JP2010509285A5 - - Google Patents

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Publication number
JP2010509285A5
JP2010509285A5 JP2009535729A JP2009535729A JP2010509285A5 JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5 JP 2009535729 A JP2009535729 A JP 2009535729A JP 2009535729 A JP2009535729 A JP 2009535729A JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5
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JP
Japan
Prior art keywords
alkyl
aryl
heterocyclyl
heteroaryl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009535729A
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English (en)
Japanese (ja)
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JP2010509285A (ja
JP5456479B2 (ja
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Publication date
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Priority claimed from PCT/EP2007/062034 external-priority patent/WO2008055947A1/en
Publication of JP2010509285A publication Critical patent/JP2010509285A/ja
Publication of JP2010509285A5 publication Critical patent/JP2010509285A5/ja
Application granted granted Critical
Publication of JP5456479B2 publication Critical patent/JP5456479B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009535729A 2006-11-09 2007-11-08 グルタミニルシクラーゼの新規阻害剤 Expired - Fee Related JP5456479B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86498806P 2006-11-09 2006-11-09
US60/864,988 2006-11-09
PCT/EP2007/062034 WO2008055947A1 (en) 2006-11-09 2007-11-08 Novel inhibitors of glutaminyl cyclase

Publications (3)

Publication Number Publication Date
JP2010509285A JP2010509285A (ja) 2010-03-25
JP2010509285A5 true JP2010509285A5 (https=) 2011-02-17
JP5456479B2 JP5456479B2 (ja) 2014-03-26

Family

ID=39156601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009535729A Expired - Fee Related JP5456479B2 (ja) 2006-11-09 2007-11-08 グルタミニルシクラーゼの新規阻害剤

Country Status (5)

Country Link
EP (1) EP2091945B1 (https=)
JP (1) JP5456479B2 (https=)
DK (1) DK2091945T3 (https=)
ES (1) ES2468546T3 (https=)
WO (1) WO2008055947A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
BRPI0718507A2 (pt) 2006-09-21 2013-11-12 Probiodrug Ag Genes relacionados à glutaminil ciclase
EP2320942B1 (en) 2008-07-21 2018-03-14 Probiodrug AG Diagnostic antibody assay
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
AU2009289238B2 (en) * 2008-09-04 2014-09-04 Vivoryon Therapeutics N.V. Novel inhibitors
JP5934645B2 (ja) * 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011076854A1 (en) 2009-12-22 2011-06-30 Probiodrug Ag CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN
EP2537029A1 (en) 2010-02-18 2012-12-26 Probiodrug AG Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US8409837B2 (en) 2010-08-19 2013-04-02 Probiodrug Ag Crystal structure of glutaminyl cyclase
WO2012110946A1 (en) * 2011-02-17 2012-08-23 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate
BR112013023211B1 (pt) 2011-03-16 2022-11-08 Vivoryon Therapeutics N.V. Anticorpo monoclonal, seu uso, composição, linhagem celular, método diagnóstico in vitro e kit
EP2686313B1 (en) * 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
WO2016097305A1 (en) 2014-12-19 2016-06-23 Probiodrug Ag Novel method for the detection of pglu-abeta peptides
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
TW202317549A (zh) 2021-06-24 2023-05-01 香港商英科智能有限公司 用於治療疾病之β-內醯胺衍生物
KR20260040085A (ko) * 2023-07-21 2026-03-23 인실리코 메디신 아이피 리미티드 결정형 베타-락탐 유도체 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4806628B2 (ja) * 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
WO2006044497A2 (en) * 2004-10-13 2006-04-27 Merck & Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease
CN101395142B (zh) * 2006-03-08 2012-03-28 弗·哈夫曼-拉罗切有限公司 4-氨基-1,5-取代的1,5-二氢-咪唑-2-酮

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