JP2009524676A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009524676A5 JP2009524676A5 JP2008552421A JP2008552421A JP2009524676A5 JP 2009524676 A5 JP2009524676 A5 JP 2009524676A5 JP 2008552421 A JP2008552421 A JP 2008552421A JP 2008552421 A JP2008552421 A JP 2008552421A JP 2009524676 A5 JP2009524676 A5 JP 2009524676A5
- Authority
- JP
- Japan
- Prior art keywords
- indole
- pyrido
- composition
- tetrahydro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 claims 8
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- -1 2- (6-methyl-3-pyridyl) ethyl Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- IPONLHAIQBCUCY-UHFFFAOYSA-N 1h-indole;dihydrochloride Chemical compound Cl.Cl.C1=CC=C2NC=CC2=C1 IPONLHAIQBCUCY-UHFFFAOYSA-N 0.000 claims 1
- CYJQCYXRNNCURD-UHFFFAOYSA-N 2,8-dimethyl-1,3,4,4a,5,9b-hexahydropyrido[4,3-b]indole Chemical compound N1C2=CC=C(C)C=C2C2C1CCN(C)C2 CYJQCYXRNNCURD-UHFFFAOYSA-N 0.000 claims 1
- MUZFLDUALLSEBH-UHFFFAOYSA-N 2,8-dimethyl-1,3,4,5-tetrahydropyrido[4,3-b]indole Chemical compound N1C2=CC=C(C)C=C2C2=C1CCN(C)C2 MUZFLDUALLSEBH-UHFFFAOYSA-N 0.000 claims 1
- TWZCZLLZJDKWFN-UHFFFAOYSA-N 2-benzyl-1,3,4,5-tetrahydropyrido[4,3-b]indole Chemical compound C1CC=2NC3=CC=CC=C3C=2CN1CC1=CC=CC=C1 TWZCZLLZJDKWFN-UHFFFAOYSA-N 0.000 claims 1
- MYUAGMGKBGUWEN-UHFFFAOYSA-N 2-ethyl-1,3,4,5-tetrahydropyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1CCN(CC)C2 MYUAGMGKBGUWEN-UHFFFAOYSA-N 0.000 claims 1
- FYHWPFXPFFPQRT-UHFFFAOYSA-N 2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1CCN(C)C2 FYHWPFXPFFPQRT-UHFFFAOYSA-N 0.000 claims 1
- FAJHPHBADBLSHG-UHFFFAOYSA-N 2-methyl-2,3,4,5-tetrahydro-1h-1,4-benzodiazepin-9-amine Chemical group N1C(C)CNCC2=CC=CC(N)=C21 FAJHPHBADBLSHG-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- YWABBGOBXHZUMB-UHFFFAOYSA-N 5-(2-methylpyridin-3-yl)-1-propyl-1,2,3,4-tetrahydropyrido[4,3-b]indole Chemical compound CCCC1NCCC2=C1C1=CC=CC=C1N2C1=CC=CN=C1C YWABBGOBXHZUMB-UHFFFAOYSA-N 0.000 claims 1
- NGNVOGPUTBVHTL-UHFFFAOYSA-N 5-benzyl-2,8-dimethyl-3,4-dihydro-1h-pyrido[4,3-b]indole Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2CC1=CC=CC=C1 NGNVOGPUTBVHTL-UHFFFAOYSA-N 0.000 claims 1
- 150000008043 acidic salts Chemical class 0.000 claims 1
- 238000011257 definitive treatment Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- JNODQFNWMXFMEV-UHFFFAOYSA-N latrepirdine Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1 JNODQFNWMXFMEV-UHFFFAOYSA-N 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2006101999/15A RU2338537C2 (ru) | 2006-01-25 | 2006-01-25 | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| PCT/US2007/002117 WO2007087425A1 (en) | 2006-01-25 | 2007-01-25 | Methods and compositions for treating schizophrenia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010013671A Division JP2010116412A (ja) | 2006-01-25 | 2010-01-25 | 精神分裂病を治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009524676A JP2009524676A (ja) | 2009-07-02 |
| JP2009524676A5 true JP2009524676A5 (cg-RX-API-DMAC10.html) | 2010-03-11 |
Family
ID=37946164
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552421A Pending JP2009524676A (ja) | 2006-01-25 | 2007-01-25 | 精神分裂病を治療するための方法および組成物 |
| JP2010013671A Withdrawn JP2010116412A (ja) | 2006-01-25 | 2010-01-25 | 精神分裂病を治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010013671A Withdrawn JP2010116412A (ja) | 2006-01-25 | 2010-01-25 | 精神分裂病を治療するための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070225316A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1976518A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2009524676A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007208223A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2640223A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL193014A0 (cg-RX-API-DMAC10.html) |
| RU (1) | RU2338537C2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007087425A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007041697A2 (en) * | 2005-10-04 | 2007-04-12 | Medivation, Inc. | Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease |
| US20110269777A1 (en) * | 2007-08-01 | 2011-11-03 | Medivation Neurology, Inc. | Methods and compositions for treating schizophrenia using antipsychotic combination therapy |
| EP2194980A4 (en) * | 2007-09-20 | 2012-01-18 | D2E Llc | PYRIDO FLUORINE DERIVATIVES [4,3-B] HYDROGENATED INDOLES HAVING NEUROPROTECTIVE AND COGNITIVE PROPERTIES, PREPARATION METHOD AND USE |
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) * | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| JP5666036B2 (ja) * | 2008-01-25 | 2015-02-04 | メディベイション テクノロジーズ， インコーポレイテッド | 新規２，３，４，５−テトラヒドロ−１Ｈ−ピリド［４，３−ｂ］インドール化合物およびその使用方法 |
| TWI498328B (zh) * | 2008-01-25 | 2015-09-01 | Medivation Technologies Inc | 新穎之２，３，４，５－四氫－１ｈ－吡啶并〔４，３－ｂ〕吲哚化合物及其使用方法 |
| WO2009111540A1 (en) * | 2008-03-04 | 2009-09-11 | Medivation Neurology, Inc. | Methods for preparing pyridylethyl-substituted carbolines |
| CN104387382A (zh) | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
| CN102046625B (zh) | 2008-03-24 | 2015-04-08 | 梅迪维新技术公司 | 桥连杂环化合物及其使用方法 |
| RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
| US8569287B2 (en) | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
| CA2742320A1 (en) | 2008-10-31 | 2010-05-06 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| JP5766614B2 (ja) | 2009-01-09 | 2015-08-19 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ | 神経新生促進化合物 |
| US9095572B2 (en) | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| SG173639A1 (en) * | 2009-02-11 | 2011-09-29 | Sunovion Pharmaceuticals Inc | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| EP2236160A3 (en) | 2009-03-31 | 2011-12-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Modified release dimebolin formulations |
| CN102480955B (zh) * | 2009-04-29 | 2015-08-05 | 梅迪维新技术公司 | 吡啶并[4,3-b]吲哚类和使用方法 |
| BRPI1006608A2 (pt) | 2009-04-29 | 2015-08-25 | Medivation Technologies Inc | Composto, método para modular um receptor de histamina em um indivíduo, composição farmacêutica, kit e método para tratar um distúrbio cognitivo ou um distúrbio induzido por pelo menos um sintoma associado com a alteração da cognição |
| JP2013504581A (ja) * | 2009-09-11 | 2013-02-07 | スノヴィオン ファーマシューティカルズ インコーポレイテッド | ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法 |
| US8859561B2 (en) | 2009-09-23 | 2014-10-14 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
| EP2480081A4 (en) * | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | Bridged heterocyclic compounds and methods for their use |
| AU2010298168B2 (en) | 2009-09-23 | 2015-11-19 | Medivation Technologies, Inc. | Pyrido(3,4-b)indoles and methods of use |
| WO2011039686A1 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine oral sustained release dosage forms |
| WO2011039675A2 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine transdermal therapeutic dosage forms |
| WO2011039670A1 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Novel forms of (2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1h-pyrido[4,3-b] indole) |
| RU2425046C1 (ru) * | 2009-12-04 | 2011-07-27 | Сергей Олегович Бачурин | АНТИДЕПРЕССИВНОЕ И ПРОТИВОГИПОКСИЧЕСКОЕ СРЕДСТВО НА ОСНОВЕ СОЛЕЙ 2,8-ДИМЕТИЛ-5-[2-(6-МЕТИЛ-ПИРИДИЛ-3)ЭТИЛ]-2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛА И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ |
| US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
| WO2012016707A2 (en) | 2010-08-06 | 2012-02-09 | Ratiopharm Gmbh | Oral dosage form for the modified release of dimebolin |
| WO2012016708A1 (en) | 2010-08-06 | 2012-02-09 | Ratiopharm Gmbh | Oral dosage form comprising dimebolin and donepezil |
| RU2451686C1 (ru) * | 2010-12-27 | 2012-05-27 | Александр Васильевич Иващенко | ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ |
| US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| WO2012112961A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
| WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
| JP2014505738A (ja) | 2011-02-18 | 2014-03-06 | メディベイション テクノロジーズ， インコーポレイテッド | 高血圧を処置するための化合物および方法 |
| RU2477131C1 (ru) * | 2012-01-17 | 2013-03-10 | Алиса Владимировна Алесенко | СРЕДСТВО ДЛЯ НЕЙТРАЛИЗАЦИИ ТОКСИЧЕСКОГО ДЕЙСТВИЯ ФАКТОРА НЕКРОЗА ОПУХОЛИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ, ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ АУТОИММУННЫХ ЗАБОЛЕВАНИЙ НА ОСНОВЕ НЕЙТРАЛИЗАЦИИ ТОКСИЧЕСКОГО ДЕЙСТВИЯ ФАКТОРА НЕКРОЗА ОПУХОЛИ |
| DE102012003065A1 (de) * | 2012-02-13 | 2013-08-14 | Friedrich-Schiller-Universität Jena | Neue bivalente Gammacarbolinderivate sowie deren Herstellung und Verwendung als Antidementiva |
| RU2495685C1 (ru) * | 2012-04-26 | 2013-10-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) | Способ выбора тактики лечения шизофрении, резистентной к психофармакотерапии |
| EP2887803A4 (en) | 2012-08-24 | 2016-08-03 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| US9902713B2 (en) | 2013-11-11 | 2018-02-27 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| US12084440B2 (en) | 2021-02-01 | 2024-09-10 | Bigespas Ltd. | Polymorph of latrepirdine dihydrochloride |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3419568A (en) * | 1966-12-07 | 1968-12-31 | Abbott Lab | Derivatives of 1,2,3,4-tetrahydro-5h-pyrido[4,3b]indoles |
| US3743740A (en) * | 1968-10-31 | 1973-07-03 | I Zhukova | 3,6-dimethyl - 1,2,3,4,4a,9a - hexahydro-ypsilon-carboline dihydrochloride for treating mental diseases |
| US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
| US3743470A (en) * | 1971-05-06 | 1973-07-03 | Price Co H | Manual beveler and sealer for pipe coatings |
| CS229067B1 (en) * | 1981-08-20 | 1984-04-16 | Svorad Stolc | Medicinal preparation with antiarhythmic and supporting effect applied with hypoxia,and method of preparing active substance thereof |
| US4672117A (en) * | 1985-09-16 | 1987-06-09 | American Home Products Corporation | Antipsychotic gamma-carbolines |
| US4636563A (en) * | 1985-09-16 | 1987-01-13 | American Home Products Corporation | Antipsychotic γ-carbolines |
| RU2067980C1 (ru) * | 1992-06-30 | 1996-10-20 | Глэксо Груп Лимитед | Производные лактама и фармацевтическая композиция, являющаяся антагонистом 5-окситраптамина /5-нт/ на 5- нт3 -рецепторах или их физиологически приемлемые соли и соловаты |
| RU2081117C1 (ru) * | 1992-09-09 | 1997-06-10 | Глэксо Груп Лимитед | Производные лактама или их физиологические приемлемые соли или сольваты |
| US5300645A (en) * | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
| US5631265A (en) * | 1994-03-11 | 1997-05-20 | Eli Lilly And Company | 8-substituted tetrahydro-beta-carbolines |
| GB9418326D0 (en) * | 1994-09-12 | 1994-11-02 | Lilly Industries Ltd | Pharmaceutical compounds |
| RU2140417C1 (ru) * | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
| RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| TW470745B (en) * | 1996-05-23 | 2002-01-01 | Janssen Pharmaceutica Nv | Hexahydro-pyrido[4,3-b]indole derivatives |
| AU2980797A (en) * | 1996-06-11 | 1998-01-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and medicinal uses thereof |
| US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| GB9727546D0 (en) * | 1997-12-31 | 1998-03-18 | Pharmacia & Upjohn Spa | Anthracycline glycosides |
| US6849619B2 (en) * | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| ES2250689T3 (es) * | 2001-08-08 | 2006-04-16 | PHARMACIA & UPJOHN COMPANY LLC | 1h-pirido(4,3-b)indoles terapeuticos. |
| ES2364046T3 (es) * | 2002-12-19 | 2011-08-23 | Bristol-Myers Squibb Company | Gamma-carbolinas tricíclicas sustituidas utilizadas como agonistas y antagonistas de los receptores de la serotonina. |
| US20050101623A1 (en) * | 2003-07-23 | 2005-05-12 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
| US7592454B2 (en) * | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
| WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
| ES2338139T3 (es) * | 2004-12-15 | 2010-05-04 | F. Hoffmann-La Roche Ag | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
| WO2007041697A2 (en) * | 2005-10-04 | 2007-04-12 | Medivation, Inc. | Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease |
-
2006
- 2006-01-25 RU RU2006101999/15A patent/RU2338537C2/ru active
-
2007
- 2007-01-25 JP JP2008552421A patent/JP2009524676A/ja active Pending
- 2007-01-25 AU AU2007208223A patent/AU2007208223A1/en not_active Abandoned
- 2007-01-25 US US11/698,318 patent/US20070225316A1/en not_active Abandoned
- 2007-01-25 CA CA002640223A patent/CA2640223A1/en not_active Abandoned
- 2007-01-25 EP EP07717036A patent/EP1976518A1/en not_active Withdrawn
- 2007-01-25 WO PCT/US2007/002117 patent/WO2007087425A1/en not_active Ceased
-
2008
- 2008-07-24 IL IL193014A patent/IL193014A0/en unknown
-
2010
- 2010-01-25 JP JP2010013671A patent/JP2010116412A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009524676A5 (cg-RX-API-DMAC10.html) | ||
| RU2006101999A (ru) | Средство для лечения шизофрении на основе гидрированных пиридо(4,3-b)индолов (варианты), фармакологическое средство на его основе и способ его применения | |
| JP2007513201A5 (cg-RX-API-DMAC10.html) | ||
| RU2009120048A (ru) | Способы и комбинированные средства для лечения болезни альцгеймера | |
| JP2006143751A5 (cg-RX-API-DMAC10.html) | ||
| JP2008513498A5 (cg-RX-API-DMAC10.html) | ||
| MY163791A (en) | SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS cFMS INHIBITORS | |
| CA2628131A1 (en) | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods | |
| JP2009534368A5 (cg-RX-API-DMAC10.html) | ||
| JP2013541514A5 (cg-RX-API-DMAC10.html) | ||
| WO2011093826A3 (en) | Effervescent formulations comprising cefaclor and clavulanic acid as active agents | |
| MX2010008097A (es) | Acido (-) 2-[1-(7-metil-2-(morfolin-4-il)-4-oxo-4h-pirido [1,2-a] pirimidin-9-il) etilamino]benzoico enantiomericamente puro, su uso en terapia medica, y una composicion farmaceutica que lo comprende - 026. | |
| JP2010155827A5 (cg-RX-API-DMAC10.html) | ||
| RU2006142521A (ru) | Средство для улучшения когнитивных функций и памяти на основе гидрированных пиридо(4,3-b)индолов (варианты), фармакологическое средство на его основе и способ его применения | |
| JP2009533343A5 (cg-RX-API-DMAC10.html) | ||
| JP2008517913A5 (cg-RX-API-DMAC10.html) | ||
| UA92670C2 (ru) | Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе | |
| WO2008010238A3 (en) | Antidiabetic azabicyclo [3. 1. 0] hexan compounds | |
| NZ603108A (en) | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators | |
| MX2009010165A (es) | Nuevas imidazo[4,5-b]piridina-7-carboxamidas 704. | |
| MX2010009395A (es) | Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y procesos para preparacion de los mismos. | |
| JP2007516193A5 (cg-RX-API-DMAC10.html) | ||
| RU2014122858A (ru) | Лечение когнитивных расстройств (r)-7-хлор-n-(хинуклидин-3-ил)бензо[в]тиофен-2-карбосамидом и его фармацевтически приемлемыми солями | |
| MX2014005075A (es) | Formulaciones de sal de meglumina del acido 1-(5,6-dicloro-1h-benz o[d]imidazol-2-il)-1h-pirazol-4-carboxilico. | |
| IL195818A0 (en) | Derivatives of 2-benzoyl-imidazopyridines, preparation ,method thereof and use of same in therapeutics |