JP2008538549A - 高血圧剤としてのアリスキレンの有効性に関するバイオマーカー - Google Patents

高血圧剤としてのアリスキレンの有効性に関するバイオマーカー Download PDF

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Publication number
JP2008538549A
JP2008538549A JP2008503059A JP2008503059A JP2008538549A JP 2008538549 A JP2008538549 A JP 2008538549A JP 2008503059 A JP2008503059 A JP 2008503059A JP 2008503059 A JP2008503059 A JP 2008503059A JP 2008538549 A JP2008538549 A JP 2008538549A
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Prior art keywords
gene
individual
snp
aliskiren
treatment
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JP2008503059A
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Japanese (ja)
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JP2008538549A5 (enExample
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ジェシー・グ
ジョアン・マイヤー
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ノバルティス アクチエンゲゼルシャフト
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Publication of JP2008538549A publication Critical patent/JP2008538549A/ja
Publication of JP2008538549A5 publication Critical patent/JP2008538549A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
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  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
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  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008503059A 2005-03-22 2006-03-20 高血圧剤としてのアリスキレンの有効性に関するバイオマーカー Pending JP2008538549A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66424805P 2005-03-22 2005-03-22
US74240106P 2006-02-06 2006-02-06
PCT/US2006/009913 WO2006102177A2 (en) 2005-03-22 2006-03-20 Biomarkers for efficacy of aliskiren as a hypertensive agent

Publications (2)

Publication Number Publication Date
JP2008538549A true JP2008538549A (ja) 2008-10-30
JP2008538549A5 JP2008538549A5 (enExample) 2009-04-09

Family

ID=37024459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008503059A Pending JP2008538549A (ja) 2005-03-22 2006-03-20 高血圧剤としてのアリスキレンの有効性に関するバイオマーカー

Country Status (8)

Country Link
US (1) US20100240760A1 (enExample)
JP (1) JP2008538549A (enExample)
KR (1) KR20080005926A (enExample)
AU (1) AU2006227283B2 (enExample)
BR (1) BRPI0609702A2 (enExample)
CA (1) CA2600525A1 (enExample)
MX (1) MX2007011697A (enExample)
WO (1) WO2006102177A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006227283B2 (en) * 2005-03-22 2010-07-01 Novartis Ag Biomarkers for efficacy of aliskiren as a hypertensive agent
ATE505203T1 (de) * 2007-09-28 2011-04-15 Novartis Ag Pharmazeutische kombination aus aliskiren und valsartan
CN108660205A (zh) * 2018-07-04 2018-10-16 刘城 一种糖尿病遗传风险评估试剂盒及其运用
CN111024960B (zh) * 2019-12-27 2023-02-17 广州阳普医疗科技股份有限公司 用于高血压血样检测的添加剂、试剂盒和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097098A1 (en) * 2002-05-17 2003-11-27 Novartis Ag Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic
JP2008528054A (ja) * 2005-02-02 2008-07-31 ロイヤル カレッジ オブ サージョンズ イン アイルランド 血圧降下剤のファーマコゲノミクス

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008457A1 (en) * 1987-04-30 1988-11-03 Biotechnology Research Partners, Ltd. Hypertension-related blood tests useful as genetic markers
AU6116399A (en) * 1998-10-14 2000-05-01 Pyrosequencing Ab Genes for assessing cardiovascular status and compositions for use thereof
AU2006227283B2 (en) * 2005-03-22 2010-07-01 Novartis Ag Biomarkers for efficacy of aliskiren as a hypertensive agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097098A1 (en) * 2002-05-17 2003-11-27 Novartis Ag Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic
JP2008528054A (ja) * 2005-02-02 2008-07-31 ロイヤル カレッジ オブ サージョンズ イン アイルランド 血圧降下剤のファーマコゲノミクス

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6012002848; KURLAND,L. et al, Angiotensinogen gene polymorphisms: relationship to blood pressure response to ant *
JPN6012002854; ARNETT, D.K. et al, Pharmacogenetics of Antihypertensive Treatment, DRUG DEVELOPMENT RESEARCH, 2004, *
JPN6013000420; GRADMAN,A.H. et al: 'Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive effica' Circulation Vol.111, No.8, 200503, p.1012-8 *

Also Published As

Publication number Publication date
KR20080005926A (ko) 2008-01-15
AU2006227283A1 (en) 2006-09-28
WO2006102177A3 (en) 2007-05-10
WO2006102177A2 (en) 2006-09-28
US20100240760A1 (en) 2010-09-23
CA2600525A1 (en) 2006-09-28
AU2006227283B2 (en) 2010-07-01
MX2007011697A (es) 2007-11-16
BRPI0609702A2 (pt) 2010-04-20

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