ　ＩＮ　ＭＥＤＩＣＩＮＡ Ｖｏｌ．８８，　Ｎｏ．９, 1997, ｐｐ．３９７-４００ *
JPN6012019226; ＲＯＬＡＮＤＯ，　Ｍ．　ｅｔ　ａｌ．: Ａｄｖａｎｃｅｓ　ｉｎ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｍｅｄｉｃｉｎｅ　ａｎｄ　Ｂｉｏｌｏｇｙ Ｖｏｌ．５０６，　Ｐａｒｔ．Ｂ, 2002, ｐｐ．１２３７-１２４０ *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513416A (ja) * 2008-03-03 2011-04-28 アラーガン、インコーポレイテッド 眼痛を処置または防止するためのケトロラックトロメタミン組成物
JP2013503873A (ja) * 2009-09-01 2013-02-04 アラーガン インコーポレイテッド 眼痛を処置または予防するためのケトロラクトロメタミン組成物
JP2014510018A (ja) * 2010-12-15 2014-04-24 シェンヤン、シンチ、ファーマシューティカル、カンパニー、リミテッド ブロムフェナク有機塩、ならびにその製造方法、組成物および使用
JP2014513073A (ja) * 2011-04-05 2014-05-29 オプトソルヴ リミテッド ライアビリティー パートナーシップ 眼科治療
JP2017141243A (ja) * 2011-04-05 2017-08-17 オプトソルヴ リサーチ アンド ディベロップメント リミテッド 眼科治療
JP2014521606A (ja) * 2011-07-22 2014-08-28 インサイト・ビジョン・インコーポレイテッド 眼表面アレルギーの処置のための組成物および方法
JP2020122009A (ja) * 2013-12-25 2020-08-13 株式会社Ｌｔｔバイオファーマ ドライアイ治療用点眼剤

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Publication number Publication date
WO2007087609A2 (en) 2007-08-02
EP1981491A2 (en) 2008-10-22
AU2007208054A1 (en) 2007-08-02
US20070254841A1 (en) 2007-11-01
WO2007087609A3 (en) 2007-11-29
CA2636646A1 (en) 2007-08-02
EP1981491A4 (en) 2009-09-23

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