JP2009505973A5 - - Google Patents
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- Publication number
- JP2009505973A5 JP2009505973A5 JP2008525637A JP2008525637A JP2009505973A5 JP 2009505973 A5 JP2009505973 A5 JP 2009505973A5 JP 2008525637 A JP2008525637 A JP 2008525637A JP 2008525637 A JP2008525637 A JP 2008525637A JP 2009505973 A5 JP2009505973 A5 JP 2009505973A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- aryl
- alkyl
- optionally substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000037805 labour Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70643105P | 2005-08-09 | 2005-08-09 | |
| GB0516439A GB0516439D0 (en) | 2005-08-10 | 2005-08-10 | EP2 receptor agonists |
| PCT/GB2006/002979 WO2007017687A2 (en) | 2005-08-09 | 2006-08-09 | Ep2 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009505973A JP2009505973A (ja) | 2009-02-12 |
| JP2009505973A5 true JP2009505973A5 (https=) | 2009-09-03 |
Family
ID=37671407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525637A Pending JP2009505973A (ja) | 2005-08-09 | 2006-08-09 | Ｅｐ２受容体アゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8080567B2 (https=) |
| EP (1) | EP1951701A2 (https=) |
| JP (1) | JP2009505973A (https=) |
| AU (1) | AU2006277786B2 (https=) |
| CA (1) | CA2618486A1 (https=) |
| WO (1) | WO2007017687A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20190509T1 (hr) * | 2008-03-12 | 2019-05-03 | Ube Industries, Ltd. | Spoj piridilaminooctene kiseline |
| PT2415763E (pt) | 2009-03-30 | 2016-03-30 | Ube Industries | Composição farmacêutica para tratamento ou prevenção do glaucoma |
| CA2848229C (en) * | 2011-09-16 | 2019-08-27 | Fovea Pharmaceuticals | Aniline derivatives, their preparation and their therapeutic application |
| CA2867527A1 (en) * | 2012-05-03 | 2013-11-07 | Takeda Gmbh | Novel ep2 receptor agonists |
| HK1219103A1 (en) | 2013-03-28 | 2017-03-24 | Ube Industries, Ltd. | Substituted biaryl compound |
| KR20160036568A (ko) * | 2013-07-18 | 2016-04-04 | 노파르티스 아게 | 보체 인자 d 억제제로서의 아미노메틸-비아릴 유도체 및 그의 용도 |
| US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| JP2024016311A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | Ｅｐ２アンタゴニスト |
| WO2023111996A1 (en) | 2021-12-17 | 2023-06-22 | Reglagene Holding, Inc. | Compositions and methods of making and using small molecules in the treatment of cancer |
| US12215102B2 (en) | 2023-02-28 | 2025-02-04 | Reglagene, Inc. | Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9418483D0 (en) | 1994-09-14 | 1994-11-02 | British Tech Group | Compound for use in pre-term labour |
| US5576347A (en) | 1994-11-14 | 1996-11-19 | Sredni; Benjamin | Method of treating gastric ulcers |
| ES2303341T3 (es) | 1996-12-20 | 2008-08-01 | Pfizer Inc. | Prevencion y tratamiento de trastorno del esqueleto con agonistas de la prostaglandina e2 selectivos del subtipo de receptor ep2. |
| JP4044967B2 (ja) | 1997-02-10 | 2008-02-06 | 小野薬品工業株式会社 | １１，１５−ｏ−ジアルキルプロスタグランジンｅ誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
| US5939332A (en) | 1998-02-27 | 1999-08-17 | Roche Diagnostics Corp. | Phencyclidine analogs for immunoassay |
| ATE299499T1 (de) | 1998-11-09 | 2005-07-15 | Black James Foundation | Gastrin und cholecystokinin rezeptor ligande |
| US6121253A (en) | 1998-11-20 | 2000-09-19 | Merck Frosst Canada & Co. | Prostaglandin conjugates for treating or preventing bone disease |
| SE9900025D0 (sv) | 1999-01-08 | 1999-01-08 | Synphora Ab | Method and composition for treatment of female sexual dysfunction |
| AP2001002357A0 (en) | 1999-12-22 | 2001-12-31 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis. |
| GB0011098D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | Pharmaceutical compositions comprising protpn pump inhibitors and gastrin/cholecystokinin receptor ligands |
| WO2002024647A1 (en) | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| JP2005507413A (ja) | 2001-10-26 | 2005-03-17 | アラーガン インコーポレイテッド | ＥＰ２−受容体作用薬としてのω−シクロアルキル１７−ヘテロアリールプロスタグランジンＥ２類似物 |
| NZ532519A (en) | 2001-11-05 | 2006-11-30 | Allergan Inc | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists |
| PL370914A1 (en) | 2001-11-30 | 2005-06-13 | Pfizer Products Inc. | Pharmaceutical compositions and methods for administering ep2 receptor selective agonists |
| JPWO2004007439A1 (ja) | 2002-07-10 | 2005-11-10 | 住友製薬株式会社 | ビアリール誘導体 |
| AU2003252149A1 (en) * | 2002-08-02 | 2004-02-23 | Applied Research Systems Ars Holding N.V. | Thiophene and furan derivatives as prostaglandin agonists and use thereof |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0329620D0 (en) | 2003-12-22 | 2004-01-28 | Pharmagene Lab Ltd | EP2 receptor agonists |
| WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
-
2006
- 2006-08-09 CA CA002618486A patent/CA2618486A1/en not_active Abandoned
- 2006-08-09 EP EP06779103A patent/EP1951701A2/en not_active Withdrawn
- 2006-08-09 JP JP2008525637A patent/JP2009505973A/ja active Pending
- 2006-08-09 US US12/063,421 patent/US8080567B2/en not_active Expired - Fee Related
- 2006-08-09 AU AU2006277786A patent/AU2006277786B2/en not_active Expired - Fee Related
- 2006-08-09 WO PCT/GB2006/002979 patent/WO2007017687A2/en not_active Ceased