JP2009514899A - チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 - Google Patents
チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 Download PDFInfo
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- JP2009514899A JP2009514899A JP2008539136A JP2008539136A JP2009514899A JP 2009514899 A JP2009514899 A JP 2009514899A JP 2008539136 A JP2008539136 A JP 2008539136A JP 2008539136 A JP2008539136 A JP 2008539136A JP 2009514899 A JP2009514899 A JP 2009514899A
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- Prior art keywords
- pyridin
- phenyl
- compound
- amino
- mammal
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- 229940125670 thienopyridine Drugs 0.000 title abstract description 3
- 239000002175 thienopyridine Substances 0.000 title abstract description 3
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title description 2
- 229940102297 B-raf kinase inhibitor Drugs 0.000 title 1
- 239000002774 b raf kinase inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 59
- -1 thienopyridine compound Chemical class 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 218
- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 claims description 54
- 101100381978 Mus musculus Braf gene Proteins 0.000 claims description 54
- 241000124008 Mammalia Species 0.000 claims description 44
- 108091000080 Phosphotransferase Proteins 0.000 claims description 41
- 102000020233 phosphotransferase Human genes 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 239000012453 solvate Substances 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- 230000001404 mediated effect Effects 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 6
- 229910052796 boron Inorganic materials 0.000 claims description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- LCLZFKKNWQGXDP-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C=CC(=CC=4)C(F)(F)F)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 LCLZFKKNWQGXDP-UHFFFAOYSA-N 0.000 claims description 3
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- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 3
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- GUGOWVXOJCARSB-UHFFFAOYSA-N n-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-2-phenylacetamide Chemical compound C1=2SC=C(C=3C=C(NC(=O)CC=4C=CC=CC=4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 GUGOWVXOJCARSB-UHFFFAOYSA-N 0.000 claims description 3
- VGQPVNJKBMPKFK-UHFFFAOYSA-N n-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(trifluoromethyl)benzamide Chemical compound C1=2SC=C(C=3C=C(NC(=O)C=4C=C(C=CC=4)C(F)(F)F)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 VGQPVNJKBMPKFK-UHFFFAOYSA-N 0.000 claims description 3
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- YYSRZYPRBXVEIU-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(2,6-difluorophenyl)urea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C(=CC=CC=4F)F)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 YYSRZYPRBXVEIU-UHFFFAOYSA-N 0.000 claims description 2
- UGZBHWFAAFZIDJ-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(3,5-dimethyl-1,2-oxazol-4-yl)urea Chemical compound CC1=NOC(C)=C1NC(=O)NC1=CC=CC(C=2C3=C(N)N=CC(=C3SC=2)C=2C=NC=CC=2)=C1 UGZBHWFAAFZIDJ-UHFFFAOYSA-N 0.000 claims description 2
- UTVLJNYAYZKYFZ-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(3-methoxyphenyl)urea Chemical compound COC1=CC=CC(NC(=O)NC=2C=C(C=CC=2)C=2C3=C(N)N=CC(=C3SC=2)C=2C=NC=CC=2)=C1 UTVLJNYAYZKYFZ-UHFFFAOYSA-N 0.000 claims description 2
- HXFBGOIUOJUBQE-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-(4-phenylmethoxyphenyl)urea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C=CC(OCC=5C=CC=CC=5)=CC=4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 HXFBGOIUOJUBQE-UHFFFAOYSA-N 0.000 claims description 2
- GUGXYRKRBNBSOR-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C(=CC=C(C=4)C(F)(F)F)F)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 GUGXYRKRBNBSOR-UHFFFAOYSA-N 0.000 claims description 2
- DRBFRYQLZCMILT-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C=C(C(Cl)=CC=4)C(F)(F)F)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 DRBFRYQLZCMILT-UHFFFAOYSA-N 0.000 claims description 2
- PLYXLANLVDYNNM-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-benzylurea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NCC=4C=CC=CC=4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 PLYXLANLVDYNNM-UHFFFAOYSA-N 0.000 claims description 2
- ORVLYSPTAVNDEK-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-cyclohexylurea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC4CCCCC4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 ORVLYSPTAVNDEK-UHFFFAOYSA-N 0.000 claims description 2
- JJMLDNZHKBGHNA-UHFFFAOYSA-N 1-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-3-phenylurea Chemical compound C1=2SC=C(C=3C=C(NC(=O)NC=4C=CC=CC=4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 JJMLDNZHKBGHNA-UHFFFAOYSA-N 0.000 claims description 2
- SDTYPDLXSIGNRO-UHFFFAOYSA-N 5-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)-n-[3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide Chemical compound C1=2SC=C(C=3C=C4CCN(C4=CC=3)C(=O)NC=3C=C(C=CC=3)C(F)(F)F)C=2C(N)=NC=C1C1=CC=CN=C1 SDTYPDLXSIGNRO-UHFFFAOYSA-N 0.000 claims description 2
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- ITQPAYAQGJMSTK-UHFFFAOYSA-N n-[3-(4-amino-7-pyridin-3-ylthieno[3,2-c]pyridin-3-yl)phenyl]-2-thiophen-2-ylacetamide Chemical compound C1=2SC=C(C=3C=C(NC(=O)CC=4SC=CC=4)C=CC=3)C=2C(N)=NC=C1C1=CC=CN=C1 ITQPAYAQGJMSTK-UHFFFAOYSA-N 0.000 claims description 2
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- 239000002893 slag Substances 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical class [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- OOORQXGLIKPNDK-UHFFFAOYSA-N tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydroindole-1-carboxylate Chemical compound C=1C=C2N(C(=O)OC(C)(C)C)CCC2=CC=1B1OC(C)(C)C(C)(C)O1 OOORQXGLIKPNDK-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73356605P | 2005-11-04 | 2005-11-04 | |
| PCT/US2006/060145 WO2007056625A2 (en) | 2005-11-04 | 2006-10-23 | Thienopyridine b-raf kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514899A true JP2009514899A (ja) | 2009-04-09 |
| JP2009514899A5 JP2009514899A5 (enExample) | 2009-07-16 |
Family
ID=38024028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539136A Pending JP2009514899A (ja) | 2005-11-04 | 2006-10-23 | チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080255184A1 (enExample) |
| EP (1) | EP1951728A4 (enExample) |
| JP (1) | JP2009514899A (enExample) |
| WO (1) | WO2007056625A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013534902A (ja) * | 2010-03-25 | 2013-09-09 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202363B2 (en) | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
| WO2009111278A2 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| US8394795B2 (en) * | 2008-02-29 | 2013-03-12 | Array Biopharma Inc. | Pyrazole [3, 4-B] pyridine Raf inhibitors |
| CA2716949A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
| CA2716947A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
| ES2524966T3 (es) | 2008-12-05 | 2014-12-16 | Abbvie Bahamas Ltd. | Derivados de tieno[3,2-c]piridina como inhibidores de quinasas para uso en el tratamiento del cáncer |
| US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| US8436179B2 (en) | 2011-07-20 | 2013-05-07 | Abbvie Inc. | Kinase inhibitor with improved solubility profile |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| WO2019133810A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| CN119638639A (zh) * | 2024-12-10 | 2025-03-18 | 中国药科大学 | 具有抗细胞坏死性凋亡活性的联芳基类化合物及其衍生物与应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005010009A1 (en) * | 2003-07-24 | 2005-02-03 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| WO2005028444A1 (en) * | 2003-09-24 | 2005-03-31 | Novartis Ag | 1,4-disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases |
| WO2005047292A1 (de) * | 2003-11-04 | 2005-05-26 | Merck Patent Gmbh | Verwendung von thienopyrimidinen |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0121490D0 (en) * | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Ciompounds |
| US7144885B2 (en) * | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
| US20050020619A1 (en) * | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
-
2006
- 2006-10-23 JP JP2008539136A patent/JP2009514899A/ja active Pending
- 2006-10-23 EP EP06839498A patent/EP1951728A4/en not_active Withdrawn
- 2006-10-23 US US12/090,575 patent/US20080255184A1/en not_active Abandoned
- 2006-10-23 WO PCT/US2006/060145 patent/WO2007056625A2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005010009A1 (en) * | 2003-07-24 | 2005-02-03 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| WO2005028444A1 (en) * | 2003-09-24 | 2005-03-31 | Novartis Ag | 1,4-disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases |
| WO2005047292A1 (de) * | 2003-11-04 | 2005-05-26 | Merck Patent Gmbh | Verwendung von thienopyrimidinen |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013534902A (ja) * | 2010-03-25 | 2013-09-09 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1951728A4 (en) | 2011-04-20 |
| WO2007056625A3 (en) | 2008-09-12 |
| US20080255184A1 (en) | 2008-10-16 |
| WO2007056625A2 (en) | 2007-05-18 |
| EP1951728A2 (en) | 2008-08-06 |
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