JP2009523141A5 - - Google Patents
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- Publication number
- JP2009523141A5 JP2009523141A5 JP2008549782A JP2008549782A JP2009523141A5 JP 2009523141 A5 JP2009523141 A5 JP 2009523141A5 JP 2008549782 A JP2008549782 A JP 2008549782A JP 2008549782 A JP2008549782 A JP 2008549782A JP 2009523141 A5 JP2009523141 A5 JP 2009523141A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- aryl
- halogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003545 alkoxy group Chemical group 0.000 claims 33
- -1 Amino, hydroxyl Chemical group 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 17
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims 14
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims 14
- 125000003282 alkyl amino group Chemical group 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 2
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 2
- GFICWFZTBXUVIG-UHFFFAOYSA-N 6-n,6-n,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Chemical compound CC1N=C(N)NC(N(C)C)=N1 GFICWFZTBXUVIG-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 238000003419 tautomerization reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0600343A FR2896158B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'inhibiteurs de la hmg-coa reductase. |
| PCT/EP2006/012184 WO2007079916A2 (en) | 2006-01-13 | 2006-12-18 | Combination of triazine derivatives and hmg- coa reductase inhibitors for the treatment of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009523141A JP2009523141A (ja) | 2009-06-18 |
| JP2009523141A5 true JP2009523141A5 (enExample) | 2010-02-12 |
Family
ID=36649749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008549782A Pending JP2009523141A (ja) | 2006-01-13 | 2006-12-18 | トリアジン誘導体およびＨＭＧ−ＣｏＡレダクターゼ阻害剤の組合せ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100158999A1 (enExample) |
| EP (1) | EP1978951A2 (enExample) |
| JP (1) | JP2009523141A (enExample) |
| KR (1) | KR20080085208A (enExample) |
| CN (1) | CN101355935A (enExample) |
| AR (1) | AR059031A1 (enExample) |
| AU (1) | AU2006334733A1 (enExample) |
| BR (1) | BRPI0621420A2 (enExample) |
| CA (1) | CA2636840A1 (enExample) |
| EA (1) | EA200801666A1 (enExample) |
| FR (1) | FR2896158B1 (enExample) |
| IL (1) | IL192594A0 (enExample) |
| WO (1) | WO2007079916A2 (enExample) |
| ZA (1) | ZA200806937B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| JP5320399B2 (ja) * | 2007-08-31 | 2013-10-23 | ハナル バイオファーマ カンパニーリミテッド | １，３，５−トリアジン−２，４，６−トリアミン化合物またはその薬学的に許容可能な塩と、それを含む薬学組成物 |
| CA2745854A1 (en) * | 2008-12-12 | 2010-06-17 | Daniel Cravo | Tetrahydrotriazine compounds for treating diseases associated with ampk activity |
| FR2948028B1 (fr) * | 2009-07-17 | 2011-12-02 | Merck Sante Sas | Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine |
| EP2602249B1 (en) * | 2011-12-06 | 2015-08-12 | F.I.S. Fabbrica Italiana Sintetici S.p.A. | Synthesis of rosuvastatin by means of co-crystals |
| CA3102412A1 (en) | 2018-06-06 | 2019-12-12 | Metavant Sciences Gmbh | Methods of treating subjects having diabetes with chronic kidney disease |
| WO2019238647A1 (en) * | 2018-06-14 | 2019-12-19 | Poxel | Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes |
| WO2021117861A1 (ja) * | 2019-12-13 | 2021-06-17 | 大日本住友製薬株式会社 | 製造性及び溶出性に優れた小型錠剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3651816B2 (ja) * | 1995-07-03 | 2005-05-25 | 三共株式会社 | 動脈硬化症予防および治療剤 |
| FR2804113B1 (fr) * | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| EP1510208A1 (en) * | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Pharmaceutical composition comprising a combination of metformin and statin |
-
2006
- 2006-01-13 FR FR0600343A patent/FR2896158B1/fr not_active Expired - Fee Related
- 2006-12-18 WO PCT/EP2006/012184 patent/WO2007079916A2/en not_active Ceased
- 2006-12-18 BR BRPI0621420-7A patent/BRPI0621420A2/pt not_active IP Right Cessation
- 2006-12-18 US US12/160,504 patent/US20100158999A1/en not_active Abandoned
- 2006-12-18 EP EP06829705A patent/EP1978951A2/en not_active Withdrawn
- 2006-12-18 CN CNA2006800508489A patent/CN101355935A/zh active Pending
- 2006-12-18 EA EA200801666A patent/EA200801666A1/ru unknown
- 2006-12-18 CA CA002636840A patent/CA2636840A1/en not_active Abandoned
- 2006-12-18 AU AU2006334733A patent/AU2006334733A1/en not_active Abandoned
- 2006-12-18 JP JP2008549782A patent/JP2009523141A/ja active Pending
- 2006-12-18 KR KR1020087019392A patent/KR20080085208A/ko not_active Withdrawn
-
2007
- 2007-01-12 AR ARP070100137A patent/AR059031A1/es unknown
-
2008
- 2008-07-02 IL IL192594A patent/IL192594A0/en unknown
- 2008-08-12 ZA ZA200806937A patent/ZA200806937B/xx unknown
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