JP2009504192A5 - - Google Patents
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- Publication number
- JP2009504192A5 JP2009504192A5 JP2008527196A JP2008527196A JP2009504192A5 JP 2009504192 A5 JP2009504192 A5 JP 2009504192A5 JP 2008527196 A JP2008527196 A JP 2008527196A JP 2008527196 A JP2008527196 A JP 2008527196A JP 2009504192 A5 JP2009504192 A5 JP 2009504192A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- nucleotide sequence
- test molecule
- molecule
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002773 nucleotide Substances 0.000 claims 28
- 125000003729 nucleotide group Chemical group 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 25
- 102000039446 nucleic acids Human genes 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004418 ribosomal RNA Proteins 0.000 claims 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000003705 ribosome Anatomy 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000001668 nucleic acid synthesis Methods 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091005461 Nucleic proteins Proteins 0.000 claims 1
- 108020001027 Ribosomal DNA Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70959805P | 2005-08-19 | 2005-08-19 | |
| US73246005P | 2005-11-01 | 2005-11-01 | |
| US75159305P | 2005-12-19 | 2005-12-19 | |
| US77592406P | 2006-02-22 | 2006-02-22 | |
| US77932706P | 2006-03-02 | 2006-03-02 | |
| US78380106P | 2006-03-16 | 2006-03-16 | |
| US78910906P | 2006-04-03 | 2006-04-03 | |
| PCT/US2006/032508 WO2007022474A2 (en) | 2005-08-19 | 2006-08-18 | HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504192A JP2009504192A (ja) | 2009-02-05 |
| JP2009504192A5 true JP2009504192A5 (OSRAM) | 2009-10-01 |
Family
ID=37758472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008527196A Pending JP2009504192A (ja) | 2005-08-19 | 2006-08-18 | ヒトリボソームＤＮＡ（ｒＤＮＡ）およびリボソームＲＮＡ（ｒＲＮＡ）核酸ならびにそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20070117770A1 (OSRAM) |
| EP (1) | EP1926372A2 (OSRAM) |
| JP (1) | JP2009504192A (OSRAM) |
| CA (1) | CA2619663A1 (OSRAM) |
| WO (1) | WO2007022474A2 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100063046A1 (en) * | 2006-05-17 | 2010-03-11 | Whitten Jeffrey P | Tetracyclic imidazole analogs |
| US8278057B2 (en) * | 2007-09-14 | 2012-10-02 | Nestec S.A. | Addressable antibody arrays and methods of use |
| PT3092901T (pt) | 2007-10-05 | 2020-05-21 | Senhwa Biosciences Inc | Análogos de quinolona e respetivos métodos relacionados |
| CA2723076A1 (en) * | 2008-05-09 | 2009-11-12 | Zhiping Liu | A molecule detecting system |
| EP2376657B1 (en) * | 2008-12-10 | 2017-01-25 | University of Washington | Ratiometric pre-rrna analysis |
| JP2012526535A (ja) * | 2009-05-15 | 2012-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＮｏＣＲの発現が低下した改良細胞系及びその使用 |
| KR100998365B1 (ko) * | 2009-06-29 | 2010-12-06 | 압타바이오 주식회사 | 치료 효능이 있는 변형핵산 및 구아노신을 함유하는 올리고뉴클레오티드 변형체 |
| CN103533934B (zh) * | 2011-03-17 | 2016-03-30 | 特尔汗什莫尔医学基础设施研究和服务公司 | 用于治疗自身免疫性疾病的喹诺酮类似物 |
| WO2015079411A1 (en) | 2013-11-28 | 2015-06-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
| CN119185322A (zh) | 2015-11-20 | 2024-12-27 | 生华生物科技股份有限公司 | 用于治疗癌症的四环喹诺酮类似物组合疗法 |
| US9957282B2 (en) | 2015-12-14 | 2018-05-01 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
| CA3006502A1 (en) * | 2015-12-14 | 2017-06-22 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
| CN116077439A (zh) | 2016-04-29 | 2023-05-09 | 西奈山伊坎医学院 | 靶向先天免疫系统以诱导长期耐受性及解决动脉粥样硬化中的巨噬细胞累积 |
| RU2020130050A (ru) | 2018-02-15 | 2022-03-15 | Сэньхва Байосайенсиз, Инк. | Аналоги хинолонов и их соли, композиции и способ их применения |
| US11859021B2 (en) | 2021-03-19 | 2024-01-02 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
| CN116472066B (zh) * | 2021-08-23 | 2024-05-31 | 北京嘉树佳业科技有限公司 | 来源于药用植物的sRNA及其应用 |
| WO2025114459A1 (en) * | 2023-11-28 | 2025-06-05 | Genome Therapeutics Ltd | Tetracyclic compounds for use in antibody-drug conjugates for the treatment of cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641632A (en) * | 1983-01-10 | 1997-06-24 | Gen-Probe Incorporated | Method for preparing rRNA for hybridization with a probe |
| US5723597A (en) * | 1983-01-10 | 1998-03-03 | Gen-Probe Incorporated | Ribosomal nucleic acid probes for detecting organisms or groups of organisms |
| US5681698A (en) * | 1991-04-25 | 1997-10-28 | Gen-Probe Incorporated | 23S rRNA nucleic acid probes to mycobacterium kansasii |
| PL181867B1 (pl) * | 1994-06-14 | 2001-09-28 | Dainippon Pharmaceutical Co | Nowe zwiazki, sposoby ich wytwarzania i srodki przeciw nowotworowe PL |
| US20050191661A1 (en) * | 1996-11-06 | 2005-09-01 | Tetsuya Gatanaga | Treatment of inflammatory disease by cleaving TNF receptors |
| EP0938548B1 (en) * | 1996-11-06 | 2008-08-06 | The Regents of the University of California | Isolated tumor necrosis factor receptor releasing enzyme, compositions comprising the enzyme and methods of the use thereof |
| US6593456B1 (en) * | 1996-11-06 | 2003-07-15 | The Regents Of The University Of California | Tumor necrosis factor receptor releasing enzyme |
| US6930084B1 (en) * | 1996-11-06 | 2005-08-16 | The Regents Of The University Of California | Treating arthritis with TNF receptor releasing enzyme |
| US7138384B1 (en) * | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| WO1999040093A2 (en) * | 1998-02-04 | 1999-08-12 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents |
| US6911314B2 (en) * | 1999-05-14 | 2005-06-28 | The Regents Of The University Of California | Screening for drugs that affect TNF receptor releasing enzyme |
| US20030204075A9 (en) * | 1999-08-09 | 2003-10-30 | The Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| AU2001296224A1 (en) * | 2000-08-07 | 2002-02-18 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| US20030166213A1 (en) * | 2000-12-15 | 2003-09-04 | Greenspan Ralph J. | Methods for identifying compounds that modulate disorders related to nitric oxide/ cGMP-dependent protein kinase signaling |
| US6645749B2 (en) * | 2001-05-25 | 2003-11-11 | Novozymes A/S | Lipolytic enzyme |
| CA2481339A1 (en) * | 2002-04-05 | 2003-10-23 | Cyternex, Inc. | Methods for targeting quadruplex dna |
| AU2003272389A1 (en) * | 2002-09-12 | 2004-04-30 | Cyternex, Inc. | Expanded porphyrin compositions for tumor inhibition |
| US7354916B2 (en) * | 2003-04-07 | 2008-04-08 | Cylene Pharmaceuticals | Substituted quinobenzoxazine analogs |
| US20040115706A1 (en) * | 2003-09-11 | 2004-06-17 | Jin Cheng He | High-throughput methods for identifying quadruplex forming nucleic acids and modulators thereof |
| JP5317472B2 (ja) * | 2004-03-15 | 2013-10-16 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ｓｎｓ−５９５、及びその使用方法 |
-
2006
- 2006-08-18 CA CA002619663A patent/CA2619663A1/en not_active Abandoned
- 2006-08-18 JP JP2008527196A patent/JP2009504192A/ja active Pending
- 2006-08-18 US US11/506,588 patent/US20070117770A1/en not_active Abandoned
- 2006-08-18 EP EP06801941A patent/EP1926372A2/en not_active Withdrawn
- 2006-08-18 WO PCT/US2006/032508 patent/WO2007022474A2/en not_active Ceased
-
2008
- 2008-02-04 US US12/025,705 patent/US20090181377A1/en not_active Abandoned
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