JP2014521606A - 眼表面アレルギーの処置のための組成物および方法 - Google Patents
眼表面アレルギーの処置のための組成物および方法 Download PDFInfo
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- JP2014521606A JP2014521606A JP2014521778A JP2014521778A JP2014521606A JP 2014521606 A JP2014521606 A JP 2014521606A JP 2014521778 A JP2014521778 A JP 2014521778A JP 2014521778 A JP2014521778 A JP 2014521778A JP 2014521606 A JP2014521606 A JP 2014521606A
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- bromfenac
- ocular surface
- polymer
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Abstract
Description
医薬を眼に局所(topical)投与して眼表面アレルギーを処置するには、様々な要素が重要であるが、その中でも、投与量の快適性、制御、粘稠度および正確性、何らかの視覚妨害の種類および時間、投与容易性、投与量を投与しなければならない回数、ならびに送達のタイミングがある。眼表面アレルギーを処置するための従来の眼科用送達システムは、それらの領域の1つ以上における欠点について悩まされていた。
本発明は一般に、季節性アレルゲンおよびその他のアレルゲン、例えば動物の鱗屑および動物の毛による眼表面アレルギーを含む眼表面アレルギーの処置に関する。本明細書において使用される場合、「眼季節性アレルギー」という用語は、アレルゲンによるアレルギー性結膜炎の症状および徴候を意味する。低用量のブロムフェナク(非ステロイド性抗炎症薬(NSAID))と、流動性粘膜付着性ポリマーとを含有する局所眼科用製剤が使用される。本出願人らは、該方法が眼表面アレルギーを有効に処置する(軽度の徴候の処置を含む)ことを見出しただけではなく、予想外のことに、本出願人らは、低投与量のブロムフェナクがこれらの症状を有効に処置することも見出した。
*表3の組成物は、列挙されている4個の血管拡張剤から選択される1個の血管拡張剤を含有する。あるいは、それぞれについて表3に示されている範囲内において、血管拡張剤の組み合わせを組成物に含めてもよいが、組成物中の血管拡張剤の総量は、組成物の0.25重量%を超えるべきではない。
Claims (24)
- 眼表面アレルギーを処置するための眼科用組成物であって、該組成物の0.01重量%〜0.05重量%の量のブロムフェナクと、流動性粘膜付着性ポリマーとを含み、液滴の形態で哺乳動物の眼に投与するために規定された粘度を有する、眼科用組成物。
- 前記流動性粘膜付着性ポリマーが架橋カルボキシ含有ポリマーである、請求項1に記載の眼科用組成物。
- 前記架橋カルボキシ含有ポリマーがポリカルボフィルである、請求項2に記載の眼科用組成物。
- 前記流動性粘膜付着性ポリマーが、前記組成物の約0.5重量%〜約1.5重量%の量である、請求項1に記載の眼科用組成物。
- 前記ブロムフェナクが、前記組成物の0.01重量%〜0.04重量%の量である、請求項1に記載の眼科用組成物。
- 約8.0〜8.6のpHを有する、請求項1に記載の眼科用組成物。
- 前記組成物の前記粘度が、約1,000〜約2,000cpsの範囲内である、請求項1に記載の眼科用組成物。
- 血管拡張剤をさらに含む、請求項1に記載の眼科用組成物。
- 前記血管拡張剤が、塩酸エフェドリン、塩酸ナファゾリン、塩酸フェニレフリンおよび塩酸テトラヒドロゾリンからなる群より選択される、請求項8に記載の眼科用組成物。
- 持続放出ブロムフェナク送達システムであって、眼科用組成物中に流動性粘膜付着性ポリマーと、治療有効量のブロムフェナクとを含み、該流動性粘膜付着性ポリマーが、該組成物の約0.5重量%〜約1.5重量%の量であり、ブロムフェナクが、該組成物の約0.005重量%〜約0.5重量%の量である、持続放出ブロムフェナク送達システム。
- 前記流動性粘膜付着性ポリマーがカルボキシ含有ポリマーである、請求項10に記載の持続放出ブロムフェナク送達システム。
- 前記カルボキシ含有ポリマーがポリカルボフィルである、請求項11に記載の持続放出ブロムフェナク送達システム。
- 前記組成物が約8.0〜8.6のpHを有する、請求項10に記載の持続放出ブロムフェナク送達システム。
- 前記組成物の前記粘度が、約1,000〜約2,000cpsの範囲内である、請求項10に記載の持続放出ブロムフェナク送達システム。
- 血管拡張剤をさらに含む、請求項10に記載の持続放出ブロムフェナク送達システム。
- 眼表面アレルギーを処置する方法であって、
(a)組成物の約0.01重量%〜約0.5重量%の量のブロムフェナクと、組成物の約0.5重量%〜約1.5重量%の量の流動性粘膜付着性ポリマーとを含む眼科用組成物を提供する工程;
(b)眼表面アレルギーの処置を必要とする哺乳動物の眼に該組成物を投与して、該眼の眼表面アレルギーを処置する工程
を含む、方法。 - 前記眼表面アレルギーが、花粉、ブタクサ、樹木、草類およびカビからなる群より選択される季節性アレルゲンによって引き起こされる、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記流動性粘膜付着性ポリマーが架橋カルボキシ含有ポリマーである、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記架橋カルボキシ含有ポリマーがポリカルボフィルである、眼表面アレルギーを処置するための請求項18に記載の方法。
- 前記組成物が1日1回投与される、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記組成物が約8.0〜8.6のpHを有する、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記組成物の粘度が、約1,000〜約2,000cpsの範囲内である、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記ブロムフェナクが、前記組成物の0.01重量%〜0.04重量%の量である、眼表面アレルギーを処置するための請求項16に記載の方法。
- 前記眼科用組成物が血管拡張剤をさらに含む、眼表面アレルギーを処置するための請求項16に記載の方法。
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US13/188,730 US20130023575A1 (en) | 2011-07-22 | 2011-07-22 | Compositions and methods for the treatment of ocular surface allergies |
US13/188,730 | 2011-07-22 | ||
PCT/US2012/047359 WO2013016125A1 (en) | 2011-07-22 | 2012-07-19 | Compositions and methods for the treatment of ocular surface allergies |
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WO2015087267A2 (en) * | 2013-12-12 | 2015-06-18 | Sentiss Pharma Private Limited | Stable bromfenac ophthalmic solution |
US11213480B1 (en) | 2015-08-06 | 2022-01-04 | Hikma Pharmaceuticals International Limited | Phenylephrine hydrochloride ready-to-use solution |
CN111743858B (zh) * | 2019-03-29 | 2023-06-27 | 天津药业研究院股份有限公司 | 一种溴芬酸钠的药物组合物 |
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Also Published As
Publication number | Publication date |
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WO2013016125A1 (en) | 2013-01-31 |
EP2734188A4 (en) | 2014-11-05 |
EP2734188A1 (en) | 2014-05-28 |
US20130023575A1 (en) | 2013-01-24 |
CA2840727A1 (en) | 2013-01-31 |
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