JP2009511583A5 - - Google Patents
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- Publication number
- JP2009511583A5 JP2009511583A5 JP2008535601A JP2008535601A JP2009511583A5 JP 2009511583 A5 JP2009511583 A5 JP 2009511583A5 JP 2008535601 A JP2008535601 A JP 2008535601A JP 2008535601 A JP2008535601 A JP 2008535601A JP 2009511583 A5 JP2009511583 A5 JP 2009511583A5
- Authority
- JP
- Japan
- Prior art keywords
- amyloid
- tissue
- binding
- compound according
- binding compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 35
- 210000001519 tissue Anatomy 0.000 claims 15
- 208000037259 Amyloid Plaque Diseases 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 7
- 210000004556 brain Anatomy 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 210000001638 cerebellum Anatomy 0.000 claims 5
- 230000003941 amyloidogenesis Effects 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 238000001574 biopsy Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 210000005013 brain tissue Anatomy 0.000 claims 2
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000012299 Alzheimer disease 5 Diseases 0.000 claims 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000037048 Prodromal Symptoms Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72478205P | 2005-10-11 | 2005-10-11 | |
| US60/724,782 | 2005-10-11 | ||
| PCT/US2006/039412 WO2007047204A1 (en) | 2005-10-11 | 2006-10-10 | Isotopically-labeled benzofuran compounds as imagingagents foramyloidogenic proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511583A JP2009511583A (ja) | 2009-03-19 |
| JP2009511583A5 true JP2009511583A5 (enExample) | 2009-11-19 |
| JP5557449B2 JP5557449B2 (ja) | 2014-07-23 |
Family
ID=37695002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535601A Active JP5557449B2 (ja) | 2005-10-11 | 2006-10-10 | アミロイド生成性タンパク質の造影剤としての同位体標識ベンゾフラン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8138360B2 (enExample) |
| EP (1) | EP1945622B1 (enExample) |
| JP (1) | JP5557449B2 (enExample) |
| CN (1) | CN101360731B (enExample) |
| AT (1) | ATE539069T1 (enExample) |
| CY (1) | CY1112737T1 (enExample) |
| DK (1) | DK1945622T3 (enExample) |
| ES (1) | ES2379987T3 (enExample) |
| PL (1) | PL1945622T3 (enExample) |
| PT (1) | PT1945622E (enExample) |
| SI (1) | SI1945622T1 (enExample) |
| WO (1) | WO2007047204A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230581B1 (hu) * | 2000-08-24 | 2017-01-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
| US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| US20070244128A1 (en) * | 2005-11-04 | 2007-10-18 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| US8362066B2 (en) * | 2006-11-17 | 2013-01-29 | Treventis Corporation | Compounds and methods for treating protein folding disorders |
| TW200901998A (en) | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| US8557222B2 (en) | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
| US20110160249A1 (en) | 2008-05-23 | 2011-06-30 | Schaab Kevin Murray | 5-lipoxygenase-activating protein inhibitor |
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| CN104274875A (zh) * | 2008-12-22 | 2015-01-14 | 学校法人藤田学园 | Aβ 除去材料、Aβ 除去器和Aβ 除去系统 |
| ES2620177T3 (es) | 2009-10-15 | 2017-06-27 | Guerbet | Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| AP2014007805A0 (en) | 2011-12-28 | 2014-07-31 | Cytokinetics Inc The Regents Of The University Of California | Substituted benzaldehyde compounds and methods fortheir use in increasing tissue oxygenation |
| JP6133053B2 (ja) * | 2012-12-21 | 2017-05-24 | 浜松ホトニクス株式会社 | アミロイドの凝集体の定量方法及びその定量装置 |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| ES2852054T3 (es) | 2013-03-15 | 2021-09-10 | Global Blood Therapeutics Inc | Compuestos y usos de los mismos para la modulación de hemoglobina |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| PE20151900A1 (es) | 2013-03-15 | 2016-01-20 | Global Blood Therapeutics Inc | Compuestos y sus usos para modular la hemoglobina |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2015009988A1 (en) * | 2013-07-19 | 2015-01-22 | The Johns Hopkins University | Cardiac imaging methods and use in diagnosis and treatment of heart failure and related disease |
| WO2015051188A1 (en) * | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2015120133A1 (en) | 2014-02-07 | 2015-08-13 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| RU2681537C2 (ru) * | 2014-04-14 | 2019-03-07 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Амидные производные и их фармацевтически приемлемые соли, способ их получения и медицинское применение |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| JP7114074B2 (ja) | 2015-08-18 | 2022-08-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用 |
| WO2017055627A1 (en) * | 2015-10-02 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Apoc3 mutations for the diagnosis and therapy of hereditary renal amyloidosis disease |
| SG10201912511WA (en) | 2015-12-04 | 2020-02-27 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| TWI644665B (zh) * | 2017-12-08 | 2018-12-21 | 衛生福利部國家中醫藥研究所 | Use of stilbene and benzofuran derivatives for the treatment of neurological diseases |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| CN114890958B (zh) * | 2022-02-23 | 2023-10-20 | 四川警察学院 | 双光子染料化合物、其制备方法及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130305D0 (en) * | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| WO2004100998A2 (en) | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
-
2006
- 2006-10-10 WO PCT/US2006/039412 patent/WO2007047204A1/en not_active Ceased
- 2006-10-10 DK DK06825654.4T patent/DK1945622T3/da active
- 2006-10-10 EP EP06825654A patent/EP1945622B1/en active Active
- 2006-10-10 JP JP2008535601A patent/JP5557449B2/ja active Active
- 2006-10-10 PT PT06825654T patent/PT1945622E/pt unknown
- 2006-10-10 US US12/064,146 patent/US8138360B2/en active Active
- 2006-10-10 ES ES06825654T patent/ES2379987T3/es active Active
- 2006-10-10 PL PL06825654T patent/PL1945622T3/pl unknown
- 2006-10-10 SI SI200631304T patent/SI1945622T1/sl unknown
- 2006-10-10 CN CN200680042082XA patent/CN101360731B/zh not_active Expired - Fee Related
- 2006-10-10 AT AT06825654T patent/ATE539069T1/de active
-
2012
- 2012-01-26 US US13/359,077 patent/US20120189545A1/en not_active Abandoned
- 2012-01-26 US US13/359,040 patent/US20120148494A1/en not_active Abandoned
- 2012-03-14 CY CY20121100275T patent/CY1112737T1/el unknown
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