JP2009511892A - 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド - Google Patents

抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Download PDF

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JP2009511892A
JP2009511892A JP2008535094A JP2008535094A JP2009511892A JP 2009511892 A JP2009511892 A JP 2009511892A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2008535094 A JP2008535094 A JP 2008535094A JP 2009511892 A JP2009511892 A JP 2009511892A
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Japan
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variable domain
antibody
chain variable
light chain
heavy chain
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Japanese (ja)
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JP2009511892A5 (enExample
Inventor
ジェスパーズ,ローラン
クルーブ,ジャスパー
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ドマンティス リミテッド
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Priority claimed from GB0520644A external-priority patent/GB0520644D0/en
Priority claimed from GB0521140A external-priority patent/GB0521140D0/en
Application filed by ドマンティス リミテッド filed Critical ドマンティス リミテッド
Publication of JP2009511892A publication Critical patent/JP2009511892A/ja
Publication of JP2009511892A5 publication Critical patent/JP2009511892A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008535094A 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド Pending JP2009511892A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0520644A GB0520644D0 (en) 2005-10-11 2005-10-11 Antibody polypeptide library screening and selected antibody polypeptides
GB0521140A GB0521140D0 (en) 2005-10-18 2005-10-18 Antibody polypeptide library screening and selected antibody polypeptides
PCT/GB2006/003781 WO2007042809A2 (en) 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides

Publications (2)

Publication Number Publication Date
JP2009511892A true JP2009511892A (ja) 2009-03-19
JP2009511892A5 JP2009511892A5 (enExample) 2009-10-22

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JP2008535094A Pending JP2009511892A (ja) 2005-10-11 2006-10-11 抗体ポリペプチドライブラリーのスクリーニングと選択された抗体ポリペプチド

Country Status (6)

Country Link
US (1) US20100168393A1 (enExample)
EP (1) EP1951754A2 (enExample)
JP (1) JP2009511892A (enExample)
AU (1) AU2006300951A1 (enExample)
CA (1) CA2625222A1 (enExample)
WO (1) WO2007042809A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法

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* Cited by examiner, † Cited by third party
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EP1355666B1 (en) 2000-12-22 2012-06-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of repulsive guidance molecule (RGM) and its modulators
WO2007039256A2 (de) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
WO2009155723A2 (en) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα
MX345395B (es) 2008-06-25 2017-01-30 Esbatech Alcon Biomed Res Unit Humanizacion de anticuerpos de conejos usando una estructura de anticuerpos universal.
AU2020201002B2 (en) * 2008-06-25 2022-04-07 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
CA2780069C (en) 2009-12-08 2018-07-17 Abbott Gmbh & Co. Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
UY33679A (es) 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles
US9850315B2 (en) 2011-02-01 2017-12-26 Bac Ip B.V. Antigen-binding protein directed against epitope in the CH1 domain of human IgG antibodies
MX391536B (es) 2012-01-27 2025-03-21 Abbvie Deutschland Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas.
CN107814845B (zh) * 2016-09-14 2021-02-09 浙江特瑞思药业股份有限公司 新的抗pd-1纳米抗体及其应用
CN107857816B (zh) * 2017-10-17 2020-11-06 北京大学 一种抗干扰素α-2b纳米抗体及其应用
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN112955465A (zh) 2018-07-03 2021-06-11 马伦戈治疗公司 抗tcr抗体分子及其用途
GB2595980B (en) * 2019-01-04 2023-06-14 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
WO2020172605A1 (en) 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス,インコーポレーテッド T細胞関連のがん細胞に結合する多機能性分子およびその使用
CA3166629A1 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
US20240210419A1 (en) * 2021-06-22 2024-06-27 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interactions and signaling
CN116217723A (zh) * 2021-12-22 2023-06-06 北京世纪沃德生物科技有限公司 一种crp驼源单域抗体及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ErbB2抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
EP1536005A4 (en) * 2002-08-16 2006-05-17 Univ Tokyo METHOD FOR TESTING THE INTERACTION BETWEEN PROTEINS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508397A (ja) * 1997-12-12 2002-03-19 ジェネンテク・インコーポレイテッド 抗ErbB2抗体を用いた治療方法
WO2004065611A1 (ja) * 2003-01-21 2004-08-05 Chugai Seiyaku Kabushiki Kaisha 抗体の軽鎖スクリーニング方法
WO2005058251A2 (en) * 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883985B2 (en) 2010-02-16 2014-11-11 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
US9598501B2 (en) 2010-02-16 2017-03-21 National University Corporation Kyoto Institute Of Technology Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier
JP2017043611A (ja) * 2010-08-16 2017-03-02 ノビミューン エスアー 多重特異性多価抗体の生成方法
US9834615B2 (en) 2010-08-16 2017-12-05 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies
US9926382B2 (en) 2010-08-16 2018-03-27 Novimmune S.A. Methods for the generation of multispecific and multivalent antibodies
US10597465B2 (en) 2010-08-16 2020-03-24 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies

Also Published As

Publication number Publication date
US20100168393A1 (en) 2010-07-01
WO2007042809A3 (en) 2007-07-19
WO2007042809A2 (en) 2007-04-19
EP1951754A2 (en) 2008-08-06
AU2006300951A1 (en) 2007-04-19
CA2625222A1 (en) 2007-04-19

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