JP2008538362A5 - - Google Patents

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Publication number
JP2008538362A5
JP2008538362A5 JP2008506634A JP2008506634A JP2008538362A5 JP 2008538362 A5 JP2008538362 A5 JP 2008538362A5 JP 2008506634 A JP2008506634 A JP 2008506634A JP 2008506634 A JP2008506634 A JP 2008506634A JP 2008538362 A5 JP2008538362 A5 JP 2008538362A5
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JP
Japan
Prior art keywords
composition
compound
substituted
group
molecular chaperone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008506634A
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English (en)
Japanese (ja)
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JP2008538362A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/013646 external-priority patent/WO2006110814A2/en
Publication of JP2008538362A publication Critical patent/JP2008538362A/ja
Publication of JP2008538362A5 publication Critical patent/JP2008538362A5/ja
Withdrawn legal-status Critical Current

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JP2008506634A 2005-04-12 2006-04-12 タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法 Withdrawn JP2008538362A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67022605P 2005-04-12 2005-04-12
PCT/US2006/013646 WO2006110814A2 (en) 2005-04-12 2006-04-12 Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents

Publications (2)

Publication Number Publication Date
JP2008538362A JP2008538362A (ja) 2008-10-23
JP2008538362A5 true JP2008538362A5 (https=) 2009-10-22

Family

ID=36954891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008506634A Withdrawn JP2008538362A (ja) 2005-04-12 2006-04-12 タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法

Country Status (6)

Country Link
US (1) US20070015803A1 (https=)
EP (2) EP2047850A3 (https=)
JP (1) JP2008538362A (https=)
AU (1) AU2006235490A1 (https=)
CA (1) CA2604640A1 (https=)
WO (1) WO2006110814A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2907A (en) 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment
US8524278B2 (en) 2009-02-13 2013-09-03 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
ES2376931B1 (es) * 2009-04-02 2013-06-25 Universidad Del Pais Vasco Composiciones farmacéuticas para el tratamiento de la metástasis.
ES2425298B1 (es) * 2009-04-02 2014-10-01 Universidad Del País Vasco Composiciones farmacéuticas para el tratamiento de la metástasis
PE20121118A1 (es) * 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
AP2012006064A0 (en) * 2009-06-26 2012-02-29 Romark Lab Lc Compounds and methods for treating influenza.
KR20140003658A (ko) 2011-05-04 2014-01-09 에테하 쭈리히 올리고당전달효소-촉매화된 아스파라진-결합된 글리코실화의 구성 요소들의 합리적 설계
CN103648282B (zh) 2011-05-16 2017-02-15 罗马克实验室有限公司 噻唑化物类化合物用于预防和治疗病毒性疾病、癌症和由细胞内感染引起的疾病的用途
SI2546410T1 (sl) * 2011-07-11 2014-03-31 Omya International Ag Hidrofobirani delci kalcijevega karbonata
CN107105660A (zh) 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
CN108289961A (zh) * 2016-03-31 2018-07-17 罗马克实验室有限公司 用于治疗病毒性感染的噻唑化物化合物
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
MX2023002208A (es) 2020-08-24 2023-05-17 Romark Laboratories Lc Uso de tiazolidas contra los coronavirus.
CA3196479A1 (en) * 2020-11-17 2022-05-27 Philippe Delataille Methods of treatment of liver failure
CN115197164B (zh) * 2021-04-12 2025-04-01 杜心赟 新型噻唑类化合物及其制备方法和用途

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
GB1440212A (en) * 1973-08-29 1976-06-23 Phavic Sprl Derivatives of 2-phenoxyacetamido-5-nitrothiazoles
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
US5532154A (en) * 1994-03-21 1996-07-02 Research Development Foundation Mutated alpha virus
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5965590A (en) * 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5856348A (en) * 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US6248872B1 (en) * 1996-12-03 2001-06-19 Heska Corporation Parasitic nematode transglutaminase, nucleic acid molecules, and uses thereof
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
US6340696B1 (en) * 1999-03-31 2002-01-22 The Procter & Gamble Company Viral treatment
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
US7341717B2 (en) * 2001-04-13 2008-03-11 Gpc Biotech Ag Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor
FR2826018B1 (fr) * 2001-06-18 2005-01-07 Pasteur Institut Tunis Gene associe a la virulence du parasite leishmania
US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
CA2577928A1 (en) * 2004-09-01 2006-03-09 Mitsubishi Pharma Corporation Molecular chaperone function regulator
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
AP2907A (en) * 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment

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