JP2008546706A5 - - Google Patents
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- Publication number
- JP2008546706A5 JP2008546706A5 JP2008517095A JP2008517095A JP2008546706A5 JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5 JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5
- Authority
- JP
- Japan
- Prior art keywords
- trimethoxy
- methoxy
- group
- composition
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCc1ccccc1* Chemical compound CCCCc1ccccc1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69068905P | 2005-06-14 | 2005-06-14 | |
| US60/690,689 | 2005-06-14 | ||
| PCT/US2006/023251 WO2006138427A2 (en) | 2005-06-14 | 2006-06-14 | Combretastatin analogs with tubulin binding activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546706A JP2008546706A (ja) | 2008-12-25 |
| JP2008546706A5 true JP2008546706A5 (cg-RX-API-DMAC10.html) | 2009-11-26 |
| JP5354775B2 JP5354775B2 (ja) | 2013-11-27 |
Family
ID=37076178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517095A Expired - Fee Related JP5354775B2 (ja) | 2005-06-14 | 2006-06-14 | チューブリン結合活性を有するコンブレタスタチンアナログ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7429681B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1896391B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5354775B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2611712C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2551086T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006138427A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2048126A1 (de) * | 2007-10-11 | 2009-04-15 | Bayer Schering Pharma AG | Benzocycloheptanderivate als selektiv wirksame Estrogene |
| JP5302328B2 (ja) | 2007-11-21 | 2013-10-02 | オキシジーン， インコーポレイテッド | 造血性新生物を治療するための方法 |
| WO2010132498A1 (en) * | 2009-05-11 | 2010-11-18 | Oxigene, Inc. | Vascular disrupting agents for treatment of polypoidal choroidal vasculopathy |
| CN106822083A (zh) | 2009-08-27 | 2017-06-13 | 生物学特性有限公司 | 用于治疗增生性疾病的联合疗法 |
| US20150018566A1 (en) | 2011-08-25 | 2015-01-15 | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy | Tubulin binding agents |
| AU2013204313C1 (en) | 2012-06-01 | 2016-04-07 | Bionomics Limited | Combination Therapy |
| CN104817519B (zh) * | 2015-05-11 | 2016-11-16 | 中国药科大学 | 一类ca-4的衍生物、其制法及其医药用途 |
| JP2018523712A (ja) | 2015-08-18 | 2018-08-23 | マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. | 腫瘍に対する免疫調節療法を向上させる為のｖｄａｓの使用 |
| WO2017066668A1 (en) * | 2015-10-15 | 2017-04-20 | Baylor University | Drug-linker conjugate pharmaceutical compositions |
| SG11201806829TA (en) * | 2016-02-15 | 2018-09-27 | Sanofi Sa | 6,7-dihydro-5h-benzo[7]annulene derivatives as estrogen receptor modulators |
| US20180002355A1 (en) * | 2016-07-01 | 2018-01-04 | Baylor University | Benzocyclooctene-based and indene-based anticancer agents |
| EP3541809B1 (en) | 2016-11-17 | 2025-06-25 | Sanofi | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| WO2020037209A1 (en) * | 2018-08-17 | 2020-02-20 | Baylor University | Benzosuberene analogues and related compounds with activity as anticancer agents |
| DK3847157T3 (da) | 2018-09-07 | 2022-08-08 | Sanofi Sa | Fremgangsmåde til fremstilling af methyl-[6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylat] og salt deraf |
| WO2021063967A1 (en) | 2019-10-01 | 2021-04-08 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| CA3160897A1 (en) | 2019-12-09 | 2021-06-17 | Sanofi | Crystalline form of a 7h-benzo[7]annulene-2-carboxylic acid derivative |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| IL302152B1 (en) | 2020-10-19 | 2026-07-01 | Sanofi Sa | 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES |
| IL302153B1 (en) | 2020-10-19 | 2026-07-01 | Sanofi Sa | 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2447099A (en) * | 1944-08-23 | 1948-08-17 | Hoffmann La Roche | 2-phenylindene derivatives and process for the manufacture of same |
| US2493730A (en) * | 1946-10-23 | 1950-01-03 | Hoffmann La Roche | 2-(p-oxyphenyl)-3-isopropyl-6-oxyindanes |
| US3859358A (en) * | 1967-12-20 | 1975-01-07 | Standard Oil Co Ohio | Process for the oxidation of olefins to unsaturated aldehydes |
| US3813430A (en) * | 1970-10-26 | 1974-05-28 | Sterling Drug Inc | 1-aryl-2-alkyl or-alkenyl-3,4-dihydronaphthalenes |
| US3859356A (en) * | 1972-07-24 | 1975-01-07 | Sandoz Ag | Benzylidene substituted bicyclic and tricyclic compounds |
| FR2320734A1 (fr) | 1975-08-14 | 1977-03-11 | Roussel Uclaf | Nouveaux derives de l'aminomethyl benzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments de ces produits |
| NZ225307A (en) * | 1987-07-10 | 1991-06-25 | Hoffmann La Roche | Heterocyclic containing alkene derivatives and pharmaceutical compositions |
| US4927838A (en) | 1987-07-10 | 1990-05-22 | Hoffman-La Roche Inc. | Pyridine compounds which are useful in treating a disease state characterized by an excess of platelet activating factors |
| JP3487598B2 (ja) * | 1991-11-29 | 2004-01-19 | オキシス・アイル・オブ・マン・リミテッド | 自動酸化可能な化合物を用いることによるｓｏｄ活性のアッセイ法，自動酸化可能な化合物およびその製造 |
| JPH06256244A (ja) * | 1993-03-01 | 1994-09-13 | Sankyo Co Ltd | インデンストロール誘導体 |
| US5561122A (en) | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| US5811421A (en) | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
| US5886025A (en) * | 1997-03-06 | 1999-03-23 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| US6162930A (en) | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| US7001926B2 (en) * | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| WO2000048606A1 (en) * | 1999-02-18 | 2000-08-24 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
| JP4187441B2 (ja) * | 1999-09-17 | 2008-11-26 | ベイラー・ユニバーシテイ | インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤 |
| US7091240B2 (en) * | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| AU4352701A (en) | 2000-03-10 | 2001-09-24 | Univ Baylor | Tubulin binding ligands and corresponding prodrug constructs |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| US6838584B2 (en) * | 2001-05-10 | 2005-01-04 | Merck & Co., Inc. | Estrogen receptor modulators |
| US7011926B2 (en) * | 2001-10-11 | 2006-03-14 | Taiwan Semiconductor Manufacturing Co., Ltd. | Gap forming pattern fracturing method for forming optical proximity corrected masking layer |
| US6919324B2 (en) * | 2001-10-26 | 2005-07-19 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
| CA2512000C (en) * | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
| CA2531327A1 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | Compounds and therapeutical use thereof |
-
2006
- 2006-06-14 CA CA2611712A patent/CA2611712C/en not_active Expired - Lifetime
- 2006-06-14 ES ES06773214.9T patent/ES2551086T3/es not_active Expired - Lifetime
- 2006-06-14 US US11/454,074 patent/US7429681B2/en not_active Expired - Lifetime
- 2006-06-14 EP EP06773214.9A patent/EP1896391B1/en not_active Expired - Lifetime
- 2006-06-14 WO PCT/US2006/023251 patent/WO2006138427A2/en not_active Ceased
- 2006-06-14 JP JP2008517095A patent/JP5354775B2/ja not_active Expired - Fee Related
-
2008
- 2008-08-22 US US12/197,094 patent/US8394859B2/en active Active