JP2008540506A5 - - Google Patents
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- Publication number
- JP2008540506A5 JP2008540506A5 JP2008510670A JP2008510670A JP2008540506A5 JP 2008540506 A5 JP2008540506 A5 JP 2008540506A5 JP 2008510670 A JP2008510670 A JP 2008510670A JP 2008510670 A JP2008510670 A JP 2008510670A JP 2008540506 A5 JP2008540506 A5 JP 2008540506A5
- Authority
- JP
- Japan
- Prior art keywords
- antifungal agent
- active substance
- therapeutically active
- mixtures
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 239000013543 active substance Substances 0.000 claims 13
- 229940121375 antifungal agent Drugs 0.000 claims 12
- 239000003429 antifungal agent Substances 0.000 claims 12
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims 12
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims 6
- 239000005770 Eugenol Substances 0.000 claims 6
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims 6
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims 6
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims 6
- 235000007746 carvacrol Nutrition 0.000 claims 6
- 229960002217 eugenol Drugs 0.000 claims 6
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 6
- 229960004884 fluconazole Drugs 0.000 claims 6
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims 6
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical group NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims 4
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 4
- 229960004740 voriconazole Drugs 0.000 claims 4
- PSQYTAPXSHCGMF-BQYQJAHWSA-N β-ionone Chemical compound CC(=O)\C=C\C1=C(C)CCCC1(C)C PSQYTAPXSHCGMF-BQYQJAHWSA-N 0.000 claims 4
- 229960004413 flucytosine Drugs 0.000 claims 3
- SFEOKXHPFMOVRM-UHFFFAOYSA-N (+)-(S)-gamma-ionone Natural products CC(=O)C=CC1C(=C)CCCC1(C)C SFEOKXHPFMOVRM-UHFFFAOYSA-N 0.000 claims 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims 2
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 2
- 108010049047 Echinocandins Proteins 0.000 claims 2
- 239000005844 Thymol Substances 0.000 claims 2
- UZFLPKAIBPNNCA-UHFFFAOYSA-N alpha-ionone Natural products CC(=O)C=CC1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-UHFFFAOYSA-N 0.000 claims 2
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 claims 2
- 150000003851 azoles Chemical class 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229940116229 borneol Drugs 0.000 claims 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims 2
- 229960004130 itraconazole Drugs 0.000 claims 2
- 150000003230 pyrimidines Chemical class 0.000 claims 2
- 229960000790 thymol Drugs 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 108010020326 Caspofungin Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims 1
- 229960003034 caspofungin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2005/001317 WO2006120496A1 (fr) | 2005-05-13 | 2005-05-13 | Combinaison pharmaceutique comprenant un agent antifongique et un actif choisi parmi le carveol, l’ eugenol, le thymol, le borneol, et le carvacrol |
| IBPCT/IB2005/001317 | 2005-05-13 | ||
| PCT/IB2006/001329 WO2006120565A2 (fr) | 2005-05-13 | 2006-05-15 | Combinaison pharmaceutique comprenant un agent antifongique et un actif choisi parmi le carveol, l'eugenol, le thymol, le borneol, le carvacrol, et les i0n0nes alpha- et beta-. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540506A JP2008540506A (ja) | 2008-11-20 |
| JP2008540506A5 true JP2008540506A5 (enExample) | 2009-07-02 |
| JP5410747B2 JP5410747B2 (ja) | 2014-02-05 |
Family
ID=35427301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510670A Expired - Fee Related JP5410747B2 (ja) | 2005-05-13 | 2006-05-15 | 抗真菌剤およびカルベオール、オイゲノール、チモール、ボルネオール、カルバクロール、ならびにアルファ−およびベータ−イオノンから選択される活性物質を含んでなる製薬組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080214568A1 (enExample) |
| EP (1) | EP1879654B1 (enExample) |
| JP (1) | JP5410747B2 (enExample) |
| CN (1) | CN101189044B (enExample) |
| BR (1) | BRPI0610132B8 (enExample) |
| CA (1) | CA2607561C (enExample) |
| DK (1) | DK1879654T3 (enExample) |
| EA (1) | EA014068B1 (enExample) |
| ES (1) | ES2390472T3 (enExample) |
| MA (1) | MA29907B1 (enExample) |
| PT (1) | PT1879654E (enExample) |
| TN (1) | TNSN07425A1 (enExample) |
| WO (2) | WO2006120496A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005289313B2 (en) | 2004-09-28 | 2012-02-09 | Avivagen Inc. | Compositions and methods for promoting weight gain and feed conversion |
| DK2214656T3 (en) * | 2007-10-26 | 2019-03-25 | Avivagen Inc | COMPOSITIONS AND PROCEDURES TO ENHANCE IMMUNE RESPONSE |
| AU2010242502B2 (en) | 2009-04-30 | 2016-11-10 | Avivagen Inc. | Methods and compositions for improving the health of animals |
| JP5844260B2 (ja) | 2009-09-24 | 2016-01-13 | ユニリーバー・ナームローゼ・ベンノートシヤープ | オイゲノール、テルピネオールおよびチモールを含む殺菌剤 |
| CN102550610B (zh) * | 2010-12-07 | 2014-12-10 | 菲勒斯株式会社 | 含有从红松球果中提取的植物杀菌素的天然抗菌剂及包含它的水果病害防除原料 |
| US9408870B2 (en) | 2010-12-07 | 2016-08-09 | Conopco, Inc. | Oral care composition |
| EP2672845A2 (en) * | 2011-02-07 | 2013-12-18 | Firmenich SA | Antifungal flavouring ingredients and compositions |
| EA024551B1 (ru) | 2011-11-03 | 2016-09-30 | Юнилевер Н.В. | Индивидуальная композиция для очищения |
| JP5925605B2 (ja) * | 2012-06-04 | 2016-05-25 | 花王株式会社 | リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤 |
| CA2963923A1 (en) | 2014-10-08 | 2016-04-14 | Pacific Northwest Research Institute | Methods and compounds for increasing the potency of antifungal agents |
| CN104642326B (zh) * | 2015-02-16 | 2016-02-10 | 河南科技学院 | 一种含戊苯吡菌胺和香芹酚的杀菌组合物及其用途 |
| MA44286A (fr) | 2016-06-02 | 2019-01-09 | Advanced Scient Developements | Formulation pharmaceutique de cinéol et d'amoxicilline |
| US10918647B2 (en) | 2016-07-26 | 2021-02-16 | University Of Southern California | Selective bromodomain inhibition of fungal Bdf1 |
| CN113116916B (zh) * | 2021-05-25 | 2023-07-04 | 河北医科大学第二医院 | 一种治疗妇科疾病的药物组合物及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5294645A (en) * | 1993-06-14 | 1994-03-15 | Doyle E. Chastain | Using menth-1-en-9-ol to kill bacteria, yeast, and fungi |
| CA2106032C (en) * | 1993-09-13 | 1995-11-07 | Gamini Weeratunga | Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole |
| DE69526216T2 (de) * | 1994-01-14 | 2002-11-14 | Xoma Technology Ltd., Berkeley | Antifungaleverfahren und mitteln |
| CA2224227A1 (en) * | 1995-06-07 | 1996-12-19 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US6319507B1 (en) * | 1997-05-02 | 2001-11-20 | Kobo Products, Inc. | Agar gel bead composition and method |
| US6414036B1 (en) * | 1999-09-01 | 2002-07-02 | Van Beek Global/Ninkov Llc | Composition for treatment of infections of humans and animals |
| AU2002217316A1 (en) * | 2001-01-03 | 2002-07-30 | Medpharma Plc | Use of terpenes for the treatment of digestive tract infections |
| JP2002284702A (ja) * | 2001-01-19 | 2002-10-03 | Teika Seiyaku Kk | 外用抗真菌製剤 |
| US20030064948A1 (en) * | 2001-02-08 | 2003-04-03 | Alfred Fahr | Invasomes for therapy of disorders, their preparation and use |
| JP2002363070A (ja) * | 2001-06-06 | 2002-12-18 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収貼付剤 |
| US20040071757A1 (en) * | 2001-11-20 | 2004-04-15 | David Rolf | Inhalation antiviral patch |
| AU2002360517A1 (en) * | 2001-12-07 | 2003-06-23 | Ximed Group Plc | Respiratory infection prevention and treatment with terpene-containing compositions |
| US20030225003A1 (en) * | 2002-04-18 | 2003-12-04 | Dusan Ninkov | Antimicrobial therapeutic compositions for oral and topical use |
| US20040151771A1 (en) * | 2003-02-04 | 2004-08-05 | Gin Jerry B. | Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth |
| WO2004089357A2 (en) * | 2003-04-02 | 2004-10-21 | Regents Of The University Of Minnesota | Anti-fungal formulation of triterpene and essential oil |
-
2005
- 2005-05-13 WO PCT/IB2005/001317 patent/WO2006120496A1/fr not_active Ceased
-
2006
- 2006-05-15 BR BRPI0610132A patent/BRPI0610132B8/pt not_active IP Right Cessation
- 2006-05-15 US US11/914,005 patent/US20080214568A1/en not_active Abandoned
- 2006-05-15 ES ES06744740T patent/ES2390472T3/es active Active
- 2006-05-15 EP EP06744740A patent/EP1879654B1/fr not_active Not-in-force
- 2006-05-15 DK DK06744740.9T patent/DK1879654T3/da active
- 2006-05-15 WO PCT/IB2006/001329 patent/WO2006120565A2/fr not_active Ceased
- 2006-05-15 CN CN2006800164908A patent/CN101189044B/zh not_active Expired - Fee Related
- 2006-05-15 PT PT06744740T patent/PT1879654E/pt unknown
- 2006-05-15 EA EA200702482A patent/EA014068B1/ru not_active IP Right Cessation
- 2006-05-15 JP JP2008510670A patent/JP5410747B2/ja not_active Expired - Fee Related
- 2006-05-15 CA CA2607561A patent/CA2607561C/fr not_active Expired - Fee Related
-
2007
- 2007-11-13 TN TNP2007000425A patent/TNSN07425A1/fr unknown
- 2007-12-28 MA MA30529A patent/MA29907B1/fr unknown
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