JP2008540655A5 - - Google Patents
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- Publication number
- JP2008540655A5 JP2008540655A5 JP2008512374A JP2008512374A JP2008540655A5 JP 2008540655 A5 JP2008540655 A5 JP 2008540655A5 JP 2008512374 A JP2008512374 A JP 2008512374A JP 2008512374 A JP2008512374 A JP 2008512374A JP 2008540655 A5 JP2008540655 A5 JP 2008540655A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- contacting
- cyclopropyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 10
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000012320 chlorinating reagent Substances 0.000 claims description 4
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 238000005906 dihydroxylation reaction Methods 0.000 claims description 2
- 239000007800 oxidant agent Substances 0.000 claims description 2
- 150000004968 peroxymonosulfuric acids Chemical class 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68129805P | 2005-05-16 | 2005-05-16 | |
| US60/681,298 | 2005-05-16 | ||
| PCT/US2006/018522 WO2006124657A1 (en) | 2005-05-16 | 2006-05-12 | Method for preparing substituted pyrimidines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540655A JP2008540655A (ja) | 2008-11-20 |
| JP2008540655A5 true JP2008540655A5 (https=) | 2009-07-02 |
| JP5069677B2 JP5069677B2 (ja) | 2012-11-07 |
Family
ID=36867439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512374A Expired - Fee Related JP5069677B2 (ja) | 2005-05-16 | 2006-05-12 | 置換ピリミジンの製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8013155B2 (https=) |
| EP (1) | EP1888536B1 (https=) |
| JP (1) | JP5069677B2 (https=) |
| KR (1) | KR101348458B1 (https=) |
| CN (1) | CN101175730B (https=) |
| AT (1) | ATE465999T1 (https=) |
| AU (1) | AU2006247581B2 (https=) |
| BR (1) | BRPI0612414A2 (https=) |
| DE (1) | DE602006013970D1 (https=) |
| IL (1) | IL185884A (https=) |
| PL (1) | PL1888536T3 (https=) |
| WO (1) | WO2006124657A1 (https=) |
| ZA (1) | ZA200707974B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20105099B (en) * | 2005-05-06 | 2010-10-25 | Du Pont | Method for preparation of optionally 2-substituted 1,6- dihydrocarboxil acids |
| KR20090024120A (ko) * | 2006-04-10 | 2009-03-06 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 제초성 혼합물 |
| WO2013124246A1 (de) | 2012-02-22 | 2013-08-29 | Bayer Intellectual Property Gmbh | Herbizid wirksame 4-dialkoxymethyl-2-phenylpyrimidine |
| CN102977050B (zh) * | 2012-11-20 | 2015-04-22 | 浙江工业大学 | 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法 |
| CN116063179A (zh) * | 2023-02-20 | 2023-05-05 | 南京杰运医药科技有限公司 | 一种4-甲氧基乙酰乙酸甲酯的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA207185A (en) | 1921-01-04 | C. Wagner Virgil | Warming plate | |
| GB2095240A (en) * | 1981-03-05 | 1982-09-29 | Fujisawa Pharmaceutical Co | Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| JPS57158779A (en) * | 1981-03-05 | 1982-09-30 | Fujisawa Pharmaceut Co Ltd | Dihydropyrimidine derivative and its salt, their preparation and antiallergic containing the same |
| DE3935277A1 (de) | 1989-10-24 | 1991-05-02 | Hoechst Ag | Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren |
| CN1071049A (zh) * | 1991-10-09 | 1993-04-21 | 纳幕尔杜邦公司 | 用于稻中杂草防治的除草剂 |
| BR9908004A (pt) | 1998-02-17 | 2001-12-18 | Tularik Inc | Composto, composição e método para prevençãoou supressão de uma infecção viral |
| ES2240093T3 (es) | 1999-04-15 | 2005-10-16 | Basf Aktiengesellschaft | Procedimiento para la preparacion de pirimidinas substituidas. |
| AU2002258400A1 (en) | 2001-02-16 | 2002-08-28 | Tularik Inc. | Methods of using pyrimidine-based antiviral agents |
| DE602004022819D1 (de) | 2003-06-06 | 2009-10-08 | Vertex Pharma | Von atp-bindende kassette transportern |
| TWI355894B (en) * | 2003-12-19 | 2012-01-11 | Du Pont | Herbicidal pyrimidines |
| GEP20105099B (en) * | 2005-05-06 | 2010-10-25 | Du Pont | Method for preparation of optionally 2-substituted 1,6- dihydrocarboxil acids |
-
2006
- 2006-05-12 JP JP2008512374A patent/JP5069677B2/ja not_active Expired - Fee Related
- 2006-05-12 US US11/886,653 patent/US8013155B2/en not_active Expired - Fee Related
- 2006-05-12 KR KR1020077029280A patent/KR101348458B1/ko not_active Expired - Fee Related
- 2006-05-12 PL PL06759727T patent/PL1888536T3/pl unknown
- 2006-05-12 CN CN2006800169422A patent/CN101175730B/zh not_active Expired - Fee Related
- 2006-05-12 WO PCT/US2006/018522 patent/WO2006124657A1/en not_active Ceased
- 2006-05-12 ZA ZA200707974A patent/ZA200707974B/xx unknown
- 2006-05-12 BR BRPI0612414-3A patent/BRPI0612414A2/pt not_active Application Discontinuation
- 2006-05-12 AU AU2006247581A patent/AU2006247581B2/en not_active Ceased
- 2006-05-12 AT AT06759727T patent/ATE465999T1/de not_active IP Right Cessation
- 2006-05-12 EP EP06759727A patent/EP1888536B1/en not_active Not-in-force
- 2006-05-12 DE DE602006013970T patent/DE602006013970D1/de active Active
-
2007
- 2007-09-10 IL IL185884A patent/IL185884A/en not_active IP Right Cessation
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