JP2009515893A5 - - Google Patents
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- Publication number
- JP2009515893A5 JP2009515893A5 JP2008540236A JP2008540236A JP2009515893A5 JP 2009515893 A5 JP2009515893 A5 JP 2009515893A5 JP 2008540236 A JP2008540236 A JP 2008540236A JP 2008540236 A JP2008540236 A JP 2008540236A JP 2009515893 A5 JP2009515893 A5 JP 2009515893A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- cycloalkyl
- alkoxy
- cycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73656405P | 2005-11-14 | 2005-11-14 | |
| US84533106P | 2006-09-18 | 2006-09-18 | |
| US84529106P | 2006-09-18 | 2006-09-18 | |
| PCT/US2006/043920 WO2007070201A1 (en) | 2005-11-14 | 2006-11-13 | Aspartic protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515893A JP2009515893A (ja) | 2009-04-16 |
| JP2009515893A5 true JP2009515893A5 (enExample) | 2010-07-15 |
Family
ID=37812974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540236A Withdrawn JP2009515893A (ja) | 2005-11-14 | 2006-11-13 | アスパラギン酸プロテアーゼ抑制剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8487108B2 (enExample) |
| EP (1) | EP1966139B1 (enExample) |
| JP (1) | JP2009515893A (enExample) |
| KR (1) | KR101379663B1 (enExample) |
| AR (1) | AR057890A1 (enExample) |
| AT (1) | ATE538092T1 (enExample) |
| AU (1) | AU2006325322B2 (enExample) |
| BR (1) | BRPI0618585A2 (enExample) |
| CA (1) | CA2628952C (enExample) |
| NO (1) | NO20082108L (enExample) |
| NZ (1) | NZ568042A (enExample) |
| PE (2) | PE20070804A1 (enExample) |
| SG (1) | SG169983A1 (enExample) |
| TW (1) | TWI411607B (enExample) |
| WO (1) | WO2007070201A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0516132A (pt) | 2004-10-07 | 2007-12-04 | Vitae Pharmaceuticals Inc | compostos, composição destes, método de antagonização de uma ou mais proteases aspárticas e método para tratar ou melhorar um distúrbio mediado por protease aspártica |
| US20090275581A1 (en) * | 2006-04-05 | 2009-11-05 | Baldwin John J | Renin inhibitors |
| WO2007117557A2 (en) | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Diaminopropanol renin inhibitors |
| WO2007117560A2 (en) * | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Piperidine and morpholine renin inhibitors |
| EP2010488A2 (en) * | 2006-04-05 | 2009-01-07 | Vitae Pharmaceuticals, Inc. | Renin inhibitors |
| CL2007002689A1 (es) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
| JP2010503682A (ja) * | 2006-09-18 | 2010-02-04 | ビテ ファーマシューティカルズ， インコーポレイテッド | レニン阻害剤としてのピペリジン誘導体 |
| WO2009038719A1 (en) * | 2007-09-17 | 2009-03-26 | Vitae Pharmaceuticals, Inc. | Process for the preparation of renin inhibitors |
| WO2009038715A1 (en) * | 2007-09-17 | 2009-03-26 | Vitae Pharmaceuticals, Inc. | Process for the preparation of renin inhibitors |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| CN102088850A (zh) * | 2008-06-26 | 2011-06-08 | 生命医药公司 | 甲基2-((r)-(3-氯苯基)((r)-1-((s)-2-(甲氨基)-3((r)-四氢-2h-吡喃-3-基)丙基氨甲酰基)哌啶-3-基)甲氧基)氨基甲酸乙酯的盐 |
| US20100010228A1 (en) * | 2008-06-26 | 2010-01-14 | Vitae Pharmaceuticals, Inc. | Process for the asymmetric reduction of 3-benzoylpiperidines |
| DK2308877T3 (da) | 2008-08-05 | 2014-04-22 | Daiichi Sankyo Co Ltd | Imidazopyridin-2-on-derivater |
| WO2010111634A2 (en) * | 2009-03-26 | 2010-09-30 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| US20110021570A1 (en) | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| AR077692A1 (es) | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| WO2012081582A1 (ja) * | 2010-12-15 | 2012-06-21 | 国立大学法人北海道大学 | ジアステレオ選択的にアルコール化合物を製造する方法及びルテニウム化合物 |
| WO2012081585A1 (ja) * | 2010-12-15 | 2012-06-21 | 国立大学法人北海道大学 | 光学活性アルコール化合物の製造方法 |
| BR112015003393A2 (pt) | 2012-08-16 | 2017-07-04 | Janssen Pharmaceutica Nv | pirazóis substituídos como bloqueadores de canal de cálcio de tipo-n |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| GB201706102D0 (en) | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| CA3173676A1 (en) * | 2020-04-24 | 2021-10-28 | Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd. | A formulation for treating ophthalmic conditions |
| CN116490507A (zh) | 2020-09-10 | 2023-07-25 | 薛定谔公司 | 用于治疗癌症的杂环包缩合cdc7激酶抑制剂 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| TW202300150A (zh) | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| AR129265A1 (es) | 2022-05-12 | 2024-08-07 | Syngenta Crop Protection Ag | Compuestos de alcoxi-heteroaril-carboxamida o tioamida |
| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| JP2026500298A (ja) | 2022-12-15 | 2026-01-06 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物剤として有用である新規な二環式カルボキサミド化合物 |
| CN116987090B (zh) * | 2023-07-25 | 2025-06-27 | 乳源东阳光药业有限公司 | (4aR,7aS)-6-(2,2-二乙氧基乙基)六氢-5H-[1,4]二恶烷并[2,3-c]吡咯的合成方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3071618A (en) | 1956-02-02 | 1963-01-01 | Pfizer & Co C | Diquaternary ammonium salts of n, n, n', n'-tetra substituted alkylene diamines |
| GB1351761A (en) | 1971-02-04 | 1974-05-01 | Wilkinson Sword Ltd | Substituted p-menthane carboxamides and compositions containing them |
| US4136163A (en) | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
| JPS5115098A (ja) | 1974-07-26 | 1976-02-06 | Asahi Chemical Ind | Akurirukeiseniseihinno shorihoho |
| US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| GB8810067D0 (en) | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| US4908372A (en) | 1988-10-13 | 1990-03-13 | Merrell Dow Pharmaceuticals Inc. | Antihistaminic piperidinyl benzimidazoles |
| US5696270A (en) | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
| DE4018070A1 (de) | 1990-06-06 | 1991-12-12 | Bayer Ag | Morpholinoharnstoff-derivate |
| EP0561973A1 (en) | 1990-12-14 | 1993-09-29 | Merrell Dow Pharmaceuticals Inc. | Antiallergic compounds |
| DE69330823T2 (de) | 1992-02-13 | 2002-05-02 | Merrell Pharmaceuticals Inc., Cincinnati | Thiacyclische piperidinylderivate |
| EP0773921B1 (en) | 1994-07-29 | 1999-12-01 | Abbott Laboratories | Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane |
| US6162927A (en) | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
| US6946481B1 (en) | 1994-08-19 | 2005-09-20 | Abbott Laboratories | Endothelin antagonists |
| US5767144A (en) | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| CA2291157A1 (en) | 1997-05-29 | 1998-12-03 | Eli Lilly And Company | Process for preparing heterocyclic compounds |
| AU3716499A (en) | 1998-04-21 | 1999-11-08 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| GB9826540D0 (en) | 1998-12-02 | 1999-01-27 | Darwin Discovery Ltd | Process |
| US6613764B1 (en) * | 1999-01-06 | 2003-09-02 | The United States Of America As Represented By The Department Of Health And Human Services | Aspartic protease inhibitors |
| JP2000302757A (ja) | 1999-04-16 | 2000-10-31 | Shiseido Co Ltd | Ｎ−置換ピペリジン誘導体 |
| OA12323A (en) | 2000-03-21 | 2006-05-15 | Smithkline Beecham Corp | Protease inhibitors. |
| US6900329B2 (en) | 2001-03-21 | 2005-05-31 | Schering Corporation | MCH antagonists and their use in the treatment of obesity |
| AU2002320490B2 (en) | 2001-07-11 | 2008-10-02 | Elan Pharmaceuticals, Inc. | N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds |
| AR039555A1 (es) * | 2001-11-08 | 2005-02-23 | Upjohn Co | Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano |
| TW200408645A (en) | 2002-04-26 | 2004-06-01 | Gilead Sciences Inc | Non nucleoside reverse transcriptase inhibitors |
| WO2004002483A1 (en) * | 2002-06-27 | 2004-01-08 | Actelion Pharmaceuticals Ltd | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer’s disease |
| US7557137B2 (en) | 2002-08-05 | 2009-07-07 | Bristol-Myers Squibb Company | Gamma-lactams as beta-secretase inhibitors |
| AU2003273310A1 (en) | 2002-09-10 | 2004-04-30 | Pharmacia And Upjohn | Substituted aminoethers for the treatment of alzheimer's disease |
| AU2004290499C1 (en) | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US20070093492A1 (en) | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
| CA2576971A1 (en) | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| BRPI0516132A (pt) * | 2004-10-07 | 2007-12-04 | Vitae Pharmaceuticals Inc | compostos, composição destes, método de antagonização de uma ou mais proteases aspárticas e método para tratar ou melhorar um distúrbio mediado por protease aspártica |
| EP1882684B1 (en) | 2005-05-19 | 2014-12-10 | Astellas Pharma Inc. | Pyrrolidine derivative or salt thereof |
| WO2007117560A2 (en) | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Piperidine and morpholine renin inhibitors |
| WO2007117557A2 (en) | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Diaminopropanol renin inhibitors |
| CL2007002689A1 (es) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
| JP2010503682A (ja) | 2006-09-18 | 2010-02-04 | ビテ ファーマシューティカルズ， インコーポレイテッド | レニン阻害剤としてのピペリジン誘導体 |
| US20100160424A1 (en) | 2007-06-20 | 2010-06-24 | Baldwin John J | Renin inhibitors |
| WO2009096996A1 (en) | 2007-06-20 | 2009-08-06 | Smithkline Beecham Corporation | Renin inhibitors |
| US7773441B2 (en) * | 2008-06-18 | 2010-08-10 | Micron Technology, Inc. | Memory malfunction prediction system and method |
| WO2009154766A1 (en) | 2008-06-20 | 2009-12-23 | Vitae Pharmaceuticals, Inc. | Renin inhibitors and method of use thereof |
| CN102088850A (zh) | 2008-06-26 | 2011-06-08 | 生命医药公司 | 甲基2-((r)-(3-氯苯基)((r)-1-((s)-2-(甲氨基)-3((r)-四氢-2h-吡喃-3-基)丙基氨甲酰基)哌啶-3-基)甲氧基)氨基甲酸乙酯的盐 |
| AR077692A1 (es) | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
-
2006
- 2006-10-31 TW TW095140163A patent/TWI411607B/zh not_active IP Right Cessation
- 2006-11-13 SG SG201101062-6A patent/SG169983A1/en unknown
- 2006-11-13 CA CA2628952A patent/CA2628952C/en not_active Expired - Fee Related
- 2006-11-13 US US12/084,928 patent/US8487108B2/en not_active Expired - Fee Related
- 2006-11-13 AU AU2006325322A patent/AU2006325322B2/en not_active Ceased
- 2006-11-13 NZ NZ568042A patent/NZ568042A/en not_active IP Right Cessation
- 2006-11-13 WO PCT/US2006/043920 patent/WO2007070201A1/en not_active Ceased
- 2006-11-13 PE PE2006001432A patent/PE20070804A1/es not_active Application Discontinuation
- 2006-11-13 AT AT06837406T patent/ATE538092T1/de active
- 2006-11-13 JP JP2008540236A patent/JP2009515893A/ja not_active Withdrawn
- 2006-11-13 BR BRPI0618585-1A patent/BRPI0618585A2/pt not_active IP Right Cessation
- 2006-11-13 KR KR1020087014407A patent/KR101379663B1/ko not_active Expired - Fee Related
- 2006-11-13 EP EP06837406A patent/EP1966139B1/en active Active
- 2006-11-14 AR ARP060104967A patent/AR057890A1/es unknown
-
2008
- 2008-05-07 NO NO20082108A patent/NO20082108L/no not_active Application Discontinuation
-
2010
- 2010-08-06 PE PE2010000496A patent/PE20120229A1/es not_active Application Discontinuation
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