JP2009521496A5 - - Google Patents

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Publication number
JP2009521496A5
JP2009521496A5 JP2008547744A JP2008547744A JP2009521496A5 JP 2009521496 A5 JP2009521496 A5 JP 2009521496A5 JP 2008547744 A JP2008547744 A JP 2008547744A JP 2008547744 A JP2008547744 A JP 2008547744A JP 2009521496 A5 JP2009521496 A5 JP 2009521496A5
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JP
Japan
Prior art keywords
seq
amino acid
acid sequence
set forth
lcvr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2008547744A
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English (en)
Japanese (ja)
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JP2009521496A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/062397 external-priority patent/WO2007076391A1/en
Publication of JP2009521496A publication Critical patent/JP2009521496A/ja
Publication of JP2009521496A5 publication Critical patent/JP2009521496A5/ja
Ceased legal-status Critical Current

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JP2008547744A 2005-12-23 2006-12-20 TGF−β結合組成物 Ceased JP2009521496A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75395605P 2005-12-23 2005-12-23
PCT/US2006/062397 WO2007076391A1 (en) 2005-12-23 2006-12-20 Tgf-beta binding compositions

Publications (2)

Publication Number Publication Date
JP2009521496A JP2009521496A (ja) 2009-06-04
JP2009521496A5 true JP2009521496A5 (https=) 2010-02-12

Family

ID=37898733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547744A Ceased JP2009521496A (ja) 2005-12-23 2006-12-20 TGF−β結合組成物

Country Status (10)

Country Link
US (3) US7494651B2 (https=)
EP (1) EP1966243B1 (https=)
JP (1) JP2009521496A (https=)
CN (1) CN101346394B (https=)
AT (1) ATE545657T1 (https=)
AU (1) AU2006330542B2 (https=)
BR (1) BRPI0620240A2 (https=)
CA (1) CA2632799A1 (https=)
ES (1) ES2379194T3 (https=)
WO (1) WO2007076391A1 (https=)

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EP1740615B1 (en) * 2004-03-31 2014-11-05 Genentech, Inc. Humanized anti-tgf-beta antibodies
EP1966243B1 (en) * 2005-12-23 2012-02-15 Eli Lilly And Company Tgf-beta binding antibodies
US8350006B2 (en) * 2008-10-24 2013-01-08 Mead Johnson Nutrition Company Methods for determining the bioactivity of TGF-β in a composition
JP5818688B2 (ja) * 2009-01-08 2015-11-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 核酸増幅反応の効率を改善するための方法および組成物
WO2010124276A2 (en) * 2009-04-24 2010-10-28 Vanderbilt Universtiy Anti-tgf-beta induction of bone cell function and bone growth
CN103732623B (zh) * 2011-06-03 2017-09-29 佐马技术有限公司 对TGF‑β具有特异性的抗体
CA2866378A1 (en) 2012-03-08 2013-09-12 Selig Sealing Products, Inc. Container sealing member with protected security component and removal tab
US9518112B2 (en) 2012-03-08 2016-12-13 Ludwig Institute For Cancer Research Ltd TGF-β1 specific antibodies and methods and uses thereof
HRP20181939T4 (hr) * 2013-03-20 2022-05-13 Genzyme Corporation Postupci za liječenje osteogenesis imperfecta
WO2016024628A1 (ja) * 2014-08-14 2016-02-18 学校法人東京医科大学 樹状細胞の抗癌免疫賦活能の促進方法およびその用途
WO2016115345A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Treatment of cancer with anti-lap monoclonal antibodies
TWI733661B (zh) 2015-03-04 2021-07-21 美商健臻公司 以高親合性、結合性及特異性結合轉化生長因子-β1的經修飾IgG抗體
TWI726870B (zh) 2015-03-04 2021-05-11 美商健臻公司 具有高親和性、結合性及專一性之結合轉形生長因子-β1的scFv-Fc二聚體
EP3770171A1 (en) 2015-04-03 2021-01-27 XOMA Technology Ltd. Treatment of cancer using inhibitors of tgf-beta and pd-1
US10723793B2 (en) 2015-06-12 2020-07-28 Ludwig Institute For Cancer Research, Ltd. TGF-β3 specific antibodies and methods and uses thereof
AU2017268234A1 (en) 2016-05-17 2018-12-13 Genentech, Inc. Stromal gene signatures for diagnosis and use in immunotherapy
GB201610044D0 (en) 2016-06-08 2016-07-20 Ucb Biopharma Sprl Antibodies
WO2018128939A1 (en) 2017-01-05 2018-07-12 Gensun Biopharma Inc. Checkpoint regulator antagonists
TWI832600B (zh) * 2017-01-20 2024-02-11 美商健臻公司 骨靶向抗體
TW201923089A (zh) 2017-11-06 2019-06-16 美商建南德克公司 癌症之診斷及治療方法
US10597453B2 (en) 2018-06-29 2020-03-24 Gensun Biopharma, Inc. Antitumor immune checkpoint regulator antagonists
CN113613725B (zh) 2018-11-05 2025-09-23 路德维格癌症研究所有限公司 人源化和变体TGF-β1特异性抗体及其方法和用途
EP3877053A1 (en) 2018-11-05 2021-09-15 Ludwig Institute for Cancer Research Ltd Humanized and variant tgf-beta3 specific antibodies and methods and uses thereof
CN114340735B (zh) 2019-06-28 2024-11-12 璟尚生物制药公司 突变的TGFβ1-RII胞外域和免疫球蛋白支架组成的抗肿瘤拮抗剂
AU2020322474A1 (en) 2019-08-01 2022-03-10 Vaccinex,Inc. Combined inhibition of semaphorin-4D and TGFβ and compositions therefor
WO2021167703A1 (en) 2020-02-19 2021-08-26 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof
CN113563473A (zh) 2020-04-29 2021-10-29 三生国健药业(上海)股份有限公司 四价双特异性抗体、其制备方法和用途
US20220119513A1 (en) * 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US20240002479A1 (en) * 2020-11-23 2024-01-04 The Regents Of The University Of Michigan Single-chain antibody against flavivirus ns1 protein
EP4251645A1 (en) 2020-11-25 2023-10-04 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
CN112940119B (zh) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 一种单克隆抗体及其与间充质干细胞外泌体的联合应用
CN115707716A (zh) * 2021-08-18 2023-02-21 丹生医药技术(上海)有限公司 一种TGF-β/VEGF双功能抗体融合蛋白
WO2023080900A1 (en) 2021-11-05 2023-05-11 Genentech, Inc. Methods and compositions for classifying and treating kidney cancer
CN119213034A (zh) 2022-05-17 2024-12-27 苏州创胜医药集团有限公司 双功能蛋白质及其制剂和用途
WO2024077095A1 (en) 2022-10-05 2024-04-11 Genentech, Inc. Methods and compositions for classifying and treating bladder cancer
EP4599088A1 (en) 2022-10-05 2025-08-13 Genentech, Inc. Methods and compositions for classifying and treating lung cancer
TW202434643A (zh) * 2023-01-09 2024-09-01 大陸商北京拓界生物醫藥科技有限公司 TGFβ1結合分子、GARP-TGFβ1結合分子及其醫藥用途

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
WO2005010049A2 (en) * 2003-07-09 2005-02-03 Eli Lilly And Company Tgf-beta1 ligands
EP1740615B1 (en) * 2004-03-31 2014-11-05 Genentech, Inc. Humanized anti-tgf-beta antibodies
EP1966243B1 (en) * 2005-12-23 2012-02-15 Eli Lilly And Company Tgf-beta binding antibodies

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