CA2625222A1 - Antibody polypeptide library screening and selected antibody polypeptides - Google Patents

Antibody polypeptide library screening and selected antibody polypeptides Download PDF

Info

Publication number
CA2625222A1
CA2625222A1 CA002625222A CA2625222A CA2625222A1 CA 2625222 A1 CA2625222 A1 CA 2625222A1 CA 002625222 A CA002625222 A CA 002625222A CA 2625222 A CA2625222 A CA 2625222A CA 2625222 A1 CA2625222 A1 CA 2625222A1
Authority
CA
Canada
Prior art keywords
antibody
variable domain
chain variable
light chain
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002625222A
Other languages
English (en)
French (fr)
Inventor
Laurent Jespers
Jasper Clube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520644A external-priority patent/GB0520644D0/en
Priority claimed from GB0521140A external-priority patent/GB0521140D0/en
Application filed by Individual filed Critical Individual
Publication of CA2625222A1 publication Critical patent/CA2625222A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002625222A 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides Abandoned CA2625222A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0520644A GB0520644D0 (en) 2005-10-11 2005-10-11 Antibody polypeptide library screening and selected antibody polypeptides
GB0520644.6 2005-10-11
GB0521140A GB0521140D0 (en) 2005-10-18 2005-10-18 Antibody polypeptide library screening and selected antibody polypeptides
GB0521140.4 2005-10-18
PCT/GB2006/003781 WO2007042809A2 (en) 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides

Publications (1)

Publication Number Publication Date
CA2625222A1 true CA2625222A1 (en) 2007-04-19

Family

ID=37943170

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002625222A Abandoned CA2625222A1 (en) 2005-10-11 2006-10-11 Antibody polypeptide library screening and selected antibody polypeptides

Country Status (6)

Country Link
US (1) US20100168393A1 (enExample)
EP (1) EP1951754A2 (enExample)
JP (1) JP2009511892A (enExample)
AU (1) AU2006300951A1 (enExample)
CA (1) CA2625222A1 (enExample)
WO (1) WO2007042809A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355666B1 (en) 2000-12-22 2012-06-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of repulsive guidance molecule (RGM) and its modulators
WO2007039256A2 (de) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
WO2009155723A2 (en) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα
MX345395B (es) 2008-06-25 2017-01-30 Esbatech Alcon Biomed Res Unit Humanizacion de anticuerpos de conejos usando una estructura de anticuerpos universal.
AU2020201002B2 (en) * 2008-06-25 2022-04-07 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
CA2780069C (en) 2009-12-08 2018-07-17 Abbott Gmbh & Co. Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
WO2011102342A1 (ja) 2010-02-16 2011-08-25 国立大学法人京都工芸繊維大学 抗体固定化担体、抗体固定化担体の製造方法および当該抗体固定化担体の利用
PL2606064T3 (pl) 2010-08-16 2015-07-31 Novimmune Sa Sposoby wytwarzania wieloswoistych i wielowartościowych przeciwciał
UY33679A (es) 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles
US9850315B2 (en) 2011-02-01 2017-12-26 Bac Ip B.V. Antigen-binding protein directed against epitope in the CH1 domain of human IgG antibodies
MX391536B (es) 2012-01-27 2025-03-21 Abbvie Deutschland Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas.
CN107814845B (zh) * 2016-09-14 2021-02-09 浙江特瑞思药业股份有限公司 新的抗pd-1纳米抗体及其应用
CN107857816B (zh) * 2017-10-17 2020-11-06 北京大学 一种抗干扰素α-2b纳米抗体及其应用
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN112955465A (zh) 2018-07-03 2021-06-11 马伦戈治疗公司 抗tcr抗体分子及其用途
GB2595980B (en) * 2019-01-04 2023-06-14 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
WO2020172605A1 (en) 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス,インコーポレーテッド T細胞関連のがん細胞に結合する多機能性分子およびその使用
CA3166629A1 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
US20240210419A1 (en) * 2021-06-22 2024-06-27 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interactions and signaling
CN116217723A (zh) * 2021-12-22 2023-06-06 北京世纪沃德生物科技有限公司 一种crp驼源单域抗体及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
ZA9811162B (en) * 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
EP1536005A4 (en) * 2002-08-16 2006-05-17 Univ Tokyo METHOD FOR TESTING THE INTERACTION BETWEEN PROTEINS
US8337841B2 (en) * 2003-01-21 2012-12-25 Chugai Seiyaku Kabushiki Kaisha Methods of screening for antibody light chains
US8354507B2 (en) * 2003-12-15 2013-01-15 Dendreon Corporation HLA-DR specific antibodies, compositions and methods

Also Published As

Publication number Publication date
US20100168393A1 (en) 2010-07-01
WO2007042809A3 (en) 2007-07-19
WO2007042809A2 (en) 2007-04-19
EP1951754A2 (en) 2008-08-06
AU2006300951A1 (en) 2007-04-19
JP2009511892A (ja) 2009-03-19

Similar Documents

Publication Publication Date Title
US20100168393A1 (en) Antibody Polypeptide Libray Screening and Selected Antibody Polypeptides
CA2583417C (en) Antagonists and methods of use therefor
AU2003244817B2 (en) Antigen-binding immunoglobulin single variable domains and dual-specific constructs
AU2008212682B2 (en) Antibody single variable domains against serum albumin
RU2401842C2 (ru) Антагонисты и способы их применения
US20060257406A1 (en) Ligand
JP2009504685A (ja) 新世界霊長類フレームワーク領域を用いる設計された抗体
JP5901517B2 (ja) 抗原結合性タンパク質
US20080233130A1 (en) Ligand that has binding specificity for IL-4 and/or IL-13
US9028822B2 (en) Antagonists against TNFR1 and methods of use therefor
US20080008713A1 (en) Single domain antibodies against tnfr1 and methods of use therefor
JP2009504686A (ja) 新世界霊長類領域を用いるキメラ抗体
CN101312988A (zh) 抗体多肽文库筛选和选择的抗体多肽类
CN101084014A (zh) 抗肿瘤坏死因子受体1的单域抗体及其使用方法
JP2012518399A (ja) 抗原結合性構築物
US20110223168A1 (en) Ligand that has binding specificity for il-4 and/or il-13
AU2013273775A1 (en) Antibody single variable domains against serum albumin
MX2008006882A (en) Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131011