JP2008543911A - 非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 - Google Patents
非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 Download PDFInfo
- Publication number
- JP2008543911A JP2008543911A JP2008517445A JP2008517445A JP2008543911A JP 2008543911 A JP2008543911 A JP 2008543911A JP 2008517445 A JP2008517445 A JP 2008517445A JP 2008517445 A JP2008517445 A JP 2008517445A JP 2008543911 A JP2008543911 A JP 2008543911A
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- alkyl
- ethynyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UMQUGGIDFGVKGE-UHFFFAOYSA-N OC(CC1(CC1)c1cc(C(F)(F)F)ccc1F)(C(Nc(cc1CO2)ccc1C2=O)=O)C#Cc1ccccc1 Chemical compound OC(CC1(CC1)c1cc(C(F)(F)F)ccc1F)(C(Nc(cc1CO2)ccc1C2=O)=O)C#Cc1ccccc1 UMQUGGIDFGVKGE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005030294A DE102005030294A1 (de) | 2005-06-24 | 2005-06-24 | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| PCT/EP2006/006532 WO2006136462A1 (en) | 2005-06-24 | 2006-06-22 | Benzofuranone derivatives as nonsteroidal progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2008543911A true JP2008543911A (ja) | 2008-12-04 |
Family
ID=36716643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517445A Pending JP2008543911A (ja) | 2005-06-24 | 2006-06-22 | 非ステロイド性プロゲステロン受容体モジュレーターとしてのベンゾフラノン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1899315A1 (ru) |
| JP (1) | JP2008543911A (ru) |
| KR (1) | KR20080018275A (ru) |
| CN (1) | CN101248056A (ru) |
| AR (1) | AR057409A1 (ru) |
| AU (1) | AU2006261049A1 (ru) |
| BR (1) | BRPI0612305A2 (ru) |
| CA (1) | CA2611900A1 (ru) |
| CR (1) | CR9595A (ru) |
| DE (1) | DE102005030294A1 (ru) |
| DO (1) | DOP2006000150A (ru) |
| EA (1) | EA200702604A1 (ru) |
| EC (1) | ECSP078043A (ru) |
| GT (1) | GT200600272A (ru) |
| IL (1) | IL188022A0 (ru) |
| MX (1) | MX2008000070A (ru) |
| NO (1) | NO20080441L (ru) |
| PE (1) | PE20070170A1 (ru) |
| TW (1) | TW200738665A (ru) |
| UY (1) | UY29626A1 (ru) |
| WO (1) | WO2006136462A1 (ru) |
| ZA (1) | ZA200800689B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
| DE102007032800A1 (de) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| DE102007058747A1 (de) * | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| TWI477276B (zh) | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
| SG11201407397WA (en) | 2012-05-31 | 2014-12-30 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins |
| WO2014070517A1 (en) | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19723722A1 (de) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
| US6358948B1 (en) * | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| CA2371273A1 (en) * | 1999-05-04 | 2000-11-09 | Andrew Fensome | Tetracyclic progesterone receptor modulator compounds and methods |
| DE60309829T2 (de) * | 2002-01-14 | 2007-09-13 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Glucocorticoidmimetika, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische formulierungen und ihre verwendungen |
| PL372490A1 (en) * | 2002-03-11 | 2005-07-25 | Schering Aktiengesellschaft | 5-{2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino}-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy |
| DE10346939A1 (de) * | 2003-10-06 | 2005-05-19 | Schering Ag | Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
-
2005
- 2005-06-24 DE DE102005030294A patent/DE102005030294A1/de not_active Ceased
-
2006
- 2006-06-22 CN CNA2006800306699A patent/CN101248056A/zh active Pending
- 2006-06-22 KR KR1020087001789A patent/KR20080018275A/ko not_active Application Discontinuation
- 2006-06-22 JP JP2008517445A patent/JP2008543911A/ja active Pending
- 2006-06-22 BR BRPI0612305-8A patent/BRPI0612305A2/pt not_active Application Discontinuation
- 2006-06-22 AU AU2006261049A patent/AU2006261049A1/en not_active Abandoned
- 2006-06-22 EA EA200702604A patent/EA200702604A1/ru unknown
- 2006-06-22 EP EP06762405A patent/EP1899315A1/en not_active Withdrawn
- 2006-06-22 CA CA002611900A patent/CA2611900A1/en not_active Abandoned
- 2006-06-22 WO PCT/EP2006/006532 patent/WO2006136462A1/en active Application Filing
- 2006-06-22 MX MX2008000070A patent/MX2008000070A/es not_active Application Discontinuation
- 2006-06-23 TW TW095122741A patent/TW200738665A/zh unknown
- 2006-06-26 DO DO2006000150A patent/DOP2006000150A/es unknown
- 2006-06-26 UY UY29626A patent/UY29626A1/es not_active Application Discontinuation
- 2006-06-26 PE PE2006000732A patent/PE20070170A1/es not_active Application Discontinuation
- 2006-06-26 GT GT200600272A patent/GT200600272A/es unknown
- 2006-06-27 AR ARP060102752A patent/AR057409A1/es unknown
-
2007
- 2007-12-10 IL IL188022A patent/IL188022A0/en unknown
- 2007-12-14 CR CR9595A patent/CR9595A/es not_active Application Discontinuation
- 2007-12-21 EC EC2007008043A patent/ECSP078043A/es unknown
-
2008
- 2008-01-23 ZA ZA200800689A patent/ZA200800689B/xx unknown
- 2008-01-23 NO NO20080441A patent/NO20080441L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600272A (es) | 2007-08-20 |
| AR057409A1 (es) | 2007-12-05 |
| CN101248056A (zh) | 2008-08-20 |
| TW200738665A (en) | 2007-10-16 |
| DOP2006000150A (es) | 2006-12-31 |
| NO20080441L (no) | 2008-03-07 |
| EP1899315A1 (en) | 2008-03-19 |
| BRPI0612305A2 (pt) | 2010-11-03 |
| EA200702604A1 (ru) | 2008-06-30 |
| KR20080018275A (ko) | 2008-02-27 |
| CR9595A (es) | 2008-05-05 |
| WO2006136462A1 (en) | 2006-12-28 |
| MX2008000070A (es) | 2008-03-19 |
| IL188022A0 (en) | 2008-03-20 |
| UY29626A1 (es) | 2007-01-31 |
| AU2006261049A1 (en) | 2006-12-28 |
| ECSP078043A (es) | 2008-01-23 |
| PE20070170A1 (es) | 2007-03-02 |
| ZA200800689B (en) | 2009-07-29 |
| CA2611900A1 (en) | 2006-12-28 |
| DE102005030294A1 (de) | 2007-01-04 |
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