JP2008546390A - 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 - Google Patents
分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 Download PDFInfo
- Publication number
- JP2008546390A JP2008546390A JP2008517126A JP2008517126A JP2008546390A JP 2008546390 A JP2008546390 A JP 2008546390A JP 2008517126 A JP2008517126 A JP 2008517126A JP 2008517126 A JP2008517126 A JP 2008517126A JP 2008546390 A JP2008546390 A JP 2008546390A
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nthi
- gene
- strain
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/285—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69121405P | 2005-06-16 | 2005-06-16 | |
| PCT/US2006/023428 WO2006138527A2 (en) | 2005-06-16 | 2006-06-15 | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012062469A Division JP2012120543A (ja) | 2005-06-16 | 2012-03-19 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008546390A true JP2008546390A (ja) | 2008-12-25 |
| JP2008546390A5 JP2008546390A5 (https=) | 2009-07-02 |
Family
ID=37057493
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517126A Pending JP2008546390A (ja) | 2005-06-16 | 2006-06-15 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2012062469A Pending JP2012120543A (ja) | 2005-06-16 | 2012-03-19 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2014095656A Pending JP2014147397A (ja) | 2005-06-16 | 2014-05-07 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2015224493A Pending JP2016054739A (ja) | 2005-06-16 | 2015-11-17 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2017000108A Pending JP2017074071A (ja) | 2005-06-16 | 2017-01-04 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012062469A Pending JP2012120543A (ja) | 2005-06-16 | 2012-03-19 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2014095656A Pending JP2014147397A (ja) | 2005-06-16 | 2014-05-07 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2015224493A Pending JP2016054739A (ja) | 2005-06-16 | 2015-11-17 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
| JP2017000108A Pending JP2017074071A (ja) | 2005-06-16 | 2017-01-04 | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US8283114B2 (https=) |
| EP (3) | EP1899366A2 (https=) |
| JP (5) | JP2008546390A (https=) |
| CA (2) | CA2871088A1 (https=) |
| WO (1) | WO2006138527A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
| EP1871888A4 (en) * | 2005-03-30 | 2013-08-21 | Novartis Vaccines & Diagnostic | HAEMOPHILUS INFLUENZAE OF TYPE B |
| US8785130B2 (en) * | 2005-07-07 | 2014-07-22 | Bio-Id Diagnostic Inc. | Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material |
| US9132183B2 (en) * | 2007-03-09 | 2015-09-15 | Newport Laboratories | Modified live (JMSO strain) Haemophilus parasuis vaccine |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| EP2405938A2 (en) * | 2009-02-13 | 2012-01-18 | Intercell AG | Nontypable haemophilus influenzae antigens |
| KR101334981B1 (ko) * | 2010-06-10 | 2013-12-02 | 한국과학기술원 | 탄화수소 생성능을 가지는 변이 미생물 및 이를 이용한 탄화수소의 제조방법 |
| EP3567121B1 (en) | 2011-01-17 | 2023-08-30 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
| ES2645953T3 (es) | 2011-01-17 | 2017-12-11 | Life Technologies Corporation | Ligamiento enzimático de ácidos nucleicos |
| US20120276145A1 (en) * | 2011-03-28 | 2012-11-01 | House Research Institute | Extracellular matrix proteins from haemophilus influenzae biofilms: targets for therapeutic or diagnostic use |
| SG194886A1 (en) * | 2011-05-11 | 2013-12-30 | Riesbeck Healthcare Sweden Ab | Protein f - a novel haemophilus influenzae adhesin with laminin and vitronectin binding properties |
| RU2727476C2 (ru) * | 2012-04-26 | 2020-07-21 | Новартис Аг | Антигены и антигенные композиции |
| WO2014138748A1 (en) | 2013-03-08 | 2014-09-12 | Research Institute At Nationwide Children's Hospital | Transcutaneous dosage formulation |
| US9052314B2 (en) | 2013-03-14 | 2015-06-09 | Silver Lake Research Corporation | Biomarkers for detecting the presence of bacteria |
| US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
| US11248040B2 (en) | 2013-09-26 | 2022-02-15 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| JP6754694B2 (ja) * | 2014-03-06 | 2020-09-16 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | プロバイオティクス製剤および使用のための方法 |
| US10624934B2 (en) | 2014-03-06 | 2020-04-21 | Research Institute At Nationwide Children's Hospital | Prebiotic formulations |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3307307A4 (en) * | 2015-06-09 | 2019-05-01 | The Board of Regents of the University of Oklahoma | COMPOSITIONS AND TREATMENTS FOR HAEMOPHILUS INFLUENZAE |
| WO2017023863A1 (en) | 2015-07-31 | 2017-02-09 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
| CN106567949A (zh) * | 2015-10-12 | 2017-04-19 | 海南广天恒科技发展有限公司 | 燃气阀专用限流装置 |
| EP3365027B1 (en) | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
| JP2019522675A (ja) * | 2016-04-27 | 2019-08-15 | ▲拝▼西欧斯(北京)生物技▲術▼有限公司 | 興奮製神経毒性に関連した損傷の治療方法 |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11564982B2 (en) | 2017-01-04 | 2023-01-31 | Research Institute At Nationwide Children's Hospital | DNABII vaccines and antibodies with enhanced activity |
| JP7661008B2 (ja) | 2017-01-04 | 2025-04-14 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | バイオフィルム関連障害の処置のための抗体断片 |
| CN111315287A (zh) * | 2017-05-18 | 2020-06-19 | 纽若蒂埃克斯有限公司 | 前庭声学信号处理 |
| CN107478627B (zh) * | 2017-08-30 | 2019-09-10 | 温州大学激光与光电智能制造研究院 | 基于荧光纤维丝示踪的壁湍流时空演化过程检测方法 |
| AU2019354829B2 (en) | 2018-10-05 | 2025-04-17 | Research Institute At Nationwide Children's Hospital | Hmgb1 protein derivatives for the removal of biofilms |
| EP3870154A4 (en) | 2018-10-22 | 2022-07-27 | Research Institute at Nationwide Children's Hospital | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ANTIBIOTIC-INDUCED PATHOLOGIES USING PROBIOTICS IN BIOFILM STATE |
| WO2020174044A1 (en) * | 2019-02-27 | 2020-09-03 | Evaxion Biotech Aps | Vaccines targeting h. influenzae |
| CN111693691B (zh) * | 2019-03-14 | 2023-09-05 | 天津华科泰生物技术有限公司 | 一种基于卟啉结构的聚合物标签 |
| EP3979830B1 (en) | 2019-06-03 | 2025-11-26 | Research Institute at Nationwide Children's Hospital | Formulations for the treatment of neurodevelopmental deficiencies induced by necrotizing enterocolitis |
| CN112575041B (zh) * | 2019-09-30 | 2022-12-13 | 江南大学 | 一种混合碳源高效发酵生产phb的工程菌及其应用 |
| US11624734B2 (en) * | 2020-06-29 | 2023-04-11 | Waters Technologies Corporation | Chromatographic dimension selection in multidimensional liquid chromatography |
| CN112808285B (zh) * | 2021-01-14 | 2023-08-04 | 武汉科技大学 | 一种非均相类芬顿催化剂及其制备方法和应用 |
| CN114574456B (zh) * | 2022-03-18 | 2022-08-12 | 华南理工大学 | 一种亚硝酸盐还原酶突变体及其编码基因和应用 |
| CN120775878A (zh) * | 2025-07-04 | 2025-10-14 | 华中农业大学 | 一种副猪革拉瑟氏菌高效转座突变系统及其构建方法与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078949A2 (en) * | 2003-03-06 | 2004-09-16 | Children's Hospital, Inc. | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996033276A1 (en) * | 1995-04-21 | 1996-10-24 | Human Genome Sciences, Inc. | NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF |
| DE19728833A1 (de) | 1997-07-05 | 1999-01-07 | Bayer Ag | Verfahren zur Beseitigung von Oberflächengewässer verschmutzenden organischen Flüssigkeiten |
| CA2671261A1 (en) | 1997-11-06 | 1999-05-20 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigens |
| EP1149164A2 (en) | 1999-01-22 | 2001-10-31 | SmithKline Beecham Biologics SA | Neisseria meningitidis polypeptides |
| US6605709B1 (en) * | 1999-04-09 | 2003-08-12 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics |
| GB0026002D0 (en) | 2000-10-24 | 2000-12-13 | Smithkline Beecham Biolog | Novel compounds |
| WO2004087749A2 (en) * | 2003-03-27 | 2004-10-14 | Children's Hospital, Inc. | Nontypeable haemophilus influenzae virulence factors |
| GB0410866D0 (en) * | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
-
2006
- 2006-06-15 CA CA2871088A patent/CA2871088A1/en not_active Abandoned
- 2006-06-15 EP EP06773314A patent/EP1899366A2/en not_active Withdrawn
- 2006-06-15 WO PCT/US2006/023428 patent/WO2006138527A2/en not_active Ceased
- 2006-06-15 US US11/917,368 patent/US8283114B2/en not_active Expired - Fee Related
- 2006-06-15 EP EP10176053A patent/EP2343312A1/en not_active Withdrawn
- 2006-06-15 JP JP2008517126A patent/JP2008546390A/ja active Pending
- 2006-06-15 EP EP08022435A patent/EP2070945A1/en not_active Withdrawn
- 2006-06-15 CA CA002612240A patent/CA2612240A1/en not_active Abandoned
-
2012
- 2012-03-19 JP JP2012062469A patent/JP2012120543A/ja active Pending
- 2012-09-12 US US13/612,176 patent/US8652773B2/en not_active Expired - Fee Related
-
2014
- 2014-01-09 US US14/151,227 patent/US9034642B2/en not_active Expired - Fee Related
- 2014-05-07 JP JP2014095656A patent/JP2014147397A/ja active Pending
-
2015
- 2015-04-15 US US14/687,548 patent/US20150218231A1/en not_active Abandoned
- 2015-11-17 JP JP2015224493A patent/JP2016054739A/ja active Pending
-
2016
- 2016-06-09 US US15/177,584 patent/US20160289278A1/en not_active Abandoned
-
2017
- 2017-01-04 JP JP2017000108A patent/JP2017074071A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078949A2 (en) * | 2003-03-06 | 2004-09-16 | Children's Hospital, Inc. | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130078254A1 (en) | 2013-03-28 |
| JP2016054739A (ja) | 2016-04-21 |
| JP2014147397A (ja) | 2014-08-21 |
| US9034642B2 (en) | 2015-05-19 |
| JP2017074071A (ja) | 2017-04-20 |
| US8652773B2 (en) | 2014-02-18 |
| WO2006138527A3 (en) | 2007-03-29 |
| US20160289278A1 (en) | 2016-10-06 |
| JP2012120543A (ja) | 2012-06-28 |
| WO2006138527A2 (en) | 2006-12-28 |
| US20140127221A1 (en) | 2014-05-08 |
| CA2612240A1 (en) | 2006-12-28 |
| US8283114B2 (en) | 2012-10-09 |
| US20110135646A1 (en) | 2011-06-09 |
| EP2343312A1 (en) | 2011-07-13 |
| EP2070945A1 (en) | 2009-06-17 |
| US20150218231A1 (en) | 2015-08-06 |
| EP1899366A2 (en) | 2008-03-19 |
| CA2871088A1 (en) | 2006-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017074071A (ja) | 分類不能型インフルエンザ菌の中耳炎単離物の遺伝子 | |
| JP2014132901A (ja) | 類型不能haemophilusinfluenzaeの中耳炎単離株の遺伝子 | |
| US7901692B2 (en) | Nontypeable Haemophilus influenzae virulence factors | |
| JP3440221B2 (ja) | アクチノバチルス・プレウロニウモニアからのタンパク質 | |
| JP2002233390A (ja) | 溶血素群毒素に関するN.meningitidis由来抗原性鉄抑制蛋白質 | |
| JP2001514894A (ja) | ナイセリア・ラクトフェリン結合プロテイン | |
| JP2005532789A (ja) | 減少した酵素活性を有する型別不能なインフルエンザ菌(Haemophilusinfluenza)のP4タンパク質の変異体 | |
| PL199497B1 (pl) | Wyizolowany polipeptyd, jego immunogenny fragment, wyizolowany polinukleotyd, wektor ekspresyjny, komórka gospodarza, błona komórki gospodarza, sposób wytwarzania polipeptydu lub immunogennego fragmentu, sposób wyrażania polinukleotydu, kompozycja szczepionki, przeciwciało, zastosowanie kompozycji zawierającej polipeptyd, zastosowanie kompozycji zawierającej polinukleotyd, kompozycja terapeutyczna oraz sposób diagnozowania zakażenia Moraxella catarrhalis | |
| WO2011137334A1 (en) | Compositions and methods for stimulating immune response against moraxella catarrhalis | |
| ES2239609T3 (es) | Antigen basb117 de moraxella catarrhalis. | |
| EP1923399A1 (en) | Genes of an otitis media isolate of nontypeable Haemophilus influenzae | |
| JP2003506043A (ja) | 新規化合物 | |
| JP2003506045A (ja) | モラクセラ・カタラーリス(Moraxellacatarrhalis)由来のBASB119ポリペプチドおよびポリヌクレオチド | |
| HK1118839A (en) | Genes of an otitis media isolate of nontypeable haemophilus influenzae | |
| HK1153757A (en) | Genes of an otitis media isolate of nontypeable haemophilus influenzae |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090513 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090513 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100507 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111020 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120119 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120126 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120217 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120224 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120319 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120703 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121102 |