JP2009511061A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009511061A5 JP2009511061A5 JP2008535742A JP2008535742A JP2009511061A5 JP 2009511061 A5 JP2009511061 A5 JP 2009511061A5 JP 2008535742 A JP2008535742 A JP 2008535742A JP 2008535742 A JP2008535742 A JP 2008535742A JP 2009511061 A5 JP2009511061 A5 JP 2009511061A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cells
- pancreatic
- ngn3
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 14
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 12
- 102000004877 Insulin Human genes 0.000 claims 6
- 108090001061 Insulin Proteins 0.000 claims 6
- 229940125396 insulin Drugs 0.000 claims 6
- 101100519293 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pdx-1 gene Proteins 0.000 claims 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 3
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 3
- 102000040945 Transcription factor Human genes 0.000 claims 3
- 108091023040 Transcription factor Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000001850 reproductive effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 108010059616 Activins Proteins 0.000 claims 2
- 102000056058 Betacellulin Human genes 0.000 claims 2
- 101800001382 Betacellulin Proteins 0.000 claims 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 2
- 101100257359 Caenorhabditis elegans sox-2 gene Proteins 0.000 claims 2
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 claims 2
- 108010011459 Exenatide Proteins 0.000 claims 2
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 2
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 101100257363 Mus musculus Sox2 gene Proteins 0.000 claims 2
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 2
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims 2
- 101710150336 Protein Rex Proteins 0.000 claims 2
- 108010017842 Telomerase Proteins 0.000 claims 2
- 239000000488 activin Substances 0.000 claims 2
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims 2
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000003981 ectoderm Anatomy 0.000 claims 2
- 229960001519 exenatide Drugs 0.000 claims 2
- 229960003966 nicotinamide Drugs 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 239000011570 nicotinamide Substances 0.000 claims 2
- 101000810330 Arabidopsis thaliana Eukaryotic translation initiation factor 3 subunit E Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101000704130 Escherichia coli (strain K12) Signal recognition particle protein Proteins 0.000 claims 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
- 208000028572 Hereditary chronic pancreatitis Diseases 0.000 claims 1
- 206010056976 Hereditary pancreatitis Diseases 0.000 claims 1
- 108700014808 Homeobox Protein Nkx-2.2 Proteins 0.000 claims 1
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 claims 1
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 101000738523 Homo sapiens Pancreas transcription factor 1 subunit alpha Proteins 0.000 claims 1
- 101710186630 Insulin-1 Proteins 0.000 claims 1
- 101000720386 Mus musculus Acyl-coenzyme A thioesterase 9, mitochondrial Proteins 0.000 claims 1
- 101000741177 Oat chlorotic stunt virus (isolate United Kingdom) Capsid protein Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims 1
- 101150081664 PAX6 gene Proteins 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- 102100037878 Pancreas transcription factor 1 subunit alpha Human genes 0.000 claims 1
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 206010033627 Pancreatic injury Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 101150075928 Pax4 gene Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000024691 pancreas disease Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000000277 pancreatic duct Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72675005P | 2005-10-14 | 2005-10-14 | |
| PCT/US2006/040212 WO2007047509A2 (en) | 2005-10-14 | 2006-10-16 | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009511061A JP2009511061A (ja) | 2009-03-19 |
| JP2009511061A5 true JP2009511061A5 (enExample) | 2010-11-18 |
Family
ID=37831731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535742A Pending JP2009511061A (ja) | 2005-10-14 | 2006-10-16 | 膵臓表現型を有する細胞への非胚性幹細胞の分化 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8409859B2 (enExample) |
| EP (1) | EP1941032A2 (enExample) |
| JP (1) | JP2009511061A (enExample) |
| CN (1) | CN101310012B (enExample) |
| AU (1) | AU2006304318B2 (enExample) |
| CA (1) | CA2625883A1 (enExample) |
| NZ (1) | NZ567082A (enExample) |
| SG (1) | SG169324A1 (enExample) |
| WO (1) | WO2007047509A2 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| KR101221302B1 (ko) | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| AU2011203583B2 (en) * | 2004-07-09 | 2013-03-07 | Viacyte, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| WO2008021196A2 (en) * | 2006-08-09 | 2008-02-21 | The Mclean Hospital Corporation | Methods and compositions for the treatment of medical disorders |
| AU2007321928A1 (en) | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| CA2712496C (en) | 2008-01-18 | 2021-01-12 | Wei-Shou Hu | Stem cell aggregates and methods for making and using |
| RU2551772C2 (ru) | 2008-02-21 | 2015-05-27 | Сентокор Орто Байотек Инк. | Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| EP2297298A4 (en) * | 2008-05-09 | 2011-10-05 | Vistagen Therapeutics Inc | PANCREATIC ENDOCRINE PROGENITOR CELLS FROM PLURIPOTENT STEM CELLS |
| WO2009154606A1 (en) * | 2008-06-03 | 2009-12-23 | Cythera, Inc. | Growth factors for production of definitive endoderm |
| AU2009267137A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| MX2011004563A (es) * | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| BRPI0921996A2 (pt) | 2008-11-20 | 2015-08-18 | Centocor Ortho Biotech Inc | Métodos e composições para cultura e ligação de células em substratos planos. |
| EP3260534A1 (en) | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| WO2010114136A1 (ja) * | 2009-03-30 | 2010-10-07 | 第一三共株式会社 | 多能性幹細胞及び心筋細胞以外の分化細胞に対する細胞死誘導方法 |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| EP2456862A4 (en) | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| CN105456292B (zh) * | 2009-10-30 | 2019-03-26 | 北卡罗来纳大学教堂山分校 | 来自肝外胆管树的专能干细胞及其分离方法 |
| US9453205B2 (en) * | 2009-10-31 | 2016-09-27 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| PH12012501254A1 (en) * | 2009-12-23 | 2012-11-05 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| US9969981B2 (en) | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| US9085757B2 (en) | 2010-06-17 | 2015-07-21 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| JP6133776B2 (ja) | 2010-08-31 | 2017-05-24 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の分化 |
| KR101836850B1 (ko) | 2010-08-31 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| CA2809300A1 (en) * | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| AU2012272586B2 (en) * | 2011-06-23 | 2016-07-07 | The Children's Hospital Of Philadelphia | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
| AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| RU2018128383A (ru) | 2012-03-07 | 2019-03-14 | Янссен Байотек, Инк. | Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток |
| RU2018108850A (ru) | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| EP4039798A1 (en) | 2012-12-31 | 2022-08-10 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells |
| MX2015008577A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Cultivo de celulas madre embrionarias humanas en la interfase aire-liquido para la diferenciacion en celulas endocrinas pancreaticas. |
| SG10201707811XA (en) | 2012-12-31 | 2017-11-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| IL290717B2 (en) * | 2013-02-06 | 2024-10-01 | Viacyte Inc | Cell compositions derived from dedifferentiated reprogrammed cells |
| CN103409366A (zh) * | 2013-02-20 | 2013-11-27 | 潘骏 | 成人多能祖细胞的培养基以及采用成人多能祖细胞的培养基培养成人多能祖细胞的方法 |
| TW201522637A (zh) * | 2013-03-15 | 2015-06-16 | Jackson Lab | 非胚胎幹細胞之單離及其用途 |
| CN103194424A (zh) * | 2013-03-28 | 2013-07-10 | 于涛 | 一种诱导胚胎干细胞为胰腺组织样细胞的方法 |
| AU2014250761B2 (en) | 2013-04-12 | 2019-02-28 | Robert J. Deans | Improving organs for transplantation |
| US10520494B2 (en) | 2014-03-26 | 2019-12-31 | Helmholtz Zentrum München-Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Flattop (FLTP) is a novel biomarker for beta cell maturation |
| KR102162138B1 (ko) | 2014-05-16 | 2020-10-06 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 |
| WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| US20180327719A1 (en) * | 2015-09-18 | 2018-11-15 | Kyoto University | Method for producing pancreatic bud cells |
| AU2017205194A1 (en) * | 2016-01-08 | 2018-07-19 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
| HK1256413A1 (zh) | 2016-01-21 | 2019-09-20 | Abt Holding Company | 用於伤口癒合的干细胞 |
| KR101810385B1 (ko) * | 2016-02-04 | 2017-12-20 | 주식회사 강스템바이오텍 | Gdf11을 포함하는 조성물 및 그의 용도 |
| MA45479A (fr) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| US11062073B2 (en) | 2016-12-23 | 2021-07-13 | Google Llc | Integrated circuit design system and method |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| AU4543193A (en) * | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| WO1999035243A2 (en) | 1998-01-12 | 1999-07-15 | Cold Spring Harbor Laboratory | Extension of cellular lifespan, methods and reagents |
| US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| US6967019B2 (en) * | 1999-04-06 | 2005-11-22 | The Regents Of The University Of California | Production of pancreatic islet cells and delivery of insulin |
| US20050169896A1 (en) * | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| CA2378140A1 (en) | 1999-07-29 | 2001-02-08 | Steven Baranowitz | Methods for transdifferentiation of body tissues |
| DK1226233T3 (da) | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| WO2001021766A2 (en) | 1999-09-23 | 2001-03-29 | Cell Science Therapeutics | Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells |
| EP1218489B1 (en) | 1999-09-24 | 2009-03-18 | Cybios LLC | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| EP1224259A4 (en) | 1999-09-27 | 2005-04-27 | Univ Florida | INVERSION OF INSULIN DEPENDENT DIABETES BY ISOLATED STEM CELLS, PROGENITOR ISLANDIC CELLS, AND INSULAR TYPE STRUCTURES |
| EP1257282A4 (en) | 1999-12-06 | 2003-05-02 | Gen Hospital Corp | PANCREATIC STEM CELLS AND THEIR USE IN TRANSPLANTATION |
| EP1261694B1 (en) | 2000-02-26 | 2008-01-16 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
| EP1176189A1 (en) | 2000-07-21 | 2002-01-30 | Fornix Biosciences N.V. | Stem cell-like cells |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| GB0026252D0 (en) | 2000-10-26 | 2000-12-13 | Univ Edinburgh | Pluripotential stem cells |
| US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
| WO2002046373A1 (en) * | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| NZ527849A (en) | 2001-02-14 | 2006-09-29 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US7056738B2 (en) * | 2001-03-23 | 2006-06-06 | Tulane University | Early stage multipotential stem cells in colonies of bone marrow stromal cells |
| WO2002079457A1 (en) | 2001-03-29 | 2002-10-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
| KR100449141B1 (ko) * | 2001-04-19 | 2004-09-21 | (주)라이프코드 | 간엽 간세포를 신경세포로 분화시키는 방법 |
| US20030003090A1 (en) * | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| GB2399823B (en) * | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| CA2494040A1 (en) | 2002-07-29 | 2004-02-05 | Es Cell International Pte Ltd. | Multi-step method for the differentiation of insulin positive, glucose |
| US20040235165A1 (en) * | 2003-05-19 | 2004-11-25 | Darwin Prockop | In vitro differentiation of adult stem cells |
| CA2536909A1 (en) * | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
-
2006
- 2006-10-16 SG SG201100187-2A patent/SG169324A1/en unknown
- 2006-10-16 JP JP2008535742A patent/JP2009511061A/ja active Pending
- 2006-10-16 WO PCT/US2006/040212 patent/WO2007047509A2/en not_active Ceased
- 2006-10-16 CN CN2006800382989A patent/CN101310012B/zh not_active Expired - Fee Related
- 2006-10-16 AU AU2006304318A patent/AU2006304318B2/en not_active Ceased
- 2006-10-16 NZ NZ567082A patent/NZ567082A/xx not_active IP Right Cessation
- 2006-10-16 CA CA002625883A patent/CA2625883A1/en not_active Abandoned
- 2006-10-16 US US12/089,868 patent/US8409859B2/en not_active Expired - Fee Related
- 2006-10-16 EP EP06825960A patent/EP1941032A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009511061A5 (enExample) | ||
| US11505783B2 (en) | Differentiation of human embryonic stem cells | |
| Giobbe et al. | Functional differentiation of human pluripotent stem cells on a chip | |
| EP2350265B1 (en) | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage | |
| Takeuchi et al. | Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture | |
| JP2022095886A5 (enExample) | ||
| ES2659393T3 (es) | Diferenciación de células madre embrionarias humanas | |
| EP2603226B1 (en) | Treatment of diabetes with pancreatic endocrine precursor cells | |
| JP2020108394A (ja) | ＳＣ−β細胞及び組成物並びにその生成方法 | |
| US20110014703A1 (en) | Differentiation of Human Embryonic Stem Cells | |
| JP6312591B2 (ja) | 多能性幹細胞からの胚体内胚葉の効率的な誘導 | |
| EP3527658A1 (en) | Differentiation of human embryonic stem cells | |
| JP2019535265A5 (enExample) | ||
| CA2809305A1 (en) | Differentiation of pluripotent stem cells | |
| BR112012022145A2 (pt) | métodos para purificar células derivadas de células-tronco pluripotentes | |
| Dayer et al. | Sonic hedgehog pathway suppression and reactivation accelerates differentiation of rat adipose-derived mesenchymal stromal cells toward insulin-producing cells | |
| Kaczorowski et al. | Glucose‐responsive insulin‐producing cells from stem cells | |
| Weir et al. | β-cell precursors—a work in progress | |
| JPWO2021042027A5 (enExample) | ||
| Baeyens et al. | Cellular plasticity of the pancreas | |
| Inada et al. | How can we get more beta cells? | |
| RU2836628C1 (ru) | Дифференцирование эмбриональных стволовых клеток человека | |
| Hashemi-Tabar et al. | Kinetics of gene expression during exposure of mouse stem cells to activin A. | |
| Lu et al. | In Vivo Reprogramming for Regenerating Insulin-Secreting Cells | |
| Cao et al. | Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord |