KR20080005926A - 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 - Google Patents

항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 Download PDF

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Publication number
KR20080005926A
KR20080005926A KR1020077024124A KR20077024124A KR20080005926A KR 20080005926 A KR20080005926 A KR 20080005926A KR 1020077024124 A KR1020077024124 A KR 1020077024124A KR 20077024124 A KR20077024124 A KR 20077024124A KR 20080005926 A KR20080005926 A KR 20080005926A
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KR
South Korea
Prior art keywords
gene
snp
aliskiren
individual
angiotensin
Prior art date
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Ceased
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KR1020077024124A
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English (en)
Korean (ko)
Inventor
제시 구
조안 마이어
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노파르티스 아게
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Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080005926A publication Critical patent/KR20080005926A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077024124A 2005-03-22 2006-03-20 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커 Ceased KR20080005926A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66424805P 2005-03-22 2005-03-22
US60/664,248 2005-03-22
US74240106P 2006-02-06 2006-02-06
US60/742,401 2006-02-06

Publications (1)

Publication Number Publication Date
KR20080005926A true KR20080005926A (ko) 2008-01-15

Family

ID=37024459

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077024124A Ceased KR20080005926A (ko) 2005-03-22 2006-03-20 항고혈압제로서 알리스키렌의 효능에 대한 바이오마커

Country Status (8)

Country Link
US (1) US20100240760A1 (enExample)
JP (1) JP2008538549A (enExample)
KR (1) KR20080005926A (enExample)
AU (1) AU2006227283B2 (enExample)
BR (1) BRPI0609702A2 (enExample)
CA (1) CA2600525A1 (enExample)
MX (1) MX2007011697A (enExample)
WO (1) WO2006102177A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006227283B2 (en) * 2005-03-22 2010-07-01 Novartis Ag Biomarkers for efficacy of aliskiren as a hypertensive agent
ATE505203T1 (de) * 2007-09-28 2011-04-15 Novartis Ag Pharmazeutische kombination aus aliskiren und valsartan
CN108660205A (zh) * 2018-07-04 2018-10-16 刘城 一种糖尿病遗传风险评估试剂盒及其运用
CN111024960B (zh) * 2019-12-27 2023-02-17 广州阳普医疗科技股份有限公司 用于高血压血样检测的添加剂、试剂盒和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008457A1 (en) * 1987-04-30 1988-11-03 Biotechnology Research Partners, Ltd. Hypertension-related blood tests useful as genetic markers
AU6116399A (en) * 1998-10-14 2000-05-01 Pyrosequencing Ab Genes for assessing cardiovascular status and compositions for use thereof
ES2369216T3 (es) * 2002-05-17 2011-11-28 Novartis Pharma Ag Composición farmacéutica que comprende un inhibidor de renina, un bloqueador del canal de calcio y un diurético.
WO2006082570A1 (en) * 2005-02-02 2006-08-10 Royal College Of Surgeons In Ireland Pharmacogenomics of blood pressure lowering agents
AU2006227283B2 (en) * 2005-03-22 2010-07-01 Novartis Ag Biomarkers for efficacy of aliskiren as a hypertensive agent

Also Published As

Publication number Publication date
AU2006227283A1 (en) 2006-09-28
WO2006102177A3 (en) 2007-05-10
WO2006102177A2 (en) 2006-09-28
US20100240760A1 (en) 2010-09-23
CA2600525A1 (en) 2006-09-28
AU2006227283B2 (en) 2010-07-01
MX2007011697A (es) 2007-11-16
JP2008538549A (ja) 2008-10-30
BRPI0609702A2 (pt) 2010-04-20

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