JP2009506985A5 - - Google Patents

Info

Publication number

JP2009506985A5

JP2009506985A5 JP2008521907A JP2008521907A JP2009506985A5 JP 2009506985 A5 JP2009506985 A5 JP 2009506985A5 JP 2008521907 A JP2008521907 A JP 2008521907A JP 2008521907 A JP2008521907 A JP 2008521907A JP 2009506985 A5 JP2009506985 A5 JP 2009506985A5

Authority

JP

Japan

Prior art keywords

plexin

use according

binding molecule

molecule

seq

Prior art date

2006-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 101001094868 Homo sapiens Plexin-D1 Proteins 0.000 claims 26
• 102100035380 Plexin-D1 Human genes 0.000 claims 26
• 102000002022 plexin Human genes 0.000 claims 10
• 108050009312 plexin Proteins 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000012636 effector Substances 0.000 claims 6
• 239000003446 ligand Substances 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 208000007536 Thrombosis Diseases 0.000 claims 3
• 238000003745 diagnosis Methods 0.000 claims 3
• 230000001939 inductive effect Effects 0.000 claims 3
• 208000027866 inflammatory disease Diseases 0.000 claims 3
• 230000002452 interceptive effect Effects 0.000 claims 3
• 239000003550 marker Substances 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 230000002285 radioactive effect Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 208000029742 colonic neoplasm Diseases 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
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• 108090000623 proteins and genes Proteins 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 claims 1
• WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 claims 1
• WUIABRMSWOKTOF-OYALTWQYSA-O 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS(O)(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-O 0.000 claims 1
• 108020005544 Antisense RNA Proteins 0.000 claims 1
• 206010003571 Astrocytoma Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 108010006654 Bleomycin Proteins 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
• 108091008102 DNA aptamers Proteins 0.000 claims 1
• GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 claims 1
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 201000010133 Oligodendroglioma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 108091008103 RNA aptamers Proteins 0.000 claims 1
• 108010039491 Ricin Proteins 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 206010041067 Small cell lung cancer Diseases 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
• GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical group [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 1
• 102000002262 Thromboplastin Human genes 0.000 claims 1
• 108010000499 Thromboplastin Proteins 0.000 claims 1
• VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 229960004395 bleomycin sulfate Drugs 0.000 claims 1
• 229920001400 block copolymer Polymers 0.000 claims 1
• 210000004204 blood vessel Anatomy 0.000 claims 1
• 229960005243 carmustine Drugs 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
• 229960004630 chlorambucil Drugs 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 239000003184 complementary RNA Substances 0.000 claims 1
• 229960004397 cyclophosphamide Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000002919 epithelial cell Anatomy 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 229940006110 gallium-67 Drugs 0.000 claims 1
• 201000002222 hemangioblastoma Diseases 0.000 claims 1
• 229960001330 hydroxycarbamide Drugs 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• OHSVLFRHMCKCQY-NJFSPNSNSA-N lutetium-177 Chemical compound [177Lu] OHSVLFRHMCKCQY-NJFSPNSNSA-N 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 230000005298 paramagnetic effect Effects 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 229920000575 polymersome Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108020001580 protein domains Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• WUAPFZMCVAUBPE-IGMARMGPSA-N rhenium-186 Chemical compound [186Re] WUAPFZMCVAUBPE-IGMARMGPSA-N 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 229940056501 technetium 99m Drugs 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1