AU2006235490A1 - Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents - Google Patents
Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents Download PDFInfo
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- AU2006235490A1 AU2006235490A1 AU2006235490A AU2006235490A AU2006235490A1 AU 2006235490 A1 AU2006235490 A1 AU 2006235490A1 AU 2006235490 A AU2006235490 A AU 2006235490A AU 2006235490 A AU2006235490 A AU 2006235490A AU 2006235490 A1 AU2006235490 A1 AU 2006235490A1
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- molecular chaperone
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67022605P | 2005-04-12 | 2005-04-12 | |
| US60/670,226 | 2005-04-12 | ||
| PCT/US2006/013646 WO2006110814A2 (en) | 2005-04-12 | 2006-04-12 | Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2006235490A1 true AU2006235490A1 (en) | 2006-10-19 |
Family
ID=36954891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006235490A Abandoned AU2006235490A1 (en) | 2005-04-12 | 2006-04-12 | Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070015803A1 (enExample) |
| EP (2) | EP2047850A3 (enExample) |
| JP (1) | JP2008538362A (enExample) |
| AU (1) | AU2006235490A1 (enExample) |
| CA (1) | CA2604640A1 (enExample) |
| WO (1) | WO2006110814A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA015560B1 (ru) | 2006-01-09 | 2011-08-30 | Ромарк Лэборетериз, Эл.Си. | Способ лечения вирусного гепатита |
| KR101697800B1 (ko) | 2009-02-13 | 2017-01-18 | 로마크 레버러토리즈, 엘.씨. | 니타족사니드의 서방성 제약 제형 |
| ES2425298B1 (es) * | 2009-04-02 | 2014-10-01 | Universidad Del País Vasco | Composiciones farmacéuticas para el tratamiento de la metástasis |
| ES2376931B1 (es) * | 2009-04-02 | 2013-06-25 | Universidad Del Pais Vasco | Composiciones farmacéuticas para el tratamiento de la metástasis. |
| AU2010247816B2 (en) | 2009-05-12 | 2015-12-17 | Romark Laboratories L.C. | Haloalkyl heteroaryl benzamide compounds |
| US9023877B2 (en) * | 2009-06-26 | 2015-05-05 | Romark Laboratories L.C. | Compounds and methods for treating influenza |
| CA2833457C (en) | 2011-05-04 | 2018-01-30 | Eth Zurich | Rational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation |
| EP2709453B1 (en) * | 2011-05-16 | 2019-10-23 | Romark Laboratories, L.C. | Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections |
| PL2546410T3 (pl) * | 2011-07-11 | 2014-05-30 | Omya Int Ag | Hydrofobizowane cząstki węglanu wapnia |
| BR112017009651A2 (pt) | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
| CA3113354A1 (en) * | 2016-03-31 | 2017-10-05 | Romark Laboratories, L.C. | Thiazolide compounds for treating viral infections |
| US20230303504A1 (en) | 2020-07-20 | 2023-09-28 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
| KR20230098780A (ko) | 2020-08-24 | 2023-07-04 | 로마크 레버러토리즈, 엘.씨. | 코로나바이러스에 대한 티아졸리드의 용도 |
| MX2023005797A (es) * | 2020-11-17 | 2023-05-29 | Genfit | Metodos de tratamiento de la insuficiencia hepatica. |
| CN115197164B (zh) * | 2021-04-12 | 2025-04-01 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
Family Cites Families (25)
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| GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| GB1440212A (en) * | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
| US4315018A (en) * | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| US5532154A (en) * | 1994-03-21 | 1996-07-02 | Research Development Foundation | Mutated alpha virus |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5856348A (en) * | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5859038A (en) * | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| US5968961A (en) * | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) * | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US6248872B1 (en) * | 1996-12-03 | 2001-06-19 | Heska Corporation | Parasitic nematode transglutaminase, nucleic acid molecules, and uses thereof |
| US5935591A (en) * | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| US5925622A (en) * | 1998-07-13 | 1999-07-20 | Romark Laboratories, L.C. | Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same |
| US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
| US6340696B1 (en) * | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| US7341717B2 (en) * | 2001-04-13 | 2008-03-11 | Gpc Biotech Ag | Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor |
| FR2826018B1 (fr) * | 2001-06-18 | 2005-01-07 | Pasteur Institut Tunis | Gene associe a la virulence du parasite leishmania |
| US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
| EP1792898A1 (en) * | 2004-09-01 | 2007-06-06 | Mitsubishi Pharma Corporation | Molecular chaperone function regulator |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| US20060194853A1 (en) * | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
| EA015560B1 (ru) * | 2006-01-09 | 2011-08-30 | Ромарк Лэборетериз, Эл.Си. | Способ лечения вирусного гепатита |
-
2006
- 2006-04-12 WO PCT/US2006/013646 patent/WO2006110814A2/en not_active Ceased
- 2006-04-12 EP EP08170730A patent/EP2047850A3/en not_active Withdrawn
- 2006-04-12 JP JP2008506634A patent/JP2008538362A/ja not_active Withdrawn
- 2006-04-12 US US11/402,259 patent/US20070015803A1/en not_active Abandoned
- 2006-04-12 AU AU2006235490A patent/AU2006235490A1/en not_active Abandoned
- 2006-04-12 EP EP06749878A patent/EP1871365A2/en not_active Withdrawn
- 2006-04-12 CA CA002604640A patent/CA2604640A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1871365A2 (en) | 2008-01-02 |
| EP2047850A3 (en) | 2009-07-29 |
| US20070015803A1 (en) | 2007-01-18 |
| WO2006110814A2 (en) | 2006-10-19 |
| CA2604640A1 (en) | 2006-10-19 |
| WO2006110814A3 (en) | 2008-01-31 |
| EP2047850A2 (en) | 2009-04-15 |
| JP2008538362A (ja) | 2008-10-23 |
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