JP2008538700A5 - - Google Patents
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- Publication number
- JP2008538700A5 JP2008538700A5 JP2008508001A JP2008508001A JP2008538700A5 JP 2008538700 A5 JP2008538700 A5 JP 2008538700A5 JP 2008508001 A JP2008508001 A JP 2008508001A JP 2008508001 A JP2008508001 A JP 2008508001A JP 2008538700 A5 JP2008538700 A5 JP 2008538700A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- endosialin
- cell
- out anti
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 38
- 210000004962 mammalian cell Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 15
- 102100038083 Endosialin Human genes 0.000 claims 12
- 101710144543 Endosialin Proteins 0.000 claims 12
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 230000000973 chemotherapeutic effect Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012642 immune effector Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 210000000628 antibody-producing cell Anatomy 0.000 description 3
- 241000699800 Cricetinae Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 241000282552 Chlorocebus aethiops Species 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 241000256251 Spodoptera frugiperda Species 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000003098 myoblast Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000000717 sertoli cell Anatomy 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67434405P | 2005-04-22 | 2005-04-22 | |
| PCT/US2006/015724 WO2006116451A2 (en) | 2005-04-22 | 2006-04-24 | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290448A Division JP2012100676A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538700A JP2008538700A (ja) | 2008-11-06 |
| JP2008538700A5 true JP2008538700A5 (enExample) | 2009-07-02 |
Family
ID=37215438
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508001A Pending JP2008538700A (ja) | 2005-04-22 | 2006-04-24 | 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 |
| JP2011290448A Pending JP2012100676A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290448A Pending JP2012100676A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7615372B2 (enExample) |
| EP (1) | EP1871809A2 (enExample) |
| JP (2) | JP2008538700A (enExample) |
| AU (1) | AU2006241235B2 (enExample) |
| CA (1) | CA2607455A1 (enExample) |
| WO (1) | WO2006116451A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005011735A1 (en) * | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| DE602005022757D1 (de) * | 2004-12-03 | 2010-09-16 | Morphotek Inc | Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen |
| EP1871809A2 (en) | 2005-04-22 | 2008-01-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| HUE031269T2 (en) | 2007-04-05 | 2017-06-28 | Morphotek Inc | Methods for inhibiting the binding of endosial ligands |
| WO2010037124A1 (en) * | 2008-09-29 | 2010-04-01 | The Trustees Of The University Of Pennsylvania | Tumor vascular marker-targeted vaccines |
| US20100260769A1 (en) * | 2009-04-09 | 2010-10-14 | Morphotek, Inc. | Endosialin binding molecules |
| JP2013543379A (ja) | 2010-09-29 | 2013-12-05 | モルフォテック， インコーポレイテッド | 操作されたヒトエンドシアリン発現齧歯動物 |
| NL2007179C2 (en) | 2011-07-26 | 2013-01-29 | Stichting Katholieke Universiteit | Chitosan-based hydrogels containing enzyme alkaline phosphatase. |
| HK1219980A1 (zh) | 2013-03-09 | 2017-04-21 | Baylor College Of Medicine | 靶向血管的t细胞疗法 |
| GB201702926D0 (en) * | 2017-02-23 | 2017-04-12 | Univ Birmingham | Modulators |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5342757A (en) * | 1992-11-13 | 1994-08-30 | Ludwig Institute For Cancer Research | Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof |
| EP0686260B1 (en) * | 1993-02-05 | 2003-07-09 | Epigen, Inc. | Human carcinoma antigen (hca), hca antibodies, hca immunoassays, methods of imaging and therapy |
| DE4335025A1 (de) * | 1993-10-14 | 1995-04-20 | Boehringer Ingelheim Int | Endosomolytisch wirksame Partikel |
| WO1995024483A1 (en) | 1994-03-08 | 1995-09-14 | Scotgen Biopharmaceuticals, Inc. | Recombinant humanized anti-fb5 antibodies |
| DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
| US6146894A (en) | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
| CA2355337A1 (en) | 1998-09-09 | 2000-03-16 | U.S. Army Institute Of Surgical Research | Method for monitoring arterial oxygen saturation |
| US20040048254A1 (en) * | 2000-03-15 | 2004-03-11 | Alexander Olek | Diagnosis of diseases associated with tumor supressor genes and oncogenes |
| US7402660B2 (en) | 2000-08-02 | 2008-07-22 | The Johns Hopkins University | Endothelial cell expression patterns |
| ATE501635T1 (de) | 2001-01-15 | 2011-04-15 | Morphotek Inc | Chemische hemmstoffe des mismatch-repair |
| US20040043928A1 (en) * | 2001-08-02 | 2004-03-04 | Ramesh Kekuda | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20030124579A1 (en) * | 2001-09-05 | 2003-07-03 | Eos Biotechnology, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US20040014058A1 (en) * | 2001-10-05 | 2004-01-22 | Alsobrook John P. | Novel human proteins, polynucleotides encoding them and methods of using the same |
| EP1576131A4 (en) * | 2002-08-15 | 2008-08-13 | Genzyme Corp | EXPRESSION PATTERN IN BRAIN DENTHELIC CELLS |
| AU2003298786A1 (en) * | 2002-11-26 | 2004-06-18 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| BRPI0409575A (pt) * | 2003-03-04 | 2006-04-18 | Kirin Brewery | anticorpos especìficos às células endoteliais e usos dos mesmos |
| US6905082B1 (en) * | 2003-12-05 | 2005-06-14 | Sheng Li Wu | Sprayer device having buffering structure |
| WO2005086713A2 (en) | 2004-03-04 | 2005-09-22 | Kirin Brewery Co., Ltd. | Role of human endothelial precursor cells and vascular pericytes tumor in angiogenesis |
| WO2006017759A2 (en) | 2004-08-05 | 2006-02-16 | Kirin Brewery Co., Ltd. | Tumor endothelial marker-1 (tem1) binding antibodies and uses thereof |
| WO2006029045A2 (en) | 2004-09-03 | 2006-03-16 | Kirin Brewery Co., Ltd. | Endothelial cell specific antibodies and uses thereof |
| WO2006032705A2 (en) * | 2004-09-23 | 2006-03-30 | Guerbet | Contrast agents encapsulating systems for cest imaging |
| DE602005022757D1 (de) | 2004-12-03 | 2010-09-16 | Morphotek Inc | Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen |
| US7998695B2 (en) * | 2005-02-10 | 2011-08-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| EP1871809A2 (en) | 2005-04-22 | 2008-01-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| DE102005050933A1 (de) * | 2005-10-21 | 2007-04-26 | Justus-Liebig-Universität Giessen | Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen |
| US7908090B2 (en) * | 2005-11-30 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Signatures for human aging |
| JP2009523709A (ja) * | 2005-12-16 | 2009-06-25 | ジェネンテック・インコーポレーテッド | 神経膠腫の診断、予後の予測及び治療の方法 |
| WO2008084331A2 (en) | 2006-06-21 | 2008-07-17 | Hopitaux Universitaires De Geneve | Biomarkers for renal disorders |
| US20090239223A1 (en) * | 2006-07-13 | 2009-09-24 | Siemens Healthcare Diagnostics Inc. | Prediction of Breast Cancer Response to Taxane-Based Chemotherapy |
| US20090176656A1 (en) * | 2006-07-21 | 2009-07-09 | Halloran Philip F | Tissue rejection |
| ES2548690T3 (es) | 2006-08-11 | 2015-10-20 | Johns Hopkins University | Secuencias consenso de codificación de cánceres colorrectales humanos |
| US20080300170A1 (en) * | 2006-09-01 | 2008-12-04 | Cohava Gelber | Compositions and methods for diagnosis and treatment for type 2 diabetes |
| US20100092476A1 (en) * | 2006-11-17 | 2010-04-15 | Hanash Samir M | Pancreatic cancer biomarkers |
| US20110119776A1 (en) | 2007-02-05 | 2011-05-19 | Wong Kwok-Kin | Methods of diagnosing and prognosing lung cancer |
| WO2008101118A2 (en) | 2007-02-14 | 2008-08-21 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | A gene expression signature identifying pro-angiogenic genes in ovarian tumor endothelial cell isolates |
| HUE031269T2 (en) * | 2007-04-05 | 2017-06-28 | Morphotek Inc | Methods for inhibiting the binding of endosial ligands |
| EP1986010A1 (en) | 2007-04-05 | 2008-10-29 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Methods and tools for discriminating colorectal adenomas and adenocarcinomas |
| EP2696203A3 (en) | 2007-08-16 | 2014-05-28 | The Royal Institution for the Advancement of Learning/McGill University | Tumor cell-derived microvesicles |
| BRPI0907050B1 (pt) * | 2008-02-01 | 2022-03-22 | The General Hospital Corporation | Método para detectar em um indivíduo a presença ou ausência de um ácido nucleico biomarcador predeterminado associado com câncer de próstata |
| EP2250287B1 (en) | 2008-02-19 | 2013-09-18 | MDxHealth SA | Detection and prognosis of lung cancer |
| WO2009120877A2 (en) | 2008-03-26 | 2009-10-01 | The Johns Hopkins University | Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| US20110256560A1 (en) | 2008-10-20 | 2011-10-20 | University Health Network | Methods and compositions for the detection of ovarian cancer |
| CA2749601C (en) | 2009-01-14 | 2020-07-21 | Stephen M. Hewitt | Ratio based biomarkers and methods of use thereof |
| US20100260769A1 (en) * | 2009-04-09 | 2010-10-14 | Morphotek, Inc. | Endosialin binding molecules |
-
2006
- 2006-04-24 EP EP06769889A patent/EP1871809A2/en not_active Withdrawn
- 2006-04-24 AU AU2006241235A patent/AU2006241235B2/en active Active
- 2006-04-24 WO PCT/US2006/015724 patent/WO2006116451A2/en not_active Ceased
- 2006-04-24 JP JP2008508001A patent/JP2008538700A/ja active Pending
- 2006-04-24 US US11/410,472 patent/US7615372B2/en active Active
- 2006-04-24 CA CA002607455A patent/CA2607455A1/en not_active Abandoned
-
2009
- 2009-09-30 US US12/570,334 patent/US8389691B2/en active Active
-
2011
- 2011-12-29 JP JP2011290448A patent/JP2012100676A/ja active Pending
-
2012
- 2012-11-26 US US13/685,231 patent/US8524237B2/en active Active
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