JP2008545426A5 - - Google Patents
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- JP2008545426A5 JP2008545426A5 JP2008514187A JP2008514187A JP2008545426A5 JP 2008545426 A5 JP2008545426 A5 JP 2008545426A5 JP 2008514187 A JP2008514187 A JP 2008514187A JP 2008514187 A JP2008514187 A JP 2008514187A JP 2008545426 A5 JP2008545426 A5 JP 2008545426A5
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- JP
- Japan
- Prior art keywords
- tcr
- chain variable
- variable region
- seq
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091008153 T cell receptors Proteins 0.000 claims 29
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 29
- 230000000875 corresponding Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100014838 FCGRT Human genes 0.000 claims 1
- 101710003435 FCGRT Proteins 0.000 claims 1
- 102100020458 HLA-A Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 102100009727 TRBC1 Human genes 0.000 claims 1
- 101700083255 TRBC1 Proteins 0.000 claims 1
- 102100009726 TRBC2 Human genes 0.000 claims 1
- 101700003299 TRBC2 Proteins 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (15)
- Ｔ細胞レセプター(TCR)が、
(ｉ)少なくとも１つの相補性決定領域中又は少なくとも１つの可変領域フレームワーク領域中で天然型MEL TCRのα鎖可変領域(配列番号１)及び/又はβ鎖可変領域(配列番号２)に対して変異しており、
(ii)３μMより少ないか等しいAAGIGILTV−HLA-A*0201複合体に対するKD及び/又は１×10-3 Ｓ-1かそれより遅い解離速度(koff)を有することを特徴とするAAGIGILTV−HLA-A*0201への結合特性を有し且つ少なくとも１つのTCRα鎖可変ドメイン及び/又は少なくとも１つのTCRβ鎖可変ドメインを含有するTCR。 - α鎖可変ドメイン及びTCRβ鎖可変ドメインの両方を含有する請求項１に記載のTCR。
- 配列番号１に示される番号付けを用いてα鎖可変領域アミノ酸28D、29R、30G、31S、49M、51I、53S、54N、72Y、94V、95A、96G、97K、98S及び99Tの１又はそれより多くが変異している請求項１又は２に記載のTCR。
- 配列番号２に示される番号付けを用いてβ鎖可変領域アミノ酸45L、51S、52V、53G、54I、76I、100G、101T、102G、103E、104L及び105Fの１又はそれより多くが変異している請求項１〜３のいずれか１項に記載のTCR。
- 配列番号11〜24又は47〜53のα鎖可変領域アミノ酸配列の１つを含有する請求項１又は２に記載のTCR。
- 配列番号54〜67のβ鎖可変領域アミノ酸配列の１つを含有する請求項１、２及び５のいずれか１項に記載のTCR。
- 下記の表
- 配列番号25に示されるα鎖定常領域アミノ酸配列及び/又は配列番号26及び27に示されるβ鎖アミノ酸定常領域配列の一方を更に含有する請求項１〜７のいずれか１項に記載のTCR。
- 二量体Ｔ細胞レセプター(dTCR)又は単鎖Ｔ細胞レセプター(scTCR)である請求項１〜８のいずれか１項に記載のTCR。
- TCRα鎖可変領域配列に相当する配列がTCRα鎖定常ドメイン細胞外配列に相当する配列のＮ末端に融合した第１のポリペプチドと、
TCRβ鎖可変領域配列に相当する配列がTCRβ鎖定常ドメイン細胞外配列に相当する配列のＮ末端に融合した第２のポリペプチドと
を含有し、該第１のポリペプチド及び該第２のポリペプチドが、天然型αβＴ細胞レセプター中に等価物を有さないジスルフィド結合により連結し、TRAC * 01のエキソン１のThr 48及びTRBC1 * 01若しくはTRBC2 * 01のエキソン１のSer 57、又はこれらの非ヒト等価物から置換されたシステイン残基同士間にあるdTCRである請求項９に記載のTCR。 - 治療剤又は検出可能部分と組み合わされている請求項１〜１０のいずれか１項に記載のTCR。
- 前記治療剤が
(ｉ)免疫エフェクター分子、
(ii)サイトカイン若しくは放射性核種、又は
(iii)細胞毒性剤
である請求項１１に記載のTCR。 - 請求項１〜１２のいずれかに記載の少なくとも２つのTCRを含有する多価TCR複合体。
- 請求項１〜１０のいずれか１項に記載のTCRを提示する単離細胞。
- 請求項１〜１２のいずれか１項に記載のTCR若しくは請求項１３に記載の多価TCR複合体、又は請求項１４に記載の複数の細胞を、医薬的に許容されるキャリアと共に含有する医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0511124.0A GB0511124D0 (en) | 2005-06-01 | 2005-06-01 | High affinity melan-a t cell receptors |
| PCT/GB2006/001980 WO2006129085A2 (en) | 2005-06-01 | 2006-05-31 | High affinity melan-a t cell receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008545426A JP2008545426A (ja) | 2008-12-18 |
| JP2008545426A5 true JP2008545426A5 (ja) | 2009-07-09 |
Family
ID=34834931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514187A Pending JP2008545426A (ja) | 2005-06-01 | 2006-05-31 | 高親和性メラン−ａｔ細胞レセプター |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8217144B2 (ja) |
| EP (1) | EP1893642A2 (ja) |
| JP (1) | JP2008545426A (ja) |
| CN (1) | CN101189261B (ja) |
| AU (1) | AU2006253941B2 (ja) |
| BR (1) | BRPI0611326A2 (ja) |
| CA (1) | CA2610786A1 (ja) |
| EA (1) | EA012507B1 (ja) |
| GB (1) | GB0511124D0 (ja) |
| MX (1) | MX2007014919A (ja) |
| WO (1) | WO2006129085A2 (ja) |
| ZA (1) | ZA200710009B (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006036445A2 (en) | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
| US8088379B2 (en) * | 2006-09-26 | 2012-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified T cell receptors and related materials and methods |
| WO2008038002A2 (en) * | 2006-09-29 | 2008-04-03 | Medigene Limited | T cell therapies |
| US8119772B2 (en) * | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| GB0816096D0 (en) * | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| GB0911566D0 (en) | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| BR112013022557A2 (pt) * | 2011-03-04 | 2017-08-01 | Shire Human Genetic Therapies | ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| BR112014027374B1 (pt) | 2012-05-03 | 2022-05-31 | Fred Hutchinson Cancer Research Center | Método para gerar um receptor de células t (tcr) com afinidade aumentada |
| EP3505537A1 (en) | 2012-05-07 | 2019-07-03 | Trustees of Dartmouth College | Anti-b7-h6 antibody, fusion proteins, and methods of using the same |
| EP2892544A4 (en) | 2012-09-05 | 2016-11-02 | Univ Virginia Patent Found | TARGET PEPTIDES FOR THERAPY AND DIAGNOSIS OF COLORECTAL CARCINOMAS |
| JP6476182B2 (ja) | 2013-11-22 | 2019-02-27 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 改変された高親和性ヒトｔ細胞受容体 |
| EP3137100B1 (en) | 2014-04-15 | 2023-12-20 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
| EP2944652A1 (en) * | 2014-05-13 | 2015-11-18 | Technische Universität München | Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma |
| CA2955984A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| GB201417803D0 (en) * | 2014-10-08 | 2014-11-19 | Adaptimmune Ltd | T cell receptors |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516272D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| CA3025894A1 (en) | 2016-06-02 | 2017-12-07 | Immunocore Limited | Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein |
| GB201617714D0 (en) | 2016-10-19 | 2016-11-30 | Ucl Business Plc | T Cell receptor |
| EA201992131A1 (ru) * | 2017-03-15 | 2020-02-06 | Фред Хатчинсон Кэнсер Рисерч Сентер | Высокоаффинные специфичные к mage-a1 tcr и их применение |
| US11352389B2 (en) * | 2017-06-30 | 2022-06-07 | Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) | Treatment of haematological malignancies |
| EP3692058A1 (en) | 2017-10-06 | 2020-08-12 | Oslo Universitetssykehus HF | Chimeric antigen receptors |
| CN112646024B (zh) * | 2019-10-10 | 2023-03-24 | 香雪生命科学技术（广东）有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60203125T2 (de) | 2001-08-31 | 2006-04-06 | Avidex Ltd., Abingdon | Löslicher t zell rezeptor |
| US7751825B2 (en) | 2002-06-27 | 2010-07-06 | Qualcomm Incorporated | Controlling geographic location information of devices operating in wireless communication systems |
| NZ539225A (en) | 2002-10-09 | 2006-09-29 | Avidex Ltd | Single chain recombinant T cell receptors |
| ATE432290T1 (de) * | 2002-11-09 | 2009-06-15 | Immunocore Ltd | T ZELL REZEPTOR ßDISPLAYß |
| JP2006523437A (ja) * | 2002-12-03 | 2006-10-19 | アヴィデックス リミテッド | レセプター複合体 |
| EP1765860B1 (en) | 2004-05-19 | 2008-12-10 | MediGene Ltd. | High affinity ny-eso t cell receptor |
| DE602005009825D1 (de) * | 2004-05-19 | 2008-10-30 | Medigene Ltd | Verfahren zur verbesserung von t-zellrezeptoren |
-
2005
- 2005-06-01 GB GBGB0511124.0A patent/GB0511124D0/en not_active Ceased
-
2006
- 2006-05-31 EA EA200702677A patent/EA012507B1/ru not_active IP Right Cessation
- 2006-05-31 EP EP06744042A patent/EP1893642A2/en not_active Withdrawn
- 2006-05-31 MX MX2007014919A patent/MX2007014919A/es not_active Application Discontinuation
- 2006-05-31 AU AU2006253941A patent/AU2006253941B2/en not_active Ceased
- 2006-05-31 CA CA002610786A patent/CA2610786A1/en not_active Abandoned
- 2006-05-31 WO PCT/GB2006/001980 patent/WO2006129085A2/en active Application Filing
- 2006-05-31 JP JP2008514187A patent/JP2008545426A/ja active Pending
- 2006-05-31 US US11/915,766 patent/US8217144B2/en not_active Expired - Fee Related
- 2006-05-31 BR BRPI0611326-5A patent/BRPI0611326A2/pt not_active IP Right Cessation
- 2006-05-31 CN CN2006800195624A patent/CN101189261B/zh not_active Expired - Fee Related
-
2007
- 2007-11-20 ZA ZA200710009A patent/ZA200710009B/xx unknown
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