JP2008538362A - タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法 - Google Patents
タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67022605P | 2005-04-12 | 2005-04-12 | |
| PCT/US2006/013646 WO2006110814A2 (en) | 2005-04-12 | 2006-04-12 | Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538362A true JP2008538362A (ja) | 2008-10-23 |
| JP2008538362A5 JP2008538362A5 (enExample) | 2009-10-22 |
Family
ID=36954891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506634A Withdrawn JP2008538362A (ja) | 2005-04-12 | 2006-04-12 | タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070015803A1 (enExample) |
| EP (2) | EP1871365A2 (enExample) |
| JP (1) | JP2008538362A (enExample) |
| AU (1) | AU2006235490A1 (enExample) |
| CA (1) | CA2604640A1 (enExample) |
| WO (1) | WO2006110814A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014513725A (ja) * | 2011-05-16 | 2014-06-05 | ロマーク ラボラトリーズ エル．シー． | ウイルス性疾患、ガンおよび細胞内感染により引き起こされる疾患の予防および処置のためのチアゾリド化合物の使用 |
| JP2014516519A (ja) * | 2011-05-04 | 2014-07-17 | イーティーエイチ・チューリッヒ | オリゴサッカリルトランスフェラーゼ触媒アスパラギン結合型グリコシル化の成分の合理的設計 |
| JP2019510044A (ja) * | 2016-03-31 | 2019-04-11 | ロマーク ラボラトリーズ，リミティド カンパニー | ウイルス感染症の治療用チアゾリド化合物 |
| JP2023549883A (ja) * | 2020-11-17 | 2023-11-29 | ジェンフィット | 肝不全の治療方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1976516T3 (da) | 2006-01-09 | 2013-07-15 | Romark Lab Lc | Behandling af viral hepatitis |
| MX381895B (es) * | 2009-02-13 | 2025-03-13 | Romark Laboratories Lc | Formulaciones farmaceuticas de liberacion controlada de nitazoxanida. |
| ES2425298B1 (es) * | 2009-04-02 | 2014-10-01 | Universidad Del País Vasco | Composiciones farmacéuticas para el tratamiento de la metástasis |
| ES2376931B1 (es) * | 2009-04-02 | 2013-06-25 | Universidad Del Pais Vasco | Composiciones farmacéuticas para el tratamiento de la metástasis. |
| SG176045A1 (en) * | 2009-05-12 | 2011-12-29 | Romark Lab Lc | Haloalkyl heteroaryl benzamide compounds |
| KR20180032689A (ko) | 2009-06-26 | 2018-03-30 | 로마크 레버러토리즈, 엘.씨. | 인플루엔자를 치료하기 위한 화합물 및 방법 |
| ES2446390T3 (es) * | 2011-07-11 | 2014-03-07 | Omya International Ag | Partículas de carbonato de calcio hidrofobizadas |
| BR112017009651A2 (pt) | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
| EP4182304A1 (en) | 2020-07-20 | 2023-05-24 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
| WO2022046622A1 (en) | 2020-08-24 | 2022-03-03 | Romark Laboratories L.C. | Use of thiazolides against coronaviruses |
| WO2022218239A1 (zh) * | 2021-04-12 | 2022-10-20 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| GB1440212A (en) * | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
| US4315018A (en) * | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| US5532154A (en) * | 1994-03-21 | 1996-07-02 | Research Development Foundation | Mutated alpha virus |
| US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5968961A (en) * | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5859038A (en) * | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5856348A (en) * | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) * | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US6248872B1 (en) * | 1996-12-03 | 2001-06-19 | Heska Corporation | Parasitic nematode transglutaminase, nucleic acid molecules, and uses thereof |
| US5935591A (en) * | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| US5925622A (en) * | 1998-07-13 | 1999-07-20 | Romark Laboratories, L.C. | Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same |
| US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
| US6340696B1 (en) * | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| US7341717B2 (en) * | 2001-04-13 | 2008-03-11 | Gpc Biotech Ag | Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor |
| FR2826018B1 (fr) * | 2001-06-18 | 2005-01-07 | Pasteur Institut Tunis | Gene associe a la virulence du parasite leishmania |
| US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
| JPWO2006025490A1 (ja) * | 2004-09-01 | 2008-05-08 | 田辺三菱製薬株式会社 | 分子シャペロン機能調節剤 |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| US20060194853A1 (en) * | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
| DK1976516T3 (da) * | 2006-01-09 | 2013-07-15 | Romark Lab Lc | Behandling af viral hepatitis |
-
2006
- 2006-04-12 CA CA002604640A patent/CA2604640A1/en not_active Abandoned
- 2006-04-12 AU AU2006235490A patent/AU2006235490A1/en not_active Abandoned
- 2006-04-12 JP JP2008506634A patent/JP2008538362A/ja not_active Withdrawn
- 2006-04-12 EP EP06749878A patent/EP1871365A2/en not_active Withdrawn
- 2006-04-12 WO PCT/US2006/013646 patent/WO2006110814A2/en not_active Ceased
- 2006-04-12 EP EP08170730A patent/EP2047850A3/en not_active Withdrawn
- 2006-04-12 US US11/402,259 patent/US20070015803A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014516519A (ja) * | 2011-05-04 | 2014-07-17 | イーティーエイチ・チューリッヒ | オリゴサッカリルトランスフェラーゼ触媒アスパラギン結合型グリコシル化の成分の合理的設計 |
| JP2014513725A (ja) * | 2011-05-16 | 2014-06-05 | ロマーク ラボラトリーズ エル．シー． | ウイルス性疾患、ガンおよび細胞内感染により引き起こされる疾患の予防および処置のためのチアゾリド化合物の使用 |
| US10336058B2 (en) | 2011-05-16 | 2019-07-02 | Romark Laboratories L.C. | Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections |
| US10814612B2 (en) | 2011-05-16 | 2020-10-27 | Romark Laboratories L.C. | Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections |
| JP2019510044A (ja) * | 2016-03-31 | 2019-04-11 | ロマーク ラボラトリーズ，リミティド カンパニー | ウイルス感染症の治療用チアゾリド化合物 |
| JP2023549883A (ja) * | 2020-11-17 | 2023-11-29 | ジェンフィット | 肝不全の治療方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1871365A2 (en) | 2008-01-02 |
| WO2006110814A2 (en) | 2006-10-19 |
| EP2047850A2 (en) | 2009-04-15 |
| CA2604640A1 (en) | 2006-10-19 |
| EP2047850A3 (en) | 2009-07-29 |
| WO2006110814A3 (en) | 2008-01-31 |
| US20070015803A1 (en) | 2007-01-18 |
| AU2006235490A1 (en) | 2006-10-19 |
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