JP2011247640A - Unit construct device for forming embedding block for biological sample, including independent basket for biological sample processing that can perform fixation, transfer and liquid chemical processing of biological sample and be unit-connected and fitted with embedding frame-like base body, unit connected and fitted construct cassette for biological sample and burr-free embedding tray which is the unit construct device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a system for surely transmitting patient and biological sample data, surely connecting pathology/sample formation side data, storing/transmitting an information amount equal to or more than a conventional cassette direct bar code print data amount, preventing the contamination/damage/loss/shift of the sample and a data recording/storage part, and not generating medical waste, in a cassette for pathological/biological sample.SOLUTION: Molding is performed as three kinds of construct units respectively separated and made independent in the function forms of a bottom part, a lid body freely detachably fitted/connected to the upper side opening of the embedding frame-like base body, and the embedding frame-like base body. An independent basket for the biological sample processing capable of fixation/transfer/chemical processing/data transmission connection of the biological sample, an embedding frame-like base body porous liquid permeable container bottom part which is a chemical processing basket of the sample, and a lid body which is the chemical processing basket of the sample and has porous liquid permeable holes are turned to the independent constructs of a support base for fixing a block sample usable that are usable without being abandoned. As the unit construct device of a unit connected and fitted construct cassette system for the biological sample, an embedding tray with a watertight frame made of a synthetic resin is molded.

Description

  The present invention relates to reliable data transmission and preparation of an embedded block cassette sample in pathological and histological examinations of patients and biological samples.

As shown in FIG. 33A, the conventional cassette for pathological / biological samples has an opening on the upper side, and a porous liquid-permeable bottom U3 on the lower side or a small compartment for storing a small sample (U6 in FIG. B) and its Two of a frame-shaped substrate U formed with a data recording portion U1 on the outer side wall and a lid V having a perforated liquid passage hole V3 detachably fitted and connected to the upper opening of the embedded frame-shaped substrate. A frame-shaped base formed of parts and having a data recording portion U1 formed on the outer wall, which is the porous bottom, and a porous liquid passage hole V3 that is detachably fitted and connected to the upper opening of the embedded frame-shaped base. The path of the pathology / biological sample constructed with the lid V having the function and the role of the rootstock at the time of preparation of the sample embedding block and the sample data number by handwriting of the pathology / biological sample or the printing machine for plastic Responsible for three functions responsible for the transmission of sample names.
The conventional cassette for pathological / biological sample in practical use is a porous liquid passage hole that is detachably fitted and connected to the molded frame-like base U that is the porous bottom U3 and the upper opening of the embedded frame-like base. A specimen storage basket for pathology / biological samples constructed with a lid V having V3 has a recording unit U1 for pathology / biological sample data, and the molded frame-like substrate U, which is the porous bottom, is provided with a sample package. The sample data that plays the role of the rootstock at the time of the preparation of the buried block takes over the sample data of the pathology / biological sample storage box as it is, and is detachably fitted and connected to the upper opening of the embedded frame-shaped substrate. When a lid body (V in FIG. 33B) having a porous fluid passage hole (B3 in FIG. 33) is formed of a transparent synthetic resin, the pathology stored in the pathology / biological sample storage container・ Only the biological pathology and biological sample can be confirmed without opening the lid. Practicality had been expected.

  However, the sample data of the pathology / biological sample at the time of preparation of the specimen to be transferred from the collection of the patient sample on the clinical side or the biological sample in the laboratory to the sample storage cage of the pathology / biological sample or the sample There was a drawback that it did not have any function or countermeasure against mistakes, mixing and loss.

Furthermore, recently, a printer that directly prints barcode and two-dimensional data code on pathological / biological sample data on the data recording part of the conventional cassette has been developed, and the conventional pathology / biological data directly printed on the cassette data recording part has been developed. Biological sample cassettes have been used.
Although its practicality is certain, in general, the data recording part of the synthetic resin cassette is formed with a stub for handwriting of the sample data number and the sample name, so that the printing angle of the printing press or the ink ejection Depending on the angle, rubbing or imperfect printing occurs in the printing result. In addition, even if the printing is visually normal, the reading and recognition result of the barcode or two-dimensional data code reader shows that the size, depth and angle of the data recording portion of the synthetic resin cassette and the subtle color tone of the cassette coloring. It is not recognized by the difference, and the recognition data capacity cannot be expected to be large.

  As an improvement measure, the present inventor has already disclosed in Patent Document 1 and Patent Document 4 a pathological / biological sample cassette in which an opening is formed on the upper side and a porous liquid-permeable bottom and its outer wall on the lower side. Inventing a lid with a protective plate for a data recording section having a frame-shaped base formed with a data recording section and a porous liquid passage hole detachably fitted and connected to the upper opening of the embedded frame-shaped base For example, we have proposed to protect the printed label, but since the lid with the protective plate is removed during the preparation of the sample-embedded block, a barcode or two-dimensional label affixed on the data recording section of the sample-embedded block Data code printed labels had the disadvantage of being likely to peel off after several years.

Furthermore, a lid having a porous liquid passage hole for detachably fitting and connecting a conventional cassette for pathological / biological samples has only a role of a porous lid, and a recycling lid is expected only for a stainless steel lid. In addition, many synthetic resin lids are discarded as medical waste after the preparation of the sample-embedded block, causing environmental destruction.
This is a significant loss from the standpoints of the strength of rootstock of the sample embedding block of the cassette for pathological / biological sample, the reliable connection and transmission of the sample data, and the reliable storage management of the embedded block cassette sample.

  Furthermore, in conventional pathological / biological sample cassettes, cassettes with IC chips (RFID) attached are also proposed in Patent Document 3 and Patent Document 4 invented by the present inventor. Not. For one thing, IC chips (RFID) are still expensive. Second, IC chips (RFID) with chemical-resistant coatings formed on many organic solvents are particularly expensive and scarce. Third, the IC chip (RFID) requires visual data, but its visual data recording capacity is poor.

  Furthermore, in the conventional cassette for pathological / biological sample, the burr-free embedding dish and embedding method of Patent Document 1 and Patent Document 2 invented by the present inventor and the burr-free embedding of the burr removing apparatus of Patent Application Document 4 are disclosed. The embedding plate (Fig. 43) CD, D, E, and F with less generation of burrs (12a and 12b in Fig. 43) is devised, but the watertightness and embedding of the watertight frame is still devised. There are problems such as workability and stacking and storage of embedding dishes, etc., further labor saving of burr removal work, automation of embedding work and slicing work, and sample data from clinical / sample collection side to specimen preparation side In order to achieve reliable connection and transmission, it is necessary to devise a method that further eliminates the generation of burrs in the embedding agent when preparing the sample embedding block.

Japanese Patent No. 4013192 Patent No. 4058709 Japanese Patent Laid-Open No. 2008-26097 Japanese Patent Application Laid-Open No. 2009-168737 Japanese Patent Laid-Open No. 2001-116669

  The problem to be solved is the reliable transmission of pathological / specimen preparation side data to the pathology / specimen preparation side of the sample / specimen data including sample and clinical data at the time of collection of patient samples and biological samples. To ensure the verification of the specimen (sample and specimen data) and to prevent mistakes, loss, and mixing of specimens.

  The problem to be solved is the connection data (for example, specimen spec number, chart number, patient, etc.) of sample / specimen data including pathology / specimen preparation side data including sample and clinical data at the time of collection of the patient sample or biological sample. (2) To guarantee the automatic writing and reading of the required amount of data to the data recording / storage unit of the embedded frame-shaped substrate that is the rootstock of the sample block (sample name, etc.).

  The problem to be further solved is that the sample data recording / storage unit of the embedding frame-shaped substrate, which is the root block of the sample block, is protected and the embedding is the root block of the sample block even after the sample block cassette is manufactured. This is to prevent the data recording portion / recording portion of the frame-shaped substrate from being contaminated or dropped out.

  Further, the problem to be solved is that when a patient sample or a biological sample is fixedly transferred, only the sample is immersed directly in a fixed transfer container, or for a conventional pathological / biological sample containing the biopsy sample. The sample data including the clinical data that can be fixedly transferred to the biopsy sample and reliably transmitted (messenger) and linked (linked) without directly immersing the cassette in the fixative solution. It is fixed transfer integrally.

  Further, the problem to be solved is that the lid is not used as a medical waste unlike the cassette for pathological / biological samples in the past, but it is used as an integrated frame base material which is a rootstock of the sample block cassette. is there.

  Furthermore, the problem to be solved is the same burrability in embedding work, and complete burr-free packaging with less burr (12a and 12b in Fig. 43) than the conventional embedding method (Fig. 43). Establish an embedding dish and embedding method as a cassette system unit that can embed, eliminate the deburring work around the sample embedding block cassette, This is to improve the workability by preventing the data recording unit / recording unit from being damaged or scratched.

  A further problem to be solved is that if trouble occurs, it can be verified at a later date.

  A further problem to be solved is to construct a ubiquitous unit cassette system that enables the ubiquitous and unit system to be combined, which is not found in conventional cassettes for pathological / biological samples.

  Furthermore, the problem to be solved is that the number of use steps is hardly increased while maintaining various conveniences and functions not found in the conventional cassette for pathological / biological samples.

The present invention includes an embedded frame-shaped base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a detachable fitting / connecting to the upper opening of the embedded frame-shaped base. A pathological / biological sample cassette comprising a lid having a porous liquid passage hole;
A lid (unit 2) Y having a bottom (unit 1) X and a porous liquid-permeable surface Y3 that is detachably fitted and connected to the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) Molding the functional form of Z as three separate structural units,
The bottom X forms an opening X9 on the upper side that is separated and independent from the embedded frame base (unit 3) Z, and forms a bowl-shaped plane X11 that protrudes in the horizontal direction surrounding the outer periphery of the upper opening X9. And a bottom portion (unit 1) X for biological sample storage and transfer processing comprising a sample storage portion X6 having a porous liquid-permeable bottom surface X10 formed at least on the bottom side thereof, and the embedded frame-shaped substrate ( Unit 3) A lid (unit 2) Y having the porous liquid passage hole Y3 in the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing is unique even without the presence of Z. The biological sample storage fixed transfer processing porous container cage (unit structure 1) (X) which has independent functions for fixing and transferring the sample 5a, chemical solution processing, and sample data transmission connection by detachably fitting and connecting to each other and Y), and the biological sample storage fixed transfer process The porous perforated vessel (unit structure 1) (X and Y) is detachably fitted and connected to the embedded frame base (unit 3) Z to determine the sample data and to mount the burr-free embedded block. Unit system embedding frame shape consisting of a three-unit system composite structure that constructs a fixed support base (unit structure 3) (X and Y and Z) capable of carrying the function of a tree and a conventional cassette for pathology and biological samples It is a unit system cassette for pathological / biological samples characterized by being a substrate structure.

The present invention also provides an embedded frame base having an opening formed on the upper side and a porous liquid-permeable bottom formed on the lower side thereof, and an upper opening of the embedded frame-shaped base so as to be detachably fitted. In a pathological / biological sample cassette comprising a lid having a perforated liquid passage to be connected;
It has a bottom (unit 1) X, and a porous liquid passage hole Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening (X9 and W18) of the embedded frame-shaped base (unit 3) W. The functional forms of the lid (unit 2) Y and the embedded frame-shaped base (unit 3) W are molded as three separate structural units,
The bottom X forms an opening X9 on the upper side that is separated and independent from the embedded frame base (unit 3) W, and forms a bowl-shaped plane X11 that protrudes in the horizontal direction surrounding the outer periphery of the upper opening X9. And a bottom part (unit 1) X for biological sample storage and transfer treatment comprising a sample storage part X6 having a porous liquid-permeable bottom surface X10 formed at least on the bottom side thereof, and the embedded frame-like substrate ( Unit 3) Even if there is no W, the lid (unit 2) Y having the porous liquid passing hole Y3 in the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing is unique. Porous container for biological sample storage and transfer processing (unit structure 1) (X and X), which have independent functions for detachably fitting and connecting to each other to perform fixed transfer of sample, chemical solution processing and sample data transfer connection Y) can be constructed, and the embedded frame substrate (unit 3) W is An embedding frame-like substrate (unit 3) W that forms a porous liquid-permeable bottom W10 different from the bottom X, which is a porous container-like bottom (unit 1) X for biological sample storage and transfer processing, and the embedding frame The lid (unit 2) Y having the porous liquid passage hole Y3 is detachably fitted to and connected to the upper opening W18 of the substrate (unit 3) W, and the sample data is determined and embedded without burrs. The support base for fixing (unit structure 3) (Y and W) that can support the function of the block stock and the conventional cassette function for pathological / biological samples is constructed.
The porous liquid through-hole, which is a constituent unit of the biological sample storage fixed transfer treatment porous container jar (unit structure 1) (X and Y) and the fixing support base (unit structure 3) (Y and W) Lid with Y3 (Unit 2) 3 units system composite structure that can share Y It is a unit system cassette for pathological / biological samples, characterized in that it is a unit system-embedded frame-shaped substrate structure composed of a support base (unit structure 3) (Y and W).

The present invention also provides an embedded frame base having an opening formed on the upper side and a porous liquid-permeable bottom formed on the lower side thereof, and an upper opening of the embedded frame-shaped base so as to be detachably fitted. In a pathological / biological sample cassette comprising a lid having a perforated liquid passage to be connected;
A lid (unit 2) Y having a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) ) Forming the functional form of Z as three separate structural unit units,
The embedded frame base (unit 3) Z has an opening Z18 on the upper side, and protrudes inwardly on the upper upper end surface Z6 of the outer wall surrounding the periphery of the opening Z18 or on the inner wall continuous to the opening Z18. An embedding frame-like base body (unit 3) in which an outer long side wall Z15 is erected and extended on the end surfaces of both long side upper end surfaces Z6 of the upper part of the outer wall surrounding the upper opening Z18. Z, and the outer long side wall upper end surface Z5 of the embedding frame-shaped substrate (unit 3) Z is the outer periphery of the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing Of the lid (unit 2) Y having a thickness of a bowl-shaped plane X11 projecting in a horizontal direction surrounding the base and a porous liquid-permeable surface Y3 detachably fitted and connected to the opening X9 of the bottom (unit 1) X The embedded frame-shaped substrate (unit 3) Z is the same as the thickness of the outer peripheral plane Y10 of the open / close guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y3. The outer wall upper upper end surface Z6 surrounding the periphery of the opening Z18 and a convex plane Z6 projecting inwardly on the inner wall continuous to the opening Z18 are formed at a higher position.
Biological sample storage fixed transfer processing porous container bottom (unit 1) X and the bottom (unit), which are constituent units of the biological sample storage fixed transfer processing porous container basket (unit structure 1) (X and Y) 1) A lid (unit 2) Y having a porous liquid passing surface Y9 detachably fitted and connected to the upper opening X9 of X is a horizontal surrounding the outer periphery of the upper opening X9 of the bottom (unit 1) X The long side of the bowl-shaped plane X11 projecting in the direction and the long side of the outer peripheral plane of the open / close guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y9 of the lid (unit 2) Y are formed in the shape of the embedded frame. A base (unit 1) X and a lid (unit 2) Y in which cutouts (X11a and Y10a) are formed in a shape that allows both outer side long side walls Z15 of the base body (unit 3) Z to be sandwiched and fitted; Perforated in the horizontal direction surrounding the outer periphery of the upper opening X9 of the porous container-like bottom part (unit 1) X for sample storage, fixed transfer processing The thickness of the outer peripheral plane of the opening / closing guide rib Y8 surrounding the outer periphery of the perforated liquid passing surface Y9 of the bowl-shaped plane X11 and the lid (unit 2) Y is the outer long side wall Z15 of the embedded frame-shaped substrate (unit 3) Z. The area of the data recording portion outside the side wall of the embedded frame-shaped substrate (unit 3) Z is kept large, and the sample data can be confirmed without discarding the lid (unit 2) Y. One of the root blocks of the embedding block, which is a fixed support base (unit structure 3) (X and Y and Z) that can support the function of the root block of the burr-free embedding block and the conventional cassette function for pathology and biological samples It is a unit system cassette for pathological / biological samples characterized in that it is a unit system embedding frame-like substrate structure composed of a three-unit system composite structure that can be embedded and used integrally as a part. .

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a removably fitted to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
It has a bottom (unit 1) X and a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening (X9 and W18) of the embedded frame base (unit 3) W. The functional forms of the lid (unit 2) Y and the embedded frame-shaped base (unit 3) W are molded as three separate structural units,
The embedded frame-shaped substrate (unit 3) W has an opening W18 on the upper side and an embedded frame-shaped substrate (unit 3) forming a porous liquid-permeable bottom W10 different from the bottom (unit 1) on the lower side. ) W and a convex flat surface W6 projecting inwardly is formed on the upper upper end surface W6 of the outer wall that surrounds the periphery of the upper opening W18 or on the storage inner wall that is continuous with the upper opening W18, and the upper opening W8 is an embedded frame substrate (unit 3) W in which an outer long side wall W15 is extended and formed on the end surfaces of both upper ends W5 at the upper part of the outer wall surrounding the periphery of W18, and the embedded frame substrate (unit 3). ) The upper end surface W15 of the long side wall W15 on both long sides of W is a porous liquid surface Y9 that is detachably fitted and connected to the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing The embedding frame by the thickness of the outer peripheral plane of the open / close guide rib Y8 surrounding the outer periphery of the porous liquid-permeable surface Y9 of the lid (unit 2) Y having Are molded into the base body (unit 3) W higher than the convex plane W6 which projects inwardly to the inner wall contiguous to the outer wall upper upper surface W6 and opening W18 surrounding the opening W18 surrounding.
Removably fitted to the upper opening of the biological sample storage fixed transfer processing porous container bottom part (unit 1), which is a constituent unit of the biological sample storage fixed transfer processing porous container container (unit structure 1). The lid body (unit 2) having the porous liquid passage hole to be connected has the long side of the outer peripheral plane of the open / close guide rib surrounding the outer circumference of the porous liquid passage surface of the lid body (unit 2). A lid body in which the outer side long side walls of the unit 3) are formed in a shape that can be sandwiched and fitted, and a lid body (unit 2) of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing Is shared and used as a lid (unit 2) of the embedded frame substrate (unit 3), and the thickness of the outer peripheral plane of the open / close guide rib surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2). Are all contained in the embedded frame base (unit 3) and are side walls. Area of the data recording portion of the side is maintained widely. Further, in order to prevent the cover (unit 2) having the porous liquid passage hole from being accommodated in the long side wall of the embedding frame-like base (unit 3) and preventing the cassette storage volume from being reduced, the embedding frame corresponding to the thickness thereof is used. The forming position of the porous liquid-permeable bottom portion of the base substrate (unit 3) is formed into a bowl-shaped protruding side wall Z11 protrudingly formed in an area narrower than the bottom surface of the adapter fixing claw position Z14 when the cassette block is sliced.
The embedded frame-shaped substrate (unit 3) W is a lid having the porous liquid-permeable surface Y9 which is a component unit of the biological sample storage fixed transfer processing porous container basket (unit component 1) (X and Y) ( Unit 2) Y can be shared as a lid having a porous liquid-permeable surface Y9 that is also detachably fitted to and connected to the upper opening W18 of the embedded frame base (unit 3) W. 2) A supporting base for fixing a block sample (unit structure 3) that can be embedded and used as a part of the root block of the embedding block without discarding Y. W) can be built. The porous liquid-permeable surface, which is a structural unit of the biological sample storage fixed transfer processing porous container bowl (unit structural body 1) (X and Y) and the fixing support base (unit structural body 3) (Y and W) Lid with unit Y9 (Unit 2) Independent of porous specimen container (unit structure 1) (X and Y) for biological sample storage and transfer processing, which has independent functions consisting of a 3 unit system composite structure that can share Y Of fixed sample data, function of rootstock of burr-free embedded block sample, and fixed support base (unit structure 3) (Y and W) capable of carrying conventional pathology / biological sample cassette function There is a unit system cassette for pathological and biological samples characterized by

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a removably fitted to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
A lid (unit 2) Y having a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) ) Forming the functional form of Z as three separate structural unit units,
Pathology constructed by a two-unit system composite structure of the bottom part (unit 1) X, which is a porous container-like bottom part (unit 1) X for biological sample storage and transfer processing, and the embedded frame-like substrate (unit 3) Z. Unit system embedded frame-like substrate porous liquid-permeable container bottom part (unit structure 2) (X and Z) which is a functional form of the tissue sample cassette (Unit 1) X is
Porous container-like bottom part for biological sample storage fixed transfer processing comprising a sample storage part X6 in which a porous liquid-permeable bottom surface X10 is formed and the bowl-like plane X11 projecting in a horizontal direction surrounding the outer periphery of the upper opening X9 (Unit 1) A data recording section on the outer surface of the embedded frame-shaped substrate (unit 3) Z at least one side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 of X A protective plate and data recording part X1 are integrally formed by extending and molding along the inclined surface Z1 to suppress and cover the data recording part Z1 which is inclined and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) Z. Unit unit of unit system embedding frame-like substrate porous liquid-permeable container (unit structure 2) (X and Z), which is a functional form of a cassette for pathological / biological samples constructed by a molded two-unit system composite structure A unit system cassette for pathological and biological samples characterized by This is a porous liquid-permeable container-like bottom portion (unit 1) X with a protective plate and a data recording portion, which is a structural unit of the lid.

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a removably fitted to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
A lid (unit 2) Y having a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) ) Forming the functional form of Z as three separate structural unit units,
The bottom part (unit 1) X is a biological sample storage fixed transfer processing porous container-like bottom part (unit 1) X and the bottom part (unit 1) X. Porous container container for biological sample storage and transfer processing (unit structure 1) (X) having an independent function constructed by a two-unit system composite structure with the lid (unit 2) Y having the porous liquid-permeable surface Y3 and Y) at least one side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 of the bottom (unit 1) X, which is a constituent unit of the bottom (unit 1) X, 3) The data recording part Z11 which is extended and formed along the inclined surface Z1 of the data recording part on the outer side surface of Z to be inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3) Z is protected and suppressed. Further protects the protective plate and data recording part X1 of the bottom part (unit 1) X In order to achieve this, an integral protective plate is formed on at least one side of the outer peripheral plane of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y3 of the lid (unit 2) Y having the porous liquid passing surface Y3. Y1 is molded, dirt on the protective plate and data recording part X1 of the porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing, and peeling and dirt of the data label printed on the data recording part Sample data recording unit with independent function constructed by a two-unit system composite structure of a lid (unit 2) Y with protection plate Y1 and a bottom plate (unit 1) X with protection plate / data recording unit X1 Double data recording / protection plate (X1 and Y1) of perforated container for biological sample storage fixed transfer processing (unit structure 1) (X and Y) of the embedded frame-shaped substrate (unit 3) Z Clamping and protecting the outer side data recording part Z1 and discarding the cover Y with the porous liquid passing surface Y3 Fixed support base (unit composition) that can support the function of rootstock of burr-free embedding block and conventional cassette for pathology / biological sample, and confirmation of sample data constructed with 3 unit system composite structure that can be utilized without using 3) Pathological / biological sample unit system cassette composed of (X and Y and Z) (Unit 1) A lid (unit 2) Y having X and a porous liquid-permeable surface Y3 with a protective plate.

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a releasable fitting to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
It has a bottom (unit 1) X and a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening (X9 and W18) of the embedded frame base (unit 3) W. The functional forms of the lid (unit 2) Y and the embedded frame-shaped base (unit 3) W are molded as three separate structural units,
The bottom part (unit 1) X is a biological sample storage fixed transfer processing porous container-like bottom part (unit 1) X and the bottom part (unit 1) X. Porous container container for biological sample storage and transfer processing (unit structure 1) (X) having an independent function constructed by a two-unit system composite structure with the lid (unit 2) Y having the porous liquid-permeable surface Y3 and Y) and a porous unit for a biological sample storage and transfer process which is a component unit of a unit system cassette for pathology / biological sample which is a three-unit system composite component constructed from the embedded frame-like substrate (unit 3) W At least one side of the bowl-shaped plane X11 protruding in the horizontal direction surrounding the outer periphery of the upper opening X9 of the container-shaped bottom (unit 1) X is inclined to the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) W. Formed data record The data recording part X1 is formed by extending at the same inclination angle as W1, and the bottom (unit) is formed along the data recording part X1 formed on the porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing. 1) At least one side of the outer peripheral plane of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid-permeable surface Y3 of the lid (unit 2) Y having the porous liquid-permeable surface Y3 detachably fitted and connected to X Similarly, the integrated protective plate Y1 is formed into a shape that protects and suppresses the data recording portion X1 formed on the bottom portion (unit 1) X of the biological sample storage fixed transfer processing, and the data recording portion A lid with a protective plate Y1 having the porous liquid-permeable surface Y3 that is detachably fitted to and connected to the bottom portion (unit 1) X and the upper opening X9 of the bottom portion (unit 1) X independently (unit 2) Organism with independent functions constructed with a two-unit system complex with Y A cover (unit 2) Y with a protective plate Y1 having a porous liquid-permeable surface Y3, which is a constituent unit of the porous container for sample storage and transfer processing (unit structure 1) (X and Y) is formed in the shape of the embedded frame. A unit system cassette for pathological / biological specimens characterized in that it can be shared and used as a lid (unit 2) Y with a protective plate Y1 that can protect the data recording part W1 inclined and installed on the outer peripheral side surface of the substrate (unit 3) W It is a perforated container basket (unit structure 1) (X and Y) for biological sample storage fixed transfer processing with a data recording part and protective plate which is a two-unit system composite structure.

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a releasable fitting to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
A lid (unit 2) Y having a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) ) Forming the functional form of Z as three separate structural unit units,
The embedded frame-shaped substrate (unit 3) Z has an opening Z18 on the upper side, and protrudes inward to the upper upper end surface Z6 of the outer wall surrounding the periphery of the opening Z18 or the inner wall connected to the upper opening Z18. A convex plane Z6 is formed, and concave portions Z8 extending from the upper end surface Z6 to the lower end surface Z14 are formed on both front outer surfaces Z15 of the outer wall of the embedding frame-shaped substrate (unit 3) Z; Embedding the latching portion Z9 of the projecting vertical locking portion Y2 on the front side of the lid (unit 2) Y, which is also detachably fitted and connected to the bottom portion (unit 1) X, on the concave portion Z8. A part of the upper side of the outer side surface is formed in both front outer concave portions of the frame-shaped base (unit 3) Z so as to protrude as a latching portion Z9 on the concave side, and the lid (unit 2) Y is also formed on the rear outer wall. An embedding frame-shaped base (unit 3) Z formed with a latching portion Z12 for latching the rear locking portion Y4. The embedding frame-shaped base (unit 3) Z is a bottom portion (unit 3). 1) A support base for fixing (unit structure 3) (X and Y and Z) which is a three-unit system composite structure by detachably fitting and connecting with X and lid (unit 2) Y To construct.
The bottom (unit 1) X is formed with an opening X9 on the upper side that is separated and independent from the embedding frame-shaped substrate (unit 3) Z, and a porous liquid-permeable bottom surface X10 is formed on at least the bottom on the lower side. It is a porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing consisting of a sample storage part X6, and the bottom part (unit 1) X protrudes in a horizontal direction surrounding the outer periphery of the upper opening X9. X11 is formed, and at the front part of the bowl-shaped plane X11, there is a latching part X2 of the front convex hanging latching part Y2 of the lid (unit 2) X, and the latching part X2 is Notch that coincides with the recess formed by leaving the upper part of the outer surface of the outer wall Z15 of the outer frame Z15 of the embedded frame-like substrate (unit 3) Z as a latching part Z9 on the recess side. It is an end portion X2 of the portion X2a, and the latching portion X5 of the rear portion locking portion Y4 of the lid (unit 2) Y also on the rear portion of the bottom portion (unit 1) X It is formed. The bottom (unit 1) X is detachably fitted to and coupled to a lid (unit 2) Y, and is a two-unit system composite component porous container container (unit component 1) X and Y).
The lid (unit 2) Y having the porous liquid-permeating surface Y3 is formed with convex hanging locking portions Y2 on both sides of the front part, and the bottom part (unit 1) X and the embedded frame-like base body on the rear part. (Unit 3) A locking portion Y4 shared with Z is formed. The lid (unit 2) Y is constructed with a multi-unit biological assembly containing a two-unit system composite structure for a biological sample storage fixed transfer process (unit structure 1) (X and Y) and a 3-unit system composite structure. This is a common structural unit with the fixed support base (unit structural body 3) (X and Y and Z).
It is constructed from a porous container-like bottom part (unit 1) X for the biological sample storage fixed transfer process, a lid (unit 2) Y having the porous liquid-permeable surface Y3, and an embedded frame-like substrate (unit 3) Z. Perforated vessel for biological sample storage, fixed transfer process (unit structure 1) (X and Y) and support base for fixation (unit structure 3) (X and Y and Z) are the same as unit system composite structure It is a unit system cassette for pathological / biological samples, which is a unit system embedded frame-like substrate structure, which is constructed by shared utilization of a lid (unit 2) Y having a porous liquid-permeable surface Y3 .

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a releasable fitting to the upper opening of the embedding frame-like base. -In a cassette for pathological / biological samples consisting of a lid having a perforated liquid passage hole to be connected;
A lid (unit 2) Y having a porous liquid-permeable surface Y3 that is detachably fitted and connected to the bottom (unit 1) X and the upper opening X9 of the bottom (unit 1) X and an embedded frame base (unit 3) ) Forming the functional form of Z as three separate structural unit units,
The embedded frame base (unit 3) Z has openings (Z18, Z16) on the upper side and the lower side, and through-holes connected to the openings (Z18, Z16) from the upper side to the lower side Z17 is formed, and the upper end Z18 of the outer wall surrounding the periphery of the upper opening Z18 of the through hole Z17 connected to the lower opening Z16 from the upper side Z18 or the inner side of the inner wall of the through hole continuous to the upper opening Z18 A convex flat surface Z6 projecting toward the surface is formed, and a concave portion Z8 extending from the upper end surface Z6 to the lower end surface Z14 is formed on both front outer surfaces Z15 of the outer wall of the embedded frame-shaped substrate (unit 3) Z. Then, the latching portion Z9 of the front convex hanging latching portion Y2 of the lid (unit 2) Y, which is detachably fitted and connected to the bottom portion (unit 1) X, is formed on the upper portion of the recess Z8. The upper part of the outer surface is formed on both front outer recesses Z8 of the embedded frame-shaped base (unit 3) Z so as to be protruded as a latching part Z9 on the recess side, and the lid is also formed on the rear outer wall. A (unit 2) Y rear of hooked locking portion Y4 retaining portion Z12 molded embedding frame-like base of (unit 3) Z.
The bottom (unit 1) X is formed with an opening X9 on the upper side that is separated and independent from the embedding frame-shaped substrate (unit 3) Z, and a porous liquid-permeable bottom surface X10 is formed on at least the bottom on the lower side. It is a porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing comprising a sample storage part X6, and the bottom part (unit 1) X can be obtained without the inclusion of the embedded frame-like base (unit 3) Z. A lid (unit 2) Y having the porous liquid-permeable surface Y3 in the upper opening X9 is independently detachably fitted and connected to each other, and has a porous function for a biological sample storage and transfer process (unit) Construct 1) (X and Y) can be constructed.
The bottom (unit 1) X forms a bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9, and the front of the lid (unit 2) Y is formed on the front of the bowl-shaped plane X11. The front both-side latching portion X2 of the both-side convex hanging latching portion Y2 is formed, and the front both-side latching portion X2 of the bottom portion (unit 1) X is formed of the embedded frame-shaped base (unit 3) The upper side of the latching part Z9 formed on the both outer sides of the outer wall Z15 of the Z, on the upper part of the concave part Z8 leading from the upper end surface Z6 to the lower end surface Z14, leaving the upper part of the outer surface protruding from the concave side. It is molded into a shape that overlaps Further, the front side latching portions X2 of the bottom portion (unit 1) X are cut on the long sides on both sides of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 of the bottom portion (unit 1) X. The notch portion X2a is formed at the end of the notch portion X2a. The notch portion X2a is a recess Z8 leading from the upper end surface Z6 to the lower end surface Z14 on both front sides of the outer wall Z15 of the embedded frame base (unit 3) Z. The bottom portion (unit 1) X that overlaps the upper portion of the latching portion Z9 formed in a protruding manner on the concave side of the upper outer surface of the concave portion Z8 of the embedding frame-like base body (unit 3) Z. The end portion of the notch portion X2a coincides with the front side latching portion X2. Furthermore, it is a porous liquid-permeable container-like bottom part (unit 1) X in which a latching part X5 of the rear part latching part Y4 of the lid (unit 2) Y is formed at the rear part, and the embedded frame-like substrate (unit 3) The sample storage portion X6 that can be removably inserted and fitted into the through-hole portion Z17 connected to the opening portion (Z18, Z16) from the upper side to the lower side of Z and the bowl-shaped plane X11 are connected to the embedded frame-like substrate ( Unit 3) Install and fit on the upper surface Z6 of the outer periphery of the opening Z18 of Z or on the convex flat surface Z6 projecting inwardly on the inner wall of the through hole Z17 connected to the upper opening Z18. The bottom part (unit 1) X for storing and transferring biological specimens has a function of preventing the bottom part (unit 1) X from falling off to the lower opening Z16 side of the embedded frame base (unit 3) Z. ) X is a disease constructed with a two-unit system composite structure by fitting and connecting with the embedded frame base (unit 3) Z. Building unit system embedded frame-like base porous liquid permeability container bottom is a functional form of a tissue sample cassette (the unit structure 2) (X and Z).
The lid (unit 2) Y having the porous liquid-permeable surface Y3 is formed with convex hanging locking portions Y2 on both sides of the front portion, and the latching portion X5 of the bottom portion (unit 1) X and the A locking portion Y4 that can be hooked to a hooking portion constructed by a double overlap formed by the hooking portion Z12 of the embedding frame base (unit 3) Z is formed, and the bottom portion (unit 1) X The perforated liquid-permeable surface is provided with a bowl-shaped plane X11 that is detachably fitted to and connected to the upper opening X9, and further protrudes in the horizontal direction surrounding the outer periphery of the upper opening X9 of the bottom (unit 1) X. On the upper end surface Z6 of the opening outer periphery of the opening / closing guide rib Y8 surrounding the outer periphery of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y of the lid (unit 2) Y having Y3 Alternatively, a fixed support base (unit) is formed by sandwiching and fitting and connecting on a convex flat surface Z6 projecting inwardly to the inner wall of the through hole Z17 continuous with the upper opening Z18. G construct 3) (X and Y and Z). Further, the bottom part (unit 1) of the biological sample storage fixed transfer process of the convex protrusions on both front sides of the lid (unit 2) Y having the porous liquid-permeable surface Y3 and the rear locking part Y4. ) In the latching of X and the front and rear of the embedded frame-shaped base (unit 3) Z, the front both-side convex hanging latching portion Y2 and the rear latching of the lid (unit 2) Y The bottom portion (unit 1) X of the portion Y4 and the front portions (X2 and Z9 / Z10 in the enlarged view of FIGS. 1 and 3) and the rear latching portion (FIG. 7) 8 and 10 and X5 and Z12 in FIG. 11 are each constructed by a double overlap formed by the bottom (unit 1) X and the latching portion of the embedded frame-shaped substrate (unit 3) Z. Since it is composed of a latching portion to be fitted, the lid (unit 2) Y, the bottom portion (unit 1) X, and the embedding frame-like base (unit 3) Z latching portion fitting / locking fulcrum Are common to each other I use it. The fitting / locking fulcrum of the latching part of the lid (unit 2) Y, the bottom part (unit 1) X, and the latching part of the embedded frame-like base (unit 3) Z can be shared. It is a unit system cassette for pathological / biological sample comprising a unit system embedding frame-like substrate structure.

Furthermore, the present invention provides an embedding frame-like base body having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a releasable fitting to the upper opening of the embedding frame-like base. -Pathology / biological sample cassette embedding frame body consisting of a lid with a perforated hole to be connected to the outer periphery of the data recording section of the embedded frame-like substrate, and obstructing the pathology / biological sample embedding block cassette. In an embedding dish that eliminates excess burrs of the embedding agent that damages the data recording section during its removal or does not generate burrs;
Opened on the upper and lower sides that fit and connect to the horizontal plane S3 protruding in the horizontal direction surrounding the outer periphery of the embedding bottom (unit 4) S and the upper opening S4 of the embedding bottom (unit 4) S Functional form of the upper watertight embedding frame (unit 5) T that has a through hole (T12, T14) having a portion (T6, T11, T13, T19) and connected to the opening from the upper side to the lower side The embedding bottom part (unit 4) S is formed by pressing a metal plate having a good thermal conductivity, and the embedding bottom part S is formed as an upper opening S4. The lower side is a metal structure unit that has a storage bottom S1 on which an embedding sample is placed at the time of embedding and forms a bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4. ,
The upper watertight embedding frame portion T has openings on the upper side T13 and the lower side T19, and forms a through-hole portion T14 connected to the upper side to the lower side opening portions (T13, T19). The outer wall upper upper end surface T4 surrounding the periphery of the upper opening T13 of the through hole T14 connected to the lower opening (T13, T19) or the inner wall of the through hole T14 connected to the upper opening T13 is directed inward. A protruding convex surface T4 is formed and protruded inwardly on the outer wall upper upper end surface T4 surrounding the upper opening T13 or on the inner wall of the through hole T14 connected to the upper opening T13. The embedding bottom portion that can be hung and installed on all four sides of the bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of the storage bottom portion S1 of the embedding bottom portion (unit 4) S on the surface T4 (Unit 4) The lower fitting connection embedded bottom support Ta of the S and the lower fitting connection embedded bottom support Ta are connected to the upper side of the lower fitting connection embedded bottom support Ta, and the upper T6 and the lower T11 The through-hole portion T12 having an opening, forming a through-hole portion T12 connected to the opening portion (T6, T11) from the upper side to the lower side, and connected to the lower opening portion (T6, T11) from the upper side The embedding dish upper watertight 2 formed with a convex flat surface T3 projecting inwardly on the inner wall of the upper end T2 of the outer wall surrounding the upper opening T6 or the inner wall of the through hole T12 connected to the upper opening T6 This is an upper watertight embedding frame portion (unit 5) T composed of a square surface forming frame T.
In the embedding dish, the embedding bottom (unit 4) S forms a bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4, and the sample embedding bottom at the time of embedding is formed below the embedding dish. A metal embedding bottom (unit 4) S having a S1 surface, and a hooking portion for hooked flat surface S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of the embedding bottom (unit 4) S It is constructed with two types of material constituent units, an upper watertight embedding frame portion (unit 5) T made of synthetic resin that fits in a watertight manner, and the embedding bottom portion (unit 4) made of metal having good thermal conductivity. ) An embedding dish which is a two-unit system composite structure that combines the functional forms of the synthetic resin upper watertight embedding frame (unit 5) T capable of precision fitting molding with the same shrinkage as S.
The embedding bottom portion (unit 4) S is formed by pressing a metal plate having a good thermal conductivity, and is a bowl-like shape protruding in the horizontal direction surrounding the outer periphery of the opening S4 of the embedding bottom portion (unit 4) S. The flat surface S3 is securely and securely fitted into the latching portion T4 of the upper watertight embedding frame portion (unit 5) T made of the synthetic resin, and the embedding frame-like substrate bottom Z14 of the pathological / biological sample cassette and the embedding The concave / convex square surface formed by the projecting side wall Z11 projecting and forming the molding position of the porous liquid-permeable bottom portion of the frame-shaped base (unit 3) in an area narrower than the bottom surface of the adapter fixing claw position when the cassette block is sliced, and The upper watertight embedding frame part (unit 5) T made of synthetic resin is watertightly fitted and connected at the concave / convex square contact surface of the contact watertight surface formed by the upper end surface T2 of the watertight embedding frame inner wall T3,
Watertight fitting between the bottom surface of the embedded frame-shaped substrate Z of the cassette for pathological / biological samples and the watertight frame which is the watertight dihedral surface forming frame T, which has been difficult in the conventional watertight frame forming of metal embedding dishes. The embedding frame-like substrate of the pathologic / biological embedding block cassette immersed in the embedding agent 12 during the treatment of the fixed embedding solution of the sample 15a and the embedding agent 12 in the embedding dish. Synthetic resin upper watertight embedding frame part (unit 5) T and metal embedding bottom part with good thermal conductivity that completely prevent the excess burr 12b of the embedding agent that is a drooping pool of embedding agent from the surroundings (Unit 4) An embedded dish with a synthetic resin watertight frame at the bottom of an embedded frame-like substrate of a cassette for pathological / biological samples, characterized in that it is constructed with a two-unit system composite structure with S (unit structure 4) ) (S and T).

  The functions of conventional cassettes for pathological / biological samples are: (1) the function of the chemical treatment vessel for the sample, (2) the function of describing data of the patient / biological tissue sample, and (3) the root function of the sample embedding block. When a transparent porous liquid-permeable lid was used, the sample inside the cassette could only be confirmed.

  The unit system cassette for pathology / biological sample which is a unit system embedding frame-like base body structure composed of the three unit system composite structure of the present invention is a biological body with a data recording unit and a protection plate that performs independent functions of a patient / biological sample. In addition to the addition of the function of the porous container for sample storage, fixed transfer processing (unit structure 1)) (X and Y), for example, the specimen [patient A data recording unit that is a constituent unit of the perforated container 籠 (unit component 1)) (X and Y) at the time of fixed transfer of clinical patient data (pathological diagnosis request form) of a biopsy sample and a trimmed sample The patient name / sample name 3 is described with a pencil or the like on the clinical side (FIG. 44A) in the data recording section X1 of the perforated container-like bottom X for biological sample storage / transfer processing with a protective plate (FIG. 2, FIG. 9, FIG. 44c) Transparent Close the lid (unit 2) Y having a perforated liquid-permeable surface Y3 with a protective plate and store it in a dedicated fixed transfer container (6 in B of Fig. 44), along with the pathological examination request form Can be transferred to the production side. At this time, the embedded frame-shaped substrate Z is a data recording unit / protection plate having an independent function capable of fixing and transferring the patient / biopsy sample 5 and chemical treatment without being immersed in the fixing solution (15 in FIG. 44B). A patient / biopsy sample 5 is stored in a perforated container for biological sample storage / fixed transfer processing (unit structure 1) (X and Y) and immersed in the fixative 15 and transferred to the inspection / specimen preparation site. Therefore, the embedded frame-shaped substrate Z accommodates the RFID (IC chip) 2 and can be fitted and connected to the outer side of the embedded frame-shaped substrate Z (B-6 in FIG. 44). If it is sent to the clinical side together with the patient, the patient attributes and clinical sample data are sent as digital data in the RFID (IC chip) 2 and the paper of the request can be made. Of course, the embedded frame-shaped substrate Z can be placed on the inspection side.

  Furthermore, the patient sample specimen (patient sample 5 and the patient sample data such as a pathological examination request form) transferred from the clinical side (FIG. 44A) is fixed to the pathological examination request form of the patient on the pathological examination / specimen preparation site side. After receiving and receiving the patient attribute description label 6c affixed to the transfer container 6 after confirmation / collation, the operator stores the patient sample 5 from the fixed transfer container 6 in the previous period when the patient specimen is cut out (FIG. 18A). Take out the perforated container (unit structure 1) (X and Y) for the biological sample storage fixed transfer process with a data recording unit and protection plate that has an independent function and remove the patient name / sample name of the data recording unit X1 of the bottom X After confirming (3 in FIGS. 2, 9, 44c), the pathological examination request form of the patient sample 5 and the fixed transfer container 6 are collated, and the patient sample 5 is confirmed, observed, trimmed, and the bottom portion Patient name / sample name of X data recording part X1 (Fig. 2, Fig. 9, Paste specimen sample numbers 1a and a bar code or two-dimensional data code 1b like the printing data recording label from the top of 44c 3 in) (Fig. 18B · Figure 44D 1). At this time, it is more convenient to use the automatic label printing machine shown in FIG. 18B or 44D. After attaching the data recording label 1 to the data recording part X1 of the bottom X, the lid (unit 2) Y having the transparent liquid-permeable porous liquid passing surface Y3 is closed again and the patient sample (5 or 5a) is stored. 19A, B, C, and D in FIG. 20 and the perforated container cage (unit structure 1) (X and Y) fixed together with the porous container cage (unit structure 1) (X and Y). As shown in FIG. 44B and FIG. 44F, the sample 5 can be stored in the processing basket 9 of the automatic fixing and embedding apparatus, and the sample 5 can be fixed, dehydrated, degreased, penetrated, and embedded infiltrated. That is, a biological sample storage fixed transfer process with a data recording unit and a protection plate, which is a constituent unit of a unit system cassette for a pathological / biological sample which is a unit system embedding frame-like base body structure comprising the three unit system composite structure of the present invention Patient name / sample name 3 described on the clinical side (FIG. 44A) on the data recording part X1 of the porous container-shaped bottom part (unit 1) X is 5 patient samples (FIG. 44A / B / C) collected on the clinical side (FIG. 44A) Fixed transfer of patient sample specimen (patient specimen 5 and patient specimen data such as pathological examination request form) from time to time (FIG. 44B) and acceptance / reception of specimen at pathological examination / specimen preparation site (FIG. 44B) Confirmation / collation / cutting (FIG. 18A / B, FIG. 19A / B / C / D, FIG. 20A / B, FIG. 44B / C / D) and embedding (FIG. 21A / B, FIG. 22A / B, FIG. 23A / B, FIG. 24A / B, FIG. 25A / B, FIG. 26A / B, FIG. 30A / B / C, FIG. B, Fig. 32A ・ B ・ C, Fig. 44E ・ G) and all of the process of slicing the sample embedding block (Fig. 32D ・ E, Fig. 44H) and the storage management of the embedded block sample after the slicing operation is completed. The patient sample is surely attached to the process, and the patient sample specimen is received / received on the pathological examination / specimen preparation side (FIG. 44B) / confirmation / verification / cutout (FIGS. 18A and B, FIGS. 19A and B) C / D, FIG. 20A / B, FIG. 44B / C / D) At the stage of the patient name / sample name 3, the specimen sample number 1a of the patient sample is securely attached and integrated so that the patient's clinical / Direct and reliable communication (messenger) and connection (link) between the sample data and the pathology / specimen preparation side data including its attributes / history are completed. At this time, when the sponge gel mat (10 in FIG. 44B) filed at the same time by the present inventor is used in combination, the patient sample on the clinical side and the pathological examination side with no annihilation, deformation, movement, contamination, or loss of the patient sample. Data transmission and connection will be completed, and the best specimen preparation and pathological diagnosis will be possible.

  Furthermore, a removable chemical combination of a fixed chemical solution treatment basket (unit structure 1) and an embedded frame-shaped substrate (unit 3), which is not included in a conventional cassette for pathological / biological samples, and a further upper watertight package made of synthetic resin. An embedding dish with a watertight frame made of synthetic resin (unit structure 4) constructed by a two-unit system composite structure of a buried frame part (unit 5) T and a metal embedded bottom part (unit 4) S having good thermal conductivity. ) (S and T) unit system embedding allows complete burr-free embedding.

  Further, an embedded sample block in which the lid (unit 2) having a porous liquid passage hole is accommodated and integrated in the adapter fixing claw position at the time of slicing of the cassette sample embedded block, which is the thickness of the embedded frame-shaped substrate, is integrated. By manufacturing, the medical waste of a lid like the conventional cassette for pathology and biological samples does not come out.

  Furthermore, the strength of the sample-embedded block became stronger as the lid was accommodated in the block stock.

  Furthermore, since barcodes and two-dimensional data codes are printed on data recording labels and are held and protected by a transparent protective plate, data recording is basically transmitted, so sample data can be recorded rather than printed directly on conventional synthetic resin. The amount of data in the printing section can be increased, and the printing machine becomes inexpensive.

  In addition, the perforated vessel for storing and transporting biological specimens with a data recording unit and a protective plate carrying independent functions (unit structure 1) (X and Y) and the embedded frame base (unit 3) are independent and detachable. The unit configuration of mating and coupling makes it possible to use it without worrying about the chemical resistance of RFID (IC chip) 2. The RFID (IC chip) 2 can be used in a wider range and has a low chemical resistance. (IC chip) 2 can also be used.

  Furthermore, the use of the sponge gel mat filed by the inventor at the same time prevents the sample from being destroyed, deformed, moved, mixed, or lost, and reduces the manufacturing cost and inventory management cost of the unit system cassette for pathology and biological samples. did it.

  Furthermore, the system prevents the patient sample from being destroyed, deformed, moved, mixed, or lost, but if a problem occurs, the cause and responsibility can be verified at a later date.

  Furthermore, although it has the above 13 functions, its usage at the specimen preparation site is almost the same as in the past.

FIG. 1 is an explanatory view showing an embodiment of a unit system cassette for a pathological / biological sample constructed with a unit system embedding frame-like substrate structure composed of a three-unit system composite structure of the present invention. 1A is a plan view showing the fitting / connection of the unit structure 1 and the unit 3, FIG. 1B is a plan view of a unit system cassette for pathology / biological sample, FIG. 1C is a side view of FIG. 1B, and FIG. FIG. 1C is an enlarged view of a part of FIG. 1C, and FIG. 1E is a vertical cross-sectional view of a straight line portion with double arrows in FIG. 1B. The transparent part is represented by a dot pattern. FIG. 2 is an exploded view of a part of FIG. 2A is a plan view, FIG. 2B is a side view, and FIG. 2C is a longitudinal sectional view. FIG. 3 is an explanatory view showing fitting and connection for each part which is the unit of FIG. 3A is a plan view, FIG. 3B is a side view and an enlarged view of a part thereof, and FIG. 3C is a vertical cross-sectional view of a straight line portion indicated by a double arrow in FIG. 3A. The transparent part is represented by a dot pattern. FIG. 4 is an explanatory diagram for every unit in FIG. 4A is a side view, and FIG. 4B is a longitudinal sectional view. FIG. 5 is an explanatory view of the back surface of each unit shown in FIG. FIG. 6 is a backside explanatory view showing an embodiment using the unit portion of FIG. FIG. 6A is an exploded view, and FIG. 6B is a rear view of fitting and coupling. FIG. 7 is an explanatory diagram of the unit 3 which is a part of FIG. FIG. 7A is a rear view, and FIG. 7B is a plan view. FIG. 8 is an explanatory view showing another embodiment of FIG. 8A is a plan view, FIG. 8D is a rear view, and FIGS. 8B, 8C, and 8E are cross-sectional views showing the embodiment. FIG. 9 is a front view showing the embodiment of FIG. The transparent part is represented by a dot pattern. FIG. 10 is an explanatory view showing the embodiment of FIG. 10A is a rear view, FIG. 10B is a longitudinal sectional view, and FIG. 10C is a partially enlarged view of the rear part of FIG. 10B. 11A is a rear view showing the embodiment of FIG. 1, and FIG. 11B is a corresponding longitudinal sectional view and a rear enlarged view. The transparent part is represented by a dot pattern. FIG. 12 is an explanatory view showing another embodiment of FIG. 12A is a plan view, FIG. 12B is a side view, and FIG. 12C is a longitudinal sectional view. FIG. 13 is an explanatory view showing the embodiment of FIG. FIG. 14 is an explanatory view from the plan view side of the embodiment of FIG. FIG. 15 is an explanatory view from the back side of the embodiment of FIG. FIG. 16 is an explanatory view of a vertical cross section of each part in FIG. 1B. FIG. 16A is the same plan view as FIG. 1B with no data label attached, but FIGS. 16B, 16C, and 16D are longitudinal sectional views of the corresponding double-headed arrow linear portions. FIG. 17 is a longitudinal sectional view of each corresponding double-pointed arrow straight portion of the unit 3 of FIG. FIG. 18 is an explanatory diagram of an example of use using the unit system cassette for pathology / biological sample of FIG. FIG. 19 is a continuation of the explanatory diagram of the usage example of FIG. FIG. 20 is a continuation of the explanatory diagram of the usage example of FIG. FIG. 21 is a continuation of the explanatory diagram of the usage example of FIG. FIG. 22 is a continuation of the explanatory diagram of the usage example of FIG. FIG. 23 is a continuation of the explanatory diagram of the usage example of FIG. 22 and a longitudinal sectional view of the unit structure 4 which is a part used there. FIG. 24 is a continuation of the explanatory diagram of the usage example of FIG. 23 and a longitudinal sectional view of the unit structure 4 which is a part used there. FIG. 25 is a continuation of the explanatory diagram of the usage example of FIG. 24 and a side view of the unit structure 4 which is a part used there. FIG. 26 is a continuation of the explanatory diagram of the usage example of FIG. FIG. 27 is a development view of the structure of the unit structure 4 shown in the embodiment of FIGS. FIG. 28 is a vertical section and a horizontal section of each unit of the unit structure 4 shown in FIG. 28A is FIG. 1C corresponding to the unit structure 4, FIG. 28B is FIG. 9E, FIG. 28I is a longitudinal sectional view of the unit structure 4 composed of FIGS. 28C, E, and G, and FIG. It is a cross-sectional view of the unit structure 4 composed of 28D, F, and H. FIG. 29A or 29B is an exploded view of each unit of the embodiment different from FIG. FIG. 30 is a continuation of the example of use in another embodiment of FIG. FIG. 31 is an explanatory diagram of a method of use different from FIGS. FIG. 32 is a continuation of the description of the usage example of FIG. FIG. 33 is an explanatory diagram of an example of a conventional cassette for a pathological / biological sample. FIG. 34 is an explanatory diagram showing a part of the difference between the conventional pathological / biological sample cassette of FIG. 33 and the pathological / biological sample unit system cassette of FIG. 1 of the present invention. FIG. 35 is a related explanatory diagram of the three units of the unit system cassette for pathological / biological sample constructed by the unit system embedding frame-like substrate structure composed of the three unit system composite structure of FIG. FIG. 36 is an explanatory diagram of another embodiment of FIG. 36A is a plan view, FIG. 36B is a longitudinal sectional view of the corresponding double-pointed arrow C, D, E, FIG. 36F is a longitudinal section of the unit 3 as a part, FIG. 36G is a plan view, and FIG. FIG. FIG. 37 is an explanatory diagram of the unit 3 which is a part of FIG. 37A is a plan view, FIG. 37B is a longitudinal sectional view of the corresponding double-pointed linear portions C, D, and E, FIG. 37F is a side view, and FIG. FIG. 37H is a cross-sectional view of the straight line portion J of both arrows as viewed from the arrow side. FIG. 38 is an explanatory diagram of another embodiment of FIG. FIG. 39 is an explanatory diagram of another embodiment of FIG. FIG. 40 is an explanatory diagram of another embodiment of FIG. FIG. 41 is a continuation of the explanatory diagram of use of the embodiment of FIG. FIG. 42 is a continuation of the explanatory diagram of the usage example of FIGS. 27, 28, and 29. FIG. 43 is an explanatory view of an example of a conventional embedding dish. FIG. 44 is a flow explanatory diagram of the use process of the unit system structure of the present invention.

  An embodiment of the present invention will be described with reference to FIGS. 1 to 11 and FIGS. 16 and 17 of the accompanying drawings. First, as shown in FIG. 1, an opening is formed on the upper side and a porous liquid-permeable bottom is formed on the lower side. A pathological / biological sample cassette comprising a formed embedded frame-shaped substrate and a lid having a porous liquid-permeable surface that is detachably fitted and connected to the upper opening of the embedded frame-shaped substrate constitutes the bottom. Separately-separated perforated container bottom (unit 1) X for biological sample storage fixed transfer processing and perforated container bottom (unit 1) X or embedding frame shape as adapter fixing claw position Z14 when slicing sample embedding block Three types of functional units of the lid (unit 2) Y, which is detachably fitted and connected to the upper opening Z6 of the base body (unit 3) Z, and the embedded frame-shaped base body (unit 3) Z are separated and independent. It was molded as a component unit.

A unit system cassette for pathology / biological sample which is a unit system embedding frame-like substrate structure composed of the three unit system composite structure of the present invention, which is unit 1 of a separate and separate perforated container for biological sample storage and transfer processing. As shown in FIG. 1 to FIG. 11, the basic form of the patient is stored in the patient sample 5 in the fixed transfer of the patient sample 5 or in the fixing, dehydration, degreasing, penetration, and embedding agent penetration process steps of the sample. Perforated container-like bottom container X (unit structure 1) (X and Y) for biological sample storage and transfer processing with a data recording unit and protection plate that can carry an independent function. A sample container in which a bowl-shaped flat surface X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 is formed, and a porous liquid-permeable bottom surface X10 and a side wall X8 surrounding the bottom portion are formed at least on the lower side thereof. Biological trial consisting of part X6 Housing fixed transfer processing porous container-like bottom is (Unit 1) X.
Data that can have an independent function with the lid (unit 2) Y having a porous liquid passing surface Y3 that is detachably fitted and connected to the opening X9 on the upper side of the porous container-shaped bottom (unit 1) X Since a porous container basket (unit structure 1) (X and Y) for storing and transferring a biological sample with a recording / protecting plate is constructed, the basic structure of the bottom of the porous container (unit 1) X is the upper opening. At least one side of the flange-like flat surface X11 projecting in the horizontal direction surrounding the outer periphery of the portion X9 is extended and formed along the inclined surface of the outer surface data recording portion Z1 of the embedded frame-shaped substrate (unit 3) Z. Then, a protective plate / data recording portion X1 is formed integrally to cover and cover the data recording portion Z1 inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3) Z, and further, the protective plate / data recording In front of the lid Y having the porous liquid-permeable surface Y3 on both sides on the side where the portion X1 is integrally formed An end portion X2 of a notch portion X2a that is a latching portion of the both-side convex hanging latching portion Y2 is formed, and the latching portion X2 is in front of the outer wall of the embedded frame-shaped base (unit 3) Z. It is a notch X2a that coincides with the recess Z8 formed by leaving the upper part of the outer surface of the both outer recesses as a latching part Z9 on the recess side, and in the horizontal direction surrounding the outer periphery of the upper opening X9. A latching portion X5 of the rear latching portion Y4 of the lid body Y having the porous liquid passage hole is formed at the rear portion of the projecting bowl-shaped plane X11. In addition, the bottom of the porous container (unit 1) X for biological sample storage and transfer processing is a data recording unit / protection plate formed by extending and tilting a bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9. A central foam release hole X3 and both side foam release holes X4 are formed at the boundary of X1, and the central foam release hole X3 is a front tongue lock of the lid body Ya of the other embodiments of FIGS. A unit system package comprising a three-unit system composite structure that also serves as the insertion locking portion Z4 of the portion Ya1, but does not use the front tongue-shaped locking portion Ya1 molded lid but uses only the lid Y with a protective plate When molding a unit system cassette for a pathological / biological sample, which is a frame-shaped substrate structure, the size of the central bubble removal hole X3 may be matched to the shape of the bubble removal holes X4 on both sides. A bottom surface X7 of the data recording / protection plate X1 of the porous container-shaped bottom portion (unit 1) X for biological sample storage and transfer processing is inclined and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) Z. The data recording part Z1 is covered and protected. Further, both side cutout portions X11a are formed on the long side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 of the porous container-shaped bottom portion (unit 1) X. In addition, an inclined data recording / protecting plate end hanging-up molding X12 is provided for taking as much as possible the surface area of the data recording / protecting plate X1 formed by extending and tilting the bottom of the perforated container (unit 1) X. Molded. X4 in FIG. 2 is a defoaming hole on both sides of X3 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing, and X7 is FIG. 1, FIG. 4, FIG. 5, FIG. 8. As can be understood from FIG. 10, the biological sample storage fixed transfer process formed along the inclined surface of the data recording portion Z1 formed and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) Z. Uniformly on the back surface of the data recording / storage unit X1 of the porous container-shaped bottom (unit 1) X and on the inclined surface of the data recording unit Z1 formed and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) Z It is desirable to be in contact.
Z2 in FIGS. 1, 7, and 8 is an IC chip (RFID) insertion fitting installation portion. 1 and X12 in FIG. 5 and FIG. 6, which are explanatory views on the back side, are vertical moldings for further expanding the area of the data recording / storing part X1 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing. Part. By forming the vertical forming portion X12, the inclined area which is the data recording / storage portion X1 of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing is kept wide, and the amount of information increases.

In addition, the fixed transfer of an independently separated patient sample 5 which is a unit 2 of a unit system cassette for a pathological / biological sample, which is a unit system embedded frame-like substrate structure composed of a three-unit system composite structure of the present invention, or of the sample. Perforated container for biological sample storage with fixed data recording and protection plate that can store patient sample 5 and perform independent functions in fixing, dehydration, degreasing, penetration, embedding agent penetration process (Unit structure 1) The basic form of the lid (unit 2) Y having a porous liquid passage hole Y3 that is detachably fitted and connected to the upper opening X9 of the porous container-shaped bottom X of (X and Y) As shown in FIGS. 1 to 11 and FIGS. 16 and 17, convex hanging engagement portions Y <b> 2 are formed on both sides of the front portion, and the bottom portion (unit 1) X and the embedded frame-shaped substrate ( Unit 3) Locking part Y4 shared with Z Forms. The lid (unit 2) Y is constructed with a multi-unit biological structure for storing and transferring biological samples (unit structure 1) (X and Y) constructed with a 2-unit system composite structure and a 3-unit system composite structure. This is a common structural unit with the fixed support base (unit structural body 3) (X and Y and Z).
The lid (unit 2) Y having the porous liquid passing surface Y3 is also formed with an integral protective plate Y1 on at least one side of the outer peripheral plane Y10 of the open / close guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y3. Then, on the lower surface Y9 of the protective plate Y1, dirt on the protective plate / data recording part X1 of the porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing and data printed on the data recording part An independent function constructed by a two-unit system composite structure with a lid (unit 2) Y with a protective plate Y1 to prevent label peeling and dirt and a bottom (unit 1) X with a protective plate and data recording unit X1 Biological sample storage fixed transport porous container with sample data recording section to carry (unit structure 1) (X and Y) double data recording section and protective plate (X1 and Y1) is the embedded frame-shaped substrate ( Unit 3) sandwiching and protecting the data recording part Z1 on the outer side surface of Z and having a porous liquid passing surface Y3 Fixing support base that can support the function of the rootstock of the burr-free embedded block and the conventional cassette for pathological / biological specimens, as well as the confirmation of the sample data constructed with the 3 unit system composite structure that can be used without discarding the lid Y A lid (unit 2) Y having a porous liquid-permeable surface Y3 with a protective plate, which is a component unit of a unit system cassette for pathological / biological samples composed of a table (unit structure 3) (X and Y and Z) is there. Therefore, in the same manner as the both side cutouts X11a on the long side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 of the perforated container-like bottom X for biological sample storage, fixation and transfer processing, which is separated independently. A notch Y10a that coincides with both side notches X11a is also formed on the outer peripheral plane Y10 of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y3 of the lid (unit 2) Y having the porous liquid passing surface Y3. Has been. Further, the lid (unit 2) Y having the porous liquid-permeable surface Y3 is provided behind the rear locking portion Y4 of the outer peripheral plane Y10 of the open / close guide rib Y8 surrounding the outer periphery of the porous liquid-permeable surface Y3. 2) There is a claw hook portion Y5 at the time of attachment / detachment opening / closing of Y, and three bubble vents (X3) of the bottom portion X of the porous container are formed at the boundary of the inclined portion of the protective plate Y1 formed by extending the outer peripheral surface Y10 and inclined. And X4), three bubble removal holes Y6 are formed. Further, the central bubble removal hole X3 of the porous container-shaped bottom X also serves as an insertion locking portion Z4 of the front tongue-shaped locking portion Ya1 of the lid Ya of the other embodiments shown in FIGS. Is a unit system-embedded frame-like base body structure composed of a three-unit system composite structure that uses only the lid body Y with a protective plate without using the front tongue-shaped locking portion Ya1 molded lid body. In the case of forming a unit system cassette for biological samples, the size of the central bubble removal hole X3 of the porous container-like bottom (unit 1) X may be matched to the shape of the bubble removal holes X4 on both sides. At this time, it is not necessary to form the closed wall Y7 for preventing the small biopsy sample from falling out from the central bubble removing hole X3.
As described above, it has independent functions to handle chemical transmission and information transmission and connection in fixed preparation, dehydration, degreasing, penetration, and embedding agent penetration in the specimen preparation process, from the fixed transfer of samples collected from patients and organisms. Biological sample storage fixed transfer processing porous container jar (unit structure 1) (X and Y) is a biological sample storage fixed transfer processing porous container bottom (unit 1) X and a lid having a porous liquid passage hole Y3 (unit 2) A two-unit system composite constructed with Y.
The structure of the lid (unit 2) Y having the porous liquid passage hole Y3, which is one unit of the two-unit system composite structure, includes a protective plate Y1, a front convex hanging engagement portion Y2, and a porous liquid passage hole Y3. Dehydration of the sample at the bottom locking part Y4, the claw hook part Y5 and the liquid passage hole Y6 when the lid (unit 2) Y is opened / closed, and the bottom of the porous container-like bottom part (unit 1) X・ Closed wall Y7 of locking part X3 for bubble removal hole and front tongue-shaped locking lid during chemical treatment such as degreasing, penetration, embedding agent penetration, etc. (Y7 is a shape that does not use the front tongue-shaped locking lid And the opening / closing guide rib Y8 of the lid (unit 2), the back surface Y9 of the protective plate Y1 of the lid (unit 2) Y, and the embedded frame substrate (unit 3) Z. The front convex protrusion locking portion Y2 is an outer peripheral plane Y10 of the opening / closing guide rib Y8 of the lid portion (unit 2) formed with a notch Y10a shaped to be sandwiched and fitted between both long side walls Z18 of Cut off From chipping unit Y10 is engaging portion Y2 was convex and vertically in a horizontal direction.

Furthermore, the fixed transfer of the patient sample 5 which is the unit 3 of the unit system cassette for the pathological / biological sample which is the unit system embedded frame-like substrate structure composed of the three unit system composite structure of the present invention or the fixing / fixing of the sample. In the dehydration / degreasing / penetration / embedding agent infiltration process, the biological sample storage / transport plate with a data recording unit and protection plate that can hold the patient sample 5 and perform independent functions (unit) As shown in FIGS. 1 to 11 and FIGS. 16 and 17, the basic form of the embedded frame-like base (unit 3) Z to which the construct 1) (X and Y) is detachably fitted and connected is shown in FIG. The embedded frame base (unit 3) Z has openings (Z18, Z16) on the upper side and the lower side, and a through hole Z17 connected to the openings (Z18, Z16) from the upper side to the lower side. The through hole connected to the lower opening Z16 from the upper Z18 Forming a convex flat surface Z6 projecting inwardly on the inner wall of the upper end of the outer wall surrounding the upper opening Z18 of Z17 or the inner wall of the through hole continuous to the upper opening Z18, the embedded frame shape A recess Z8 that communicates from the upper end surface Z6 to the lower end surface Z14 is formed on both front outer surfaces Z15 of the outer wall of the base (unit 3) Z, and the bottom (unit 1) X is detachably fitted to the upper portion of the recess Z8. The latching portion Z9 of the front convex hanging latching portion Y2 of the lid (unit 2) Y to be joined and connected is connected to both front outer concave portions Z8 of the embedded frame base (unit 3) Z on the outer surface. An upper part of the upper portion of the cover body is formed as a latching portion Z9 on the recess side so as to be protruded, and a latching portion Z12 for latching the rear latching portion Y4 of the lid (unit 2) Y is also formed on the rear outer wall. An embedding frame-shaped substrate (unit 3) Z. Further, there is an embedding frame-like base (unit 3) Z in which an outer long side wall Z15 is erected and extended on the end surfaces of both long side upper end surfaces Z6 of the upper part of the outer wall surrounding the upper opening Z18. The upper ends Z5 of the outer long side walls of the frame-shaped substrate (unit 3) Z project in the horizontal direction surrounding the outer periphery of the upper opening X9 of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing. The outer circumference of the porous liquid passing surface Y3 of the lid (unit 2) Y having the thickness of the bowl-shaped flat surface X11 and the porous liquid passing surface Y3 detachably fitted and connected to the opening X9 of the bottom (unit 1) X The outer wall upper upper end surface Z6 surrounding the periphery of the opening Z18 of the embedded frame base (unit 3) Z and the opening Z18 by the thickness of the outer peripheral plane Y10 of the opening / closing guide rib Y8 surrounding The basic form is that it is formed at a position higher than the convex plane Z6 projecting inwardly on the continuous inner wall.
The other structure of the embedded frame-shaped substrate (unit 3) Z includes a data recording portion Z1 whose outer wall is sloped, an IC chip (RFID) Z2 formed on the data recording portion Z1, and the embedded frame-shaped substrate. (Unit 3) Upper outer wall upper end surface Z6 surrounding the periphery of the upper opening Z18 of Z, and both side foam removal holes Z3, the central foam removal hole Z4 and the upper opening Z18 formed at the boundary of the inclined data recording part Z1. The outer long side wall upper end surface Z5 is formed by extending and extending the outer long side wall Z15 on the end surfaces of both long side upper end surfaces Z6 of the upper part of the outer wall surrounding the periphery, and the cover of the embedded frame-shaped base (unit 3) Z Forming space Z7 of the nail hooking portion Y5 for attaching / detaching the body (unit 2) Y, the hooking portion Z9 of the front convex hanging locking portion Y2, the hooking inclined surface Z10 of the hooking portion Z9, and the cassette block Projection molding in an area narrower than the bottom surface of the lower end surface Z14, which is the adapter fixing claw position when slicing And skirt-like projecting sidewall Z11 and 該包 Umawaku shaped substrate (Unit 3) (Z13 in FIG. 11) after the wall Z rear seat retaining section Z12 is molded and is. As can be seen from FIGS. 7 and 8, the forming space of the nail hook portion Y5 for attaching / detaching the lid (unit 2) Y of the embedded frame-like base body (unit 3) Z of the rear wall (Z13 of FIG. 11). The width of Z7 may be changed depending on the molding convenience.
A porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing and a porous liquid-permeable surface Y3 that is detachably fitted and connected to the upper opening X9 of the porous container-like bottom portion (unit 1) X are provided. Perforated container cage (unit component 1) constructed with a lid (unit 2) Y and containing a patient sample 5 and capable of carrying an independent function and having a data recording unit / protection plate ) (X and Y) are detachably fitted to and connected to the embedded frame base (unit 3) Z to form a supporting base (unit structure 3) (X and Y and Z). The unit system embedded frame-like substrate structure composed of the combination of the three units, (1) the function of the chemical treatment tank for the sample of the conventional cassette for pathology / biological sample, and (2) the patient / biological tissue sample In addition to the function to describe the data, (3) the root function of the sample embedding block, and (4) the function of being able to confirm the sample inside the cassette when using a transparent porous liquid-permeable lid, the pathology that exhibits nine functions・ Unit system cassette for biological samples

Further, the pathological / biological sample unit that is completely fitted and connected to the bottom of the unit system cassette for pathological / biological sample, which is a unit system embedding frame-like substrate structure constituted by the combination of the three units of the present invention. It adheres to the outer periphery of the data recording part of the fixed support base (unit structure 3), which is a system cassette, and obstructs when the pathological / biological sample embedding block is sliced, and damages the data recording part when it is removed. Removes excess burrs from the embedding agent to be used, or water-tightness made of synthetic resin constructed by a two-unit system composite structure of an embedding bottom (unit 4) S and an upper water-tight embedding frame (unit 5) T that does not generate burrs The basic form of the framed embedding dish (unit structure 4) (S and T) will be described with reference to FIGS.
The embedding dish (unit structure 4) (S and T) with a watertight frame made of synthetic resin without burrs is made of a metal embedding bottom (unit 4) S and an upper opening S4 of the embedding bottom (unit 4) S. With openings (T6, T11, T13, T19) on the upper and lower sides that fit and connect to the bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening from the upper side to the lower side A combination of two units, which are two types of material component units, each of which separates the functional form of the upper watertight embedding frame portion (unit 5) T made of synthetic resin that forms through-hole portions (T12, T14) connected to It is a 2 unit system composite structure comprised by these. The synthetic resin watertight frame-embedded dish (unit structure 4) (S and T) constructed with the two-unit system composite structure is completely and securely attached to the bottom of the embedded frame-like substrate of the pathological / biological sample cassette. It is an embedding dish (unit structure 4) (S and T) in which an upper watertight embedding frame part (unit 5) T made of synthetic resin to be fitted and connected is formed, and an embedding bottom part (unit) of the embedding dish 4) S is formed by pressing a metal plate having good thermal conductivity, and the embedding bottom S is located below the upper opening S4. The accommodating bottom S1 of the accommodating part S5 on which the embedding sample 5a is placed during embedding. This is a metal component unit forming a bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4.
As shown in FIGS. 27 and 28, the upper watertight embedding frame T has openings on the upper side T13 and the lower side T19, and is connected to the openings from the upper side to the lower side (T13, T19). A through hole connected to the upper opening T13 of the outer wall surrounding the periphery of the upper opening T13 of the through hole T14 formed from the upper side and connected to the lower opening (T13, T19) from the upper side. A convex flat surface T4 projecting inwardly on the inner wall of the hole T14 is formed, and the upper upper end surface T4 of the outer wall surrounding the periphery of the upper opening T13 or the inner wall of the through hole T14 connected to the upper opening T13 On the convex flat surface T4 projecting inward, the four-sided full circumference of the bowl-shaped flat surface S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of the storage bottom S1 of the embedding bottom (unit 4) S The embedded bottom part (unit 4) S of the embedded bottom part (unit 4) S that can be hooked and installed on the upper side of the lower fitted connected embedded bottom part support Ta The upper T6 and the lower T11 are connected to each other, and an opening is formed on the upper side T6 and the lower side T11, and a through hole T12 connected to the opening from the upper side to the lower side (T6, T11) is formed. , T11) and a convex shape projecting inwardly on the upper end surface T2 of the outer wall surrounding the periphery of the upper opening T6 of the through hole T12 and the inner wall of the through hole T12 connected to the upper opening T6. It is a fitting connection structure of the upper watertight embedding frame part (unit 5) T comprised from the embedding dish upper watertight dihedral surface frame T which formed the plane T3.
In the embedding dish, the embedding bottom (unit 4) S forms a bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4, and the sample embedding bottom at the time of embedding is formed below the embedding dish. A metal embedding bottom (unit 4) S having a S1 surface, and a hooking portion for hooked flat surface S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of the embedding bottom (unit 4) S It is constructed with two types of material constituent units, an upper watertight embedding frame portion (unit 5) T made of synthetic resin that fits in a watertight manner, and the embedding bottom portion (unit 4) made of metal having good thermal conductivity. ) An embedding dish which is a two-unit system composite structure that combines the functional forms of the synthetic resin upper watertight embedding frame (unit 5) T capable of precision fitting molding with the same shrinkage as S.
The embedding bottom portion (unit 4) S is formed by pressing a metal plate having a good thermal conductivity, and is a bowl-like shape protruding in the horizontal direction surrounding the outer periphery of the opening S4 of the embedding bottom portion (unit 4) S. The flat surface S3 is securely and securely fitted into the latching portion T4 of the upper watertight embedding frame portion (unit 5) T made of the synthetic resin, and the embedding frame-like substrate bottom Z14 of the pathological / biological sample cassette and the embedding The concave / convex square surface formed by the projecting side wall Z11 projecting and forming the molding position of the porous liquid-permeable bottom portion of the frame-shaped base (unit 3) in an area narrower than the bottom surface of the adapter fixing claw position when the cassette block is sliced, and The upper watertight embedding frame part (unit 5) T made of synthetic resin is watertightly fitted and connected at the concave / convex square contact surface of the contact watertight surface formed by the upper end surface T2 of the watertight embedding frame inner wall T3,
Watertight fitting between the bottom surface of the embedded frame-shaped substrate Z of the cassette for pathological / biological samples and the watertight frame which is the watertight dihedral surface forming frame T, which has been difficult in the conventional watertight frame forming of metal embedding dishes. The embedding frame-like substrate of the pathologic / biological embedding block cassette immersed in the embedding agent 12 during the treatment of the fixed embedding solution of the sample 15a and the embedding agent 12 in the embedding dish. Synthetic resin upper watertight embedding frame part (unit 5) T and metal embedding bottom part with good thermal conductivity that completely prevent the excess burr 12b of the embedding agent that is a drooping pool of embedding agent from the surroundings (Unit 4) An embedded dish with a synthetic resin watertight frame at the bottom of an embedded frame-like substrate of a cassette for pathological / biological samples, characterized in that it is constructed with a two-unit system composite structure with S (unit structure 4) ) (S and T).
As described above, the basic form of the embedding dish (unit structure 4) (S and T) with a synthetic resin watertight frame is the embedding bottom (unit 4) S and the upper watertight embedding frame (unit 5) T. The upper watertight embedding frame part (unit 5) T has a lower fitting connection embedding bottom support Ta and an embedding dish as shown in FIG. 29A. The shape form which is the fitting connection construction body of the upper watertight dihedral surface forming frame T may be used, and as shown in FIG. 29B, it is not a fitting connection construction body but an integral embedding bottom (unit 4) S. Although not shown, the hooking portion of the bowl-shaped plane S3 protruding in the horizontal direction surrounding the outer periphery of the upper opening S4 can be formed in a staggered manner.
Other synthetic resin embedding dishes with a watertight frame (unit structure 4) (S and T) have the same structure as the synthetic resin watertight frame embedding dishes (unit structure 4) (S and T). Work handle T1 at the time of burying work, lower fitting connection embedding bottom support Ta, embedding dish upper watertight dihedral surface forming frame T locking part T10 and latching part structure (T7, T15, T16, T18) And a synthetic resin watertight frame embedding dish (unit structure 4) (S and T) and a synthetic resin watertight frame embedding dish (unit structure 4) (S and T) The leg contact avoidance portions T8 and T9 at the time of stacking and storing are important.

Next, a pathological / biological sample unit system cassette, which is a unit system embedding frame-shaped substrate structure constituted by the combination of the three units of the present invention, and a connecting fitting structure of the cassette embedding frame-shaped substrate. Accepting, receiving and cutting out 5 patient specimens using a burr-free embedding dish, fixing / dehydrating / degreasing / penetration / embedding agent infiltration process and burr-free embedding, embedding A part of usage examples from block slicing to embedded block sample storage management will be described with reference to FIGS. 18 to 26, FIGS. 30 to 32, and FIG.
This is a structural unit of the unit system embedded frame-like substrate porous liquid-permeable container bottom (unit structural body 2) which is a functional form of a cassette for pathological / biological samples constructed by a two-unit system composite structural body (unit structural body 1) ) (X and Y) describes the clinical data (patient attributes, chart number, etc.) and the sample name with a pencil etc. in the data recording part X1 that has been formed with a shaving that can be described with a pencil etc. at the bottom X (Fig. 2. Fig. 9 Fig. 44c) The lid (unit 2) Y having a transparent liquid-permeable surface Y3 with a transparent protective plate is closed and housed in a dedicated fixed transfer container (B-6 in Fig. 44) for clinical use. It can be transferred from the side to the pathological examination / specimen preparation side together with the pathological examination request form. At this time, the embedded frame-shaped substrate Z is a data recording unit / protection plate having an independent function capable of fixing and transferring the patient / biopsy sample 5 and chemical treatment without being immersed in the fixing solution (15 in FIG. 44B). A patient / biopsy sample 5 is stored in a perforated container for biological sample storage / fixed transfer processing (unit structure 1) (X and Y) and immersed in the fixative 15 and transferred to the inspection / specimen preparation site. Therefore, the embedded frame-shaped substrate Z accommodates the RFID (IC chip) 2 and can be fitted and connected to the outer side of the embedded frame-shaped substrate Z (B-6 in FIG. 44). If it is sent to the clinical side together with the patient, the patient attributes and clinical sample data are sent as digital data in the RFID (IC chip) 2 and the paper of the request can be made. Of course, the embedded frame-shaped substrate Z can be placed on the inspection side.

Furthermore, the patient specimen (patient specimen 5 and the patient specimen data such as a pathological examination request form) transferred from the clinical side (FIG. 44A) is fixedly transferred to the pathological examination request form of the patient on the pathological examination / specimen preparation site side. After receiving and receiving the patient attribute description label 6c affixed to the container 6 after confirmation / collation, the operator can store the patient sample 5 from the previous fixed transfer container 6 when the patient specimen is cut out (FIG. 18A). Take out the perforated container container (unit structure 1) (X and Y) for the biological sample storage fixed transfer process with the data recording unit and protection plate that bears the function and remove the patient name and sample name of the data recording unit X1 of the bottom X ( After confirming 3) of FIG. 2, FIG. 9, and FIG. 44c, the pathological examination request form of the patient sample 5 and the fixed transfer container 6 are collated, and the patient sample 5 is confirmed, observed, trimmed, and the bottom X Patient name / sample name (Fig. 2, Fig. 9, Fig. 4) c 3) the test sample No. 1a and a bar code or two-dimensional data code 1b like the printing data recording label from the top of the (paste 1) of FIG. 18B · Figure 44D. At this time, it is more convenient to use the automatic label printing machine shown in FIG. 18B or 44D.
Close the lid (unit 2) Y (FIGS. 19A, B, C, and D) having the transparent liquid-permeable porous liquid passing surface Y3 after the data recording label 1 is attached to the data recording portion X1 of the bottom X The perforated container basket (unit structure 1) (X and Y) in which the patient sample (5 or 5a) is stored and fixed is stored in a chemical solution processing basket (FIGS. 20A, B, and 44F). However, it is set in an automatic fixed embedding device that handles the chemical treatment process of sample fixation, dehydration, degreasing, penetration, and penetration of embedding agent. At this point, the data recording part of the porous container-like bottom part (unit 1) X for the biological sample storage fixed transfer process with a protective plate and the data recording part which is the constituent unit of the porous container basket (unit structure 1) (X and Y) The direct and reliable communication (messenger) and connection (link) between the clinical patient's clinical / biological sample data and the pathology / specimen preparation side data including its history and history are completed. This is because the collected sample 5a in the perforated container for biological sample storage / transfer processing (unit component 1) is stored on the responsibility of the clinical / biological sample collection side, and at the pathology / specimen preparation side when the sample is cut out Never move the collected sample 5a in the biological sample storage / fixed transfer processing porous container container (unit structure 1), but simply move the biological sample storage / transfer processing porous container container (unit structure 1). Open the lid (unit 2) Y having the porous liquid passage hole Y3 of (X and Y) and confirm the collected sample 5a in the bottom of the porous container (unit 1) X for the biological sample storage fixed transfer processing The fixing liquid on the data recording / storing part X1 of the bottom (unit 1) X is wiped off, and the printed and labeled label paper 1 is pasted on the top (unit 1) X so that it can be removably attached to the bottom (unit 1) X upper opening. Protective plate Y with porous liquid holes to be fitted and connected When the lid with unit 1 (unit 2) Y is closed, the lid having a porous liquid passage hole Y3 that is detachably fitted and connected to the data recording / storage unit X1 and the upper opening of the bottom (unit 1) X ( Unit 2) Between the protective plate Y1 of Y, information such as clinical data (patient attributes, medical chart numbers, etc.) and sample names described in advance on the responsibility of the clinical / biological sample collection side and the pathology / specimen Perforated vessel for storing and transferring biological samples containing unitary sample collection 5a in which double information is protected with information printed on label paper 1 and the like affixed on the production side and fixed and transferred (unit structure 1) ) (X and Y) is completed.
At this time, the label printing machine (FIG. 18B and FIG. 44D) is an automatic label sticking printing machine, and is detachably fitted to the upper opening of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing. -The lid (unit 2) Y with a protective plate Y1 having a porous liquid-permeable surface Y3 to be connected is desirably molded from a transparent synthetic resin (eg, polyethylene naphthalate) that is chemically resistant to organic solvents. It is desirable to mold the porous container-like bottom part (unit 1) X for sample storage, fixation and transfer treatment using a pigment that is opaque to a polyacetal resin that is chemically resistant to organic solvents and has a color different from that of the biological sample.

In addition, clinical data (patient attributes, medical chart numbers, etc.) and information such as sample names, which are recorded in advance on the responsibility of the clinical / biological sample collection side, and the printed label paper pasted on the pathology / specimen preparation side In the perforated container cage (unit structure 1) (X and Y) (FIGS. 19A, B, C, and D) for storing and transporting biological specimens in which double information with information such as 1 is protected and retained A patient sample (5) which has been stored and has undergone a chemical treatment process (FIGS. 20A and B and FIG. 44F) for fixation, dehydration, degreasing, penetration, and penetration of the embedding agent by the automatic fixation embedding device (5 Or embed 5a).
This embedding process is described with reference to FIGS. 21A, B to 26A, B, FIGS. 30A, B, C to 32A, B, C and FIGS. 44E, G. In FIGS. 21A and 21B, the patient sample (5 or 5a) is fixed by the biological sample storage fixed transfer processing porous container cage (unit structure 1) (X and Y) fitted and connected to the embedded frame-shaped substrate Z. Plan view A and longitudinal sectional view of the support base (unit structure 3) (X and Y and Z) having a porous liquid passage hole Y3 (unit 2) Y opened and taken out with tweezers 8 B. Also in FIGS. 21 to 23, the biological sample storage perforated container (unit structure 1) (X and Y) containing the patient sample (5 or 5a) is fitted and connected to the embedded frame-shaped substrate Z. The fixed support base (unit structure 3) (X and Y and Z) is fixed and dehydrated, degreased, penetrated, and embedded infiltrated. Although described, as shown in FIGS. 20A and 20B and FIG. 44F, the biological sample storage fixed transfer porous container for storing the patient sample (5 or 5a) (unit structure 1) (X and Y) It is also possible to carry out chemical treatment processes for fixation, dehydration, degreasing, penetration, and embedding agent penetration. In this case, as shown in FIGS. 31A and 31B and FIG. 44E, the embedding frame-shaped substrate Z is not immersed in the embedding agent, so that the embedding agent is also embedded on the outer periphery of the embedding frame-shaped substrate Z. Since there is no adhesion to the molten embedding agent, the embedding agent overflows in the embedding dish (unit structure 4) (S and T) made of the synthetic resin watertight frame of the present invention and the fixed packaging of the sample. The pathological / biological embedding block cassette, which is the support base for fixation (unit structure 3) (X and Y and Z) immersed in the embedding agent during the treatment with the embedding solution, is wrapped from around the embedding frame-shaped substrate. Since there is no dripping pool, no burr is generated on the support base (unit structure 3) (X and Y and Z) which is the rootstock of the pathological / biological-embedded block cassette. That is, a 100% complete burr-free embedding method is completed.

Further, as shown in FIGS. 21A and 21B and FIGS. 22A and 22B, as in the case of the conventional pathological / biological sample cassette, the biological sample storage and transfer processing porous container basket (unit structure 1) (X and Y) is A patient sample (5 or 5) comprising a unit system embedding frame-like substrate structure which is the fixing support base (unit structure 3) (X and Y and Z) fitted and connected to the embedding frame-shaped substrate Z Even when the unit system cassette for pathology / biological sample containing 5a) is used directly for the chemical treatment process of fixation / dehydration / degreasing / penetration / embedding agent penetration, FIG. As shown in FIGS. 32A, B, and C, the embedding bottom portion of the metal plate having a good thermal conductivity of the embedding dish (unit structure 4) (S and T) with a watertight frame made of synthetic resin is formed by pressing. Unit 4) A bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of S Openings (T6, T11, T13, T19) on the upper and lower sides that fit and connect to S3, and through holes (T12, T14) connected to the openings from the upper side to the lower side are formed. The concave / convex square contact surface of the contact water-tight surface formed by the upper end surface T2 of the upper water-tight embedding frame portion (unit 5) T made of a synthetic resin and the inner wall T3 of the water-tight embedding frame, and the unit system cassette for the pathological / biological sample Protrusion in which the embedding frame base bottom Z14 and the porous liquid-permeable bottom portion of the embedding frame base (unit 3) are formed so as to project in a narrower area than the bottom surface of the adapter fixing claw when the cassette block is sliced. Since the concave / convex square surface formed by the side wall Z11 is watertightly fitted and connected with the concave / convex square contact surface of the contact watertight surface formed by the watertight frame forming of the conventional metal embedding dish, Water-tight fitting between the bottom surface of the embedded frame-shaped substrate Z of the cassette for pathological / biological samples and the water-tight frame which is the water-tight dihedral surface forming frame T Improves the performance and spills the embedding agent 12 in the embedding dish (unit structure 4) (S and T) with a synthetic resin watertight frame and immerses it in the embedding agent 12 during the fixed embedding solution of the sample 15a. As shown in FIGS. 32A, B, and C, an extra burr 12b of the embedding agent, which is a stagnation of the embedding agent 12 from the periphery of the embedding frame-like substrate Z of the pathological / biological embedding block cassette, is shown in FIG. Synthetic resin upper watertightness of the embedding dish (unit component 4) (S and T) with the synthetic resin watertight frame that does not sag around the bottom of the embedded frame-like substrate Z of the pathological / biologically embedded block cassette Most of the embedding frame part (unit 5) T flows down to the side wall of the embedding frame portion (unit 5) T, thereby preventing the generation of burrs (12a and 12b) of the embedding agent 12 on the outer wall of the embedding frame-shaped substrate Z. At this time, the synthetic resin of the synthetic resin upper watertight embedding frame portion (unit 5) T is preferably made of a material having the same shrinkage rate and properties as the embedding frame-shaped substrate Z of the pathological / biological sample unit system cassette. For example, polyacetal Resin is good. At this time, it is convenient to change the coloring of the total resin depending on the size of the embedding dish.
The basic structure of the synthetic resin embedding dish with a watertight frame (unit structure 4) (S and T) is as shown in FIG. 27A2 longitudinal sectional view, B1 front view, B2 plan view, B3 transverse view, C2 back view, D2 Side view and FIG. 28A Pathology / biological sample unit system cassette that can be embedded and connected to the embedding dish (unit structure 4) (S and T) with a synthetic resin watertight frame (B and pathology) -Front view of the unit system cassette for biological samples-C Vertical cross-sectional view of the upper watertight dihedral plane frame T of the embedding dish-D Cross-sectional view of the upper watertight embedding frame T-E Embedded bottom (unit 4 ) Vertical view of S ・ F Cross-sectional view of the embedded bottom (unit 4) S ・ G Vertical cross-sectional view of the embedded plate bottom fitting connection embedded bottom support Ta ・ H The lower connection connection embedded bottom Cross section of support Ta ・ I Embedment dish with watertight frame made of synthetic resin consisting of two types of material component units (Unit Structure 4) Longitudinal section of (S and T)-J This is an embedding dish with a watertight frame made of synthetic resin (unit structure 4) (S and T). (Unit 4) S and embedded bottom part (Unit 4) The upper and lower openings (T6) are fitted and connected to a bowl-like flat surface S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4. , T11, T13, T19) and separating the functional form of the upper watertight embedding frame (unit 5) T that forms through holes (T12, T14) connected to the opening from the upper side to the lower side. Formed as two independent material component units, the embedding bottom (unit 4) S is formed by pressing a metal plate with good thermal conductivity, and the embedding bottom S is formed by the upper opening S4. On the lower side, there is a storage bottom S1 on which an embedded sample is placed during embedding, and a metal that forms a bowl-shaped plane S3 projecting in a horizontal direction surrounding the outer periphery of the upper opening S4 Is an adult unit,
The upper watertight embedding frame portion T has openings on the upper side T13 and the lower side T19, and forms a through-hole portion T14 connected to the upper side to the lower side opening portions (T13, T19). The outer wall upper upper end surface T4 surrounding the periphery of the upper opening T13 of the through hole T14 connected to the lower opening (T13, T19) or the inner wall of the through hole T14 connected to the upper opening T13 is directed inward. A protruding convex surface T4 is formed and protruded inwardly on the outer wall upper upper end surface T4 surrounding the upper opening T13 or on the inner wall of the through hole T14 connected to the upper opening T13. The embedding bottom portion that can be hung and installed on all four sides of the bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of the storage bottom portion S1 of the embedding bottom portion (unit 4) S on the surface T4 (Unit 4) The lower fitting connection embedded bottom support Ta of the S and the lower fitting connection embedded bottom support Ta are connected to the upper side of the lower fitting connection embedded bottom support Ta, and the upper T6 and the lower T11 The through-hole portion T12 having an opening, forming a through-hole portion T12 connected to the opening portion (T6, T11) from the upper side to the lower side, and connected to the lower opening portion (T6, T11) from the upper side The embedding dish upper watertight 2 formed with a convex flat surface T3 projecting inwardly on the inner wall of the upper end T2 of the outer wall surrounding the upper opening T6 or the inner wall of the through hole T12 connected to the upper opening T6 This is an upper watertight embedding frame portion (unit 5) T composed of a square surface forming frame T.
The embedding dish has an opening at the upper side T6 and the lower side T11 of the upper watertight dihedral surface frame T of the embedding dish, and is penetrated through the upper side to the lower side (T6, T11). A through hole connected to the upper opening T6 of the outer wall surrounding the upper opening T6 of the through hole T12 formed from the upper side and connected to the lower opening (T6, T11) from the upper side. A lower opening (T13, T19) from the upper side of the lower surface T4 of the convex plane T3 formed with the convex plane T3 projecting inwardly on the inner wall of the hole T12 and the lower fitting connection embedded bottom support Ta A convex flat surface T4 projecting inwardly on the upper end surface T4 of the outer wall surrounding the periphery of the upper opening T13 of the through hole T14 connected to the upper opening T13 or the inner wall of the through hole T14 connected to the upper opening T13. A metal plate having a good thermal conductivity is press-molded and sandwiched and fitted in a horizontal projecting flat surface S3 surrounding the outer periphery of the upper opening S4 of the embedded bottom S A linking to consist of structural two consisting Composition member unit synthetic resin watertight framed embedding dish (unit construct 4) (S and T). Therefore, as shown in FIG. 29A, there are various shapes of the embedding dish upper watertight dihedral surface forming frame T and the lower fitting connection embedding bottom support Ta, and the embedding bottom (unit 4) as shown in FIG. 29B. ) The upper opening of the embedding bottom S without separating the upper watertight embedding frame T made of synthetic resin into the embedding pan upper watertight dihedral surface forming frame T and the lower fitting connection embedding bottom support Ta. It is possible to construct a structure that holds and fits and connects the saddle-shaped flat surface S3 projecting in the horizontal direction surrounding the outer periphery of S4. A structure in which the entire periphery of the bowl-shaped plane S3 projecting in the horizontal direction surrounding the outer periphery of the upper opening S4 of S is fitted and connected is recommended. In this case, an important structure other than the above-described structure is the connection / fitting locking portion T10 and the lower fitting of the lower fitting connection embedding bottom support Ta of the embedding dish upper watertight dihedral surface forming frame T. At the time of installation of the embedding dish (unit structure 4) (S and T) with a watertight frame made of synthetic resin composed of the latch receiving portions T15 and T16 of the joint embedded bottom support Ta and the two types of material structure units The leg contact avoiding portions T8 and T9 of the leg portion T5 when the leg portion T5 for stable installation and the embedding dish (unit structure 4) (S and T) with the synthetic resin watertight frame are stacked and stored. The necessity of the leg contact avoidance portions T8 and T9 is obvious when comparing FIGS. 42A and B and FIG. 43D.

  Next, as shown in the explanatory diagram of FIG. 25, in the conventional embedding method using an embedding dish, when the embedding block is taken out from the embedding dish, the embedding block is used even if the shrinkage due to cooling of the embedding agent is used. Was often difficult to remove from the embedding dish, but in the case of the embedding dish with the synthetic resin watertight frame (unit structure 4) (S and T) of the present invention, the embedding with the synthetic resin watertight frame Holding the T1 part of the plate (unit structure 4) (S and T) and the embedded frame-shaped substrate Z part that is the root part of the embedded block, and pulling them to the opposite side, the embedded block sample without burr immediately (FIGS. 26A and B) are completed.

  Further, as shown in (FIG. 30), the embedding block sample is not the large synthetic resin embedding pan with watertight frame (unit structure 4) (S and T) shown in FIG. Medium-sized synthetic resin watertight frame-embedded dish (unit structure 4) that is the size of a porous container-like bottom part (unit 1) X for biological sample storage fixed transfer processing in which the data recording part X1 is formed (unit structure 4) T) (FIGS. 30A and 30B), as shown in FIG. 30C, the embedded block sample of the bottom part (unit 1) X for the biological sample storage fixed transfer processing in which the protective plate / data recording part X1 is formed is formed. The embedded block sample and the embedded frame-shaped substrate Z are separated, and the storage management of the embedded block sample is the bottom of the biological sample storage fixed transfer processing unit in which the protective plate and data recording unit X1 is formed (Unit 1 ) Store and manage as an embedded block sample of X, Z can also be reused in a thin Setsuji. Of course, as shown in FIG. 44I, the embedded block sample is stored and managed with the embedded frame sample Z fitted and connected to the embedded block sample for the purpose of storage management of the embedded block sample and other purposes. You can also

  Furthermore, the embedded block sample has a structure shown in FIGS. 32A, B, and C, and a cover (unit 2) Y having a porous liquid-permeable surface Y3 is provided on the embedded frame-like substrate Z of the root portion of the embedded block. Embedded block samples can be prepared by embedding together. Therefore, as shown in FIGS. 32D and 32E, the thickness of the embedded frame-shaped substrate Z in which the lid (unit 2) Y having the porous liquid-permeable surface Y3 of the rootstock portion of the embedded block is housed is the conventional thickness. This is the thickness h (21 in FIG. E) of the cassette for pathology / biological sample, and matches the cassette locking claw locking fitting position (h) of the adapter for the thin section microtome. That is, a lid (unit 2) Y having a porous liquid-permeable surface Y3 is fitted and connected in an embedded frame-shaped substrate Z which is a root part of the embedded block sample of the present invention. As shown in FIG. 2, the embedded block sample is made of an embedded frame-like substrate in which a lid (unit 2) Y having a porous liquid-permeable surface Y3 that can be sliced as it is accommodated. Therefore, the embedded frame-shaped substrate Z is stronger than the bottom of the conventional cassette for pathological / biological samples, and the medical waste in the lid portion is not produced unlike the bottom of the cassette for pathological / biological samples.

This is illustrated in FIG. 34 which is a longitudinal cross-sectional comparison diagram of the conventional pathological / biological sample cassette and the pathological / biological sample unit system cassette of the present invention. 34AE, BH, and CH are fitting / connecting bodies of conventional pathology / pathology / biological sample cassette bottom U and lid V having a conventional porous liquid-permeable surface, and FIG. 34AF is the conventional porous liquid-permeable surface. It is the cassette bottom part U for pathology, pathology, and a biological sample which removed the cover body V which has. 34 is one of the basic forms of the present invention, and is independently detachable from the bottom part (unit 1) X for biological sample storage and transfer processing which is one of the basic forms of the present invention and the upper opening part X9 of the bottom part (unit 1) X. Porous container cage for biological sample storage and transfer processing with independent function constructed by a two-unit system composite structure with the lid (unit 2) Y having the porous liquid-permeable surface Y3 fitted and connected to the unit Construct 1) (X and Y) is a constituent unit of the bottom (unit 1) X, and at least one side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 Data recording is extended and formed along the inclined surface Z1 of the data recording portion on the outer surface of the embedded frame-shaped substrate (unit 3) Z, and is inclined and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3) Z. Protection plate and data recording of the bottom (Unit 1) X that protects and covers the Z11 In order to further protect the portion X1, the same applies to at least one side of the outer peripheral plane of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid passing surface Y3 of the lid (unit 2) Y having the porous liquid passing surface Y3. An integral protective plate Y1 is formed on the protective plate and data recording part X1 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing, and data printed and pasted on the data recording part An independent function constructed by a two-unit system composite structure with a lid (unit 2) Y with a protective plate Y1 to prevent label peeling and dirt and a bottom (unit 1) X with a protective plate and data recording unit X1 Biological sample storage fixed transport porous container with sample data recording section to carry (unit structure 1) (X and Y) double data recording section and protective plate (X1 and Y1) is the embedded frame-shaped substrate ( Unit 3) Holding and protecting the data recording part Z1 on the outer surface of Z, and has a porous liquid passing surface Y3 Confirmation of sample data constructed with a three-unit system composite structure (X, Y, Z) that can be used without discarding the lid Y, functions of the root block of the burr-free embedding block, and conventional cassettes for pathology and biological samples It is a unit system cassette for pathological / biological samples characterized by comprising a support base for fixation (unit structure 3) (X and Y and Z) capable of functioning.
FIG. 34BF shows an embedded frame substrate (unit 3) Z from which the perforated container cage (unit structure 1) (X and Y) for biological sample storage and transfer processing with the sample data recording unit is removed. The outer long side wall upper end surface Z5 of the embedded frame-shaped substrate (unit 3) Z is a horizontal direction surrounding the outer periphery of the upper opening X9 of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing. The perforated liquid surface of the lid (unit 2) Y having the thickness of the bowl-shaped plane X11 projecting from the bottom and the perforated liquid surface Y3 detachably fitted and connected to the opening X9 of the bottom (unit 1) X The upper upper end surface Z6 of the outer wall surrounding the periphery of the opening Z18 of the embedded frame base (unit 3) Z and the opening by the thickness of the outer peripheral plane Y10 of the opening / closing guide rib Y8 surrounding the outer periphery of Y3 34 is formed at a position higher than the convex plane Z6 projecting inwardly on the inner wall connected to the portion Z18, so that the fixing support base (unit structure 3) (X and Y and Z) is a support base for protecting and fixing the sample data recording section without using the lid Y as medical waste (unit structure 3). Than it is embedded together embedded block specimen as part responsible for the shape strength retention of X and Y and Z).

Furthermore, FIG. 34CE also shows the X1 biological sample storage fixed transfer processing porous container bottom part (unit 1) X with the sample data recording part of the present invention, and the bottom part (unit 1) X and the embedding frame with the sample data recording part. Lid (unit 2) Y with a protective plate Y1 having a porous liquid passage hole Y3 that is detachably fitted and connected to the upper opening (X9 and W18) of the substrate (unit 3) W and the embedded frame substrate ( Unit 3) The functional form of W is formed as three separate structural units, and the bottom X forms an opening X9 on the upper side that is separate from the embedded frame-like substrate (unit 3) W. A biological sample storage and fixing comprising a sample storage portion X6 having a bowl-shaped flat surface X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 and having a porous liquid-permeable bottom surface X10 at least at the bottom on the lower side. It is a porous container-shaped bottom part (unit 1) X for transfer processing, and the embedding frame Even if the substrate (unit 3) W is not present, the lid (unit 2) Y having the porous liquid passage hole Y3 in the upper opening X9 of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing Perforated vessel for biological sample storage and transfer processing (unit component 1), which has independent functions for independently connecting and detachably fitting and connecting to each other to fix and transfer samples, process chemicals and transfer sample data ( X and Y) can be constructed, and the embedded frame-like substrate (unit 3) W is different from the bottom X, which is a porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing, which is the bottom portion X. A lid (unit 2) which is an embedding frame-like substrate (unit 3) W forming the liquid bottom W10, and has the porous liquid passage hole Y3 in the upper opening W18 of the embedding frame-like substrate (unit 3) W. ) Y is independently detachably fitted and connected to each other, confirming and validating sample data Building and fixing support base that Ninaeru functions and cassette functions for conventional pathological and biological samples rootstock embedding block (unit configuration body 3) (Y and W).
Biological sample storage fixed transfer processing porous container with sample data recording section (X1 and Y1) (unit structure 1) (X and Y) and fixing support base with sample data recording section (unit structure 3) ( Y and W) independent unit consisting of a three-unit system composite structure (X, Y, W) that can share and utilize the lid (unit 2) Y with the protective plate Y1 having the porous liquid passage hole Y3. Perforated vessel for storing and transferring biological samples (unit structure 1) (X and Y) with sample data recording section (X1 and Y1) and fixing support base (unit structure 3) with sample data recording section Y and W) is a unit system cassette for pathological / biological specimens characterized in that it is a unit system embedding frame-like substrate structure.
FIG. 34CF shows an embedded frame-shaped substrate (unit 3) W from which the perforated container cage (unit structure 1) (X and Y) for biological sample storage and transfer processing with the sample data recording unit is removed. The embedded frame-shaped substrate (unit 3) W is a convex flat surface W6 projecting inwardly on the upper upper end surface W6 of the outer wall surrounding the periphery of the upper opening W18 or on the storage inner wall continuous to the upper opening W18. And an embedded frame-shaped base (unit 3) W in which an outer long side wall W15 is erected and extended on the end surfaces of both long side upper end surfaces W5 of the upper part of the outer wall surrounding the periphery of the upper opening W18, The upper end surface W15 of the long side walls W15 on both sides of the embedded frame-shaped substrate (unit 3) W is detachably fitted into the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing. -The embedded frame-shaped substrate (unit 3) W by the thickness of the outer peripheral plane of the opening / closing guide rib Y8 surrounding the outer periphery of the porous liquid-permeable surface Y9 of the lid (unit 2) Y having the porous liquid-permeable surface Y9 to be connected. The outer wall upper upper end surface W6 surrounding the periphery of the opening W18 and a convex plane W6 projecting inwardly on the inner wall continuous to the opening W18. It is molded in position.
Further, the biological sample storage / fixed transfer processing porous container bowl (unit structure 1) is detachably fitted to the upper opening of the biological sample storage / fixed transfer processing porous container bottom (unit 1). The lid (unit 2) having a porous liquid passage hole to be connected and connected has the long side of the outer peripheral plane of the opening / closing guide rib surrounding the outer periphery of the porous liquid passage surface of the lid (unit 2) in the shape of the embedded frame. It is a lid body in which notches are formed in such a shape that both outer long side walls of the substrate (unit 3) can be sandwiched and fitted, and the lid body (unit 1) of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing 2) is also used as a lid (unit 2) of the embedded frame base (unit 3), and is an outer peripheral plane of the open / close guide rib surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2). All thicknesses are stored in the embedded frame base (unit 3). Area of the data recording portion of the side wall outside is maintained widely. Further, in order to prevent the cover (unit 2) having the porous liquid passage hole from being accommodated in the long side wall of the embedding frame-like base (unit 3) and preventing the cassette storage volume from being reduced, the embedding frame corresponding to the thickness thereof is used. The forming position of the porous liquid-permeable bottom portion of the base substrate (unit 3) is formed into a bowl-shaped protruding side wall Z11 protrudingly formed in an area narrower than the bottom surface of the adapter fixing claw position Z14 when the cassette block is sliced.
The embedded frame-shaped substrate (unit 3) W is a lid having the porous liquid-permeable surface Y9 which is a component unit of the biological sample storage fixed transfer processing porous container basket (unit component 1) (X and Y) ( Unit 2) Y can be shared as a lid having a porous liquid-permeable surface Y9 that is also detachably fitted to and connected to the upper opening W18 of the embedded frame base (unit 3) W. 2) A supporting base for fixing a block sample (unit structure 3) that can be embedded and used as a part of the root block of the embedding block without discarding Y. W) can be built. The porous liquid-permeable surface, which is a structural unit of the biological sample storage fixed transfer processing porous container bowl (unit structural body 1) (X and Y) and the fixing support base (unit structural body 3) (Y and W) Lid with Y9 (Unit 2) Perforated container for biological sample storage and transfer processing (Unit Component 1) consisting of a three-unit system complex component (X, Y, W) that can share and utilize Y (X and Y) Confirmation of sample data independent of burr-free embedding block sample rootstock function and conventional support base for carrying pathology / biological sample cassette function (unit structure 3) (Y and W) and a unit system cassette for pathological / biological specimens.
Therefore, the fixing support base (unit structure 3) (Y and W) shown in CE of FIG. 34 protects the sample data recording section and fixes the support base without using the lid Y as medical waste. (Unit structure 3) (Y and W) are embedded together in the embedded block sample as a part that plays the role of maintaining the shape strength.

Furthermore, the longitudinal cross-sectional comparison figures 35BG and CG are the three-unit system composite structure (X, Y, Z) and the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing shown in FIG. It is constructed of a two-unit system composite structure with the lid (unit 2) Y having the porous liquid-permeable surface Y3 that is independently detachably fitted and connected to the upper opening X9 of the bottom (unit 1) X. Perforated vessel for storing and transferring biological samples carrying independent functions (unit structure 1) (X and Y) Horizontal surrounding the outer periphery of the upper opening X9 of the bottom part (unit 1) X which is the constituent unit of FIG. 35BG Extending at least one side of the saddle-like plane X11 projecting in the direction along the inclined surface Z1 of the outer surface data recording portion of the embedded frame-shaped substrate (unit 3) Z, Inclined and installed on the outer peripheral side of the substrate (unit 3) Z In order to further protect the protective plate and data recording part X1 of the bottom part (unit 1) X that protects and suppresses the data recording part Z11, the porous body of the lid (unit 2) Y having the porous liquid passing surface Y3 is provided. Similarly, an integral protective plate Y1 is formed on at least one side of the outer peripheral plane of the open / close guide rib Y8 surrounding the outer periphery of the liquid surface Y3, and the bottom of the perforated container for fixing and transferring the biological sample (unit 1) Cover (unit 2) Y with protective plate Y1 and protective plate / data recording unit X1 to prevent dirt on the protective plate / data recording unit X1 and peeling or contamination of data labels printed on the data recording unit Perforated container for biological sample storage and transfer with sample data recording unit (unit component 1) (X and Y), which is constructed of a two-unit system complex structure with bottom (unit 1) X The double data recording / protection plate (X1 and Y1) of FIG. A three-unit system composite structure (X / Y / Z) that can be used without discarding the lid Y with the porous liquid-permeable surface Y3 by sandwiching and protecting the data recording part Z1 on the outer surface of the embedded frame base (unit 3) Z ) Confirmation of the sample data constructed in (4), the function of the rootstock of the burr-free embedded block, and the fixed support base (unit structure 3) that can carry the conventional cassette function for pathological / biological samples (X and Y and Z) FIG. 36 shows a unit system cassette for pathological / biological samples, characterized in that it is configured as shown in FIG. 35CG.
The longitudinal cross-sectional comparison figures 35AF and BG are three-unit system composite structure (X, Y, W) porous container bottom part for biological sample storage fixed transfer process with protective plate and data recording part X1 shown in FIG. 34CE ( Unit 1) X, and the bottom (unit 1) X and the perforated liquid that is detachably fitted and connected to the upper opening (X9 and W18) of the embedded frame-like substrate (unit 3) W with the sample data recording unit The functional form of the lid (unit 2) Y with the protective plate Y1 having the surface Y3 and the embedded frame-like base (unit 3) W are formed as three separate constituent units, and the bottom X is An opening X9 is formed on the upper side that is separated from the embedding frame-shaped substrate (unit 3) W, and a bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 is formed. Biological sample consisting of sample storage part X6 with porous liquid-permeable bottom surface X10 formed at least at the bottom Porous container-like bottom for storage and transfer processing (unit 1) X, and porous container-like bottom for biological sample storage and transfer processing (unit 1) without the inclusion of the embedded frame base (unit 3) W The lid (unit 2) Y having the porous liquid passage hole Y3 in the upper opening X9 of X is independently detachably fitted and connected to each other to fix and transfer the sample, perform chemical treatment, and transfer the sample data. It is possible to construct a perforated container container (unit structure 1) (X and Y) FIG. The embedded frame-like substrate (unit 3) W has an embedded frame shape that forms a porous liquid-permeable bottom W10 that is different from the bottom X of the porous container-like bottom (unit 1) X for storing and transferring biological samples. The base (unit 3) W, and the lid (unit 2) Y having the porous liquid passage hole Y3 in the upper opening W18 of the embedded frame base (unit 3) W is independently detachably fitted to each other.・ Fixed sample data and functions of rootstock of burr-free embedding block and conventional support base (unit structure 3) (Y and W) capable of carrying cassette function for pathology / biological sample. To construct. Perforated vessel for biological sample storage / fixed transfer treatment with sample data recording part (X1 and Y1) (unit structure 1) (X and Y) FIG. 35BG and fixing support base with sample data recording part (unit structure 3) ) (Y and W) From the three-unit system composite structure (X, Y, W) that can share the cover body (unit 2) Y with the protective plate Y1 having the porous liquid passage hole Y3, which is the structural unit of FIG. 35AF Perforated vessel for storing and transferring biological samples (unit structure 1) (X and Y) with a sample data recording unit (X1 and Y1) having an independent function of FIG. 35BG and a supporting base for fixing with a sample data recording unit (X and Y) Unit structure 3) (Y and W) A unit system cassette for pathological / biological samples, characterized in that it is a unit system-embedded frame-shaped substrate structure constituted by FIG. 35AF.

It can be understood from the longitudinal cross-sectional comparison figure 35 that the three-unit system composite structure fixing support base (unit structure 3) (X and Y and Z) FIG. 35CG and the fixing support base (unit structure) 3) (Y and W) The shape of the outer shape of FIG. 35AF is the same, and the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 can be shared. FIG. 35AD is a view of removing the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 in FIG. 35AF, and the embedded frame-shaped substrate (unit 3) W in FIG. An embedded frame-like substrate (unit 3) W that forms a porous liquid-permeable bottom W10 different from the bottom X of the porous container-like bottom (unit 1) X for biological sample storage and transfer processing, which is the bottom X. From the thickness of the substrate (unit 3) W [: the height h (21) of the outer wall (W15 in FIG. 37)] the outer periphery of the upper opening X9 of the porous container-shaped bottom part (unit 1) X for biological sample storage and transfer processing Of the lid (unit 2) Y having a thickness of a bowl-shaped plane X11 projecting in a horizontal direction surrounding the base and a porous liquid-permeable surface Y3 detachably fitted and connected to the opening X9 of the bottom (unit 1) X A virtual shape that is the thickness of the outer peripheral plane Y10 of the open / close guide rib Y8 that surrounds the outer periphery of the porous liquid passing surface Y3 ( p1) only cut the Wp2 remain (Figure 35BD). When the virtual shape (Wp1) is superimposed on the opening of the unit system embedding frame-like substrate porous liquid-permeable container bottom (unit structure 2) (X and Z) of FIG. Shaped bottom (unit 1) X coincides with the inclined angle plane of the data recording portion of FIG. 35CE, and also coincides with the inclined face of the data recording portion of the embedded frame-shaped substrate W FIG. 35AD. That is, FIG. 35AD overlaps Wp1 and Wp2 (Wp1 and Wp2). FIG. 35BE is congruent and coincides with the outer shape of FIG. 35CE. Therefore, the cover body (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 has the same external shape as FIG. 35AD, FIG. 35BE, and FIG. 35CE. ). That is, the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 is detachably fitted and connected to the upper opening X9 of the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing. And a biological sample storage fixed transfer processing porous container with a protective plate and data recording unit (X1 and Y1) (unit structure 1) (X and Y) FIG. 35BG is constructed, and the biological with sample data recording unit (X1 and Y1) Perforated container for sample storage / transfer processing (unit structure 1) (X and Y) FIG. 35BG is also detachably fitted and connected to the upper opening Z18 of the embedded frame-shaped substrate (unit 3) Z. Perforated container cage (unit structure 1) (X and Y) for biological sample storage and transfer processing with protective plate and data recording section (X1 and Y1) as the data recording section Z1 of the embedded frame-shaped substrate (unit 3) Z 35BG protective plate and data recording unit (X1 and Y1) bottom surface X 7 covers and protects.
That is, a cover (unit 2) Y with a protective plate Y1 having a porous plate-like bottom portion (unit 1) X for a biological sample storage fixed transfer process with a protective plate and data recording portion X1 of the present invention and a porous liquid-permeable surface Y3 and data. The embedded frame substrate (unit 3) Z with the recording part Z1 and the embedded frame substrate (unit 3) W with the data recording part W1 forming the porous liquid-permeable bottom W10 are the protective plate and data recording part X1. A lid (unit 2) Y with a protective plate Y1 having a porous liquid-permeable surface Y3 detachably fitted and connected to the upper opening X9 of the perforated container-like bottom part (unit 1) X for biological sample storage fixed transfer processing In Fig. 35BG, a porous container for biological sample storage and transfer processing (unit structure 1) (X and Y), which has an independent function of linking and transferring the sample, transferring chemicals and transferring sample data, is constructed. Perforated container for biological sample storage and transfer processing (unit structure Adult 1) (X and Y) FIG. 35BG is a fixing support base comprising the above-mentioned three-unit system composite structure which is detachably fitted and connected to the embedded frame-like base (unit 3) Z with the data recording section Z1. Table (unit structure 3) (X and Y and Z) FIG. 35CG is constructed. Further, the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 is the upper opening of the embedded frame-shaped substrate (unit 3) W with the data recording part W1 that forms the porous liquid-permeable bottom W10. A fixing support base with a sample data recording unit (unit structure 3) (Y and W) is detachably fitted and connected to W18 to construct FIG. 35AF.
Therefore, the sample storage part of FIG. 35 CD / CE, which is the bottom of the unit system embedded frame-like substrate porous liquid-permeable container (unit structure 2) (X and Z), stores and transfers the biological sample with the protective plate and data recording part X1. The sample container X6 of the processing porous container bottom (unit 1) X, while the sample container W17 of the embedded frame substrate (unit 3) W with the data recording part W1 forming the porous liquid-permeable bottom W10 is: Since the embedded frame-shaped substrate (unit 3) W is a sample storage portion W17 formed inside itself, it surrounds the periphery of the sample storage portion X6 of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing. There is no need to form the side wall X8, and the bottom area of the sample storage portion W17 can be increased accordingly. In other cases, the forming inclination angle of the protective plate Y1 of the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 is the bottom of the porous container for biological sample storage fixed transfer processing with the protective plate and data recording unit X1 ( Unit system embedded frame-shaped substrate porous liquid-permeable container bottom, which is a functional form of a cassette for pathological tissue sample constructed by a two-unit system composite structure of unit 1) X and embedded frame-shaped substrate (unit 3) Z (Unit structure 2) It is formed along the inclined surface of the data recording part X1 of (X and Z), and the inclined surface of the data recording part X1 is protected for the lid (unit 2) Y with the protective plate Y1. The plate Y1 is protected so as to cover it (FIGS. 35BG and 35CG). Further, the surface of the data recording part W1 of the embedded frame-like substrate (unit 3) W with the data recording part W1 forming the porous liquid-permeable bottom part W10 is for the biological sample storage fixed transfer process with the protective plate and data recording part X1. It exists on the same inclined surface as the data recording portion X1 surface of the bottom of the porous container (unit 1) X.

  Furthermore, FIG. 36 is an explanatory view of a fixing support base (unit structure 3) (Y and W) with a sample data recording section, FIG. 36A is a plan view, and FIG. 36BC is a double arrow line C in FIG. FIG. 36BD is a vertical cross-sectional view of the data recording unit W1 formed with an IC chip (RFID) 2 insertion and installation portion on the lower surface thereof. FIG. 36F is a vertical cross-sectional view of the double-headed arrow straight line E, and FIG. 36F is a vertical cross-section of the embedded frame-shaped substrate W which is one unit of the fixing support base (unit structure 3) (Y and W) with the sample data recording unit. FIG. 36G is a plan view of the embedded frame-shaped substrate W, and FIG. 36H is a rear view of the embedded frame-shaped substrate W.

  FIG. 37A is also a plan view of an embedded frame-shaped substrate W that is one unit of the fixing support base (unit structure 3) (Y and W) with the sample data recording unit, and FIG. 37BC is a plan view of FIG. FIG. 37BD is a vertical cross-sectional view of the double-headed arrow line D of FIG. 37A. FIG. 37BD is a vertical cross-sectional view of the double-headed arrow line C of FIG. FIG. 37BE is a vertical cross-sectional view of the double-headed arrow line E of FIG. 37A, and the IC chip (RFID) 2 insertion installation part may be formed on the lower surface of the data recording part W1 on this side. 37F is a side view, FIG. 37G is a left side cross-sectional view 22 of the double arrow line I in FIG. 37, and FIG. 37H is a left cross-sectional view 22 and a right side cross-sectional view 23 of the double arrow line J in FIG. is there. W1 is a data recording portion, W2 is an IC chip (RFID) insertion installation position, W3 is a bubble removal hole on both sides, W4 is a bubble removal and tongue-like locking lid latching portion on the center portion, and W5 is an upper end surface of both outer long side walls. The upper upper surface W6 of the outer wall surrounding the periphery of the upper opening W18 or the convex flat surface W6 projecting inwardly on the storage inner wall connected to the upper opening W18, and a claw for attaching and detaching the lid (unit 2) Y Recesses W8 and W9 that lead from the upper end surface W6 to the lower end surface W14 on both front outer sides of the forming space W7 of the hanging portion Y5 and the outer wall W15 are convex hanging locking portions Y2 on both sides of the front portion of the lid with a protective plate. W10 is a perforated bottom, W11 is a hook-shaped protruding side wall protrudingly formed in an area narrower than the bottom surface, W12 is a rear hooking portion of the lid, W13 is a rear wall, and W17 is a sample storage portion. .

  As shown in FIGS. 12 and 13, a lid Ya having a porous liquid-permeable surface Y3 that does not mold the protective plate Y1 of the lid (unit 2) Y with a protective plate Y1 having a porous liquid-permeable surface Y3 may be formed. I can do it. 12A, B and C and FIGS. 13A, B, and C are formed by forming a locking portion of the lid body Ya at the front by forming the same tongue-shaped locking portion Ya1 as the conventional lid and the rear locking portion Y4 at the rear. As shown in Fig. 3, the front tongue-shaped locking portion Ya1 is attached to the central portion of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing with the protective plate and data recording portion X1. The rear locking portion Y4 is inserted and locked into the locking portion X3, and the rear locking portion X5 is hooked on the rear locking portion X5 of the porous container-like bottom portion (unit 1) X, and the protection body for the data recording portion is not attached to the lid. However, a porous specimen container (unit structure 1) (X and Ya) for biological sample storage and transfer processing with a protective plate and data recording unit X1 is constructed. Furthermore, as shown in FIGS. 13D, E, F, and G, which are longitudinal sectional views and side views, FIGS. 14A and B, which are plan views, and FIGS. 15A and 15B, which are rear views, the biological sample with the protective plate and data recording unit X1. The perforated container for storage and transfer processing (unit structure 1) (X and Ya) is composed of a three-unit system composite structure by fitting and connecting with an embedded frame-like substrate (unit 3) Z with data recording section Z1. The Example of the unit system cassette for biological samples of another shape form which is a unit system embedding frame-like base | substrate structure is shown.

A lid Ya having a porous liquid-permeable surface Y3 formed with a front tongue-shaped locking portion Ya1, and a porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing with the protective plate and data recording portion X1 are detachable. As shown in FIGS. 12A, 12B and 12C, the front tongue-like locking portion Ya1 of the lid Ya is a bottom portion of a porous container for biological sample storage and transfer with the protective plate and data recording portion X1 ( Unit 1) Inserted and locked into the center part of the bubble removal and tongue-shaped locking lid latching part (X3 in FIGS. 13A and 13C) of X, and the rear locking part Y4 is shown in FIGS. 12A, B and C and FIGS. As shown in C and D, the bottom portion (unit 1) X is latched and locked to the rear latch portion X5. Further, FIGS. 14A and 14B, which are plan views, and FIGS. 15A and 15B, which are plan views, and a lid Ya having a porous liquid-permeable surface Y3 formed with a front tongue-like locking portion Ya1 as shown in FIGS. From the three-unit system composite structure of the porous container-like bottom part (unit 1) X for the biological sample storage fixed transfer process with the protective plate and data recording part X1 and the embedded frame-like substrate (unit 3) Z with the data recording part Z1 The fitting / connecting structure of the locking portion of the unit system embedded frame-like base body structure described in FIG. 13F showing the rear locking relationship is an enlarged view of FIG. 13C and FIG. Since the bottom portion (unit 1) X and the latching portion (X5 and Z12) constructed by the two overlapping portions formed by the latching portion of the embedded frame-shaped base (unit 3) Z, the lid ( Unit 2) Ya, the bottom (unit 1) X and the embedded frame base (unit 3) Connecting and locking a fulcrum of the retaining portion over the Z (X5 and Z12 and Y4) are respectively common shared.
Further, a porous container-like bottom part (unit 1) X with a protective plate and a data recording part X1 of the front tongue-like locking part Ya1 of the lid Ya and a data recording part Z1 and an embedded frame shape with a data recording part Z1 The front locking relationship with the substrate (unit 3) Z is clearly shown in FIG. 14F, which is a longitudinal sectional view, and FIGS. 15A, B, which are rear views, but the sample storage in which the porous liquid-permeable bottom surface X10 is formed. Of the upper opening X9 of the perforated container-like bottom part (unit 1) X for biological sample storage and transfer processing composed of the part X6 and the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery of the upper opening X9 At least one side of the bowl-shaped plane X11 projecting in the horizontal direction surrounding the outer periphery is extended and formed along the inclined surface Z1 of the outer surface data recording portion of the embedded frame-shaped substrate (unit 3) Z. Protective plate and data covering and restraining the data recording portion Z1 inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3) Z Unit system embedded frame-like substrate porous liquid-permeable container bottom (unit structure 2) which is a functional form of a cassette for pathology / biological sample constructed by a two-unit system composite structure in which the recording part X1 is integrally formed (unit structure 2) X and Z) cover body Y1 with a protective plate Y1 having a porous liquid-permeable surface Y3 detachably fitted and connected to the upper opening X9 (unit 2) Y and protective plate Y1 Can be used in common with a lid Ya having a porous liquid-permeable surface Y3 formed with a front tongue-shaped locking portion Ya1 that is not molded, and the lid (Y or Ya) can be used when a conventional embedded block is sliced. It is molded into a structure that fits within the support base (unit structure 3) for fixing the embedding block, which is the thickness h (21 in FIGS. 32 and 34) of the rootstock at the adapter fixing claw position Z14 of the thin section microtome. For this purpose, a vertical sectional view of the double-headed arrow line D in FIG. 37A in FIG. 37 (FIG. 37BD). 37) and the right side cross-sectional view of the double-headed straight line J in FIG. 37, the embedded frame-shaped substrate Z is also defoamed at the center of the porous container-like bottom portion (unit 1) X for biological sample storage and transfer processing. Similarly to the tongue-shaped latching lid latching portion X3, the central defoaming / tongue-shaped latching lid latching portion W4 that is released from above and from the inner side of the cross section must be formed. At this time, the lid (unit 2) Y with the protective plate Y1 having the porous liquid-permeable surface Y3 needs a closed wall Y7 for preventing the small biopsy sample from dropping out.

  Furthermore, as shown in FIGS. 38A and 38B, when using the lid Ya having the porous liquid passing surface Y3 formed with the front tongue-shaped locking portion Ya1 in which the protective plate Y1 is not formed, a transparent synthetic material is used. It is not necessary to mold the resin lid Ya, but conversely, it is convenient to mold the porous container-like bottom part (unit 1) X for biological sample storage and transfer processing with a transparent protective plate X1. At this time, the porous container-shaped bottom portion (unit 1) X with the protective plate Xa1 formed of the transparent synthetic resin is transparent to the data and the data recording label 1 on the data recording portion Za1 of the embedded frame-shaped substrate Za. A protective plate Xa1 made of synthetic resin protects.

  Furthermore, as shown in FIGS. 39A, B, and C, a simple box-shaped biological sample storage porous transfer container (unit structure 1) (Xb and Yc) is formed to form a porous lid Yc and a porous bottom. Xb can be detachably fitted and connected with lid locking portions Yc1 and Yc4 and Xc3 and Xc5, respectively, so that the biological sample storage and transfer porous container (unit structure 1) (Xb and Yc) is opened and closed by the finger hooking recess and finger hooking portion Yc5 of the finger hooking portion Yc9, and as shown in FIGS. It can also be made into the shape form latched on the stop part Zb4 and Zb12. Of course, the data recording part of the patient name / sample name 3 can be formed. The biological sample storage fixed transfer processing porous container jar (unit structure 1) (Xb and Yc) may be integrally formed by hinge-molding the boundary between the porous lid Yc and the porous bottom Xb as shown in FIG. good. Further, the bottom of the embedded frame-shaped substrate Wa to which the perforated container basket (unit component 1) (Xb and Yc) for biological sample storage and transfer processing is fitted and connected may be formed with the porous liquid passing surface Wa10. However, in this case, there is no protective plate for the data recording part of the embedded frame-shaped substrate.

X Perforated container bottom for biological sample storage and transfer processing (Unit 1)
Y Lid with a porous hole (Unit 2)
Z Embedded frame base (Unit 3)
W Embedded frame-like substrate forming a porous liquid-permeable bottom
U Conventional cassette bottom
V Perforated lid of conventional cassette 1 Data recording label 2 IC chip (RFID)
3 Patient name / sample name 4 Anal side (AW)
5 Patient sample 5a Trimming sample 6 Fixed transfer container 7 Automatic label printer 8 Tweezers 9 Chemical solution treatment pad 10 Sponge gel mat 11 Hot plate 12 Embedding agent 12a Molten embedding agent 15 Fixing solution
S Embedded bottom (Unit 4)
T Upper watertight embedding frame (Unit 5)
16 Cold plate 21 Adapter cassette claw engagement position (h)
22 Left sectional view 23 Right sectional view

Claims (10)

An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Functional form of a bottom (unit 1) and a cover (unit 2) having a porous liquid-permeable surface that is detachably fitted and connected to the upper opening of the bottom (unit 1) and an embedded frame-like base (unit 3) Are formed as three separate structural unit units,
The bottom portion forms an opening on the upper side that is separated and independent from the embedding frame-like base (unit 3), and forms a bowl-shaped plane that protrudes in the horizontal direction surrounding the outer periphery of the upper opening, And a porous container-like bottom portion (unit 1) for a biological sample storage and transfer process comprising a sample storage portion having a porous liquid-permeable bottom surface at least at the bottom, and without the inclusion of the embedded frame-like substrate (unit 3). In addition, the lid (unit 2) having the porous liquid passage hole is uniquely detachably fitted to and connected to the upper opening of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing, and the sample It is possible to construct a biological sample storage fixed transfer processing porous container cage (unit structure 1) that has an independent function of transferring and connecting fixed transfer, chemical processing, and sample data, and further, the biological sample storage fixed transfer processing Perforated container bowl (unit structure The body 1) is also detachably fitted to and connected to the embedded frame base (unit 3) to determine the sample data, the function of the root block of the burr-free embedded block, and the conventional pathology / biological sample cassette function. A unit system cassette for pathological / biological samples, characterized in that it is a unit system-embedded frame-like substrate structure comprising a three-unit system composite structure for constructing a supporting base for fixation (unit structure 3). An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Covered with a bottom (unit 1), a lid (unit 2) having a perforated liquid hole Y detachably fitted and connected to an upper opening of the bottom (unit 1) and the embedded frame base (unit 3) The functional form of the embedded frame-like base (unit 3) is formed as three types of separate structural units,
The bottom portion forms an opening on the upper side that is separated and independent from the embedding frame-like base (unit 3), and forms a bowl-shaped plane that protrudes in the horizontal direction surrounding the outer periphery of the upper opening, And a porous container-like bottom portion (unit 1) for a biological sample storage and transfer process comprising a sample storage portion having a porous liquid-permeable bottom surface at least at the bottom, and without the inclusion of the embedded frame-like substrate (unit 3). In addition, the lid (unit 2) having the porous liquid passage hole is uniquely detachably fitted to and connected to the upper opening of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing, and the sample It is possible to construct a biological sample storage fixed transfer processing porous container cage (unit component 1) that has an independent function of transferring and connecting fixed transfer, chemical solution processing, and sample data, and the embedded frame substrate (unit 3). ) Is the bottom biological sample It is an embedding frame-like base (unit 3) forming a porous liquid-permeable bottom different from the perforated container-like bottom (unit 1) for storage and transfer processing, and the upper opening of the embedding frame-like base (unit 3) The lid (unit 2) having the perforated holes is detachably fitted and connected to each other to determine the sample data, the function of the root block of the burr-free embedded block, and the conventional pathological / biological sample A fixing support base (unit structure 3) capable of carrying a cassette function is constructed, and the biological sample storage fixed transfer processing porous container basket (unit structure 1) and the fixing support base (unit structure 3) Porous container container for biological sample storage and transfer processing (unit component 1) having an independent function composed of a three-unit system composite component that can share and utilize the lid (unit 2) having the porous liquid passage hole as a component unit And fixing support Table (unit configuration body 3) the de 3 units pathological and biological specimen unit system cassette, wherein the system is a unit system embedded frame-like base structure made of a composite structure which constitutes. An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Functional forms of the lid (unit 2) and the embedded frame-like base (unit 3) having a porous liquid-permeable surface that is detachably fitted and connected to the bottom (unit 1) and the upper opening of the bottom (unit 1). Molded as three separate structural unit units,
The embedding frame-shaped substrate (unit 3) has an opening on the upper side, and has a convex flat surface projecting inwardly on the upper end surface of the outer wall surrounding the periphery of the opening or on the inner wall continuous to the opening. An embedded frame-shaped substrate (unit 3) formed and formed by extending and extending the outer long side walls on the end surfaces of the upper ends of both long sides of the upper part of the outer wall surrounding the upper opening. The upper side surfaces of the outer long side walls of the outer surface of the outer side of the porous container-like bottom part for biological sample storage and transfer processing (unit 1) and the bottom part (unit The thickness of the outer peripheral plane of the opening / closing guide rib surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2) having a porous liquid-permeable surface that is detachably fitted and connected to the opening of 1) Only on the upper end of the upper part of the outer wall surrounding the periphery of the opening of the embedded frame-shaped base (unit 3) and the opening. Is molded in a position higher than protruding from the convex plane inwardly on the inner wall comprising,
Biological sample storage fixed transfer processing porous container-like bottom part (unit 1) and upper opening of the bottom part (unit 1), which are constituent units of the biological sample storage fixed transfer processing porous container container (unit structure 1) The lid (unit 2) having a porous liquid-permeable surface that is detachably fitted to and connected to the upper side of the bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening of the bottom (unit 1) And the outer side long side walls of the embedded frame-shaped base (unit 3) can be sandwiched and fitted between the long side of the outer peripheral plane of the open / close guide rib surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2). A bottom (unit 1) and a lid (unit 2) having a notch formed in the shape, and horizontally extending around the outer periphery of the upper opening of the porous container-like bottom (unit 1) for storing and transferring biological samples. Perforated liquid passing through the protruding bowl-shaped plane and lid (unit 2) The thickness of the outer peripheral plane of the open / close guide ribs surrounding the outer periphery of the embedded frame is all stored in the outer long side wall of the embedded frame base (unit 3), and data on the outer side of the side of the embedded frame base (unit 3). The area of the recording unit is kept large, and it is possible to fix the sample data, fix the burr-free embedding block and the conventional cassette function for pathological and biological samples without discarding the lid (unit 2). Unit system embedded frame shape consisting of a three unit system composite structure that can be embedded and used as part of the root block of the embedded block that is the support base (unit structure 3) 2. The unit system cassette for pathological / biological samples according to claim 1, wherein the unit system cassette is a substrate structure. An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
The bottom (unit 1), the lid (unit 2) detachably fitted to and connected to the upper opening of the bottom (unit 1) and the embedded frame-shaped base (unit 3) and the embedded frame-shaped base (unit 3) ) Are formed as three separate structural unit units,
The embedded frame substrate (unit 3) is an embedded frame substrate (unit 3) having an opening on the upper side and forming a porous liquid-permeable bottom different from the bottom (unit 1) on the lower side. The upper upper surface of the outer wall surrounding the upper opening or a convex flat surface projecting inwardly on the storage inner wall connected to the upper opening is formed, and both lengths of the upper part of the outer wall surrounding the upper opening are formed. An embedding frame-like base body (unit 3) in which an outer long side wall is erected and extended on the end face of the side upper end face. Opening and closing surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2) having a porous liquid-permeable surface that is detachably fitted and connected to the upper opening of the porous container-shaped bottom (unit 1) for biological sample storage and transfer processing The circumference of the opening of the embedded frame base (unit 3) by the thickness of the outer peripheral plane of the guide rib Is formed at a position higher than protruding from the convex plane inwardly on the inner wall contiguous to the outer wall upper upper surface and opening surrounding,
Removably fitted to the upper opening of the biological sample storage fixed transfer processing porous container bottom part (unit 1), which is a constituent unit of the biological sample storage fixed transfer processing porous container container (unit structure 1). The lid body (unit 2) having the porous liquid passage hole to be connected has the long side of the outer peripheral plane of the open / close guide rib surrounding the outer circumference of the porous liquid passage surface of the lid body (unit 2). A lid body in which the outer side long side walls of the unit 3) are formed in a shape that can be sandwiched and fitted, and a lid body (unit 2) of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing Is shared and used as a lid (unit 2) of the embedded frame substrate (unit 3), and the thickness of the outer peripheral plane of the open / close guide rib surrounding the outer periphery of the porous liquid-permeable surface of the lid (unit 2). Are all contained in the embedded frame base (unit 3) and are side walls. Area of the data recording portion of the side is kept wide,
Further, in order to prevent the cover (unit 2) having the porous liquid passage hole from being accommodated in the long side wall of the embedding frame-like base (unit 3) and preventing the cassette storage volume from being reduced, the embedding frame corresponding to the thickness thereof is used. The forming position of the porous liquid-permeable bottom portion of the substrate (unit 3) is narrower than the adapter fixing claw position at the bottom of the embedded frame substrate (unit 3) that plays the role of the rootstock when the sample embedding block is sliced. Molding the protruding side wall protruding in area
The embedding frame-like substrate (unit 3) embeds the embedding of the lid (unit 2) having the porous liquid-permeable surface, which is a constituent unit of the biological sample storage and fixing porous container basket (unit constituent body 1). It can be shared as a lid having a porous liquid-permeable surface that is also detachably fitted and connected to the upper opening of the frame-like base (unit 3), and the embedded block without discarding the lid (unit 2) It is possible to construct a support base (unit structure 3) for fixing a block sample that can be embedded and used integrally as a part of the rootstock of the block. The biological sample storage fixed transfer processing porous container jar (unit structural body 1) and the fixing support base (unit structural body 3) are shared by the lid body (unit 2) having the porous liquid-permeable surface. Biological sample storage fixed transfer processing perforated container container (unit structure 1) with independent functions consisting of 3 unit system composite structure that can be used, independent sample data confirmation and burr-free embedded block sample rootstock function The pathological / biological sample unit system cassette according to claim 2, wherein the pathological / biological sample unit system cassette is composed of a fixed support base (unit structure 3) capable of carrying a conventional pathological / biological sample cassette function. An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Functional forms of the lid (unit 2) and the embedded frame-like base (unit 3) having a porous liquid-permeable surface that is detachably fitted and connected to the bottom (unit 1) and the upper opening of the bottom (unit 1). Molded as three separate structural unit units,
Functional form of a cassette for pathological tissue sample constructed by a two-unit system composite structure comprising a bottom part (unit 1) for a biological sample storage fixed transfer process as the bottom part and a unit for embedded frame (unit 3). The unit-embedded frame-shaped substrate porous liquid-permeable container bottom (unit structure 2) is a constituent unit of the biological sample storage fixed transfer processing porous container-shaped bottom (unit 1),
Porous container-like bottom part (unit 1) for biological sample accommodation fixed transfer processing composed of a sample accommodation part formed with a porous liquid-permeable bottom surface and the bowl-like plane projecting in the horizontal direction surrounding the outer periphery of the upper opening At least one side of the bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening of the frame is extended along the inclined surface of the data recording section on the outer surface of the embedded frame-shaped substrate (unit 3). Then, it is constructed of a two-unit system composite structure integrally formed with a protective plate and data recording portion that covers and suppresses the data recording portion that is inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3). The pathology / biology according to claim 1 or 3, wherein the pathology / biology is a structural unit of a unit system embedded frame-like substrate porous liquid-permeable container bottom (unit structure 2) which is a functional form of a pathology / biological sample cassette. Unit system cassette for sample A structure unit protection plate and the data recording unit with a porous liquid permeability container-shaped bottom portion (unit 1). An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Functional form of a bottom (unit 1) and a cover (unit 2) having a porous liquid-permeable surface that is detachably fitted and connected to the upper opening of the bottom (unit 1) and an embedded frame-like base (unit 3) Are formed as three separate structural unit units,
A lid having a porous liquid-permeable surface that is detachably fitted to and connected to the bottom part (unit 1) of the biological sample storage fixed transfer process as the bottom part and the upper opening of the bottom part (unit 1). Of the bottom part (unit 1), which is a constituent unit of the biological sample storage fixed transfer processing porous container cage (unit constituent body 1) having an independent function constructed by a two-unit system composite constituent body with the body (unit 2) At least one side of the bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening is extended and formed along the inclined surface of the data recording portion on the outer surface of the embedded frame-shaped substrate (unit 3). In order to further protect the protective plate and data recording portion of the bottom portion (unit 1) that protects and suppresses the data recording portion that is inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3), Lid having a porous liquid-permeable surface Similarly, an integral protective plate is formed on at least one side of the outer peripheral plane of the opening / closing guide rib surrounding the outer periphery of the porous liquid passing surface of the unit 2), and the bottom of the porous container for the biological sample storage fixed transfer processing ( A cover with a protective plate (unit 2) and a bottom with a protective plate and a data recording unit for preventing contamination on the protective plate and the data recording unit of the unit 1) and peeling and contamination of the data label printed on the data recording unit (Unit 1) and a dual data recording unit of the biological sample storage fixed transfer processing porous container rod (unit configuration 1) with a sample data recording unit that has an independent function constructed by a two-unit system composite configuration A sample constructed with a three-unit system composite structure in which a protective plate sandwiches and protects the data recording portion on the outer surface of the embedded frame-shaped substrate (unit 3) and can be utilized without discarding the lid having a porous liquid-permeable surface. Confirm data 6. The support base (unit structure 3) for supporting the function of the rootstock of the burr-free embedding block and the conventional cassette function for pathological / biological specimens. The unit of the pathological / biological sample unit system cassette is a porous container-like bottom part (unit 1) for protecting and transferring biological samples with a protective plate and data recording unit, and a lid having a porous liquid passage hole with a protective plate (unit 1) Unit 2). An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
The bottom (unit 1), the lid (unit 2) detachably fitted to and connected to the upper opening of the bottom (unit 1) and the embedded frame-shaped base (unit 3) and the embedded frame-shaped base (unit 3) ) Are formed as three separate structural unit units,
A lid having a porous liquid-permeable surface that is detachably fitted to and connected to the bottom part (unit 1) of the biological sample storage fixed transfer process as the bottom part and the upper opening of the bottom part (unit 1). A biological sample storage fixed transfer processing porous container container (unit structure 1) and an embedded frame-shaped base body (unit 3), which have independent functions constructed by a two-unit system composite structure with the body (unit 2) A horizontal unit that surrounds the outer periphery of the upper opening of the porous container-like bottom part (unit 1) for biological sample storage and transfer processing, which is a constituent unit of a pathological / biological sample unit system cassette that is a three-unit system composite structure to be constructed. Data is recorded by extending at least one side of the saddle-like flat surface projecting in the direction at the same inclination angle as the data recording section inclined and installed on the outer peripheral side surface of the embedded frame-shaped substrate (unit 3). The porous passage is molded and further detachably fitted to and connected to the bottom portion (unit 1) along the data recording surface formed on the bottom portion (unit 1) for the biological sample storage fixed transfer processing. Similarly, at least one side of the outer peripheral plane of the open / close guide rib surrounding the outer periphery of the porous liquid passing surface of the lid (unit 2) having a liquid surface is similarly provided with an integral protective plate on the porous container for the biological sample storage fixed transfer process. The data recording part formed on the bottom part (unit 1) is formed in a shape that protects and suppresses, and the bottom part with the data recording part (unit 1) and the upper opening of the bottom part (unit 1) are independently detached from each other. Perforated container for biological sample storage and transfer processing having an independent function constructed by a two-unit system composite structure with a lid with a protective plate (unit 2) having a porous liquid-permeable surface to be freely fitted and connected (Unit structure 1) The lid with a protective plate (unit 2) having a porous liquid-permeable surface, which is a constituent unit, can protect the data recording section that is inclined and installed on the outer peripheral side surface of the embedded frame base (unit 3). 5. A biological sample storage / fixed transfer process with a data recording unit and a protection plate, which is a two-unit system composite structure of a pathological / biological sample unit system cassette according to claim 2 or 4, characterized in that it can be shared and utilized as a body (unit 2). Perforated container bowl (unit structure 1). An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Three types of functional forms of the bottom (unit 1) and the lid (unit 2) and the embedded frame base (unit 3), which are detachably fitted and connected to the upper opening of the bottom (unit 1), are separated and independent. Molded as a component unit of
The embedding frame-shaped base (unit 3) has an opening on the upper side, and protrudes inwardly on the upper end of the upper part of the outer wall surrounding the periphery of the upper opening, or on the inner wall connected to the upper opening. A convex plane is formed, and concave portions that lead from the upper end surface to the lower end surface are formed on both front outer surfaces of the outer wall of the embedded frame-shaped substrate (unit 3), and the bottom (unit 1) is formed on the upper portion of the concave portion. ) Are detachably fitted and connected to the front (both units 2) on both front protrusions of both sides of the cover (unit 2). An embedding in which a part of the upper side of the outer surface is left protrudingly formed as a latching part on the concave side, and a latching part for latching the rear latching part of the lid (unit 2) is formed on the rear outer wall. A frame-shaped substrate (unit 3), and the embedded frame-shaped substrate (unit 3) includes a bottom (unit 1) and a lid (unit). 2) and removably fixing support base is fitted-coupled to three units System composite structure (the unit structure 3) to build.
The bottom (unit 1) is formed from a sample storage portion in which an opening is formed on the upper side that is separated and independent from the embedded frame-shaped substrate (unit 3), and a porous liquid-permeable bottom surface is formed at least on the bottom. The bottom (unit 1) is a porous container-like bottom portion (unit 1) for biological sample storage and transfer processing, and the bottom portion (unit 1) forms a bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening, and the bowl-shaped plane There is a latching portion of the front projecting hanging latching portion of the lid (unit 2) at the front portion of the lid (unit 2), and the latching portion is the front of the outer wall of the embedded frame base (unit 3). A notch portion corresponding to a concave portion formed by leaving a part of the upper side of the outer surface of the outer concave portion on the concave side as a latching portion on the concave side, and the lid (unit 1) also on the rear portion (unit 1) Unit 2) forms a latching portion for the rear latching portion, and the bottom (unit 1) is a lid Constructing a (unit 2) and removably biological sample accommodated fixed transfer processing porous container cage is fitted-coupled to 2 units system complex structure (configuration body 1),
The lid (unit 2) having the porous liquid-permeable surface is formed with convex hanging locking parts on both sides of the front part, and the bottom part (unit 1) and the embedded frame-like base body (unit 3) on the rear part. A common locking portion is formed. The lid (unit 2) is a biological sample storage fixed transfer processing porous container cage (unit structure 1) constructed with a 2-unit system composite structure and a fixing support base constructed with a 3-unit system composite structure. (Unit component 3) is a common component unit,
Unit system composite structure constructed from the porous container-like bottom part (unit 1) for the biological sample storage fixed transfer process, the lid (unit 2) having the porous liquid-permeable surface, and the embedded frame-like substrate (unit 3) Common use of the lid (unit 2) having the same porous liquid-permeable surface for the porous container cage (unit component 1) for fixing and transferring biological sample, which is a body, and the support base for fixing (unit component 3) The unit system cassette for pathological / biological samples, which is a unit system-embedded frame-like substrate structure according to claim 1, wherein the unit system cassette is constructed as described above. An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate In a cassette for pathological / biological samples consisting of a lid with holes;
Functional forms of the lid (unit 2) and the embedded frame-like base (unit 3) having a porous liquid-permeable surface that is detachably fitted and connected to the bottom (unit 1) and the upper opening of the bottom (unit 1). Molded as three separate structural unit units,
The embedding frame-shaped substrate (unit 3) has openings on the upper side and the lower side, forms a through-hole portion connected to the opening from the upper side to the lower side, and extends from the upper side to the lower opening. Forming a convex flat surface projecting inwardly on the upper end of the upper part of the outer wall surrounding the upper opening of the connected through hole or the inner wall of the through hole connected to the upper opening; The concave portion that leads from the upper end surface to the lower end surface is formed on both front outer surfaces of the outer wall of the substrate (unit 3), and the bottom portion (unit 1) is detachably fitted and connected to the upper portion of the concave portion. The latching portion of the front convex hanging latching portion of the lid (unit 2) is latched on both outer front concave portions of the embedding frame base (unit 3), and the upper part of the outer surface is latched on the concave side. A hooking portion that is formed in a protruding shape as a portion, and that hooks the rear locking portion of the lid (unit 2) on the rear outer wall. In the form the embedding frame-like base (unit 3),
The bottom (unit 1) is formed from a sample storage portion in which an opening is formed on the upper side that is separated and independent from the embedded frame-shaped substrate (unit 3), and a porous liquid-permeable bottom surface is formed at least on the bottom. A porous container-like bottom part (unit 1) for the biological sample storage and transfer process, and the porous liquid passing through the upper opening of the bottom part (unit 1) without the inclusion of the embedded frame-like base (unit 3). Biological sample storage fixed transfer processing porous container cage (unit structure 1) that has independent functions can be constructed by independently connecting and detaching the lid (unit 2) having a surface with each other,
The bottom part (unit 1) forms a bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening, and the front part of the bowl-like plane is convex on both sides of the front part of the lid (unit 2). Front side latching portions of the hanging latching portion are formed, and the front side both latching portions of the bottom portion (unit 1) are both front side outer sides of the outer wall of the embedded frame-shaped base (unit 3). The upper part of the outer surface is formed on the upper part of the recessed part that extends from the upper end surface to the lower end surface so that the upper part of the outer surface is left protrudingly formed on the concave part side, and is superimposed on the upper side of the latching part. The both side latching portions are formed by the end portions of the notches on the long sides on both sides of the bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the upper opening of the bottom (unit 1). The portion overlaps the concave portion that leads from the upper end surface to the lower end surface on both outer sides of the front portion of the outer wall of the embedded frame-shaped base (unit 3). The end of the cutout portion of the bottom portion (unit 1) that is shaped and overlaps the upper portion of the latching portion formed in a protruding manner on the concave side of the upper outer surface of the concave portion of the embedding frame-shaped substrate (unit 3) A bottom part of the porous liquid-permeable container in which the part coincides with the front side latching part and the latching part of the rear part latching part of the lid (unit 2) is formed on the rear part, and the embedding frame A sample storage portion that can be removably inserted and fitted into a through-hole portion connected to an opening portion from the upper side to the lower side of the substrate (unit 3) and the bowl-shaped plane are openings of the embedded frame substrate (unit 3). The biological sample storage fixed transfer processing perforated container is installed by latching on the upper end surface of the outer periphery or on the convex flat surface projecting inwardly on the inner wall of the through-hole portion connected to the upper opening. The bottom portion (unit 1) does not fall off to the lower opening side of the embedded frame base (unit 3). The bottom portion (unit 1) is a functional form of a cassette for pathological tissue sample constructed with a two-unit system composite structure by fitting and connecting the bottom portion (unit 1) to the embedded frame base (unit 3). Construct unit system embedded frame-like substrate porous liquid-permeable container bottom (unit structure 2),
The lid (unit 2) having the porous liquid-permeable surface is formed with convex hanging latching portions on both sides of the front portion, and the latching portion of the bottom portion (unit 1) and the embedded frame-like base body on the rear portion. A latching part that can be latched on the latching part constructed by the overlapping of the two corners formed by the latching part of (Unit 3) is formed. Further, a bowl-shaped flat surface projecting in the horizontal direction surrounding the outer periphery of the upper opening of the bottom (unit 1) is connected to the porous liquid-permeable surface of the lid (unit 2) having the porous liquid-permeable surface. Projecting inwardly on the inner peripheral wall of the through hole connected to the upper opening or the upper end surface of the outer periphery of the opening of the embedded frame-shaped base (unit 3). The fixed support base (unit structure 3) is constructed by sandwiching and fitting and connecting on a convex plane. A porous container-like bottom portion (unit 1) for the biological sample storage and transfer processing of the front side both-side convex hanging latching portion and the rear latching portion of the lid (unit 2) having a hole passing hole and the embedding frame In the latching of the front portion and the rear portion of the base body (unit 3), the front side both-side convex hanging locking portion, the bottom portion (unit 1) of the rear locking portion, and the Both front and rear latching portions of the embedding frame-shaped substrate (unit 3) are constructed by two-dimensional overlap formed by the bottom portion (unit 1) and the latching portion of the embedding frame-shaped substrate (unit 3). Since the cover (unit 2), the bottom (unit 1), and the embedded frame-like base (unit 3) are fitted and locked on each other, the fitting / locking fulcrum is commonly used. The latching portion of the lid (unit 2), the bottom (unit 1), and the embedded frame-like base (unit 3) 9. A unit system cassette for a pathological / biological sample comprising a unit system embedding frame-like substrate structure according to claim 1, wherein the fitting / locking fulcrum of each part can be shared in common. . An embedding frame-like substrate having an opening on the upper side and a porous liquid-permeable bottom on the lower side, and a porous liquid-permeable material that is detachably fitted and connected to the upper opening of the embedding frame-like substrate Pathologic / biological sample cassette embedded in a frame-shaped substrate consisting of a lid with a hole. In an embedding dish that eliminates or does not generate excess burrs of the embedding agent that sometimes damages the data record;
It has openings on the upper and lower sides that fit and connect to a horizontal plane projecting in the horizontal direction surrounding the outer periphery of the upper opening of the embedding bottom (unit 4) and the embedding bottom (unit 4). Forming the functional form of the upper watertight embedding frame portion (unit 5) forming the through-hole portion connected to the opening from the upper side to the lower side as separate and independent two types of material constituting body units, embedding bottom portion (Unit 4) is formed by pressing a metal plate with good thermal conductivity, and the embedded bottom has a storage bottom on which an embedded sample is placed at the bottom of the upper opening. A metal component unit forming a bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of
The upper watertight embedding frame portion has openings on the upper side and the lower side, forms a through-hole portion connected to the opening portion from the upper side to the lower side, and the penetrating hole connected to the lower side opening portion from the upper side A convex flat surface projecting inwardly is formed on the upper end surface of the upper part of the outer wall surrounding the periphery of the upper opening of the hole or the inner wall of the through hole continuous to the upper opening, and the periphery of the upper opening is formed. A horizontal surface surrounding the outer periphery of the upper opening of the storage bottom of the embedding bottom (unit 4) on the convex upper surface projecting inwardly on the upper wall of the upper part of the surrounding outer wall or through the inner wall of the through hole connected to the upper opening. A lower fitting connection embedded bottom support body of the embedded bottom section (unit 4) capable of being hooked and installed on all four sides of the bowl-shaped plane protruding in the direction, and above the lower fitting connection embedded bottom section support body Fits through and has openings on the upper and lower sides, and is connected to the opening from the upper side to the lower side Forming an upper portion and projecting inwardly from the upper end of the outer wall surrounding the upper opening of the through hole connected to the lower opening from the upper side and the inner wall of the through hole connected to the upper opening. An upper watertight embedding frame portion (unit 5) composed of an embedding dish upper watertight dihedral surface forming frame that forms a convex flat surface,
In the embedding dish, the embedding bottom part (unit 4) forms a bowl-shaped flat surface projecting in the horizontal direction surrounding the outer periphery of the upper opening, and the sample embedding bottom part surface at the time of embedding is formed below the embedding dish. Synthetic resin which is a metal embedded bottom portion (unit 4) and has a hook-like flat surface projecting in the horizontal direction surrounding the outer periphery of the upper opening of the embedded bottom portion (unit 4) in a watertight manner. It is constructed with two types of material constituent units, such as an upper watertight embedding frame portion (unit 5) made of metal, and is the same as the embedding bottom portion (unit 4) made of metal with good thermal conductivity and an embedding frame-shaped substrate. It is an embedding dish which is a two-unit system composite structure that combines the functional forms of the synthetic resin upper watertight embedding frame (unit 5) capable of precision fitting molding with a shrinkage rate,
The embedding bottom portion (unit 4) is formed by pressing a metal plate having a good thermal conductivity, and a bowl-shaped plane projecting in the horizontal direction surrounding the outer periphery of the opening of the embedding bottom portion (unit 4) is formed as described above. The upper water-tight embedding frame portion (unit 5) made of synthetic resin is securely and securely fitted into the latching portion, and the bottom of the embedding frame-like substrate of the cassette for pathological / biological samples and the embedding frame-like substrate (unit 3). When the cassette block is sliced, the concave / convex square surface formed by the projecting side wall projecting in a smaller area than the bottom surface of the adapter fixing claw position and the upper end surface of the synthetic resin upper watertight embedding frame (unit 5) And the watertight embedding frame inner wall formed by watertight fitting and connection with the concave and convex square contact surface of the contact watertight surface,
Improve water-tight fitting between the embedded frame-shaped substrate of the cassette for pathological / biological samples and the water-tight frame which is a water-tight dihedral surface forming frame, which has been difficult in the conventional water-tight frame forming of metal embedding dishes. The embedding agent overflows from the periphery of the embedding frame-like substrate of the pathological / biological embedding block cassette immersed in the embedding agent during the treatment of the fixed embedding solution of the sample. It is constructed by a two-unit system composite structure of the synthetic resin upper watertight embedding frame (unit 5) and the metal embedding bottom (unit 4) having good thermal conductivity that completely prevent drooping. 10. An embedding dish with a synthetic resin watertight frame (unit structure 4) at the bottom of an embedding frame-like substrate of a pathologic / biological sample cassette according to claim 1, 2, 3, 4, 8, or 9.