|
US7807706B2
(en)
|
2005-08-12 |
2010-10-05 |
Astrazeneca Ab |
Metabotropic glutamate-receptor-potentiating isoindolones
|
|
TWI417095B
(zh)
|
2006-03-15 |
2013-12-01 |
Janssen Pharmaceuticals Inc |
1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
|
|
US20080139846A1
(en)
*
|
2006-09-01 |
2008-06-12 |
Astrazeneca Ab |
New Process 298
|
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
|
WO2008130853A1
(en)
*
|
2007-04-17 |
2008-10-30 |
Astrazeneca Ab |
Hydrazides and their use as metabotropic glutamate receptor potentiators - 681
|
|
WO2008131439A1
(en)
*
|
2007-04-23 |
2008-10-30 |
House Ear Institute |
Treatment and/or prevention of presbycusis by modulation of metabotropic glutamate receptor 7
|
|
TWI443090B
(zh)
|
2007-05-25 |
2014-07-01 |
Abbvie Deutschland |
作為代謝性麩胺酸受體2(mglu2 受體)之正向調節劑之雜環化合物
|
|
TWI417100B
(zh)
*
|
2007-06-07 |
2013-12-01 |
Astrazeneca Ab |
二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途
|
|
TW200911255A
(en)
|
2007-06-07 |
2009-03-16 |
Astrazeneca Ab |
Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841
|
|
WO2009004430A1
(en)
*
|
2007-06-29 |
2009-01-08 |
Pfizer Inc. |
N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors
|
|
PL2203439T3
(pl)
|
2007-09-14 |
2011-06-30 |
Addex Pharmaceuticals Sa |
1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
|
|
US8722894B2
(en)
|
2007-09-14 |
2014-05-13 |
Janssen Pharmaceuticals, Inc. |
1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
|
|
SA109300358B1
(ar)
*
|
2008-06-06 |
2012-11-03 |
استرازينيكا ايه بي |
مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون
|
|
GB0811643D0
(en)
|
2008-06-25 |
2008-07-30 |
Cancer Rec Tech Ltd |
New therapeutic agents
|
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
|
JP5547194B2
(ja)
|
2008-09-02 |
2014-07-09 |
ジャンセン ファーマシューティカルズ, インコーポレイテッド. |
代謝型グルタミン酸受容体の調節因子としての3−アザビシクロ[3.1.0]ヘキシル誘導体
|
|
RU2517181C2
(ru)
|
2008-10-16 |
2014-05-27 |
Орто-Макнейл-Янссен Фармасьютикалз, Инк. |
Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
|
|
WO2010060589A1
(en)
|
2008-11-28 |
2010-06-03 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
|
EP2406248B1
(en)
*
|
2009-03-11 |
2013-12-25 |
Msd K.K. |
Novel isoindolin-1-one derivative
|
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
MY153912A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
CN102439008B
(zh)
|
2009-05-12 |
2015-04-29 |
杨森制药有限公司 |
1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
|
|
JP5753177B2
(ja)
*
|
2009-10-09 |
2015-07-22 |
セルジーン コーポレイション |
2−(1−フェニルエチル)イソインドリン−1−オン化合物を調製する方法
|
|
EP2496569A2
(en)
|
2009-11-02 |
2012-09-12 |
MSD Oss B.V. |
Heterocyclic derivatives
|
|
SG181958A1
(en)
*
|
2010-01-07 |
2012-07-30 |
Astrazeneca Ab |
Process for making a metabotropic glutamate receptor positive allosteric modulator - 874
|
|
US8314120B2
(en)
|
2010-03-30 |
2012-11-20 |
Abbott Gmbh & Co. Kg |
Small molecule potentiators of metabotropic glutamate receptors
|
|
US8664214B2
(en)
|
2010-03-30 |
2014-03-04 |
AbbVie Deutschland GmbH & Co. KG |
Small molecule potentiators of metabotropic glutamate receptors I
|
|
CN103261195B
(zh)
|
2010-11-08 |
2015-09-02 |
杨森制药公司 |
1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
|
|
PL2649069T3
(pl)
|
2010-11-08 |
2016-01-29 |
Janssen Pharmaceuticals Inc |
Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
|
|
EP2661435B1
(en)
|
2010-11-08 |
2015-08-19 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
|
AR088320A1
(es)
|
2011-10-14 |
2014-05-28 |
Incyte Corp |
Derivados de isoindolinona y pirrolopiridinona como inhibidores de akt
|
|
EP3153167B1
(en)
|
2011-10-28 |
2019-10-02 |
Vanderbilt University |
Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1
|
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
|
KR20220049612A
(ko)
|
2014-01-21 |
2022-04-21 |
얀센 파마슈티카 엔.브이. |
대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
|
|
HUE053734T2
(hu)
|
2014-01-21 |
2021-07-28 |
Janssen Pharmaceutica Nv |
2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
|
|
TWI713455B
(zh)
|
2014-06-25 |
2020-12-21 |
美商伊凡克特治療公司 |
MnK抑制劑及其相關方法
|
|
GB201517217D0
(en)
|
2015-09-29 |
2015-11-11 |
Astex Therapeutics Ltd And Cancer Res Technology Ltd |
Pharmaceutical compounds
|
|
GB201517216D0
(en)
|
2015-09-29 |
2015-11-11 |
Cancer Res Technology Ltd And Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
KR20180070696A
(ko)
|
2015-10-29 |
2018-06-26 |
이펙터 테라퓨틱스, 인크. |
Mnk1 및 mnk2를 억제하는 피롤로-, 피라졸로-, 이미다조-피리미딘 및 피리딘 화합물
|
|
SG11201803242TA
(en)
|
2015-10-29 |
2018-05-30 |
Effector Therapeutics Inc |
Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2
|
|
WO2017087808A1
(en)
|
2015-11-20 |
2017-05-26 |
Effector Therapeutics, Inc. |
Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers
|
|
CN105837557A
(zh)
*
|
2016-05-05 |
2016-08-10 |
青岛辰达生物科技有限公司 |
一种用于治疗ii型糖尿病的阿格列汀的制备方法
|
|
CN106279182B
(zh)
*
|
2016-07-29 |
2019-06-07 |
中国药科大学 |
一种吡咯并[2,1-a]异吲哚酮类化合物及其合成方法
|
|
BR112019016707A2
(pt)
|
2017-02-14 |
2020-04-07 |
Effector Therapeutics Inc |
inibidores de mnk substituídos por piperidina e métodos relacionados aos mesmos
|
|
GB201704965D0
(en)
|
2017-03-28 |
2017-05-10 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201704966D0
(en)
|
2017-03-28 |
2017-05-10 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
EP3459939A1
(en)
*
|
2017-09-26 |
2019-03-27 |
Pragma Therapeutics |
Novel heterocyclic compounds as modulators of mglur7
|
|
TWI857981B
(zh)
|
2018-10-24 |
2024-10-11 |
美商伊凡克特治療公司 |
Mnk抑制劑的結晶形式
|
|
WO2020102216A1
(en)
|
2018-11-13 |
2020-05-22 |
Incyte Corporation |
Substituted heterocyclic derivatives as pi3k inhibitors
|
|
US11078204B2
(en)
|
2018-11-13 |
2021-08-03 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
US11161838B2
(en)
|
2018-11-13 |
2021-11-02 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
CN110498759A
(zh)
*
|
2019-09-12 |
2019-11-26 |
天津瑞岭化工有限公司 |
异吲哚啉酮类化合物的合成方法
|