JP2009168737A - Burr-free unit system embedding frame-like substrate container structure, and specimen preparation/storage method from transmission and connection of sample data of extracted sample and fixation and transfer of sample using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent a picking error of a patient's bio-sample, to clarify where the responsibility of an accident lies, to achieve automation, labor saving and space saving of processes for fixation and transfer of a sample, collation, reception and extraction of an analyte sample, medical solution treatment such as dehydration/degreasing/clearing/penetration of an embedding agent, specimen preparation, and storage, management and retrieval of block sample data from the time of extraction of the patient's sample, and to attain accuracy management and a reduction of medical waste. <P>SOLUTION: A specimen treatment container (a medical solution treating basket and a slicing embedding block support base) separated from the clinical sample extraction side, and an independent specimen preparation instrument for an embedding plate are independently separated into unit system composite components to form a constitutive unit of instruments used in all operation processes of reception from a sample fixing transfer container, specimen preparation and storage, management and retrieval of the block sample, thus proposing a specimen preparation/management system for moving a common unit constitution forming body integrally with the patient's sample to form an information transmission body (a messenger) with the patient's sample and patient data always moving integrally in all operation processes of storage, management and retrieval of the medical solution treating basket, the embedding block sample and sample data from a sample fixing transfer container when extracting the patient's sample. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  This invention is a medical or research data for doctors and life scientists who decide on the diagnosis and treatment of diseases, or make biological specimens collected from patients or living organisms for the purpose of life research. Sample preparation and preparation of specimens (sample and specimen data) from a fixed transfer container that enables reliable correlation of collected specimen data, specimen number, and past history, etc., used in a pathological tissue specimen management system It relates to embedding method using it, storage management of block sample data and labor saving.

None of the conventional cassette systems of any manufacturer has developed significantly from the specimen processing container apparatus and embedding method first proposed by Miles (USA) and developed from ring or frame cassettes. The new signs are about the burr-free embedding dish proposed by the present inventor and its method (see Patent Documents 1 and 2), and others are imitations of Miles' sample preparation and embedding methods and instruments. Only.
In the conventional cassette system, the so-called cassette substrate (specimen processing vessel) serves only as a cassette chemical processing vessel and a thin-cut block base, and is used as a chemical processing vessel used for chemical processing when embedding blocks are manufactured. Although the used cassette base is used as a base, the fixed transfer container and the embedding dish for the sample have been proposed as instruments prepared in advance.

  Therefore, in order to produce a slide specimen of a biological sample, data such as a sample number is written or printed in a specimen processing container also serving as a so-called cassette base, and the biological sample is stored in the container. The entire table (specimen processing container) is treated with dehydration, degreasing, penetration, and embedding agent penetration. Therefore, when starting full-scale use of this Miles-type cassette system, it is from the start of sample cutting and trimming, and when using other containers when collecting or transferring patient samples, or when using a Miles-type cassette system, So-called cassettes contaminated with formalin, etc., are washed and wiped again before using the data, or the cassette container is discarded and replaced with a new cassette. There is no idea of reliable correlation between sample data and cost reduction of fixed transfer containers.

  The biological sample stored in the cassette substrate is subjected to chemical treatment such as dehydration, degreasing, penetration, penetration of embedding agent, and transferred to the bottom of the embedding dish. It is installed at a predetermined position from the opening of the embedding dish, and the biological specimen is integrally embedded as a block sample using the cassette base as a block support base for slicing.

  Thereafter, the block sample is sliced by fixing the base to a cassette adapter for slicing microtome, and subjected to microscopic judgment and diagnosis after work steps such as data transfer, extension, dry pasting, staining, and encapsulation.

Japanese Patent Laid-Open No. 2002-303568 Japanese Patent Laid-Open No. 2004-125631

  Since the conventional technique is as described above, the cassette base is limited by the size, amount and shape of the biological sample to be accommodated, which also affects the role, size and shape of the container. For this purpose, it is reasonable to standardize the size of the block sample, but it is reasonable, but the thickness of the biological sample is about 5 mm, which is suitable for chemical treatment such as dehydration, degreasing, penetration, and embedding agent penetration. The size of the standard type of slide glass is about 26.5 mm x 76.5 mm, and the size of the conventional plastic cassette base is also in terms of material strength. The limited body method was 31 × 26 × 5mm, and the outer method was 40 × 28 × 6mm. However, the technology of the specimen preparation and the performance of the equipment have improved, and the cassettes with more depth and width are now on the market. Although it is being sought, molding is performed by spending various costs at the bottom of the cassette each time due to the difference in the depth of the cassette. This is to reduce the molding cost.

  In addition, the introduction of data storage media is indispensable for collating block samples with patient data such as patient information such as past history, associating them with data including images, automating specimen preparation, and building a storage management system. Inadequate information transmission methods or easy mistakes made by workers have resulted in mistaking patient samples and data, resulting in many serious medical accidents. Make sure that this patient sample and patient data specimen are communicated to the specimen preparation / diagnostic side, eliminate mistakes and loss of specimens in specimen preparation, and store / manage diagnosis / reports / history data It is useful for search.

  In addition, the cassette base of the conventional cassette system is used from the time of cutting out for the purpose of serving as a treatment tank from the beginning of chemical treatment of the biological sample. The sample data, sample number, etc. must be printed, printed or described in the data recording section, and before that, reliable data description is impossible. However, it is time consuming and unreasonable to write, print, and print sample data such as sample numbers and barcodes directly in the conventional cassette data description section at the time of cutting, and a large pathological laboratory. Unless it is a laboratory, it is impossible to budget a direct printing machine for cassettes made of synthetic resin such as barcodes and two-dimensional data codes. This is to build a system cassette system that can secure the data description, printing, and recording time and transfer the data with an inexpensive printing machine.

  Further, conventionally, the fixed transfer of the collected sample is performed by separately preparing a fixed transfer container for the collected biopsy sample on the clinical side (the fixed transfer container in which the sample is stored and the inspection request form are collected together with the specimen). Say: hereinafter referred to as a specimen) The biopsy sample fixed as a specimen is removed from the fixed transfer container at the time of excision and stored in the cassette in which new data is written or printed, or the fixed transfer The cassette containing the collected biopsy sample is placed in a container and transferred as a specimen. The cassette that has already been contaminated with the fixative at the time of cutting is washed and dried, or discarded to obtain a new one. Although data is written or printed on the cassette, the cassette base is originally passed through the chemical treatment tank and the embedding support agent penetration tank together with the collected sample, so the sample data printed and printed around it. The data recording section is also affected by being immersed in the chemical solution, and if it is contaminated and wet before that, the data recording section cannot record or print data, and at this point the sampling that has been fixed and transferred to a new cassette A mistake occurs when the sample is replaced, and it is cheap. To eliminate this contradiction, a low-cost sample transfer container in which the cassette substrate is not immersed in a chemical solution is proposed.

  In addition, conventional IC tags are immersed in a fixative solution such as formalin or an embedding agent such as water, alcohol, xylene, chloroform, acid, paraffin or the like unless it is molded in advance so as to be embedded in plastic. IC circuits could be destroyed, and it was impossible to commercialize them from the viewpoint of the price of consumable cassettes. However, although the IC chip that is not affected by various reagents has been developed at present, there is no cassette that can reliably perform its function. Therefore, in anticipation that the price of the IC chip will be reduced in the future, the IC chip can be easily and reliably inserted, fitted, installed and removed, and the data on the IC chip and the data recorded on the cassette base are printed. It is to propose a system transmission body (messenger) that reliably transmits data description / recording section data.

  For this purpose, in conventional cassette printers, depending on the accuracy of the ink and the printing method, the printed characters of the cassette base immersed in the embedding agent become unclear and difficult to read, or data such as barcodes. Reading with a storage media reader is difficult. This is to propose a system device that protects the data description / printing / recording section and suppresses the generation of burrs in the embedding agent during the preparation of the sample embedding block, or removes it easily or automatically.

  Furthermore, another object of the present invention is to record data on the block support base with a margin and to prevent obscuring recording including clinical data from the time of patient sample collection. Is to propose a functional device that is used in the central functional part of the functional device of the chemical treatment vessel of the cassette and the functional device of the fixed transfer container of the sample and is not contaminated by the fixed solution.

  Furthermore, for this purpose, it is commonly used for the functional device of the chemical treatment vessel of the cassette and the functional device of the fixed transfer container of the sample. Whether there is a data recording unit linked to patient attributes such as sample data and clinical data, and whether there is a description / printing / recording location of the sample reference number at the specimen preparation site such as a pathology laboratory Alternatively, there is a data recording unit that associates data between the clinical sample collection side and the specimen preparation side. That is, the bottom portion and the lid portion formed with the porous liquid passage hole are latched and fitted to each other to form a chemical treatment tank, and the bottom portion and the lid portion not molded with the porous liquid passage hole are latched and fitted to each other. It is to propose a common latch fitting device (common unit forming body: organizer) for constructing a fixed transfer container that does not leak.

  In addition, clinical specimen data (specimens) such as the fixed transfer container and the request form collected and stored responsibly on the clinical side, etc. are received and received at the specimen preparation site such as a pathology laboratory, In order to prevent the sample from being lost / mixed at the time when the sample in the fixed transfer container is transferred to the embedded frame-shaped substrate (chemical solution processing), the description on the clinical sample collection side It is certain to ensure that the recorded data record and the sample are transferred together to the chemical treatment tank of the sample. For this purpose, it is reliable to use an important component unit in common for the fixed transfer container for the sample and the chemical solution processing tank, and it also saves the molding cost of the fixed transfer container.

  Further, the present invention embeds a burr-free unit system in which an embedding frame-like base body, which is an outer peripheral wall of a cassette frame-like base, which is a block support base, and a bottom part, which is also a holding and fixing part for an embedding support, and a lid part are independently separated In addition to the space saving of the storage space of the frame-shaped substrate container structure previously filed by the inventor of the present application (Japanese Patent Application No. 2006-197702), the function of the reliable transmission of sample data and the function of the fixed transfer container for the sample And the unit system embedding frame-like substrate container structure only by changing a part of the unit, the capacity of the fixed transfer container and the function of expanding the sample storage space of the frame-like substrate vessel which is a chemical solution treatment vessel can be added. It is.

  Furthermore, in order to maintain a reliable transmission function of fixed sample and clinical sample data (specimen), the data description of the embedded frame-like substrate, which is a common latch fitting instrument for the fixed transfer container and the chemical solution treatment basket, It is important to protect the recording section. This instrument requires a function to prevent or easily remove burrs of various reagents and embedding agents from the time of chemical treatment of the sample to the preparation of the block sample.

  In addition, under the current situation of concern for environmental pollution, many containers and equipment that can be used together are also used, and they have a role necessary for storage management of data and information, and can be reused or used without disposal. Change to what you can, sample collection, data transmission system, fixed transfer container, chemical solution processing bowl, block sample base (stock), embedding dish-like instrument, automation of specimen preparation, block sample storage and retrieval system series It is to be provided as a system unit composite structure that is involved or used in the work process.

In the present invention, the inventor of the present application (Japanese Patent Application No. 2006-197702) previously filed an upper side of an embedding frame-shaped substrate having a through-hole in an opening from the upper side to the lower side of a so-called embedding frame-shaped substrate. In addition, the embedding frame-shaped substrate of the invention of the present application is a shape and form that is detachably attached to the lower opening, and the porous liquid-permeable lid portion is also a lid portion for a block support base substitute. The internal structure of the sample storage hardly changes from the previous application, but the external shape and its functionality can be changed in various ways. This is because the components of a chemical solution treatment basket (embedded frame-shaped substrate basket) having the function of a conventional cassette for pathological tissue samples are connected to the opening from the upper side to the lower side and the outer periphery of the upper opening Has an upper end surface of the outer wall that surrounds the opening, and further forms a data recording part and a data recording part installation part where storage media such as barcodes, two-dimensional data codes, and IC chips can be installed. Embedding frame base body (unit 1) which is a latch fitting instrument (common / connection forming body unit) common to this unit system, which plays a central role in fitting and coupling between unit units and units. A container-like bottom part having a porous liquid-permeable bottom surface formed at least at the bottom, which is an independent unit from the embedding frame-like base body as the unit 1, and from the upper side to the lower side of the embedding frame-like base body Through hole connected to the opening A sample storage part having a porous liquid-permeable bottom surface formed at least at the bottom, and a horizontal projection surrounding the outer periphery of the upper opening of the sample storage part. A porous liquid-permeable container-like bottom portion (unit 2) that forms a flat surface; and a porous liquid-permeable surface that is independent from unit 1, and the porous passage that is unit 2 on the outer peripheral back surface of the porous liquid-permeable surface. A lid (unit 3) formed with a rib to be inserted and fitted into the upper opening of the sample storage portion at the bottom of the liquid container; and, furthermore, a porous liquid passage having the same shape as the unit 2 independent of the unit 1 A non-liquid-permeable container-like bottom portion (unit 4) in which no holes are formed; and, furthermore, a non-liquid-permeable lid in which a porous liquid-permeable hole having the same shape as the unit 3 independent of the unit 1 is not formed. Body (unit 5) and 5 types of structures Burrless unit system embedding with various variations constructed from unit system composite structure with embedded unit as unit 1 embedded frame-like base body as common / connected formed body unit A frame-shaped substrate structure,
Furthermore, the package which is a component auxiliary unit position, which is another functional unit independent of the component unit of the five types of units, is a sample data transmission / connector (messenger). For reliable data protection of the embedded frame substrate (unit 1), do not have an installation position inside the embedded frame substrate (unit 1), which is the sample data transmission / connector (messenger). A lid with a data recording part protection plate formed integrally with the lid of the (units 3 and 5), which also protects the data description part or data recording part installed, written or printed on the outer surface of the outer wall (Unit 3 or unit 5) or a data recording unit including a data description unit and an IC chip formed independently as a unit and installed on the outer surface of the embedded frame base (unit 1) Auxiliary functions that are independent of the constituent unit of the five-type unit and have a function of preventing or simply removing the burrs of the embedding agent adhering to the periphery of the embedding frame substrate (unit 1). The presence of a plate-like frame protection device that is unitary is necessary.
Furthermore, although it is in the position of the functional component auxiliary unit that is independent of the component unit of the five types of units, it has openings on the upper side and the lower side, and from the upper side to the lower side. A through-hole portion connected to the upper opening portion of the outer wall and surrounding the periphery of the upper-side opening portion of the through-hole portion connected from the upper side to the lower-side opening portion, or a through-hole portion connected to the upper-side opening portion. Another function that is independent of the constituent unit of the above-mentioned five types of units that can be inserted and engaged with an embedded frame-like base (unit 1) that forms a convex flat surface projecting inwardly on the inner wall. The bottom made of stainless steel for embedding dishes, which is an auxiliary unit of nature, is similar to the bottom (unit 4), but is a container-like bottom formed with a closed surface that does not leak liquid, Connected to the opening from the upper side to the lower side of the base (unit 1) A sample storage part that can be removably inserted and fitted into the through-hole part and formed with a non-liquid-permeable closed surface, and a bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening of the sample storage part A container-like bottom formed by a non-liquid-permeable closed surface, and a through-hole that is connected to the upper end surface of the outer periphery of the opening of the embedded frame-shaped base (unit 1) or to the upper opening The non-liquid-permeable metal container-like bottom is placed on the lower opening side of the embedded frame-shaped substrate (unit 1). This is a burr-free embedding dish constructed of a two-unit system composite structure having a dish-like bottom portion that has a function of preventing it from falling off.
In other words, in addition to the above-mentioned five types of component units, various units constructed from unit system composite components that can be inserted, fitted and latched into the embedded frame-like base body (unit 1), which is the two types of auxiliary units, This is because it is a burr-free unit system-embedded frame-shaped substrate structure having variations.

  Further, in a so-called cassette porous liquid-permeable bottom portion constructed from a porous liquid-permeable container-like bottom portion (unit 2) which is a unit independent of the embedding frame-like base body which is the central unit 1 of the unit system composite structure. The porous liquid-permeable container-like bottom portion (unit 2) is a sample storage portion that can be removably inserted and fitted into a through-hole portion extending from the upper opening portion to the lower opening portion of the embedded frame-shaped substrate, and is porous at least on the bottom surface. A sample storage portion having a liquid passage hole, and a sample storage portion on the upper peripheral surface of the upper opening periphery of the embedded frame-shaped substrate, and the sample storage portion on the lower side. A saddle-like outer peripheral convex surface having a structure that does not fall out is formed.

  Alternatively, a porous liquid-permeable container-like bottom portion (unit 2) which is a unit independent of the embedding frame-like substrate (unit 1) is provided on the embedding frame-like substrate which is the central unit 1 of the unit system composite structure. In the so-called cassette porous liquid-permeable bottom portion constructed by installing and holding the storage latch, at least the bottom surface is perforated at least in the sample storage portion of the porous liquid-permeable container-like bottom portion, which is the constituent unit 2 of the cassette porous liquid-permeable bottom portion. A sample storage portion in which a liquid hole is formed is removably inserted and fitted into a through-hole portion extending from the upper opening to the lower opening of the embedded frame-shaped substrate (unit 1), and the bottom of the porous liquid-permeable container A convex surface projecting toward the inner side of the inner wall of the through hole connected to the upper side opening of the embedding frame-shaped base, the flange-shaped outer peripheral convex surface formed on the outer peripheral surface of the opening of (Unit 2) The embedded frame-shaped substrate ( Knit 1 sample storage portion on the lower side of) may form a flanged outer peripheral convex surface is a structure which does not fall out.

  Therefore, a so-called cassette porous fluid passage for a pathological tissue sample having the same shape and function as the conventional one by the two-unit structure of the embedded frame-like base (unit 1) and the porous liquid-permeable container-like bottom (unit 2). The bottom is constructed (a block support base having a latching portion of a locking pawl for fixing a microtome adapter for slicing).

  Therefore, a so-called porous liquid-permeable bottom portion comprising a two-unit structure of the embedded frame-shaped substrate and the porous liquid-permeable container-shaped bottom portion (unit 2) through the embedded frame-shaped substrate (unit 1); A porous liquid-permeable container in which a combined shape composed of a three-unit composite structure of independent porous liquid-permeable lids (unit 3) to be hooked and connected has the same shape and function as a conventional cassette for pathological tissue samples It is an embedded frame-shaped base body (chemical solution processing base) including a so-called cassette function composed of a three-unit composite structure.

  Furthermore, another object of the present invention is to record data on the block support base with a margin and to prevent recording data including clinical data from the time of patient sample collection from being replaced, lost or obscured. Yes, the last filed by the inventor of the present application (Japanese Patent Application No. 2006-197702) is that an embedding frame-shaped substrate bag and a porous material that serve both as a chemical solution processing basket (frame-shaped substrate basket) and an embedding dish-like instrument. It consists of 3 units of 3 functions, 1 device, which is a composite structure with the bottom part where the lid part is also the holding and fixing part (block support base) of the embedding support agent. In addition to the shape function of the perforated lid or bottom of the embedding frame-shaped substrate 、, the bottom of the same shape having no porous liquid passage hole as a unit system embedded frame-shaped substrate structure (unit 4) And lid (unit 5 By adding various functions to the unit system composite structure system by adding and forming, and latching and fitting through the embedded frame-like base body to add the function of the fixed transfer container, more synergistic functionality It is to raise.

  Furthermore, the embedded frame-shaped substrate (unit 1), the porous liquid-permeable container-like bottom (unit 2), the porous liquid-permeable lid (unit 3), and the unit 2 having the central functions in this unit system have the same shape. The container-shaped bottom portion (unit 4) having no porous liquid passage holes, the lid body (unit 5) having the same shape as the unit 3 and having no porous liquid passage holes, and the lid bodies (units 3 and 5) are integrally formed. The embedded frame-shaped substrate (unit) which is formed independently as a cover with a data recording unit protection plate or an auxiliary unit, and has an installation site outside the outer wall of the embedded frame-shaped substrate (unit 1) 1) A board with a function to protect the data recording part including the data description part and IC chip, or to prevent or remove the burrs of the embedding agent adhering to the embedding frame base (unit 1). Five types of frame protectors added Unit complex structure of the is to one of burrs without unit system embedded frame-like base system connection system constructed from the auxiliary unit.

  Furthermore, although the component unit of the five types of units is also located at the position of a functional component auxiliary unit that is independent from the unit unit, the embedded frame-shaped substrate (unit 1) that plays a central function in the unit system. A sample storage portion formed by a non-liquid-permeable closing surface that can be removably inserted into a through-hole portion connected to the opening portion from the upper side to the lower side, and a horizontal surrounding the outer periphery of the upper opening portion of the sample storage portion A container-like bottom formed by a liquid-impervious closed surface formed with a bowl-shaped flat surface projecting in the direction, on the upper end surface of the outer periphery of the opening of the embedded frame-shaped substrate (unit 1) Alternatively, the non-liquid-permeable metal container-like bottom is mounted on the convex flat surface projecting inwardly on the inner wall of the through-hole portion continuous with the upper opening, and the embedded frame-shaped base (Unit 1) Dish-shaped bottom with a function to prevent it from falling off the lower opening Add a burr-free embedding dish constructed with a two-unit system composite structure to a connection system for a burr-free unit system-embedded frame-shaped substrate system constructed from five types of unit composite structure and two types of auxiliary units It is to be.

The depth (outside wall height) of the independent embedded frame-like substrate (unit 1) of the two-unit structure is set to a block support base for slicing (cassette base) of an adapter of a conventional block sample cassette slicing microtome. If it is fixed so that it can be placed on the locking pawl for
Even if the depth of the porous liquid-permeable container-like bottom (unit 2) or the width corresponding to the locking claw for fixing of the conventional cassette fixing adapter of the sample slicing microtome is changed in the longitudinal direction,
The embedded frame-like substrate (unit) having a through-hole in an opening from the upper side to the lower side where the porous liquid-permeable container-like bottom (unit 2) and the porous liquid-permeable container-like bottom can be hooked and fitted. 1) The cassette porous liquid-permeable bottom portion constructed from 1) has a locking portion that matches the locking pawl of the cassette fixing adapter,
A porous liquid-permeable bottom portion of a so-called pathological tissue sample cassette comprising a two-unit structure having a large depth and width that can be fixed to the fixing latching claw of the adapter can be freely formed.

  Therefore, if the shape of the porous liquid-permeable container-like bottom portion (unit 2), which is also the support base for the thin-cut block, is made into a shallowly shaped bottom portion, storage of the block sample of the block sample after completion of the thin-cut operation. By changing the position of the bottom part of the block sample at the time of slicing at the time of slicing, the sample embedding side on the support base for the slicing block is placed on the embedding frame-shaped substrate. The inside of the block sample can be reduced in size by about half the shape and shape of the block sample, and the inventor's previous application (specialized in the labor saving of the block sample storage space and reliable storage and management of the block sample). It is possible to maintain and add a function that can be guaranteed in the same manner as in Application No. 2006-197702).

That is, the present invention adds the role function of the fixed transfer container composed of a bottom and a lid constructed through the embedded frame base (unit 1), so that the five types of components are provided. Classifying the type of unit system embedded frame-like substrate structure constructed from the unit composite structure of the unit and the morphological function change by unit independence;
1) Fixed transfer of a sample composed of a three-unit composite structure comprising the embedded frame base (unit 1), a liquid-impervious container-like bottom (unit 4), and a liquid-impervious lid (unit 5). A conventional pathological tissue comprising a three-unit composite structure of a container and 2) the embedded frame-shaped substrate (unit 1), a porous liquid-permeable container-like bottom (unit 2), and a porous liquid-permeable lid (unit 3) An embedding frame-shaped base body that functions as a sample cassette (chemical solution processing base); and 3) a two-unit composite structure of the embedded frame-shaped base body (unit 1) and a porous liquid-permeable container-like bottom (unit 2). A support base for an embedding block sample of an embedding support agent that functions as a bottom of the cassette for pathological tissue sample, and 4) a thin slice that is one of the shape functions of the embedding frame-shaped substrate (unit 1) Integrated with the bottom of the cassette for pathological tissue samples at the adapter latching and locking part 5) Adapter latching at the time of slicing the block support base composed of a two-unit composite structure of the embedded frame-like base (unit 1) and the porous liquid-permeable container-like bottom (unit 2) The function of expanding the sample storage space of the cassette for a pathological tissue sample, which is the drug solution treatment basket, made possible by the independent function of the locking part (unit 1). 6) The embedded frame-shaped substrate (unit 1) and the container. Slicing is completed by the independent function (unit 1) of the adapter latching locking part at the time of slicing the block support base consisting of a two-unit composite structure with a cylindrical porous liquid-permeable bottom (unit 2) 7) A unit system composite structure that fulfills seven forms of an embedding dish-like instrument composed of an embedding frame-like substrate made possible by the independence of the frame-like substrate (unit 1). Furthermore, the embedding frame-shaped base body (chemical solution processing base) that is one of the unit system embedding frame-shaped base body structures constructed by the unit system composite structure of the five types of structural body units, and another The clinical side collects a sample on the embedded frame-shaped substrate (unit 1), which is also a common latching fitting device (common / connection formation unit) of the fixed transfer container that is a unit system embedded frame-shaped substrate structure. 8) The patient sample data and clinical data transmitted through the description / printing / insertion / installed description data or the data recording part of the fixed transfer container of the stored patient sample 8) Embedded frame-shaped substrate Synergistic effect of various functions of the unit system composite configuration system that has 8 function forms in addition to the function form as a data recording unit (messenger) that reliably transmits and connects to (chemical treatment tank) By expanding the functions, the pathological sample collection, specimen preparation, diagnosis / reporting, various sample data transmission, storage management and retrieval work, the various costs between the work process are further reduced, and the patient sample data is reliably transmitted / connected and work It can aim to improve workability by guaranteeing on-site accuracy control.

Furthermore, when the functionality is viewed from the embedded frame-like substrate side, which is a unit 1 that is responsible for the central function of the connection system of the unit system without embedded burrs,
1) Each of the other four types of component units, which are the above-mentioned five types of component units, are fitted and connected to each other to construct one functional component container, for example, serving as a connection forming body. It plays a central function in the unit system.
2) One of the functional component containers has the function of a conventional cassette for pathological tissue sample,
This is a chemical solution processing basket (embedded frame-shaped substrate basket) for a sample, and this unit component is a porous liquid-permeable container-shaped bottom portion (unit 2) that is fitted and connected to each other via an embedded frame-shaped substrate (unit 1). And a three-unit composite container of a porous liquid-permeable lid (unit 3).
3) It also has a function to serve as a latching portion of a latching claw of the adapter for fixing the cassette when the block sample is sliced, which is an important function of the function of the cassette for pathological tissue sample.
4) Therefore, even if the depth of the bottom is freely changed, the locking position of the locking portion of the latching claw of the fixing adapter of the cassette is the same when the block sample of the cassette for pathological tissue sample is sliced. It is.
5) Another functional component container is a functional component container as a fixed transfer container for a sample. This unit composite structure has the same shape as the unit 3 and the container-like bottom part (unit 4) having no porous liquid passage hole having the same shape as the unit 2 fitted and connected to each other via the embedded frame-like base (unit 1). It is a three-unit composite structure container with a lid portion (unit 5) having no porous liquid passage hole, and its internal volume changes only by changing the depth of the container-like bottom portion (unit 4) without the porous liquid passage hole. .
6) The bottom and the lid of the two functional component containers are mutually connected via an embedded frame-like base body, which is a unit 1 responsible for the central function of the connection system of the burr-free unit system embedded frame-like base system. The functional component container is a sample chemical treatment container (embedded frame-shaped substrate container) having the functions of the fixed transfer container and the conventional pathological tissue sample cassette. The embedded frame-shaped substrate, which is a common connection formation of the mutual functional component containers, includes, for example, a description part of a patient sample data of a collected sample on the clinical side, data such as an IC chip, a barcode, and a two-dimensional data code The recording part installation site is molded.
7) The embedding frame-like base body, which is a joint-forming body common to the two functional constituent containers, is used in a constituent unit of a fixed transfer container for collected samples on the clinical side, and is an embedding-frame-like body that is the joint-forming body. Clinical patient sample data is recorded in the data description part and data recording part of the substrate and transferred as a specimen (fixed transfer container of the sample and its examination request form data), and further received by the pathological specimen preparation and examination side・ When cutting out, the inspection side data is transmitted to the data description part and data recording part of the embedded frame-like base body that is the fitting / connection forming body (organizer) and is the information transmission / connection body (messenger) The sample taken out from the container-shaped bottom part which is a part of the unit composite structure of the fixed transfer container is a part of the unit composite structure of the same fixed transfer container, and is a fitting / connection forming body. Embedding Through Jo substrate is transferred housed in the chemical processing basket of the sample that is equal to a newly constructed conventional pathologic tissue sample cassette (embedding frame-shaped body cage) are sample preparation. Therefore, it prevents contamination of the cassette with the fixative when the biopsy sample is carried using a conventional cassette, eliminates the need for a separately prepared container, and reduces time and equipment costs. Reduced medical waste.
8) Further, the patient sample data of the fixed sample collected from the patient on the clinical side and transferred by the fixed transfer container is a fitting / connection forming body common to the two functional component containers, and the data transmission / connection is performed. It is surely connected and recorded via the data description part and data recording part of the body-embedded frame-like base (unit 1), so that the sample can be prevented from being inserted or lost.
9) Furthermore, it is a porous base that is also a support base for a thin-cut block of an embedding frame-like base body constructed through an embedding frame-like base body that is a fitting / connection formation common to the two functional component containers. If the bottom of the liquid-permeable container-like bottom (unit 2) is formed shallowly, the bottom of the porous liquid-permeable container-like bottom (unit 2), which is also the support base for the thin-cut block of the block sample after completion of thin-cutting, is formed. The sample side is housed inside the embedded frame-like substrate inside out, and the pathological tissue sample cassette (embedded frame-like substrate 籠) is further filled with a used porous liquid-permeable lid (unit 3). If the opening is closed, the storage of the patient sample will be perfect, and the thickness of the storage block sample will be reduced to nearly half that of the conventional block sample, realizing space saving in the block sample storage warehouse. Medical functionality has been reviewed by revising the important functionality of the lid Leading to the reduction.
10) Furthermore, the embedded frame-shaped substrate (unit 1) is also a support base for a thin-cut block of the embedded frame-shaped substrate bag (a cassette for a pathological tissue sample), and the bottom of the porous liquid-permeable container shape A through-hole portion that can be inserted and fitted into the porous liquid-permeable sample storage bottom portion of (Unit 2) and that extends from the upper opening portion to the lower opening portion is formed, and is fitted to the porous liquid-permeable lid body (Unit 3). It is a central unit among the three independent constituent units that are combined and connected to construct the cassette for pathological tissue sample, which is a three-unit composite constituent container. Organizer).
In addition, the liquid embedding agent adheres to the surroundings in the process of performing the function of the chemical solution processing vessel such as fixation, dehydration, degreasing, penetration, penetration of the embedding agent of the sample stored in the pathological tissue sample cassette In the embedding operation of the sample of the embedding frame-shaped substrate basin (the cassette for pathological tissue sample), the porous liquid-permeable container-like bottom portion (unit 2) which is also a support base for the sliced block of the embedding frame-shaped substrate is removed. The upper embedded frame-shaped substrate made of synthetic resin that fits or connects with the through-hole portion of the embedded frame-shaped substrate or a part of the tip is fitted or connected to the stainless steel bottom for the embedded plate An end face is formed into an acute angle, and is formed into a shape that fits water tightly with the bottom of the embedded frame-shaped substrate ridge (pathological tissue sample cassette), and the inner wall of the embedded frame-shaped substrate and the embedded dish The embedding frame-shaped substrate ridge (pathological tissue test) is a concave dihedral surface composed of a cocoon-shaped flat surface at the bottom made of stainless steel. For example, the inventor has already filed an application for a watertight fit rather than a metal-integrated embedding dish. And the liquid embedding agent around the cassette flows down from the outer peripheral side surface of the embedding frame-shaped base plate (pathological tissue sample cassette). , Embedding without burr can be done. At this time, integral molding with a synthetic resin is not recommended because of poor thermal conductivity.

  Furthermore, the present invention provides a cylindrical hole portion through which the porous liquid-permeable container-like bottom portion (unit 2) passes from the upper opening portion to the lower opening portion of the embedding frame-like substrate through the embedding frame-like substrate. A sample storage portion that can be removably inserted into the sample storage portion, and a porous liquid passage hole is formed at least on the bottom surface, and an upper end surface of the upper periphery of the upper opening portion of the embedded frame-like substrate on the outer periphery of the opening of the sample storage portion The embedding frame-shaped base (unit 1) and the porous body are latched by being inserted and latched with a hook-like outer peripheral convex surface having a structure in which the sample storage part is not dropped off on the lower side. From the two-unit structure of the liquid-permeable container-like bottom (unit 2), the same porous liquid-permeable bottom as before (block support base having a latching claw locking part for fixing a thin-walled microtome adapter) Constructed in front of the porous liquid-permeable bottom of the cassette for pathological tissue samples A unit system embedding frame-like substrate porous liquid-permeable container, which is a three-unit composite structure constructed by detachably hanging and connecting a porous liquid-permeable lid (unit 3), is a conventional so-called pathological tissue sample. It is a unit system-embedded frame-shaped substrate porous liquid-permeable container that has the same external shape of the cassette and can also hold the functional forms of the chemical treatment rod and the block support base for slicing, which were first announced by Miles.

  This is because the shape of the chemical treatment bowl, which is a cassette for pathological tissue samples that is currently used, is easy due to the problems related to the sample preparation equipment and work process systems that are often used in the preparation site of the specimen and the operator's familiarity. However, it is important to develop functionality and convenience in a category that maintains its shape. In other words, the conventional sample processing container (cassette substrate) previously announced by Miles has been proposed centering on a cassette system that doubles as a sample chemical processing vessel and a block support base for slicing. The invention of the present invention is similar to that of the above-mentioned Miles Co., Ltd., without changing the shape of the outer shape of the cassette system other than the cassette system having both the functions of the chemical treatment vessel for the sample and the block support base for slicing. A unit system-embedded frame-shaped substrate structure constructed from a unit composite structure in which eight functions are added to the above-mentioned two functions in a square shape and the functionality is expanded.

  To that end, it is a unit / embedded unit unit (organizer) that is a unit system embedded frame-like base body structure constructed from a unit composite structure of each of the above structural body units. Specimen transfer / specimen preparation / specimen diagnosis report and specimen embedding block storage management / retrieval data recording part transmission / concatenation body (messenger) It is indispensable to have a functional component unit that protects the description / printing / insertion / installation description data or the data recording portion of the installation site provided on the outer surface of the outer wall of the unit 1).

In the unit system according to the present invention, the central functional component container composed of the unit system composite component is a liquid-burrless unit system embedded frame-like substrate component I with sample data transmission / connection function. As shown in FIGS. 1A and 1B, a cassette (embedded frame-shaped substrate 籠) 1 and a non-liquid-permeable burr-free unit system with a sample data transmission / connection function are embedded frame-shaped substrate structure II. is there.
This embedded frame-shaped base rod 1 is a chemical solution processing rod for a sample having the function of a conventional cassette 1 for pathological tissue sample, and the outer shape of the construction structure is the shape of the conventional cassette as can be understood from FIG. 1A. Can be kept in the same shape.
Furthermore, this structural unit includes a porous liquid-permeable container-like bottom portion 7 (unit 2) and a porous liquid-permeable surface 7c that are fitted and connected to each other via an embedded frame-shaped substrate 9 (unit 1). A porous liquid-permeable lid 3 (unit) in which a rib 3e is formed on the outer peripheral rear surface of the porous surface to be inserted and fitted into the upper opening 7f of the sample storage portion 7a of the porous liquid-permeable container-like bottom 7 as the unit 2. 3) Liquid-permeable 3-unit composite structure container.
The sample fixed transfer container 2 which is another central functional component container also has a porous liquid passage hole having the same shape as the unit 2 fitted and connected to each other via the embedded frame-shaped base body 9 (unit 1). This is a non-liquid-permeable three-unit composite container of a non-liquid-permeable container-like bottom 8 (unit 4) and a non-liquid-permeable lid 5 (unit 5) having the same shape as the unit 3 and no porous liquid-permeable holes. .

The embedded frame base 9 (unit 1) includes a through-hole 9a and an upper opening connected to the lower opening 9m from the upper opening 9l as shown in FIGS. The outer periphery is provided with an upper end surface 9b of the outer wall surrounding the opening, and is provided with a data description surface / data recording portion 9d inclined downward from above the front portion, and the upper side of the data description portion / data recording portion 9d side On the end face 9b, three connecting holes 9g, 9f, and 9g that open to the lower bottom of the embedded frame base 9 are opened. 2A, FIG. 12, FIG. 13, FIG. 17, FIG. 19, FIG. 19, FIG. 21, FIG. 22 and FIG. Protection of the cover 3 or 5 with a protective plate of the data description part / data recording part in contact with the bottom surface of the embedded frame-like substrate 9 (unit 1) below the data description part / data recording part 9d inclined to the side A locking portion 9c is formed on the lower portion of the plate 3b or 5b so as to be engaged with the locking claw 3c or 5c, and is formed on the outside of the rear wall of the embedded frame-like base body 9 (unit 1). A latching portion 9j (FIGS. 8 to 12 and FIGS. 14 to 25) into which the rear latching claw 3d of the lid 3or 5 with the protective plate is latched and fitted is formed. However, the latching portions 9j in FIGS. 15 and 16 and FIG. 18 are formed in two places in parallel. Further, FIGS. 8 and 9 show the data description section / data recording section in order to increase the description area / printing area of the data description surface / data recording section 9d inclined from the top to the bottom of the front portion of the cassette 1 for pathological tissue sample. Although the upper projection forming surface 9k is formed, if this portion is not formed as shown in FIG. 12, the upper shape of the inclined surface which is the data recording portion / data recording portion is shown in FIGS. 19 and 22, the front part of the bowl-shaped outer peripheral convex surface (7b and 8b) of the container-like bottom part (unit 2 and unit 4), which is another constituent unit of the unit system composite structure. It is preferable to form the tip at an inclined shape.
7 is an embedding frame-like substrate 9 (unit 1) that is a constituent unit of the two-unit composite container and a non-liquid-permeable container-like bottom portion 8 (unit 4) Although it is explanatory drawing of two structural units, A, C, and E of FIG. 7 are detachable in the through-hole part which passes from the upper side opening part of the said embedding frame-shaped base | substrate 9 (unit 1) to a lower side opening part. The flange-like outer peripheral convex surface 8b formed on the outer peripheral surface of the opening of the non-liquid-permeable container-like bottom 8 (unit 4) is inserted into the upper side of the embedded frame-shaped base 9 (unit 1). A through-hole portion 9a connected to the opening portion 9l is hooked on a convex surface 9h projecting toward the inner side of the inner wall, and the sample storage portion falls off below the embedded frame-like substrate (unit 1). It is shape explanatory drawing of the other Example of the unit system which formed the bowl-shaped outer periphery convex surface 8b which is a structure which is not.

  Further, as shown in FIG. 1 to FIG. 7 and FIG. 24 to FIG. 29, on both sides of the embedded frame-shaped substrate 9 which is a constituent unit 1 of the cassette 1 for pathological tissue sample which is also a data description part / data recording part 9d. On the outside of the front side wall and the outside of the rear wall, there are independent protective frame plates for protecting the data description unit / data recording unit 9d and for preventing and easily removing burrs of the embedding support agent during embedding. The latch fitting recesses 9e on both sides for latching and fitting the front side latch fixing portions 4b on the front side of the plate-like instrument 4 and the fitting latching projections 4g on the rear plate frame 4f of the plate-like frame protection instrument 4 A locking fitting recess 9e is formed.

  Further, the engagement fitting recesses 9e on both sides of the embedding frame-shaped substrate 9 are not provided with the cover with the protective plate shown in FIGS. 1 to 3, but with a protective plate as shown in FIG. 55D / E. Instead of the latching portion 9j to which the rear latching claw 3d of the lid 3 or 5 latches and fits, a front fitting portion latching portion is projected symmetrically on both sides of the front portion of the lid body on the bottom side. The locking fitting convex portions 3c or 5c projecting on both inner sides are formed, and between the locking fitting concave portions 9e formed on the outer sides of both side walls of the bottom of the pathological tissue sample cassette 1 as the frame-like base 9. The bottom portion of the cassette for pathological tissue sample, which is the frame-like base 9 formed between the bottom portion and the rear locking portion 9j of the bottom embedded frame-like base 9 comprising the two-unit composite structure container, It also has a function of detachably fitting and connecting to a certain upper opening 7f.

  That is, as easily understood from the description of FIG. 1A / B and FIGS. 2A / B and “0033” to “0036”, the pathological tissue sample cassette 1 which is the embedded frame-shaped base rod 1 and the fixed transfer The container 2 is a common fitting / connection forming body, and the container-shaped bottom part (unit 2) 7 and the container-like bottom part (unit 2) 7 are fitted and connected to each other via the embedded frame-shaped base (unit 1) 9. Since the unit 4) is a three-unit composite container of a lid (unit 3) 3 and a lid (unit 5) 5 having the same shape as the unit 8, the difference is a porous liquid-permeable container or a bottom surface is porous. The only difference is whether it is a sealed container that is not liquid-permeable, the other partial shapes and the shapes of the fitting / connecting structures are all the same, and the conventional shape of the cassette for pathological tissue samples can be maintained. It is done. Therefore, the following description is demonstrated using the explanatory symbol of a porous liquid-permeable unit structure. The symbols for the non-liquid-permeable unit structure are shown in parallel in the explanatory diagram.

Data description section / data recording section:
Conventional cassettes for histopathological specimens have a uniform shape, and their functions are also two functions: chemical treatment of the sample and block base, which promotes rational specimen preparation work by suppressing some sample contamination. I came. However, no proposals have been made for prevention or responsibility confirmation systems for collecting or transferring patient samples, accepting specimens, losing specimens during specimen preparation, or mistaking patient data.
The present invention is an invention that focuses on automation and labor saving by preventing easy mistakes such as data transcription and sample mixing / loss of the operator. The component unit responsible for the central function of the unit system cassette system comprising the unit system embedding frame-like substrate structure is the embedding frame-like substrate 9 (unit 1), and the embedding frame-like substrate 9 (unit 1) is clinical. It is a common fitting / connecting unit (organizer unit) for container equipment related to the process of sample collection transfer, chemical processing, thin-cut specimen preparation, block sample data storage management, and retrieval process If it is a patient sample data transmission / conjugate (messenger) device, the installation method and location of the data description part and data recording part are important issues. A.
Therefore, for example, there are (1) handwritten data by humans and (2) barcodes and two types of data transmission methods that are currently used or will be used in the future in the pathological histological examination process in this medical practice. Dimensional data codes and (3) IC chips are considered mainstream for the time being.

Installation location of bar code and two-dimensional data code: As shown in FIGS. 2, 3, 5, 7, 7 to 13, and 15 to 25, the embedded frame-like base body 9 generally includes the package. It is conceivable that the data recording part / data recording part 9d inclined downward from the top to the bottom of the front part of the embedded frame-like substrate 9 or printed directly on the outside of both side walls or printed on the label 6 is pasted. In the case of direct printing with a cassette for printing, the printing machine is expensive, and it has been reported that it does not read many digits and that the reader does not identify depending on the color of the cassette. Therefore, the present inventor puts a barcode or a two-dimensional data code label printed by a label printer on the outside of the data description surface 9d of the embedded frame-shaped substrate 9 or both side walls, and FIGS. 22 and 24 are enlarged views) As shown in FIG. 22 and FIG. 24, the surface of the bar code label 6 is moved down from the top of the front portion of the embedded frame-shaped substrate 9 with the protective plates 3b or 5b of the lid 3 or 5 with a protective plate. It protects against the inclined data description part / data recording part 9d surface. As can be understood from FIGS. 22, 23, and 24, the porous liquid-permeable container-like bottom portion (unit 2) 7 that is fitted and connected to each other via the embedded frame-shaped substrate (unit 1) 9 of the present invention and the porous The pathological tissue sample cassette (FIG. 22), which is an embedded frame-shaped substrate cage 1 constructed of a liquid-permeable three-unit composite component container of the liquid-permeable lid (unit 3) 3, is a conventional pathological tissue sample. This is almost the same shape as the cassette for use (FIG. 24).
Therefore, the inventor of the present application also fits and connects to the shape of the embedded frame-like base body 1 constructed by the three-unit composite container holding the shape of the cassette for pathological tissue sample, and the lid (unit 3). Or the plate-like frame protector 4 shown in FIGS. 1 to 6, 25 to 29, and 32 independent from 5) is latched by using the fitting latching portion 9e to suppress the label surface. It has also been proposed to protect and prevent permeation of chemicals and the like and peeling due to physical force, and to prevent contamination of the label surface.
In particular, the front tongue-like protrusion fitting portion 3e of the lid (unit 3) 3 which is not formed with the conventional protective plate which is not the lid with the protective plate shown in FIGS. 4B and 5 and 6 is embedded. The above-mentioned frame-shaped substrate (unit) which is a cassette for pathological tissue sample constructed from a two-unit composite structure in which a frame-shaped substrate (unit 1) 9 and a porous liquid-permeable container-shaped bottom (unit 2) 7 are fitted and connected to each other 1) The front tongue shape of the lid body in which the protective plate is not formed in the latching hole formed by the connecting hole 9f of 9 and the cutout portion 7d of the porous liquid-permeable container-like bottom (unit 2) 7 The embedded frame-like substrate which is the outer wall of the pathological tissue sample cassette is included in the pathological tissue sample cassette comprising a three-unit composite structure container constructed by inserting and coupling the protrusion fitting portion 3e. (Unit 1) FIG. 25, FIG. 27 and FIG. The plate frame protective equipment 4 that are useful. FIG. 32A shows a plate-like frame protecting device 4 that protects the side surface that is a data description part / data recording part other than the inclined part of the cassette for pathological tissue sample, and B and C in FIG. 32 are the data description part / data recording part. 4e in FIG. 32C is a window for visual data when the plate frame protection device 4 is formed of an opaque material. 33 shows the plate frame protective device 4 formed with the connecting portion 4j to be fitted and connected to the lid 3 not forming the protective plate in FIG. 33, and FIGS. 25C and 25D show the cassette for pathological tissue sample. The front-side both-side latch fixing part 4b of the plate-shaped frame protection device 4 that also serves as an IC chip installation site formed on the outer side surface of the embedded frame-shaped substrate (unit 1) 9 that is an outer wall is latched and fitted. 4a designates the lid from the thickness of the outer wall of the cassette for pathological tissue sample containing the unit structure of the embedded frame base (unit 1) 9 therein. (Unit 3) The finger-hook portion 4a protruding when the plate-shaped frame protecting device 4 is attached and removed (the plate-shaped frame protecting device 4 illustrated is locked to the outside of the outer wall of the pathological tissue sample cassette. In order to show the relationship with the IC chip installed in the installation site of the fitting recess 9e Illustrated as a body) there. 26 to 27 and FIG. 28, B and C are latching fixings of the engagement fitting recess 9e on the rear wall surface of the bottom of the cassette for pathological tissue sample 1 and the rear plate 4f of the plate-like frame protection device 4. The separation / cutting part 4h of the plate-like frame protection device 4 and its various basic shapes for making it detachable by utilizing the fitting / holding relationship of the portion 4g and the elasticity of the plate-like frame protection device 4 are shown. FIG. 28A and FIG. 29 show the fitting and latching relationship between the front wall side latching engagement recess 9e on the bottom of the pathological tissue sample cassette 1 and the front latching fixing part 4b of the plate-like frame protection device 4 and its various types. It is the figure which showed various shapes from the side surface side.
In other unit system components, as shown in FIGS. 1B, 2B, 5B, 6B, 7B, D, and F, a container-like bottom portion (unit 4) having no porous liquid passage hole or a porous shape having the same shape as the unit 3 is used. It seems to be useful to put a data description / bar code or two-dimensional data code printing label 6 on the outside of the lid (unit 5) having no liquid passage hole. In this case, the handwritten data 5e • of the patient attribute 5f and the patient ID number 4c is also useful.

  17A, B, C, D FIG. 18A, B, FIG. 19, FIG. 20, FIG. 21A, B, C to FIG. 22A, B, C, FIG. 23A, FIG. , B, C, FIG. 25A, B, C, D, FIG. 30A, B to FIG. 31A, B, C, D, FIG. 17A, B, which is an XX cross section of FIG. As shown in the enlarged view of FIG. 20, a partition wall for partitioning the front portion of the through-hole portion 9a of the embedded frame-shaped substrate 9 and the side portions 9g of the three connecting holes 9g, 9f, and 9g on the back side of the data description portion 9d. It is considered best to mold the IC chip installation portion 11 having a shape in which the IC chip 10 is sandwiched between the IC chip holding support portion 9n protrudingly formed on the connection hole side and the back surface of the inclined data description surface 9d. As shown in FIGS. 21A, B and C and FIGS. 30A and 30B, the IC chip can be easily attached and detached with the finger 13 and the toothpick 12 as shown in FIGS. 30A and 30B.In addition, various installation parts 11 are shown in FIGS. 31A, 31B, 31C, and 31D. However, the longer the distance that the radio wave signal of the IC chip 10 can reach, the higher the price. In particular, the IC chip and signal reader (reader) In consideration of the fact that there is no thicker shielding between the two, the sensitivity of the IC chip will not be reduced, and the data description part for verification and transmission / related work with visual information, other barcodes, two-dimensional data codes, etc. -The distance of the data recording part 9d is better.

  As shown in FIG. 2A, the porous liquid-permeable container-like bottom portion 7 as a unit (unit 2) of the unit system composite structure for constructing the unit system embedded frame-like base structure without burrs is formed as shown in FIG. A sample storage portion 7c in which a porous liquid passage hole is formed at least on the bottom surface by a sample storage portion 7c that can be removably inserted and fitted into a through-hole portion 9a extending from the upper opening portion 9l to the lower opening portion 9m, and the sample storage portion A hook-shaped outer periphery having a structure in which an outer peripheral portion of the opening 7f of the portion 7a is hung on the upper end surface 9b of the outer periphery of the upper opening 9l of the embedded frame-shaped substrate 9 so that the sample storage portion 7 does not fall out on the lower side. A functional component container that is formed from a two-unit component that forms a convex surface 7b and is composed of the embedded frame-shaped substrate 9 (unit 1) and the porous liquid-permeable container-like bottom (unit 2) 7 is a conventional one. Porous liquid-permeable bottom with the same shape as the cassette 1 for pathological tissue samples As shown in FIG. 5A and FIG. 6A, the retaining portion 3e of the porous liquid-permeable lid 3 formed in the shape of the conventional cassette lid without integrally forming the protective plate is formed as shown in FIGS. 5A and 6A. The locking claw formed in the bottom connecting hole 9f and formed at the rear part of the porous liquid-permeable lid 3 is used to construct a porous liquid-permeable bottom having the same shape as the conventional pathological tissue sample cassette. The porous liquid-permeable member corresponding to the connecting hole 9f of the porous liquid-permeable bottom part, which is necessary when latched and engaged with the engaging part 9j formed on the rear wall of the embedded frame-like base body 9 (unit 1). The notch 7d formed on the front surface of the flange-like outer peripheral convex surface 7b formed on the outer peripheral portion of the opening 7f of the sample storage portion of the bottom of the porous container is formed into the porous liquid-permeable container-like bottom (unit 2) 7 Basic shape. The cutout portion formed on the flange-like outer peripheral convex surface 7b formed on the outer peripheral portion of the opening 7f of the sample storage portion of the other container-like bottom portion (unit 2) 7 is formed in the IC chip storage portion 11 shown in FIG. An engaging portion 9j formed on the rear wall of the embedded frame-like base body 9 (unit 1) constructing a notch portion 7e to be connected and a porous liquid-permeable bottom portion having the same shape as the cassette for pathological tissue sample is provided. It is molded so that it can be seen from the opening 7f of the sample storage part of the container-shaped bottom part (unit 2) 7, and is not necessarily a necessary molded part. Further, if the removable liquid lid is formed on the porous liquid-permeable bottom portion having the same shape as that of the above-mentioned cassette for pathological tissue sample with only a lid with a protective plate, there is no need for any notch as shown in FIGS. 11A and 11B. That is why it disappears.

  However, the container-like bottom part which is the unit 2 without the embedded frame-like base body 9 (unit 1) which is a common fitting / connecting formation body, which plays a central role in the unit system composite structure unit of the present invention. 7 and the cover 3 which is the unit 3 are added to the embedded frame-like base body 9 (unit 1) shown in FIGS. A container-shaped bottom locking claw 3g other than the locking claws 3c, 3d of the lid 3 which is the unit 3 to be locked is formed, and the bowl-shaped outer peripheral convex surface 7b of the container-shaped bottom 7 which is the unit 2 is further formed. The fitting portion corresponding to the lid locking claw 3g of the lid 3 is a notched portion 7e and a convex portion 7g formed by molding the notched portion at the rear portion.

  FIG. 34A shows that the container-like bottom 7 which is the unit 2 and the lid 3 which is the unit 3 are lightly connected to each other without using the embedded frame-like base body 9 (unit 1) which is the common fitting / connection forming body. Constructed with the three-unit composite structure composed of the lid 3 (unit 3) when the locking claw 3g corresponding to the container-shaped bottom 7 (unit 2) is molded and connected. 34B is a plan view of the pathological tissue sample cassette viewed from above, FIG. 34B is a rear view of the pathological tissue sample cassette viewed from the rear, and FIG. 34C is II, II-II, and III-III. It is a longitudinal cross-sectional view on a line. As can be understood from this explanatory view, in this explanatory view, the locking claw formed on the lid 3 (unit 3) is the locking claw for the embedded frame-like base body 9 (unit 1). The locking claws 3c (one) and the rear locking claws 3d (two) are three in total, and the locking claws corresponding to the container-like bottom portion 7 (unit 2) are the front-side engaging claw. Although there are 3 in total, 3 pawls 3g (2) and rear pawl 3g (1), there is no illustration, but it is molded to the lid 3 (unit 3). The position and the number of the locking claws installed are the same as the container-like shape in the center of the front locking claw 3c (one piece) that is the locking claw for the embedded frame-shaped substrate 9 (unit 1) and the rear locking claw. Move to the position of the locking claw 3g corresponding to the bottom 7 (unit 2) to make a total of 2 locking claw 3d (1), and the locking claw corresponding to the container-like bottom 7 (unit 2). Front locking claw 3g (2 ) And two rear locking claws may be installed at the positions of the locking claws 3g (two) on both sides for the embedded frame-like base body 9 (unit 1) to change the total to four. .

  The following explanatory diagrams of FIGS. 35 to 38 show the front-side locking claws 3c (one) and the rear-side locking claws 3d (two) which are the locking claws for the embedded frame-shaped substrate 9 (unit 1). On the other hand, the latching claws corresponding to the container-like bottom 7 (unit 2) are the total of the latching claw 3g (two) on the front side and the latching claw 3g (one) on the rear side. It is explanatory drawing which formed three in total of six pieces. Further, the sample storage portion of the container-like bottom 7 (unit 2) corresponding to the locking claw formed on the lid 3 (unit 3) of the container-like bottom 7 (unit 2) shown in FIG. 34C. The fitting latching portion of the flange-like outer peripheral convex surface 7b formed on the outer peripheral portion of the opening 7f is the tip of the flange-like outer peripheral convex surface 7b of the container-like bottom 7 (unit 2) shown in the enlarged view 22C of FIG. It is desirable to be slightly inclined like the lower portion of the side cutout portion 7e.

FIG. 39 shows the embodiment of the cassette for pathological tissue sample, which has all the functional forms of the basic part of the present invention, but the outer shape is a box shape and the data recording part / data recording part is not formed on the inclined surface. A box-type embedding frame base 19 (unit 1), a porous liquid-permeable container-like bottom 20 (unit 2), and a porous liquid-permeable lid 17 (unit 3), which are three structural units that are unit system composite components. It is a unit system.
The locking claw 17c fitted and connected to the box-shaped embedded frame base 19 (unit 1) of the porous liquid-permeable lid 17 (unit 3) in this explanatory view is similar to the explanatory views 1 and 2, This is a two-unit system composite structure in which a porous liquid-permeable container-like bottom portion 20 (unit 2), which is the basic functional form of the present invention, is mounted on the embedded frame-like base body 19 (unit 1) that is an insertion / connection formation body. The so-called pathological tissue sample cassette has an outer wall of the bottom of the cassette, and the embedding frame-like base body 19 (unit 1) has a function of locking and locking portions 19j. ing.

40 is not the basic form of FIG. 39, but the porous liquid-permeable lid 17 (unit 3), which is a unit system composite structure, is an embedding frame-like substrate by A, B and C of FIG. 19 (unit 1) is D, E, and F in FIG. 40, and the porous liquid-permeable container-like bottom portion 20 (unit 2) is G, H, and I in FIG. 40, and is a longitudinal sectional view, a side view, and a plan view, respectively. It corresponds.
The porous liquid-permeable lid 17 (unit 3) is not the basic shape of FIG. 39 as understood from A, B and C of FIG. 40, but has two types of locking portions (17b and 17c) at three locations each. Molded in 6 places. This is a container that is a unit 2 without the embedded frame-like base body 19 (unit 1) that is the common fitting / connection formation body of FIGS. 34 to 38 described in “0043” and “0044”. The locking claw 17b (three places) corresponding to the porous liquid-permeable container-like bottom portion 20 (unit 2), which has a function capable of lightly fitting / connecting the lid portion 17 that is the unit-shaped bottom portion 20 and the unit 3 to each other. The locking unit that engages with a locking part 19j formed on the embedded frame-like base body 19 (unit 1) for fitting and connecting the two-unit system composite structure to the embedded frame-like base body 19 (unit 1). The shape is provided with a claw 17c. Other shapes and functions are the same as those of the constituent unit of FIG. 39 of “0045”, but the IC chip installation site 11 is formed as shown in F and I of FIG.

  41A of FIG. 41 is a box-type pathological tissue sample cassette which is a three-unit system composite structure constituted by the respective constituent units of FIG. 40, and a two-dimensional data code label 6 is pasted on the outer surface. FIG. 41B is a vertical cross-sectional view of the box-type pathological tissue sample cassette, and FIG. 41C is a porous liquid-permeable lid 17 (unit 3) of the unit of the box-type pathological tissue sample cassette. Longitudinal sectional view of the box-type pathological tissue sample fixed transfer container in which the container-shaped bottom portion 20 (unit 2) is changed to the liquid-impervious lid 18 (unit 5) and the liquid-impervious container-shaped bottom portion 21 (unit 4). It is.

  FIG. 42 is similar to the explanatory diagrams of FIGS. 14 and 26 and shows the latching latching portions on both short sides of the three-unit system composite structure for the box-type pathological tissue sample and the latching engagement relationship thereof. Yes. The locking claw 17b or 18b of the lid 17 or 18 (unit 3 or 5) is connected to the locking portion 20g or 21g of the bowl-shaped outer peripheral convex surface 20b or 21b of the container-shaped bottom 20or 21 (unit 2 or 4). The engaging claw 17c or 18c of the lid 17 or 18 (unit 3 or 5) is correspondingly engaged with the engaging portion 19j of the embedded frame base 19 (unit 1). 42A is a drawing from the short side of each component unit of the three-unit system composite structure for the box-type pathological tissue sample, and FIG. 42B is a short side of the lid and another two-unit system composite structure. FIG. 42C is a view from the short side of the three-unit system composite structure.

  FIG. 43A shows a kind of lid with a protective plate (17or 18) that prevents the data label from being peeled off by suppressing the data label affixed on the data description part / data recording part of the box-type pathological tissue sample cassette from above. However, if the protective plate is formed on the entire surface, the protective plate formed near the right angle hinders the bending elasticity of the lid, and it becomes difficult to attach and detach the lid. FIG. 43B is a drawing in which the two-dimensional data code label 6 is pasted on the data description portion / data recording portion 19d on the outer wall side surface of the box-type pathological tissue sample cassette, and the data label 6 is prevented from being peeled off.

  FIG. 44 shows a functional configuration similar to that of the plate-shaped frame protection device 4 in FIGS. 26 to 29 described in [0039], but the shape of the embedded frame-shaped base body 19 (unit 1) is as shown in FIG. Since it is a box shape as shown in B and C, its shape also retains the shapes of FIGS. 44D, E, and F that match the box shape. 44D is a view of the fitting structure of the box-shaped embedded frame base 19 (unit 1) and the box-shaped plate frame protective device 22 as viewed from above, and F in FIG. 44 as viewed from below. FIG. 44E is a plan view of the plate-like frame protecting device 22. The box-type embedded frame base 19 (unit 1) and the box-type plate-like frame protection device 22 have a fitting latching portion formed of 19e and 22g, respectively. The instrument 22 is also formed with a separate cutting portion 22h, and can be detachably fitted and connected. 44 is a view as seen from the forming and setting side of the separating and cutting part 22h of the box-type plate-shaped frame protection device 22, and H in FIG. 44 is a line symmetry plane of the box-type plate-shaped frame protection device 22. FIG. 44 is a view as seen from the short side of FIG. 44. FIG. 44 shows another type of plate-shaped frame protective device of the box-shaped plate-shaped frame protective device 22 cut into a half shape by a line passing through the separating and cutting part 22h. It is.

  45A and 45C show a lid 17or 18 (unit 3 or 5) fitted and connected via the box-type embedded frame base 19 (unit 1) as viewed from the short side of FIG. 45B. FIG. 45A is a unit system composite structure in which a box-shaped container bottom 20 or 21 (unit 2 or 4) and the box-shaped plate frame protective device 22 are fitted and connected, and FIG. 45A shows the box-shaped container bottom 20 or 21. FIG. 46C is a diagram in which the box-shaped plate frame protector 22 surrounding the entire four sides of (Unit 2 or 4) is mounted, and FIG. 46C is a diagram in which the one-side half-type box-shaped plate frame protector is mounted; FIG. 45D is a view as seen from the side of the mounting side of the box-shaped plate frame protector. 45c in FIGS. 45E and F is a visual window. Transparency is not necessary when a transparent box-shaped plate frame protective device is made of a material such as Teijin Kasei pen synthetic resin.

FIG. 46 and FIG. 47 show the shape of the embedded frame-shaped substrate 9 or 19 (unit 1) in the cassette 1 for pathological tissue samples which is a unit system composite structure of the present invention (box type). Since the embedding frame-shaped base body 9 or 19 (unit 1) is independently separated at the fitting position fixedly held by the adapter fitting claw held and fixed to the adapter bottom holding and fixing part 24 of the microtome, the unit 47. Even when the depth of the container-like bottom portion inserted and fitted into 1 and the length of the adapter locking claw in FIG. 47 extending in the longitudinal direction other than the fitting width side are widened, the fitting position engages with the locking claw of the adapter. Since it does not change without influence, it shows that the change in depth can be freely changed by changing only the bottom of the container.
That is, as shown in FIGS. 53A, 53B and 53C, the external shape of the cassette for pathological tissue sample constructed by this unit system composite structure is the same as the external shape of the cassette for pathological tissue sample at the bottom of the conventional integrated type. It is proved by the drawing that it can be molded.

  In FIGS. 48 and 49, it is conceivable to insert and install a transfer container that does not form a porous fluid passage hole in a pathological tissue sample cassette of a bottom fixed molding type in which the bottom cannot be changed. Explains that it has to be very narrow or shallow, has limited practicality as a transfer container, and has no other functional spread.

  FIG. 50, FIG. 51 and FIG. 52 are explanatory views showing that the functionality is further improved when the lid is formed of a transparent synthetic resin, for example, Teijin Chemicals' pen resin.

  Further, as described in [0051], compared with the plan view (B in FIG. 10 and B in FIG. 18) of the cassette for pathological tissue sample which is the functional structure of the unit system composite structure of the present invention. As can be seen, a plan view (FIG. 54A) and a rear view (FIG. 54B) of the bottom of the cassette for a pathological tissue sample of the conventional bottom integrated molding shown in FIG. The figure, the slope view (FIG. 54E), the lid plan view (FIG. 54C), the lid back view (FIG. 54D), and the lid slope view (FIG. 54F) of the cassette for the pathological tissue sample The plan view of the cassette (B in FIG. 10 and B in FIG. 18) shows almost no change.

  FIG. 55 shows a fitting / connecting method that is not a fitting / connecting method to the embedding frame-shaped substrate 9 that is a constituent unit of the cassette for pathological tissue sample, which has already been described in “0034” and “0036”, and its locking. The nail forming positions are shown in FIGS. 55A, 55B and 55C.

  56, the depth of the porous liquid-permeable container can be freely changed in the constituent unit of the unit system of the present invention, but the pathological tissue sample cassette of FIG. 56 has a slight sample storage portion (porous liquid-permeable container) 7a. The porous liquid-permeable lid 3 (unit 3) is detachable by fitting and connecting the deep liquid-permeable container-like bottom 7 (unit 2) to the embedded frame-shaped base 9 (unit 1). FIG. 56 is a side view (FIG. 56A) and a longitudinal cross-sectional view (FIG. 56B) of a cassette for pathological tissue sample constructed with a three-unit system composite structure fitted and connected to each other. Chemical processing operations such as dehydration, degreasing, penetration, and embedding penetration are performed.

57 to 61 are constructed by a three-unit system composite structure composed of the porous liquid-permeable container-like bottom portion 7 (unit 2) formed by the slightly deep sample storage portion 7a described in the above "0056". It is a figure explaining the embedding method with the cassette for pathological tissue samples.
FIG. 57 shows an embedding frame-shaped substrate 9 (unit 1) which is a constituent unit of a three-unit system composite component having the same shape on the general-purpose embedding plate 31 already filed by the present inventor. The embedding frame-shaped substrate 9 used exclusively for embedding dishes placed on the general-purpose embedding plate 31 and the embedding frame-shaped substrate 9 used exclusively is installed. The sample 14 that has already been completed with the chemical solution processing in the pathological tissue sample cassette constructed as “0056” and used as the chemical solution processing basket is placed on the sample storage bottom that is an embedding dish-shaped bottom formed by The embedded frame-like substrate 9 (data recording / data recording unit is written with the sample data of the sample 14 used in the chemical solution processing operation of the sample 14 from the upper opening of the tweezers 29. Unit 1) is a component unit The porous liquid-permeable surface 7c of the sample storage part 7a of the porous liquid-permeable container-like bottom part 7 (unit 2) that protrudes slightly below the opening from the bottom part of the pathological tissue sample cassette that has been built. When the embedding agent 27 is cooled and solidified by the cold plate 28 after being stored and fitted, the liquid embedding agent 27 flows down from the outer periphery of the bottom of the pathological tissue sample cassette to be embedded, and the bottom of the pathological tissue sample cassette Since there is no place where extra embedding support material accumulates on the outer periphery, almost no embedding burrs are attached. FIG. 58 shows an embedding method using an embedding bottom area adjustment inner frame 30 that changes the embedding agent saving and embedding bottom area, and FIG. 59 is an embedding block sample.

  FIGS. 60 and 61, FIGS. 62 and 64A, B FIGS. 77A, B, and C show that the general embedding dish 31 and the embedding bottom area adjusting inner frame 30 are not used. An externally installed embedding pan bottom 50 having both functional forms of the embedding bottom area adjustment inner frame 30 is used. The bottom 50 for an externally installed embedding dish is similar to the bottom (unit 4), but is a container-like bottom formed with a closed surface that does not leak liquid, and the embedded frame-shaped base (unit 1). A sample storage portion 50a formed by a non-liquid-permeable closing surface that can be removably inserted into a through-hole portion connected to the opening portion from the upper side to the lower side, and an upper opening portion 50f of the sample storage portion 50a. It is a container-like bottom formed by a non-liquid-permeable closing surface that forms a bowl-shaped flat surface 50b projecting in a horizontal direction surrounding the outer periphery, and the bowl-shaped flat surface 50b is an opening of the embedded frame-shaped substrate (unit 1). 2 units of a dish-shaped bottom part which has a function of preventing the container-like bottom part from falling off to the lower opening side of the embedded frame-like base body (unit 1) by being hooked and installed on the upper end surface 9b of the outer periphery of the part. Embedding work and embedding device in embedding dish characterized by being constructed with system composite structure It is described. In this case, the bottom 50 for an externally installed embedding dish is preferably made of metal such as stainless steel.

    Furthermore, when this idea is developed, the embedding device shown in FIGS. 63, 64C, and D can be considered. This uses the bottom 51 for an internal installation type embedding dish as a constituent unit in place of the bottom 50 for the external installation type embedding dish of [0058]. Although the function and form of the bottom 51 for the internal mounting type embedding dish is almost the same as the bottom 50 for the external mounting type embedding dish, the upper opening of the sample storage part 51a of the bottom part 51 for the internal mounting type embedding dish is used. 51f The hook installation position on the embedded frame-shaped substrate 35 of the flange-shaped flat surface 51b projecting in the horizontal direction surrounding the outer periphery penetrates the upper and lower openings of the embedded frame-shaped substrate 35. The major difference is that it is on a convex flat surface 35h projecting inward from the inner wall of the hole. That is, there is almost no difference between the bottom 51 for the internal mounting type embedding dish and the bottom 50 for the external mounting type embedding dish, and the position of the outer peripheral edge of the bowl-shaped plane is almost the same. It is possible to add ingenuity to the external shape of the embedding frame-shaped substrate that is the support part of the bottom part for the embedding dish and the shape of the upper end surface 35b on the outer periphery of the opening, and the embedding dish having high functionality. An embedding dish constructed by a two-unit system composite structure composed of two constituent units of the internally installed embedding dish bottom 51 and an embedding frame-like base body fitted and connected thereto will be described below.

  The embedding dish constructed by this two-unit system composite structure is a burr-free unit system embedding dish. As shown in FIGS. 63, 64C, D and D to R in FIG. 77, the upper part of the structural unit is “having openings 35l and 35m on the upper side and the lower side, from the upper side to the lower side. A through hole 35a connected to the openings 35l and 35m is provided, and the upper end of the through hole 35a connected to the lower openings 35l and 35m from the upper side is surrounded by the upper upper end surface 35b of the outer wall surrounding the upper opening 35l. A synthetic resin which is a frame-like base body that forms an inclined surface 35x on the lower outer side and a convex flat surface 35h projecting inwardly on the inner wall 35a of the through-hole portion connected to the upper opening 35l. The lower part is a container-like bottom part formed with a closed bottom, which is separated and independent from the frame-like base body 35, and the lower part is a container-like bottom part formed of a closed surface. Through hole 35 connected to openings 35l and 35m from the upper side to the lower side of 35 a container-like bottom portion formed with a storage portion 51a that can be removably inserted into and fitted to a to store a sample, and a bowl-shaped flat surface 51b that protrudes in the horizontal direction surrounding the outer periphery of the upper opening 51f of the storage portion 51a. The burr-free unit system embedding dish composed of two independent constituent units with an internally installed embedding dish bottom 51 includes a storage part 51a of the container-like bottom 51 and a through hole 35a of the frame-shaped base 35. Is inserted and fitted into the container-like bottom portion 35, and the hook-like flat surface 35b is installed on a convex flat surface 35h that protrudes horizontally toward the inner wall of the through-hole portion 35a of the frame-like base 35. The bowl-shaped flat surface 35b of the container-like bottom portion 35 is fixedly fitted on the convex flat surface 35h projecting horizontally toward the inner wall of the through-hole portion 35a of the frame-shaped base. And the inner wall of the through-hole 35a in the upper opening 35l of the frame-shaped substrate 35 In the embedding dish-like instrument having a concave dihedral surface, the outer wall upper upper end surface 35b surrounding the upper opening 35l of the frame base 35 is inclined from the upper end to the lower outer side. And burr-free embedding constructed by two independent constituent units formed by forming a watertight frame 35b having a projecting formation surface formed by the inclined surface 35x and the inner wall of the through hole 35a of the upper opening 35l. It is a dish, and the bottom portion 51 for the internally installed embedding dish is preferably made of metal such as stainless steel.

  That is, the lower part is the bottom 51 for the internally installed embedding dish, and the upper part corresponding to the bottom part has "openings 35l and 35m on the upper side and lower side, and the opening parts 35l and 35m from the upper side to the lower side. A through hole 35a connected to the upper opening 35l of the outer wall surrounding the upper opening 35l of the through hole 35a connected to the lower openings 35l and 35m from the upper side is inclined to the lower outer side from the upper end. An embedding frame shape made of a synthetic resin, which is a frame-shaped base body that forms a surface 35x and forms a convex flat surface 35h projecting inwardly on the inner wall 35a of the through-hole portion that continues to the upper opening 35l. An embedding dish constructed of a two-unit system composite structure composed of two constituent units with the base 35 is the same as the synthetic resin embedded frame-like base on the upper part of the embedding dish. 35, and the lower part is made of stainless steel Serial is embedding dish built internally installed type embedded is composed of two constituent units formed by the dish for the bottom 51 2 unit system complex structure. When the embedding operation is performed with this embedding dish, the devices to be embedded are arranged in the order shown in FIGS. 63A and 63B. In actual operation, the conventional pathology is as shown in FIGS. 64A and 64C. The sample 14 having been subjected to the chemical treatment is transferred from the bottom portion 19 of the pathological tissue sample cassette configured integrally with the tissue sample cassette onto the storage bottom portion 51a of the embedding dish, and then the bottom portion of the cassette for pathological tissue sample. Is placed in the opening 51f on the embedding dish and the embedding operation is started. At this time, although not shown in the drawing, in the conventional embedding dish, excess embedding agent in the embedding dish oozes out to the upper side of the cassette of the pathological tissue sample cassette, or the sample in the chemical treatment process. The embedding agent on the outer peripheral surface of the cassette for pathological tissue sample, which is also a chemical treatment jar, flows out and accumulates between the inner wall of the embedding dish and the side wall of the embedding dish, and burrs of the embedding dish occur. The inventor of the present invention has already filed an invention for this countermeasure, but it is difficult to form a watertight frame with high watertightness integrally with a metal such as stainless steel having good thermal conductivity, and The manufacturing cost of the embedding dish is high. Therefore, if the upper structure of the embedding dish is molded with the same synthetic resin as the above-mentioned cassette for pathological tissue sample, the shrinkage rate at the molding of the synthetic resin is the same. Can be reliably and inexpensively molded. That is, although not shown in the drawing, the convex dihedral surface formed by the outer peripheral surface and the bottom surface of the cassette for pathological tissue sample is directed inward to the inner wall of the through-hole portion 35a of the frame-shaped substrate of the embedding dish. The inner wall of the bowl-shaped flat surface 35b of the container-shaped bottom 35 and the through-hole 35a of the upper opening 35l of the frame-shaped base 35 is installed on the convex flat surface 35h protruding horizontally. It is surely fitted to the concave dihedral surface so that the water tightness is further increased, the infiltration of the excess embedding agent in the embedding dish is suppressed, and the liquid embedding agent droops on the outer peripheral surface of the pathological tissue sample cassette. Flows down to the upper upper surface 35b of the outer wall surrounding the periphery of the opening 35l of the frame-shaped base 35 constituting the upper opening 35l of the embedding dish through an inclined surface 35x formed on the lower outer side from the upper end. The embedded block sample figure 64C with fewer burrs than the embedding dish is completed.

65 to 76 are not directly within the scope of the present invention, and the inventor of the present application is an embodiment in which most of the invention applications already filed (Japanese Patent Application No. 2006-197702) fall within the scope of rights. In the description, it is described that many synergistic effects occur when the idea of the present invention is combined with the embodiment of the previous application (Japanese Patent Application No. 2006-197702).
As shown in FIG. 46A of the present application, a box-type embedding frame in which the depth of the box-type porous liquid-permeable container-like bottom portion 20 is reduced and the box-type porous liquid-permeable container-like bottom portion is fitted and connected. When embedded in the base substrate 19, the burr-free embedded block sample can be reliably formed, and the block sample after the thin section of the embedded block sample is securely stored and managed as shown in FIG. The sample block side can be stored and miniaturized in the body. However, the order of latching and fitting to the embedding frame-shaped substrate of the present invention is usually the top of the embedding frame-shaped substrate and the next is the container-shaped bottom, and the embedding frame. Although the present inventor has previously filed an application (Japanese Patent Application No. 2006-197702), the upper lid and the lower bottom lid are fitted up and down with the embedded frame-shaped substrate interposed therebetween. Because of the combination / connection order, the storage space for the sample is greatly reduced in the shape of FIG. 46A. On the other hand, there is no diversification in functionality in the concept of the previous application, and the method of the present invention should be used as the method of fitting and latching the lid. However, in the embodiment of the previous application, it is difficult to expect the usage of the fixed transfer container.

   65A, 65C, 65E, 65G are longitudinal sectional views, and FIGS. 65B, 65D, F, and H are side views thereof. FIG. 65A is a side view of FIG. 65A. FIG. 65G is a longitudinal sectional view of the three-unit system composite structure of the three structural units of the base substrate 19 and the lower bottom cover 34 of FIG. 65E, and FIG. 65H is a side view thereof. 71, 72, and 73, which are other embodiments having a shape different from that of FIG. 65, are shown in FIG. 71A as three structural units of the upper lid 17, the embedded frame base 19, and the lower bottom lid 34. FIG. 71B is a longitudinal sectional view and a side view thereof. Further, FIG. 72A is a longitudinal sectional view of this three-unit system composite structure, and FIG. 72B is a side view thereof. 73 is a view from the short side of FIG. 72, FIG. 73A is a three-component unit of the upper lid 17, the embedded frame base 19, and the lower bottom lid 34, and FIG. 73B is the upper lid. FIG. 73C shows a three-unit system composite structure, and FIG. 73D shows an upper cover body and a lower bottom cover body. This is a lightly fitted and connected structure. This function is lightly fitted and connected without using the embedded frame-like substrate only by the two component units of the lid and the bottom of the porous liquid-permeable container as shown in FIGS.

In this way, even if there is a difference in shape and form, the same function can be introduced regardless of the shape by applying the idea of the present invention and the prior invention of the present inventor to each other. For example, of course, the chemical solution processing function (FIG. 66), which is the basic function of the cassette for pathological tissue samples, is natural, but the burr-free embedded block sample preparation function of FIGS. 67, 68, 69, 74, and 75 is used. 70 and 76, the side of the embedding block sample when storing and managing the block sample is housed in the embedding frame-shaped substrate, the lid is closed, and the thickness of the storage block is reduced to half that of the conventional block sample. A cassette system for a pathological tissue sample having a high fitting / connectability of a lid as a chemical solution processing rod that is thinned to near and maintains a function of securely storing a sample is proposed.
Improving the functionality of the cassette for pathological tissue samples as a unit system composite structure not only helps prevent accidents such as loss or contamination of sample data and controls accuracy, but also stores data from sample data transfer and specimen preparation. Streamlined, automated, space-saving, and labor-saving can be expected in all processes of management and search.

Fig. 1 (A) is a perspective view of a cassette for pathological tissue sample which is a chemical solution processing rod with a sample data transmission connection function composed of a burr-free unit system embedded frame-like substrate structure of the present invention, and Fig. 1 (B) is It is a perspective view of the fixed transfer container with a sample data transmission connection function which consists of a burr | flash unit system embedding frame-like base | substrate structure. 2A is a perspective view of the constituent unit of FIG. 1A, and FIG. 2B is a perspective view of FIG. 1B. FIG. 3 (A) is a perspective view with the lid of FIG. 1 (A) removed, and FIG. 3 (B) is a perspective view with the lid of FIG. 1 (B) removed. 4A is a side view of another embodiment of FIG. 1, and FIG. 4B is also a side view of another embodiment of FIG. FIG. 5 (A) is a perspective view of another embodiment of FIG. 2 (A), and FIG. 5 (B) is a slope view of another embodiment of FIG. 2 (B). FIG. 6A is a fitted / connected slope view of each constituent unit in FIG. 5A, and FIG. 6B is a fitted / connected slope view of the constituent unit in FIG. 5B. 7A is a perspective view of another embodiment of the constituent unit 9 of FIG. 2B, and FIG. 7B is a perspective view of another embodiment of the constituent unit 8 of FIG. 7 (C) is a perspective view of another example of the constituent unit 9 of FIG. 2 (B), and FIG. 7 (D) is a perspective view of another example of the constituent unit 8 of FIG. 2 (B). 7E is a perspective view of another example of the constituent unit 9 of FIG. 2B, and FIG. 7F is a perspective view of another example of the constituent unit 8 of FIG. 2B. It is. FIG. 8A is a side view showing the fitting / connecting relationship between unit 1, unit 2, and unit 3 which are the three main constituent units of FIG. 2A, and FIG. It is a side view of the 3 unit system structure which made. The description of the fitting locking portion at the front side portion is omitted. 9A is a longitudinal sectional view of FIG. 8A, and FIG. 9B is a longitudinal sectional view of FIG. 8B. 10A is a plan view of each of the three main constituent units shown in FIG. 8A, and FIG. 10B is a plan view of FIG. 8B. 11 (A) and 11 (B) are plan views of another embodiment of FIGS. 10 (A) and 10 (B). 12 (A) and 12 (B) are side views of another embodiment of FIGS. 8 (A) and 8 (B). 13A is a front view seen from the Y direction in FIG. 12A, and FIG. 13B is another embodiment in which the front notch portion of the component unit II in FIG. 12A is omitted. It is the front view seen from the Y direction. 14 (A) is a rear view seen from the Z direction of FIG. 12 (A), and FIG. 14 (B) is FIG. 14 (B) I and FIG. FIG. 14C is a rear view of the unit system composite structure, and FIG. 14C is a rear view of the I / II / III three-unit system composite structure. FIG. 15 (A) is a plan view of another embodiment of FIG. 10 (A), and FIG. 15 (B) shows the non-permeability of the porous liquid-permeable surfaces 3a and 7c of FIG. FIG. 3 is a plan view of a three-component unit of another embodiment having the functional configuration of FIG. 1 (B) molded with liquid surfaces 5a and 8c. FIG. 16A shows a configuration in which the constituent unit 3 is fitted and connected to a two-unit system composite structure constituted by the constituent unit 7 fitted and connected to the constituent unit 9 of FIG. FIG. 16B is a side view of the three-unit system composite structure that is fitted and connected. 17A is a cross-sectional view taken along the line XX of the plan view (FIG. 17B) of the embedding frame-shaped substrate 9 which is the unit 1 of the constituent unit of FIG. 2, and FIG. It is sectional drawing in the XX line of the back view (FIG. 17D) of the embedding frame-shaped base | substrate 9 which is the unit 1 of a structural unit. 18A is a back view of the constituent unit of FIG. 16A, and FIG. 18B is a back view of FIG. 16B. It is sectional drawing on the WW line of FIG. 16 (B) (FIG. 18B). FIG. 20 is an enlarged view of a vertical cross section on an inclined surface side which is a data recording part / data recording part of the unit 1 which is the constituent unit 9 of FIG. 19. FIG. 21A is a rear view of the structural unit 9 of the embodiment different from FIG. 18, and FIGS. 21B and 21C are enlarged views of the installation site 11 of the IC chip 10 that is a part thereof. 22 (B) and FIG. 19, FIG. 22 (A) is an enlarged view of the rear part of FIG. 22 (B), and FIG. 22 (C) is an inclined surface side that is a front data recording part / data recording part. And an enlarged view. FIG. 23 (A) is FIG. 19, FIG. 23 (B) is FIG. 4 (B), and FIG. 23 (C) is a longitudinal sectional view of a conventional cassette for pathological tissue sample, and is a comparison of the thickness of the bottom. . FIG. 24B is an enlarged view (FIG. 24A) of the rear portion of FIG. 24B, which is a longitudinal sectional view of the conventional cassette for a pathological tissue sample having the same outer shape as FIG. It is an enlarged view (FIG. 24C). 25 (A) and 25 (B) show an IC chip 10 on an inclined surface which is a data description portion and a data recording portion of the oblique view of FIG. 24 (B) of the same cassette for a pathological tissue sample as the outer shape of FIG. FIG. 25 is a perspective view (FIG. 25A) and an enlarged vertical sectional view (FIG. 25B) showing the molding position of the installation part 11 and the plate-like frame protection device 4 shown in FIGS. 25 (C) and (D) are front and both side fitting / locking portions 4b of the plate-like frame protection device 4 on the side of the outer wall, which is another embodiment of FIG. 25 (A), and both sides of the fixing portion 4b. It is a figure which shows a fitting latching and connection relationship with 9e which is a latching fitting recessed part and is also an IC chip installation site | part. 26 (A), (B), (C), (D), (E), (F), and (G) are the plate-like frame protector 4 shown in FIG. 25 and FIGS. 22 and 24. It is the figure which showed the representative example of the fitting and latching recessed part of the cassette bottom part for pathological tissue samples of the shown cover body with a protective plate. 27 (A), (B), (C), (D), (E), (F), (G) are for the pathological tissue sample having the shape shown in FIG. 26 illustrated in FIG. It is the figure which showed the typical shape and fitting / locking part of the plate-shaped frame protection instrument 4 which can be connected by fitting / locking to the fitting / locking recessed part of a cassette bottom part. FIG. 28A shows a typical fitting / locking / connecting relationship between the embedded frame-shaped substrate 9 and the plate-shaped frame protecting device 4 at the bottom of the cassette for pathological tissue samples shown in FIGS. 26 and 27. FIG. 28B is a side view, and FIGS. 28B and 28C are rear views. 29 (A), (C), (E), (G), and (I) are other embodiments of the fitting and locking recesses in the bottom of the cassette for pathological tissue sample shown in FIG. (B), (D), (F), (H), and (J) show the shape and installation position of the latching fitting / engaging recess of the plate-like frame protector shown in FIG. 27 corresponding thereto. It is a figure. FIG. 30A shows the installation site, installation method (FIG. 30A), and removal method (FIG. 30B) of the IC chip shown in FIGS. 31 (A), (B), (C), and (D) are installation parts of an IC chip that is another embodiment of FIG. 32 (A), 32 (B), and 32 (C) are explanatory views of the plate-like frame protection device 4 which is another embodiment different from the functional forms of FIGS. 25, 27, and 28. FIG. It is a figure of the plate-shaped frame protection instrument which the cover body of the other Example different from FIG. 32 can latch and fit. FIG. 34 shows an embodiment of a cassette for pathological tissue sample which is a three-unit system composite structure different from FIGS. 34A is a plan view, FIG. 34B is a rear view, and FIG. 34C is a longitudinal sectional view taken along lines II, II-II, and III-III. FIG. 35 (A) is a separated plan view of each constituent unit in the plan view of the three-unit system composite structure of FIG. 34 (A), and FIG. 35 (B) is another functional configuration three-unit system composite structure. It is a separation top view of each component unit of a transfer container. 36 (A) is a separated back view of each component unit of the three-unit system composite component of FIG. 35 (A), and FIG. 36 (B) is a three-unit system that is a fitting / connecting member of each component unit. It is a back surface top view of a composite structure. 36 (C) and 36 (D) are plan views of the back surface of the porous liquid-permeable container-like bottom portion and the lid portion that are lightly engaged and connected to each other without using the embedded frame-shaped substrate, and the engagement and connection body. . FIG. 37 (A) is a separated rear view of the constituent units of the three-unit system composite structure of FIG. 35, and FIG. 37 (B) is a two-unit system composite structure of the embedded frame-shaped substrate 9 and the container-like bottom. FIG. 37C is a rear view of the three-unit system composite structure of FIG. 35 and shows the fitting / connecting portions of each other. FIG. 38A is a separated vertical section of each component unit of the three-unit system composite structure of FIG. 37, and FIG. 38B is a side view thereof. FIG. 39 is a perspective view of a three-unit system composite structure that is an embodiment showing a shape different from those in FIGS. 1 and 2 to 38. The three-unit system composite structure of FIG. 39 is three kinds of structural units of different embodiments. FIGS. 40A, 40B, and 40C are a longitudinal section, a side view, and a plan view of the lid. 40 (D), (E), and (F) are a longitudinal section, a side view, and a plan view of the embedded frame-shaped substrate, and FIGS. 40 (G), (H), and (I) are container shapes. It is the longitudinal cross-sectional view of a bottom part, a side view, and a top view. 41 (A) is a side view of the three-unit system composite structure of FIG. 40, and FIG. 40 (B) is a longitudinal sectional view of the porous liquid-permeable box-type pathological tissue sample cassette of FIG. 40 (A). FIG. 40 (C) is a longitudinal sectional view of the non-liquid-permeable box-type fixed transfer container of FIG. 40 (A). FIG. 42A is a view from the short side of FIG. 41A, FIG. 42A is a view of each of the three types of component units, and FIG. 42B is a two-unit system composite on the lower side of FIG. FIG. 42 (C) is a diagram of a three-unit system composite structure, showing the structure and the lid. FIG. 43 (A) is a diagram of another embodiment of FIG. 40 (B), and FIG. 43 (B) is a diagram of another embodiment of FIG. 41 (A) capped with the lid. 44 (A), (B), and (C) are FIGS. 40 (D) and (F) and their back views, and FIGS. 44 (D) and (F) are shown in FIGS. 44 (A) and (C). FIG. 44B is a plan view and a rear view of the two-unit structure of the plate frame protection device having the shape of FIG. 44E that is fitted and connected, and FIG. 44G is a view of FIG. 44E viewed from the α → side. 44 (H) is an embodiment different from FIG. 44 (E) formed on one side line symmetrical with the line passing through 22h of FIG. 44 (E) in FIG. 44 (E), and FIG. 44 (I). FIG. 44 is a view of FIG. 44 (H) viewed from the β → side. 45 (A) is a diagram in which FIG. 44 (G) is fitted and connected to FIG. 42 (C), and FIG. 45 (B) is a diagram viewed from the short side of FIG. 44 (B). 45 (C) is a diagram in which FIG. 44 (I) is fitted and connected to FIG. 42 (C), FIG. 45 (D) is a side view of FIG. 45 (A), and FIG. 44 (E) is opaque. FIG. 45 (E) is a side view when the molding material is molded with a transparent synthetic resin, and FIG. 45 (F) shows visual data when the molding material is opaque. This is the window that was molded for this purpose. 46A is a box-shaped three-unit system composite structure that is an embodiment different from FIG. 1 of the three-unit system composite structure constituting the burr-free unit system-embedded frame-shaped base body structure of the present invention. FIG. 46 (B) is another embodiment different from FIG. 46 (A). FIG. 46 (B) is a longitudinal sectional view of the box-type pathological tissue sample cassette shown in FIG. 47A and 47B, which are the same shape as the longitudinal section of the box-type pathological tissue sample cassette of FIG. 46, and the fixing latching position of the latching claw of the latching fixing adapter of the pathological tissue sample cassette are shown. FIG. 47 (C). It is a perspective view of the concept of inserting and fitting a container-like bottom portion with a lid into a conventional cassette for pathological tissue sample in which a window is formed at the bottom portion. It is a perspective view of the idea of inserting and fitting a non-liquid-permeable container-like bottom into a box-shaped conventional cassette for a pathological tissue sample. It is a top view of each structural unit at the time of shape | molding the cover body and container-shaped bottom part of FIG. 35 (A) with a transparent material. It is the figure which showed the convenience of the unit system composite structure comprised by the structural unit of the transparent cover body of FIG. 50, FIG. 51 (A) is each three front views, FIG. 51 (B) is a transparent material. Fig. 51 (C) is a front view of all three unit system composite components and data of an embedded frame-like substrate having one component unit. Even in the front view of the three-unit system composite structure shown in FIG. 51C, the data label on the inclined surface, which is the description portion / data recording portion, can be seen through the transparent protective plate. FIG. 52 (A) is a longitudinal sectional view of a porous lid body with a protective plate that fits and connects with the bottom of the conventional cassette for pathological tissue sample of FIG. 23 (C), and FIG. 52 (B) is a front view thereof. is there. 53 (A) and 53 (B) are similar to FIG. 47, in the embodiment of the type of FIG. 1, the depth of the bottom can be freely changed, and the pathology which is the three-unit system composite structure of the present invention. The vertical cross-sectional view (FIG. 52B) of the tissue sample cassette bottom (two unit system composite structure) and the conventional pathological tissue sample cassette bottom (FIG. 52C) have the same thickness H, and the adapter is locked. The height H of the nail fitting / fixing position (FIG. 52A), the thickness h1 of the embedding frame-like substrate as one unit of the two-unit composite structure, and the porous liquid-permeable container shape as another unit FIG. 6 is a diagram showing that the sum of the thicknesses h2 of the bottom bowl-shaped plane is present. FIG. 53 is an explanatory diagram of the bottom of the cassette for pathological tissue sample and the lid with a protective plate in FIG. 52. 54 (A) is a plan view of the bottom of the cassette for pathological tissue sample, FIG. 54 (B) is a back view, FIG. 54 (C) is a plan view of a lid with a protective plate, and FIG. 54 (D). Is a rear view thereof, and FIGS. 54 (E) and (F) are respective slope views. In other embodiments of the porous liquid-permeable lid body 3 with a protective plate of FIGS. 2 (A) and 3 (A), there are various locking portions that are detachably fitted and connected to the bottom of the cassette for pathological tissue sample. is there. 55 (A), (B), and (C) are longitudinal sectional views, FIG. 44 (D) is a slope view, and FIG. 44 (E) is a slope view of FIG. 44D that is fitted and connected. . 1, FIG. 8, FIG. 19, a three-unit system composite configuration constructed by a configuration unit in which the depth of one porous liquid-permeable container-like bottom portion 7 (unit 2) is slightly deeper. FIG. 56 is a side view (FIG. 56A) and a longitudinal sectional view (FIG. 56B) of a cassette for a pathological tissue sample composed of a body. FIG. 57 is a plan view of an embedding operation using a bottom of a general-purpose embedding dish in a two-unit system composite structure, which is the bottom of a cassette for pathological tissue sample including the three-unit system composite structure of FIG. FIG. 58 is a longitudinal sectional view of each of the instruments relating to embedding in FIG. 57. It is sectional drawing of the embedding block sample completed by the embedding operation | work of FIG. FIG. 59 is a longitudinal sectional view of another embodiment of the instrument for embedding in FIG. 58. 61 (A), 61 (B), and 61 (C) are longitudinal sectional views of the respective instruments relating to embedding shown in FIG. FIG. 58 is a plan view of an embedding work example different from FIG. 57. 63 (A) and 63 (B) are plan views of an embedding work embodiment different from FIG. FIGS. 64A and 64B are the embedding tools used in the embedding operation example of FIG. 62, and FIGS. 64C and 64D are how to remove the block sample. Longitudinal sectional views (FIGS. 65A, C, E, and G) and side views (FIGS. 65B, D, F, and H) of each structural unit having high functionality by functional integration with the invention already filed by the inventor It is. 66 (A) and 66 (B) are longitudinal sectional views of a cassette for pathological tissue sample, which is a three-unit system composite structure constructed by the three types of structural units in FIG. 65, and a sample housed therein. . FIG. 67 is a longitudinal sectional view showing an embedded state of FIG. 66. FIG. 68 is a longitudinal sectional view of the embedded block sample in FIG. 67 taken out. 69 (A) and 69 (B) are longitudinal sectional views showing the shape and form of the embedded block sample of FIG. 68 when sliced. 70 (A) and 70 (B) are longitudinal sectional views showing the shape and form when the embedded block sample is stored after completion of the thin cutting in FIG. Longitudinal cross-sectional view of the order of fitting and connection of the upper lid, the embedded frame-like base body, and the lower lid, which are three high-functional components by functional integration with the invention already filed by this inventor It is the figure which showed (FIG. 71A) and a side view (FIG. 71B). FIG. 72 (A) is a longitudinal sectional view of a three-unit system composite structure composed of the structural units shown in FIG. 71 (A), and FIG. 72 (B) is a side view thereof. A two-unit system composite structure, a lower lid body (FIG. 73B), a three-unit system composite structure (FIG. 73C), an upper lid body, and a lower lid body, each composed of the three constituent units shown in FIG. 72 (FIG. 73A). It is the figure seen from the short surface side of the 2 unit system composite structure (FIG. 73D) lightly fitted and connected without going through the embedding frame-shaped base | substrate. FIG. 74 is a plan view (FIG. 74A) and a side view (FIG. 74B) showing the fitting order of the embedding instrument even when the lower lid body of FIG. 73 is used. 75 (A) is a longitudinal sectional view showing the order of taking out the embedded block sample after embedding with the embedding instrument shown in FIG. 74, and FIG. 75 (B) is a longitudinal sectional view of the embedded block sample. It is. FIG. 76A is a longitudinal sectional view (FIG. 76A) and a plan view (FIG. 76B) of a shape when the block sample is stored after the embedded block sample of FIG. 75 has been sliced. 77 (A) to (R) are longitudinal sectional views showing various functional forms of the burr-free embedding dish constructed by the constituent units of the unit system composite structure of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 The cassette for pathological tissue samples which is a chemical | medical solution processing tub which consists of a unit system embedding frame-like base body container without a burr | flash 2 The fixed transfer container with a sample data transmission connection function which consists of a burr-free unit system embedding frame-like base body container 3 Porous liquid permeability Lid 3a Porous liquid-permeable surface 3b Lid protective plate 4 Plate frame protection device 5 Non-liquid permeable lid 6 Data label 7 Porous liquid-permeable container bottom 8 Non-liquid permeable container-shaped bottom 9 Embedding frame Shaped substrate 10 Data storage medium such as IC chip 11 Installation location of IC chip 17 Box-type porous liquid-permeable lid 18 Box-type non-liquid-permeable lid 19 Box-type embedded frame-shaped substrate 20 Box-type porous liquid-permeable container Bottom part 21 Box-type non-liquid-permeable container-like bottom part 22 Box-type plate-like frame protection device 24 Microtome adapter fixing part 24a Adapter 27 Embedding agent 31 General-purpose embedding dish bottom part 33 Embedding frame-like substrate base bottom cover 34 Box-type embedding frame -Like substrate 籠 bottom lid 35 General-purpose watertight embedding frame-like substrate 50 Externally installed embedding pan bottom 51 Internally mounted embedding pan bottom

Claims (10)

A lid having a frame-like base formed with an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-flowing opening detachably fitted to and connected to the upper opening of the frame-like base In a cassette for a pathological tissue sample comprising the body;
Forming the functional form of the lid body, which is detachably fitted and connected to the frame-like base body, the bottom portion, and the upper opening of the frame-like base body, as separate three independent structural units,
The frame-shaped substrate has openings on the upper side and the lower side, and includes a through-hole portion connected to the opening portion from the upper side to the lower side, and the through-hole portion connected to the lower-side opening portion from the upper side. An embedded frame-shaped substrate (unit 1) that forms a convex flat surface that protrudes inwardly on the inner wall of the upper part of the outer wall surrounding the upper opening or the inner wall of the through hole that continues to the upper opening And
The bottom part is a container-like bottom part (unit 2) having a porous liquid-permeable bottom surface formed at least on the bottom part, which is separated and independent from the embedding frame-like base body (unit 1), and the embedding frame-like base body (unit 1). ) And a sample storage part in which a porous liquid-permeable bottom surface is formed at least at the bottom, the sample storage part being capable of being detachably inserted and fitted into a through-hole part connected to the opening part from the upper side to the lower side of the A porous liquid-permeable container-like bottom portion (unit 2) that forms a bowl-like flat surface projecting in the horizontal direction surrounding the outer periphery of the upper opening of the storage portion;
On the convex plane that is projected horizontally on the upper end surface of the outer periphery of the opening of the embedded frame-shaped substrate (unit 1) or on the inner wall of the through hole that is continuous with the upper opening. The porous liquid-permeable container-like bottom part (unit 2) has a function of preventing the porous liquid-permeable container-like bottom part (unit 2) from falling off to the lower opening side of the embedded frame-like base body (unit 1). Unit system which is the shape and form of a cassette for pathological tissue sample constructed by a two-unit system composite structure by fitting and connecting the bottom part (unit 2) with the embedding frame-like base body (unit 1). Unit system embedded frame-like substrate porous liquid permeability which is the shape and form of the cassette bottom portion for pathological tissue sample constructed from the two-unit system composite structure comprising the bottom of the embedded frame-like substrate porous liquid-permeable container Removable in the upper opening at the bottom of the container A chemical solution treatment vessel for a sample comprising a unit system embedding frame-like substrate structure, which is constructed of a three-unit system composite structure comprising a lid (unit 3) having a porous liquid passage port to be connected and connected. A cassette for a pathological tissue sample that is also a support base for fixing a block sample. A lid having a frame-like base formed with an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-flowing opening detachably fitted to and connected to the upper opening of the frame-like base In a cassette for a pathological tissue sample comprising the body;
Forming the functional form of the lid body, which is detachably fitted and connected to the frame-like base body, the bottom portion, and the upper opening of the frame-like base body, as separate three independent structural units,
The frame-shaped substrate has openings on the upper side and the lower side, and includes a through-hole portion connected to the opening portion from the upper side to the lower side, and the through-hole portion connected to the lower-side opening portion from the upper side. An embedded frame-shaped substrate (unit 1) that forms a convex flat surface that protrudes inwardly on the inner wall of the upper part of the outer wall surrounding the upper opening or the inner wall of the through hole that continues to the upper opening And
The bottom part is a container-like bottom part (unit 4) which is separated and independent from the embedding frame-shaped substrate (unit 1) and which is formed with a closed surface which does not form a porous liquid-permeable surface and does not leak. A non-liquid-permeable closure that can be removably inserted and fitted into a through-hole connected to the opening from the upper side to the lower side of the embedded frame-shaped substrate (unit 1) to allow storage and transfer of the sample. A container-like bottom (unit 4) formed by a non-liquid-permeable closed surface formed with a sample storage part formed by a surface and a bowl-shaped flat surface projecting in a horizontal direction surrounding the outer periphery of the upper opening of the sample storage part Yes,
On the convex plane that is projected horizontally on the upper end surface of the outer periphery of the opening of the embedded frame-shaped substrate (unit 1) or on the inner wall of the through hole that is continuous with the upper opening. The non-liquid-permeable container bottom portion (unit 4) has a function of preventing the bottom portion (unit 4) from falling off to the lower opening side of the embedded frame-like base body (unit 1). A unit system embedding which is a shape and form of a cassette for pathological tissue sample constructed by a two-unit system composite structure by fitting and connecting the bottom part (unit 4) with the embedding frame-like base body (unit 1). A unit-system-embedded frame-shaped substrate non-permeable container which is the shape and form of a fixed transfer bottom portion for a pathological tissue sample constructed by constituting a two-unit system composite structure comprising a frame-shaped substrate non-liquid-permeable container bottom Removably fits and connects to the upper opening at the bottom For a pathological tissue sample comprising a unit system-embedded frame-like substrate structure, comprising a three-unit system composite structure comprising a non-liquid-permeable lid (unit 5) that does not form a porous fluid passage opening Fixed transfer container. An opening is provided on the upper side and the lower side, the through hole is connected to the opening from the upper side to the lower side, and the periphery of the upper opening of the through hole connected to the lower side opening from the upper side An embedding frame-like base body (unit 1) that forms a convex flat surface projecting inwardly on the inner wall of the upper part of the outer wall surrounding the outer wall or the inner wall of the through hole that is continuous with the upper opening, and the embedding frame A sample storage part that can be removably inserted into and fitted to a through-hole part connected to an opening from the upper side to the lower side of the substrate (unit 1), and an outer periphery of the upper opening part of the sample storage part A unit system package which is a shape and form of a container-shaped bottom part (unit 2 or 4) forming a bowl-like plane projecting in a horizontal direction surrounding the path and a bottom part for a pathological tissue sample constructed by the two-unit system composite structure Removably fits and connects to the upper opening at the bottom of the frame-shaped substrate container In pathologic tissue sample cassette and a fixed transfer container for histopathological specimen of the lid (unit 3 or 5) for;
The function forms of the lids that are detachably fitted and connected via the frame-like base to the upper opening, which is a two-unit system composite structure constituted by the frame-like base and the bottom, are separated and independent 5 Molded as a kind of component unit,
It is constructed of a three-unit system composite structure composed of the embedded frame-shaped substrate (unit 1), the porous liquid-permeable container-like bottom (unit 2), and the lid (unit 3) having the porous liquid-permeable port. A cassette for pathological tissue sample (composite component of units 1, 2 and 3) comprising a unit system embedded frame-like substrate component;
A unit system package constructed by a three-unit system composite structure composed of the embedded frame base (unit 1), a non-liquid-permeable container-like bottom (unit 4), and a non-liquid-permeable lid (unit 5). Fitting / connection formation common to both unit system embedding frame-shaped substrate structures of the fixed transfer container for pathological tissue samples (composite structure of units 1, 4 and 5) comprising a frame-shaped substrate structure ( A function of transmitting and connecting the patient attribute and clinical data of the sample at the time of clinical sample collection and the pathological specimen number and past data at the time of preparation of the pathological specimen to the embedded frame-like substrate (unit 1) which is an organizer) It is used as a data transmission / linkage (messenger) between the unit systems formed by the unit system composite structure by forming an installation site for the data description part or data recording part Claim 1, wherein Rukoto or 2 embedding frame-shaped substrate according. An opening is provided on the upper side and the lower side, the through hole is connected to the opening from the upper side to the lower side, and the periphery of the upper opening of the through hole connected to the lower side opening from the upper side An embedding frame-like base body (unit 1) that forms a convex flat surface projecting inwardly on the inner wall of the upper part of the outer wall surrounding the outer wall or the inner wall of the through hole that is continuous with the upper opening, and the embedding frame A sample storage part that can be removably inserted into and fitted to a through-hole part connected to an opening from the upper side to the lower side of the substrate (unit 1), and an outer periphery of the upper opening part of the sample storage part A unit system package which is a shape and form of a container-shaped bottom part (unit 2 or 4) forming a bowl-like plane projecting in a horizontal direction surrounding the path and a bottom part for a pathological tissue sample constructed by the two-unit system composite structure Removably fits and connects to the upper opening at the bottom of the frame-shaped substrate container In pathologic tissue sample cassette and a fixed transfer container for histopathological specimen of the lid (unit 3 or 5) for;
Forming the functional form of the lid body detachably fitted and connected to the frame-like base body, the bottom portion, and the upper opening of the frame-like base body as five separate structural unit units,
The function forms of the lids that are detachably fitted and connected via the frame-like base to the upper opening, which is a two-unit system composite structure constituted by the frame-like base and the bottom, are separated and independent 5 Molded as a kind of component unit,
It is constructed of a three-unit system composite structure composed of the embedded frame-shaped substrate (unit 1), the porous liquid-permeable container-like bottom (unit 2), and the lid (unit 3) having the porous liquid-permeable port. A cassette for pathological tissue sample (composite component of units 1, 2 and 3) comprising a unit system embedded frame-like substrate component;
A unit system package constructed by a three-unit system composite structure composed of the embedded frame base (unit 1), a non-liquid-permeable container-like bottom (unit 4), and a non-liquid-permeable lid (unit 5). Fitting / connection formation common to both unit system embedding frame-shaped substrate structures of the fixed transfer container for pathological tissue samples (composite structure of units 1, 4 and 5) comprising a frame-shaped substrate structure ( A function of transmitting and connecting the patient attribute and clinical data of the sample at the time of clinical sample collection and the pathological specimen number and past data at the time of pathological specimen preparation to the embedded frame-like substrate (unit 1) which is an organizer) It is used as a data transmission / linkage (messenger) between the unit systems formed by the unit system composite structure by forming an installation site for the data description part or data recording part From the fixed transfer container in which the sample collected at the time of the clinical sample collection is stored, the sample is received at the inspection side (the sample fixed container and the test request data), the sample is cut out at the time of specimen preparation, Replacing and storing the sample from the fixed transfer container to the cassette for pathological tissue sample, chemical treatment of the cassette for pathological tissue sample in which the sample is stored, sample embedding block preparation work, thin slicing of the embedded block sample The patient sample and the clinical / inspection side data transmission / linkage are integrally moved in all steps of the block sample storage management / historical history data search operation after completion of the work and slicing operation. Item 1. A method for transmitting and linking information data using the unit system according to claim 1 or 2. In the pathological tissue sample cassette, which is a chemical treatment vessel for the sample and also serves as a support base for fixing the block sample;
Both the cassette for pathological tissue sample and the unit 2 and 3 and the unit 4 and 5 of the fixed transfer container for pathological tissue sample, which are constructed of the unit system embedding frame-like base body constructed by the three unit system composite structure. It is a fitting / connection formation common to the unit system composite structure, and is detachably fitted and connected to the outer peripheral side of the shape formed by the embedding frame-like base for use as a data transmission body (messenger). To protect the data description section or the data recording section formed and installed on the outer wall of the embedded frame-like base body, which is one unit of the cassette for pathological tissue sample, which is a functional container for the chemical solution processing function composed of the three-unit system composite structure. Therefore, the cassette for pathological tissue sample comprising the unit system-embedded frame-like substrate structure constructed by the three-unit system composite structure Covers and covers all or part of the embedded frame-like substrate in the configuration shape, infiltrates the processing chemicals in the data description section / data recording section, peels off by physical force, and supports the embedding of the cassette side wall It is formed integrally with the lid body which has the function of preventing excessive burr adhesion and easy removal of the agent, or is separated from the lid body and is a latching portion on the outer peripheral side surface of the embedded frame-shaped substrate. A plate-like frame protector characterized by being fitted and connected. The bottom of the cassette for pathological tissue sample, which is a frame-shaped base with an opening formed on the upper side and the bottom of the porous liquid permeability formed on the bottom, and the upper opening of the bottom of the cassette for pathological tissue sample, which is the frame-shaped base A porous fluid inlet formed integrally with a protective plate that suppresses and covers a data description portion and a data recording portion formed and installed on the outer peripheral side surface of the frame-shaped substrate at the bottom of the cassette for pathological tissue sample that is detachably fitted and connected to In a cassette for pathological tissue samples comprising a lid having
A fitting locking portion with the cassette bottom of the lid with the protective plate is formed on the rear side of the lid and the lower side of the protective plate formed integrally with the lid to form the porous liquid-permeable bottom. The frame-shaped substrate is formed at the intersection of the bottom wall of the pathological tissue sample cassette bottom and the cassette bottom portion of the pathological tissue sample and the outer side of the frame-shaped substrate outer wall data description portion / data recording portion, and is fitted and connected to each other. A lid with a protective plate, which is detachably fitted and connected to an upper opening of a bottom of a cassette for a pathological tissue sample, which is a frame-like substrate having a porous liquid-permeable bottom. The bottom of the cassette for pathological tissue sample, which is a frame-shaped base with an opening formed on the upper side and the bottom of the porous liquid permeability formed on the bottom, and the upper opening of the bottom of the cassette for pathological tissue sample, which is the frame-shaped base A porous fluid inlet formed integrally with a protective plate that suppresses and covers a data description portion and a data recording portion formed and installed on the outer peripheral side surface of the frame-shaped substrate at the bottom of the cassette for pathological tissue sample that is detachably fitted and connected to In a cassette for pathological tissue samples comprising a lid having
Locking fitting in which the fitting portion locking portion with the cassette bottom portion of the lid with the protective plate protrudes symmetrically on both sides of the rear portion of the lid and the front portion of the lid and protrudes on both sides. A mating convex part is formed and sandwiched between the engaging fitting concave parts formed on the outer sides of both sides of the cassette bottom for pathological tissue sample, which is the frame-like base, and the rear part of the cassette bottom and both side walls of the cassette bottom Removably fitting and connecting to the upper opening of the bottom of the cassette for pathological tissue sample, which is a frame-like base body formed with the porous liquid-permeable bottom between the engagement fitting recess formed on the outside A lid with a protective plate. In a pathological tissue sample cassette which is a frame-shaped substrate that serves as a chemical treatment vessel for a sample and also serves as a support base for fixing a block sample;
Data recording medium / IC chip installation site is formed in the through hole on the lower side from the upper side of the inclined surface of the data recording part / data recording part of the frame-shaped substrate constituting the cassette for pathological tissue sample A cassette for a pathological tissue sample comprising a frame-like substrate. The unit 1 of the three-unit system composite structure has an opening on the upper side and the lower side, and has a through-hole portion connected to the opening from the upper side to the lower side. Embedding to form a convex flat surface projecting inwardly on the inner wall of the upper part of the outer wall surrounding the periphery of the upper opening of the connected through hole or the inner wall of the through hole connected to the upper opening On the frame base (unit 1) and the bottom of the embedding dish that can be inserted and fitted;
The bottom for the embedding dish is similar to the bottom (unit 4), but is a container-like bottom formed with a closed surface that does not leak liquid, and extends from the upper side of the embedding frame-like substrate (unit 1). A sample storage portion that is detachably inserted into a through hole connected to the opening to the side and formed with a liquid-impervious closed surface, and is provided in a horizontal direction surrounding the outer periphery of the upper opening of the sample storage portion A container-like bottom formed by a non-liquid-permeable closed surface that forms a bowl-shaped plane, and the bowl-shaped plane is formed on the upper end surface of the outer periphery of the opening of the embedded frame-shaped substrate (unit 1) or on the upper side. The inner wall of the through hole connected to the opening is hooked and installed on a convex flat surface projecting inward horizontally, and the non-liquid-permeable container-like bottom is the embedded frame-like substrate (unit 1). Constructed with a two-unit system composite structure with a dish-like bottom that prevents it from falling off at the lower opening side Embedding dish, characterized in that. A dish-shaped container having an opening on the upper side and a bottom that can store a sample on the lower side, and is located below the opening on the inner wall that is continuous from the bottom surface of the bottom. In an embedding dish forming a convex plane projecting horizontally inward;
The component part of the embedding dish has an opening on the upper side and the lower side, includes a through-hole portion connected to the opening from the upper side to the lower side, and the penetration that is connected to the lower side opening from the upper side An embedding frame-like substrate that forms a convex flat surface projecting inwardly on the inner wall of the upper part of the outer wall surrounding the upper opening of the hole, or on the inner wall of the through hole that is continuous with the upper opening; ,
A bottom portion for an embedding dish formed with a closed surface, which is separated from the embedding frame-shaped substrate, and is attached to and detached from a through-hole portion connected to an opening from the upper side to the lower side of the embedding frame-shaped substrate. Two independent configurations: a storage section that can be freely inserted and fitted to store a sample, and a bottom for an embedding dish that forms a bowl-shaped flat surface projecting in the horizontal direction surrounding the outer periphery of the upper opening of the storage section A unit is formed, and the storage part of the bottom part for the embedding dish is inserted and fitted into the through-hole of the embedding frame-like base, and the bowl-like plane of the bottom part for the embedding dish is set to the embedding frame-like base The bottom of the embedding dish is shaped like an embedding frame on the upper end surface of the outer periphery of the opening or on the convex flat surface projecting horizontally toward the inner wall of the through hole. An embedding dish characterized in that it is constructed of two independent constituent units having a function of preventing them from falling off on the lower opening side of the substrate.

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