JP2009500397A

JP2009500397A - エピナスチンを含む眼科用経皮吸収型製剤

エピナスチンを含む眼科用経皮吸収型製剤 Download PDF

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Publication number: JP2009500397A
Authority: JP; Japan
Prior art keywords: epinastine; pharmaceutically acceptable; acceptable salt; subject; hours
Prior art date: 2005-07-08
Legal status : Abandoned

Application number

JP2008520118A

Other languages

English (en)

Japanese (ja)

Other versions

JP2009500397A5 (https=

Inventor

明治礒脇

朋子中嶋

聡大鳥

Current Assignee

Senju Pharmaceutical Co Ltd

Original Assignee

Senju Pharmaceutical Co Ltd

Priority date

2005-07-08

Filing date

2006-07-07

Publication date

2009-01-08

2006-07-07 Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd

2009-01-08 Publication of JP2009500397A publication Critical patent/JP2009500397A/ja

2009-08-20 Publication of JP2009500397A5 publication Critical patent/JP2009500397A5/ja

Status Abandoned legal-status Critical Current

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WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 title claims abstract description 107
229960003449 epinastine Drugs 0.000 title claims abstract description 93
238000002360 preparation method Methods 0.000 title claims abstract description 83
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KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
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RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
SJOXEWUZWQYCGL-UHFFFAOYSA-N salicylic acid menthyl ester Natural products CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-UHFFFAOYSA-N 0.000 description 1
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