CN101175730B - 制备取代嘧啶的方法 - Google Patents

制备取代嘧啶的方法 Download PDF

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Publication number
CN101175730B
CN101175730B CN2006800169422A CN200680016942A CN101175730B CN 101175730 B CN101175730 B CN 101175730B CN 2006800169422 A CN2006800169422 A CN 2006800169422A CN 200680016942 A CN200680016942 A CN 200680016942A CN 101175730 B CN101175730 B CN 101175730B
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CN
China
Prior art keywords
compound
formula
alkyl
prc
solvent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2006800169422A
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English (en)
Chinese (zh)
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CN101175730A (zh
Inventor
G·D·安尼斯
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EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
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Publication of CN101175730A publication Critical patent/CN101175730A/zh
Application granted granted Critical
Publication of CN101175730B publication Critical patent/CN101175730B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2006800169422A 2005-05-16 2006-05-12 制备取代嘧啶的方法 Expired - Fee Related CN101175730B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68129805P 2005-05-16 2005-05-16
US60/681,298 2005-05-16
PCT/US2006/018522 WO2006124657A1 (en) 2005-05-16 2006-05-12 Method for preparing substituted pyrimidines

Publications (2)

Publication Number Publication Date
CN101175730A CN101175730A (zh) 2008-05-07
CN101175730B true CN101175730B (zh) 2011-05-25

Family

ID=36867439

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800169422A Expired - Fee Related CN101175730B (zh) 2005-05-16 2006-05-12 制备取代嘧啶的方法

Country Status (13)

Country Link
US (1) US8013155B2 (https=)
EP (1) EP1888536B1 (https=)
JP (1) JP5069677B2 (https=)
KR (1) KR101348458B1 (https=)
CN (1) CN101175730B (https=)
AT (1) ATE465999T1 (https=)
AU (1) AU2006247581B2 (https=)
BR (1) BRPI0612414A2 (https=)
DE (1) DE602006013970D1 (https=)
IL (1) IL185884A (https=)
PL (1) PL1888536T3 (https=)
WO (1) WO2006124657A1 (https=)
ZA (1) ZA200707974B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20105099B (en) * 2005-05-06 2010-10-25 Du Pont Method for preparation of optionally 2-substituted 1,6- dihydrocarboxil acids
KR20090024120A (ko) * 2006-04-10 2009-03-06 이 아이 듀폰 디 네모아 앤드 캄파니 제초성 혼합물
WO2013124246A1 (de) 2012-02-22 2013-08-29 Bayer Intellectual Property Gmbh Herbizid wirksame 4-dialkoxymethyl-2-phenylpyrimidine
CN102977050B (zh) * 2012-11-20 2015-04-22 浙江工业大学 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法
CN116063179A (zh) * 2023-02-20 2023-05-05 南京杰运医药科技有限公司 一种4-甲氧基乙酰乙酸甲酯的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095240A (en) * 1981-03-05 1982-09-29 Fujisawa Pharmaceutical Co Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
CN1071049A (zh) * 1991-10-09 1993-04-21 纳幕尔杜邦公司 用于稻中杂草防治的除草剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
JPS57158779A (en) * 1981-03-05 1982-09-30 Fujisawa Pharmaceut Co Ltd Dihydropyrimidine derivative and its salt, their preparation and antiallergic containing the same
DE3935277A1 (de) 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
BR9908004A (pt) 1998-02-17 2001-12-18 Tularik Inc Composto, composição e método para prevençãoou supressão de uma infecção viral
ES2240093T3 (es) 1999-04-15 2005-10-16 Basf Aktiengesellschaft Procedimiento para la preparacion de pirimidinas substituidas.
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
DE602004022819D1 (de) 2003-06-06 2009-10-08 Vertex Pharma Von atp-bindende kassette transportern
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
GEP20105099B (en) * 2005-05-06 2010-10-25 Du Pont Method for preparation of optionally 2-substituted 1,6- dihydrocarboxil acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095240A (en) * 1981-03-05 1982-09-29 Fujisawa Pharmaceutical Co Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
CN1071049A (zh) * 1991-10-09 1993-04-21 纳幕尔杜邦公司 用于稻中杂草防治的除草剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chidambaram N. et al.A highly selective methodology for the direct conversion ofacetals to esters.J. Org. Chem.57 18.1992,57(18),5013-5015.
Chidambaram N. et al.A highly selective methodology for the direct conversion ofacetals to esters.J. Org. Chem.57 18.1992,57(18),5013-5015. *
Karimi et al.Efficient aerobic oxidation of acetals to esters catalysed by N-hydroxyphthalimide and Co(Ⅱ) under mild conditions.Synthesis15.2003,152373-2377. *

Also Published As

Publication number Publication date
IL185884A0 (en) 2008-01-06
DE602006013970D1 (de) 2010-06-10
EP1888536A1 (en) 2008-02-20
IL185884A (en) 2012-03-29
JP5069677B2 (ja) 2012-11-07
ATE465999T1 (de) 2010-05-15
BRPI0612414A2 (pt) 2010-11-09
US20090054647A1 (en) 2009-02-26
AU2006247581A1 (en) 2006-11-23
EP1888536B1 (en) 2010-04-28
CN101175730A (zh) 2008-05-07
US8013155B2 (en) 2011-09-06
JP2008540655A (ja) 2008-11-20
AU2006247581B2 (en) 2011-10-20
KR101348458B1 (ko) 2014-01-07
KR20080016640A (ko) 2008-02-21
WO2006124657A1 (en) 2006-11-23
ZA200707974B (en) 2008-11-26
PL1888536T3 (pl) 2010-09-30

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SE01 Entry into force of request for substantive examination
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Granted publication date: 20110525

Termination date: 20170512