JP2009513658A - メラニン凝集ホルモン受容体−１拮抗薬としてのチエノピリミジノン誘導体 - Google Patents

メラニン凝集ホルモン受容体−１拮抗薬としてのチエノピリミジノン誘導体 Download PDF

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Publication number
JP2009513658A
JP2009513658A JP2008537932A JP2008537932A JP2009513658A JP 2009513658 A JP2009513658 A JP 2009513658A JP 2008537932 A JP2008537932 A JP 2008537932A JP 2008537932 A JP2008537932 A JP 2008537932A JP 2009513658 A JP2009513658 A JP 2009513658A
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compound
mmol
group
hydrogen
formula
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JP2009513658A5 (enExample
Inventor
ウィリアム・エヌ・ウォッシュバーン
アンドレス・エセ・エルナンデス
マーク・シー・マンフレディ
ジェフリー・エイ・ロブル
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2008537932A 2005-10-26 2006-10-26 メラニン凝集ホルモン受容体−１拮抗薬としてのチエノピリミジノン誘導体 Withdrawn JP2009513658A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73045305P 2005-10-26 2005-10-26
US11/586,255 US8618115B2 (en) 2005-10-26 2006-10-25 Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
PCT/US2006/041725 WO2007050726A2 (en) 2005-10-26 2006-10-26 Thienopyrimidinone derivatives as melanin concentrating hormone receptor-1 antagonists

Publications (2)

Publication Number Publication Date
JP2009513658A true JP2009513658A (ja) 2009-04-02
JP2009513658A5 JP2009513658A5 (enExample) 2009-12-17

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ID=37888159

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008537932A Withdrawn JP2009513658A (ja) 2005-10-26 2006-10-26 メラニン凝集ホルモン受容体−１拮抗薬としてのチエノピリミジノン誘導体

Country Status (16)

Country Link
US (1) US8618115B2 (enExample)
EP (2) EP1948665B1 (enExample)
JP (1) JP2009513658A (enExample)
KR (1) KR20080067681A (enExample)
AR (1) AR056155A1 (enExample)
AU (1) AU2006306140A1 (enExample)
BR (1) BRPI0617945A2 (enExample)
CA (1) CA2627653A1 (enExample)
EA (1) EA016126B1 (enExample)
GE (1) GEP20115213B (enExample)
IL (1) IL190898A0 (enExample)
NO (1) NO20081772L (enExample)
NZ (1) NZ567659A (enExample)
PE (1) PE20070532A1 (enExample)
TW (1) TW200728289A (enExample)
WO (1) WO2007050726A2 (enExample)

Cited By (1)

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JP2023520924A (ja) * 2020-04-08 2023-05-22 リミックス セラピューティクス インコーポレイテッド スプライシングを調節するための化合物及び方法

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US8618115B2 (en) 2013-12-31
CA2627653A1 (en) 2007-05-03
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EP2298776A1 (en) 2011-03-23
EA016126B1 (ru) 2012-02-28
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EP1948665B1 (en) 2013-02-27
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WO2007050726A2 (en) 2007-05-03
KR20080067681A (ko) 2008-07-21
TW200728289A (en) 2007-08-01
US20070093509A1 (en) 2007-04-26
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