JP2009513660A5 - - Google Patents
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- Publication number
- JP2009513660A5 JP2009513660A5 JP2008537949A JP2008537949A JP2009513660A5 JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5 JP 2008537949 A JP2008537949 A JP 2008537949A JP 2008537949 A JP2008537949 A JP 2008537949A JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5
- Authority
- JP
- Japan
- Prior art keywords
- additional compound
- combination
- fasudil
- combination medicament
- medicament according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 4
- 229960002435 fasudil Drugs 0.000 claims 4
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 claims 2
- 229960003065 bosentan Drugs 0.000 claims 2
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 2
- 229960002240 iloprost Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960003310 sildenafil Drugs 0.000 claims 2
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73027305P | 2005-10-26 | 2005-10-26 | |
| PCT/US2006/041830 WO2007050783A2 (en) | 2005-10-26 | 2006-10-25 | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513660A JP2009513660A (ja) | 2009-04-02 |
| JP2009513660A5 true JP2009513660A5 (OSRAM) | 2009-08-20 |
Family
ID=37814479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537949A Pending JP2009513660A (ja) | 2005-10-26 | 2006-10-25 | 肺動脈性高血圧の治療用併用療法におけるファスジル |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7893050B2 (OSRAM) |
| EP (2) | EP2111863B1 (OSRAM) |
| JP (1) | JP2009513660A (OSRAM) |
| AT (1) | ATE551059T1 (OSRAM) |
| WO (1) | WO2007050783A2 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2580108T3 (es) * | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
| US20070135499A1 (en) * | 2005-07-11 | 2007-06-14 | Aerie Pharmaceuticals, Inc. | Hydrazide compounds |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
| US20090036465A1 (en) * | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010103040A1 (en) * | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension |
| CA2760562C (en) | 2009-05-01 | 2016-07-19 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| KR20180036807A (ko) | 2009-06-12 | 2018-04-09 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| SG178315A1 (en) * | 2009-08-07 | 2012-03-29 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
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| AU2012215606B2 (en) | 2011-02-07 | 2016-12-22 | Scipharm Sarl | Novel composition for the treatment of cystic fibrosis |
| US8871781B2 (en) | 2011-11-30 | 2014-10-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating a subject for a lymphatic malformation |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CA2918369C (en) | 2013-07-18 | 2021-06-29 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| AU2014296032A1 (en) | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| KR102276424B1 (ko) | 2014-10-06 | 2021-07-12 | 삼성전자주식회사 | 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| KR20160049435A (ko) | 2014-10-27 | 2016-05-09 | 삼성전자주식회사 | Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| EP3112466A1 (en) | 2015-07-01 | 2017-01-04 | Samsung Electronics Co., Ltd. | Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof |
| US12048761B2 (en) * | 2015-10-13 | 2024-07-30 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
| JP6832946B2 (ja) | 2015-11-17 | 2021-02-24 | アエリエ ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤およびその中間体の調製方法 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| JP6908283B2 (ja) * | 2016-04-01 | 2021-07-21 | 国立大学法人京都大学 | Fgfr3病の予防または治療剤 |
| CN109640966A (zh) | 2016-08-31 | 2019-04-16 | 爱瑞制药公司 | 眼用组合物 |
| MA46749A (fr) | 2016-11-08 | 2019-09-18 | Reata Pharmaceuticals Inc | Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier |
| SG11201908179UA (en) | 2017-03-31 | 2019-10-30 | Aerie Pharmaceuticals Inc | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| LT3609486T (lt) * | 2017-04-11 | 2021-10-11 | Ceva Santé Animale | Sarpogrelatas, skirtas naudoti žinduolių širdies ligų gydymo būdui |
| US20190125756A1 (en) * | 2017-11-01 | 2019-05-02 | Cipla Limited | Method of treating hypertension |
| US20210338699A1 (en) * | 2018-08-30 | 2021-11-04 | The Trustees Of Indiana University | Materials and methods for suppressing and/or treating cancer and/or cancer treatment induced cardiac toxicity |
| WO2020056345A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US20200360276A1 (en) | 2019-05-16 | 2020-11-19 | Aerovate Therapeutics, Inc. | Inhalable imatinib metabolite formulations, manufacture, and uses thereof |
| JP2023550463A (ja) * | 2020-11-23 | 2023-12-01 | エアロベイト セラピューティクス, インコーポレイテッド | イマチニブ処方物、その製造および使用 |
| US20240252511A1 (en) * | 2021-05-19 | 2024-08-01 | Woolsey Pharmaceuticals, Inc. | Methods of treating depression and anxiety |
| CA3217563A1 (en) * | 2021-05-19 | 2022-11-24 | Thomas Macallister | Methods of treating depression and anxiety |
| US20240415846A1 (en) * | 2021-11-12 | 2024-12-19 | Woolsey Pharmaceuticals, Inc. | Method of treating amyotrophic lateral sclerosis and dosing regimen for same |
| CN118922193A (zh) | 2022-02-17 | 2024-11-08 | 悟而喜制药公司 | 具有离子交换树脂的法舒地尔口服制剂 |
| US20230330100A1 (en) | 2022-02-17 | 2023-10-19 | Woolsey Pharmaceuticals, Inc. | Taste-masking oral formulations of fasudil |
| WO2024238454A2 (en) * | 2023-05-12 | 2024-11-21 | The Texas A&M University System | Compositions and methods for the diagnosis and treatment of microvasculature dysfunction and related diseases |
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|---|---|---|---|---|
| US377393A (en) * | 1888-02-07 | Dyeing or scouring machine | ||
| US2882271A (en) | 1959-04-14 | Xcixcxh | ||
| US56403A (en) * | 1866-07-17 | Improved machine for grinding cutlery | ||
| US3746A (en) * | 1844-09-17 | Improvement in coating iron and copper with tin and other metals | ||
| US326704A (en) * | 1885-09-22 | James h | ||
| US110553A (en) * | 1870-12-27 | Improvement in preventing incrustation of steam-boilers | ||
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| BE578515A (OSRAM) | 1958-05-07 | |||
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| FR1406805A (fr) | 1964-08-17 | 1965-07-23 | Egyt Gyogyszervegyeszeti Gyar | Procédé de préparation de nouveaux éthers basiques de cycloalkanols substitués |
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| US3773939A (en) | 1971-11-24 | 1973-11-20 | Janssen Pharmaceutica Nv | N-arallyl-n'-aralkyl piperazine pharmaceutical compositions |
| BE795735A (fr) | 1972-03-06 | 1973-06-18 | Cerm Cent Europ Rech Mauvernay | Nouvelles ethylenediamines substituees a activite cardiovasculaire |
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| DE2845770A1 (de) | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
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| SI0956865T2 (sl) | 1996-08-12 | 2011-04-29 | Mitsubishi Pharma Corp | Zdravila, ki obsegajo inhibitor Rho-kinaze |
| US6147109A (en) | 1997-10-14 | 2000-11-14 | The General Hospital Corporation | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors |
| US6180597B1 (en) | 1998-03-19 | 2001-01-30 | Brigham And Women's Hospital, Inc. | Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors |
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| JP2003511347A (ja) | 1999-03-19 | 2003-03-25 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | III型内皮細胞一酸化窒素合成酵素のHMG−CoA還元酵素阻害物質による上方制御 |
| US6228843B1 (en) | 1999-04-23 | 2001-05-08 | University Technology Corporation | Method of using PKC inhibiting compounds to treat vascular disease |
| TW200400821A (en) | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| AU2002349411A1 (en) | 2001-11-30 | 2003-06-17 | Asahi Kasei Pharma Corporation | Remedies for primary pulmonary hypertension |
| FR2833840B1 (fr) | 2001-12-21 | 2010-06-18 | Rytek | Methodes et compositions pour le traitement de pathologies respiratoires |
| CA2496797C (en) * | 2002-08-29 | 2012-01-10 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for glaucoma comprising rho kinase inhibitor and prostaglandin |
| CA2412856A1 (en) * | 2002-11-27 | 2004-05-27 | Frederic Bodin | Pharmaceutical composition for the treatment of pulmonary arterial hypertension |
| US20050101608A1 (en) * | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| AT510757B1 (de) | 2010-11-15 | 2014-01-15 | Siemens Ag Oesterreich | System zur fehlersicheren und redundanten übertragung von komplexen daten |
-
2006
- 2006-10-25 AT AT09007232T patent/ATE551059T1/de active
- 2006-10-25 JP JP2008537949A patent/JP2009513660A/ja active Pending
- 2006-10-25 WO PCT/US2006/041830 patent/WO2007050783A2/en not_active Ceased
- 2006-10-25 EP EP09007232A patent/EP2111863B1/en not_active Not-in-force
- 2006-10-25 US US11/588,185 patent/US7893050B2/en not_active Expired - Fee Related
- 2006-10-25 EP EP06826765A patent/EP1951253A2/en not_active Withdrawn
-
2011
- 2011-01-13 US US13/005,954 patent/US20110171139A1/en not_active Abandoned
-
2012
- 2012-09-12 US US13/611,849 patent/US8476259B2/en active Active
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