JP2008546810A5 - - Google Patents
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- Publication number
- JP2008546810A5 JP2008546810A5 JP2008518554A JP2008518554A JP2008546810A5 JP 2008546810 A5 JP2008546810 A5 JP 2008546810A5 JP 2008518554 A JP2008518554 A JP 2008518554A JP 2008518554 A JP2008518554 A JP 2008518554A JP 2008546810 A5 JP2008546810 A5 JP 2008546810A5
- Authority
- JP
- Japan
- Prior art keywords
- mutilin
- amino
- cycloalkyl
- acyloxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229960002771 retapamulin Drugs 0.000 claims 48
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- XZNONKDSWHVKCF-UHFFFAOYSA-N 2-[3-(2-methylpropanoyloxyamino)cyclohexyl]sulfanylacetic acid Chemical compound CC(C)C(=O)ONC1CCCC(SCC(O)=O)C1 XZNONKDSWHVKCF-UHFFFAOYSA-N 0.000 claims 1
- OFCKRECIZRHXHW-UHFFFAOYSA-N 2-[3-(acetyloxyamino)cyclohexyl]sulfanylacetic acid Chemical compound CC(=O)ONC1CCCC(SCC(O)=O)C1 OFCKRECIZRHXHW-UHFFFAOYSA-N 0.000 claims 1
- KDAUXTOIDWPFSZ-UHFFFAOYSA-N 2-[3-(hydroxyamino)cyclohexyl]sulfanylacetic acid Chemical compound ONC1CCCC(SCC(O)=O)C1 KDAUXTOIDWPFSZ-UHFFFAOYSA-N 0.000 claims 1
- MFTWJCTURNOFDW-UHFFFAOYSA-N 2-[3-(hydroxyamino)cyclopentyl]sulfanylacetic acid Chemical compound ONC1CCC(SCC(O)=O)C1 MFTWJCTURNOFDW-UHFFFAOYSA-N 0.000 claims 1
- WUYBWQYPYSVHRL-UHFFFAOYSA-N 2-[3-[acetyl(acetyloxy)amino]cyclohexyl]sulfanylacetic acid Chemical compound CC(=O)ON(C(C)=O)C1CCCC(SCC(O)=O)C1 WUYBWQYPYSVHRL-UHFFFAOYSA-N 0.000 claims 1
- FPWCUFLIYCMVIO-UHFFFAOYSA-N 2-[3-[formyl(hydroxy)amino]cyclohexyl]sulfanylacetic acid Chemical compound O=CN(O)C1CCCC(SCC(O)=O)C1 FPWCUFLIYCMVIO-UHFFFAOYSA-N 0.000 claims 1
- HNLHYCWDBQHCAX-UHFFFAOYSA-N 2-[3-[formyl(hydroxy)amino]cyclopentyl]sulfanylacetic acid Chemical compound O=CN(O)C1CCC(SCC(O)=O)C1 HNLHYCWDBQHCAX-UHFFFAOYSA-N 0.000 claims 1
- AKZJJVPIZBTWDN-UHFFFAOYSA-N C(C(C)(C)C)(=O)OOC1CC(CCC1)SCC(=O)O Chemical compound C(C(C)(C)C)(=O)OOC1CC(CCC1)SCC(=O)O AKZJJVPIZBTWDN-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 241000651994 Curio Species 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 241000588621 Moraxella Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- -1 flow regulators Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0513060A GB0513060D0 (en) | 2005-06-27 | 2005-06-27 | Organic compounds |
| GB0513060.4 | 2005-06-27 | ||
| GB0515997A GB0515997D0 (en) | 2005-08-03 | 2005-08-03 | Organic compounds |
| GB0515997.5 | 2005-08-03 | ||
| PCT/AT2006/000260 WO2007000004A1 (en) | 2005-06-27 | 2006-06-26 | Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546810A JP2008546810A (ja) | 2008-12-25 |
| JP2008546810A5 true JP2008546810A5 (https=) | 2012-10-25 |
| JP5373393B2 JP5373393B2 (ja) | 2013-12-18 |
Family
ID=36764461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518554A Expired - Fee Related JP5373393B2 (ja) | 2005-06-27 | 2006-06-26 | ヒドロキシアミノ基またはアシルオキシアミノシクロアルキル基を含むプレウロムチリン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7790767B2 (https=) |
| EP (2) | EP1896404B1 (https=) |
| JP (1) | JP5373393B2 (https=) |
| TW (1) | TW200730488A (https=) |
| WO (1) | WO2007000004A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790767B2 (en) * | 2005-06-27 | 2010-09-07 | Nabriva Therapeutics Forschungs Gmbh | Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group |
| EP1808431A1 (en) | 2006-01-16 | 2007-07-18 | Nabriva Therapeutics Forschungs GmbH | Mutilin derivatives and their use as pharmaceutical |
| EP1972618A1 (en) | 2007-03-20 | 2008-09-24 | Nabriva Therapeutics AG | Pleuromutilin derivatives for the treatment of diseases mediated by microbes |
| JP5322927B2 (ja) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| EP2159220A1 (en) | 2008-09-02 | 2010-03-03 | Nabriva Therapeutics AG | Organic compounds |
| AR090010A1 (es) | 2011-04-15 | 2014-10-15 | Bayer Cropscience Ag | 5-(ciclohex-2-en-1-il)-penta-2,4-dienos y 5-(ciclohex-2-en-1-il)-pent-2-en-4-inos sustituidos como principios activos contra el estres abiotico de las plantas, usos y metodos de tratamiento |
| CN102229580B (zh) * | 2011-05-12 | 2014-02-26 | 南通大学 | 新型截短侧耳素衍生物、其制备方法及其医药用途 |
| JP2014520776A (ja) | 2011-07-04 | 2014-08-25 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用 |
| CN103204787B (zh) * | 2012-01-17 | 2014-10-01 | 北京艾百诺科技有限公司 | 含有取代方酸的乙酸妙林酯及其应用 |
| BR112016015542B1 (pt) * | 2014-01-22 | 2022-08-30 | Nabriva Therapeutics Ag | 12-epi-pleuromutilinas, seus usos, e composição farmacêutica |
| ES2843723T3 (es) | 2015-06-17 | 2021-07-20 | Nabriva Therapeutics GmbH | Formulaciones farmacéuticas inyectables de lefamulina |
| TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
| TW202203908A (zh) * | 2020-04-17 | 2022-02-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素類之醫療用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3054875B2 (ja) * | 1995-02-13 | 2000-06-19 | 株式会社小松製作所 | プラズマトーチ |
| UY25225A1 (es) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| CO5150194A1 (es) * | 1999-01-27 | 2002-04-29 | Abbott Lab | Inhibidores hidroxamato inversos de las metalopreteinasas matriciales |
| GB0017031D0 (en) * | 2000-07-11 | 2000-08-30 | Biochemie Gmbh | Antimicrobials |
| WO2003040103A1 (en) * | 2001-11-02 | 2003-05-15 | Bristol-Myers Squibb Company | β-SULFONE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE) |
| GB0207495D0 (en) * | 2002-03-28 | 2002-05-08 | Biochemie Gmbh | Organic compounds |
| GB0209262D0 (en) * | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
| US7790767B2 (en) * | 2005-06-27 | 2010-09-07 | Nabriva Therapeutics Forschungs Gmbh | Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group |
-
2006
- 2006-06-26 US US11/814,672 patent/US7790767B2/en active Active
- 2006-06-26 TW TW095122957A patent/TW200730488A/zh unknown
- 2006-06-26 WO PCT/AT2006/000260 patent/WO2007000004A1/en not_active Ceased
- 2006-06-26 EP EP06741055.5A patent/EP1896404B1/en not_active Not-in-force
- 2006-06-26 JP JP2008518554A patent/JP5373393B2/ja not_active Expired - Fee Related
- 2006-06-26 EP EP10009685.8A patent/EP2298733B1/en not_active Not-in-force
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