JP2008538300A - 生体活性の広く織られたメッシュ - Google Patents
生体活性の広く織られたメッシュ Download PDFInfo
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- JP2008538300A JP2008538300A JP2008503111A JP2008503111A JP2008538300A JP 2008538300 A JP2008538300 A JP 2008538300A JP 2008503111 A JP2008503111 A JP 2008503111A JP 2008503111 A JP2008503111 A JP 2008503111A JP 2008538300 A JP2008538300 A JP 2008538300A
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- mesh
- woven mesh
- widely
- widely woven
- bioactive
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Abstract
Description
本出願は、2005年3月22日に出願された米国仮特許出願第60/664,134号の利益を主張し、その全体の開示は本明細書中に参考として援用される。
(技術分野)
本開示は、ヘルニア、子宮膣の脱出症およびその他の関連する損傷の処置において用いられ得る被覆された外科用メッシュに関する。
ヘルニアは、基本的に、器官が通常含まれる身体の腔の壁を通ってその器官の一部の突出を生じる欠陥である。
本開示は、メッシュの治療的効目を増加する生体活性被覆で被覆された広く織られたメッシュに関する。このメッシュは、約1mm〜約10mmのストランド間のスペース、および約5g/m2〜約50g/m2の最大残存質量密度を有するストランドに織られているフィラメントから作製される。
本開示に従って、ヘルニア、脱出症、またはその他の類似の損傷の処置のために適切な外科用インプラントが提供される。このインプラントは、1つ以上の生体活性薬剤を含む組成物で被覆されている50g/m2以下の最大残存質量密度を有する広く織られたメッシュを含む。残存質量密度は、移植および任意の生体吸収性被覆の吸収の後のメッシュの質量密度である。1つの実施形態では、上記最大残存質量密度は30g/m2以下であり得、その一方、別の有用な実施形態では、残存質量密度は25g/m2以下であり得る。従って、実施形態においては、この最大質量密度は約5g/m2〜約50g/m2であり得、実施形態においては約15g/m2〜約40g/m2、実施形態においては約25g/m2〜約35g/m2であり得る。
本開示の広く織られたメッシュの生体活性被覆を形成し得る。
Claims (33)
- 広く織られたメッシュであって:
約5g/m2〜約50g/m2の最大残存質量密度を有するストランドであって;該ストランド間に約1mm〜約10mmのスペースを有するストランド;および
生体活性被覆、を備える、広く織られたメッシュ。 - 前記生体活性被覆が、少なくとも1つの生体活性薬剤を含む、請求項1に記載の広く織られたメッシュ。
- 少なくとも1つの生体活性薬剤が、抗微生物薬剤、抗細菌薬剤、抗真菌薬剤、抗生物質、抗ウイルス剤、抗腫瘍剤、抗炎症剤、ステロイド、ホルモン、酵素、鎮痛薬、麻酔薬、筋肉弛緩剤、免疫原性試薬、成長因子、免疫抑制剤、脂質、リポ多糖、多糖、およびペプチド、ポリペプチド、タンパク質ならびにこれらの組み合わせからなる群から選択される、請求項2に記載の広く織られたメッシュ。
- 前記生体活性被覆が、前記メッシュの少なくとも1つの側面を覆う、請求項1に記載の広く織られたメッシュ。
- 前記生体活性被覆が、前記メッシュの全体を覆う、請求項1に記載の広く織られたメッシュ。
- 前記生体活性被覆が、少なくとも1つの生体活性薬剤と組み合わせた吸収可能な材料を備える、請求項1に記載の広く織られたメッシュ。
- 前記生体活性被覆が、約2日〜約14日の時間に亘って分解する、請求項6に記載の広く織られたメッシュ。
- 前記ストランドが、約15g/m2〜約40g/m2の最大残存質量密度を有する、請求項1に記載の広く織られたメッシュ。
- 前記ストランドが、約200μm〜約600μmの直径を有する、請求項1に記載の広く織られたメッシュ。
- 前記ストランドが、該ストランド中にポアを形成するように配向された少なくとも1つのフィラメントを備える、請求項1に記載の広く織られたメッシュ。
- 前記ストランドが、少なくとも2つのフィラメントから形成される、請求項10に記載の広く織られたメッシュ。
- 前記フィラメントが、約0.02mm〜約0.15mmの間の直径を有し、そして該ストランド中の前記ポアが、直径が約50μm〜約200μmである直径を有する、請求項10に記載の広く織られたメッシュ。
- 前記フィラメントが、約0.08mm〜約0.1mmの直径を有し、そして前記ストランド中のポアが、約55μm〜約75μmの直径を有する、請求項10に記載の広く織られたメッシュ。
- 前記少なくとも1つのフィラメントが、合成材料を含む、請求項10に記載の広く織られたメッシュ。
- 前記少なくとも1つのフィラメントが、ポリプロピレンを含む、請求項14に記載の広く織られたメッシュ。
- 前記少なくとも1つのフィラメントが、吸収可能な材料を含む、請求項10に記載の広く織られたメッシュ。
- 前記少なくとも1つのフィラメントが、ポリエステルを含む、請求項16に記載の広く織られたメッシュ。
- 前記メッシュ中に約50μm〜約200μmの直径を有するポアを形成する材料のリングをさらに備える、請求項1に記載の広く織られたメッシュ。
- 前記メッシュのストランドが、コア材料および表面材料を含む生体成分マイクロファイバを含む、請求項1に記載の広く織られたメッシュ。
- 前記表面材料がポリ乳酸を含み、そして前記コア材料がポリプロピレンを含む、請求項19に記載の広く織られたメッシュ。
- 前記ストランドが、記憶を有する材料を含む、請求項1に記載の広く織られたメッシュ。
- 前記メッシュが約1cm〜約10cmの幅、および約1cm〜約10cmの長さを有する、請求項1に記載の広く織られたメッシュ。
- 前記メッシュが、丸、円、卵形、楕円、および先欠け楕円からなる群から選択される形状を有する、請求項1に記載の広く織られたメッシュ。
- 前記メッシュが、該メッシュの周の少なくとも一部に沿って延び、実質的に円滑なエッジを提供する少なくとも1つの周縁部材を有する、請求項1に記載の広く織られたメッシュ。
- 前記メッシュの周の少なくも約50%が、前記少なくとも1つの周縁部材によって規定される、請求項24に記載の広く織られたメッシュ。
- 前記メッシュの周の約80%〜約100%が、前記少なくとも1つの周縁部材によって規定される、請求項24に記載の広く織られたメッシュ。
- 前記メッシュが、異なる半径方向位置に配列された複数の周縁部材を有する、請求項24に記載の広く織られたメッシュ。
- 前記周縁部材が、一体メッシュを形成するために互いとつなぐように配列される、請求項27に記載の広く織られたメッシュ。
- 前記メッシュが、前記周縁部材を横切って延びる横方向部材をさらに備え、それによって該周縁部材をつなぐ、請求項27に記載の広く織られたメッシュ。
- 子宮膣の脱出症を処置する方法であって:
膣腔の開口部に近接する膣中に切開を作製する工程;
該切開を通じ、該子宮脱出症の領域の上および該子宮脱出症の領域の周りに皮下切断を作製する工程であって、該切断が該膣壁に実質的に平行である工程;および
請求項1に記載のメッシュを、該切開を通じて、該切断によって規定されるスペース中に挿入する工程を包含する、方法。 - 前記膣壁中の切開が、該膣の腔の子宮脱出症の膀胱の後部最端にある、請求項30に記載の子宮膣の脱出症を処置する方法。
- 前記膣壁中の切開が、該膣の腔の子宮脱出症の膀胱の前部最端にある、請求項30に記載の子宮膣の脱出症を処置する方法。
- 前記メッシュが、タック、らせんファスナー、ねじファスナー、縫合糸、接着剤、ステープル、およびクリップからなる群から選択されるファスナーを利用して組織に取り付けられる、請求項30に記載の子宮膣の脱出症を処置する方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US66413405P | 2005-03-22 | 2005-03-22 | |
PCT/US2006/010330 WO2006102374A2 (en) | 2005-03-22 | 2006-03-22 | Bioactive wide-weave mesh |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008538300A true JP2008538300A (ja) | 2008-10-23 |
JP2008538300A5 JP2008538300A5 (ja) | 2009-03-05 |
Family
ID=37024551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008503111A Withdrawn JP2008538300A (ja) | 2005-03-22 | 2006-03-22 | 生体活性の広く織られたメッシュ |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090204129A1 (ja) |
EP (1) | EP1861055A4 (ja) |
JP (1) | JP2008538300A (ja) |
AU (1) | AU2006227112A1 (ja) |
CA (1) | CA2601156A1 (ja) |
WO (1) | WO2006102374A2 (ja) |
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Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US20090036907A1 (en) * | 2007-07-30 | 2009-02-05 | Yves Bayon | Bioresorbable knit |
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US9114197B1 (en) | 2014-06-11 | 2015-08-25 | Silver Bullett Therapeutics, Inc. | Coatings for the controllable release of antimicrobial metal ions |
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US8758798B2 (en) | 2010-03-24 | 2014-06-24 | Covidien Lp | Therapeutic implant |
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US20130172994A1 (en) * | 2010-06-03 | 2013-07-04 | Hilton Becker | Supporting and forming transitional material for use in supporting prosthesis devices, implants and to provide structure in a human body |
US20110301717A1 (en) * | 2010-06-03 | 2011-12-08 | Hilton Becker | Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body |
FR2962646B1 (fr) | 2010-07-16 | 2012-06-22 | Sofradim Production | Prothese avec element radio-opaque |
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US10226270B2 (en) * | 2012-08-10 | 2019-03-12 | W. L. Gore & Associates, Inc. | Microanchors for anchoring devices to body tissues |
US20140046347A1 (en) * | 2012-08-10 | 2014-02-13 | W. L. Gore & Associates, Inc. | Devices, systems and methods for engaging tissue |
US20140094681A1 (en) * | 2012-10-02 | 2014-04-03 | Covidien Lp | System for navigating surgical instruments adjacent tissue of interest |
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US10285697B2 (en) | 2013-11-08 | 2019-05-14 | C.R. Bard, Inc. | Methods and apparatus for surgical fastening |
US9452242B2 (en) | 2014-06-11 | 2016-09-27 | Silver Bullet Therapeutics, Inc. | Enhancement of antimicrobial silver, silver coatings, or silver platings |
CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
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CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
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CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
US10518004B2 (en) * | 2016-12-18 | 2019-12-31 | Cardiac Pacemakers, Inc. | Infection fighting drug eluting device |
CN111432749B (zh) | 2017-10-19 | 2023-04-04 | C.R.巴德公司 | 自抓握式疝假体 |
US11642206B1 (en) * | 2022-11-17 | 2023-05-09 | King Faisal University | System and method for laparoscopic repair of abdominal wall hernia using umbrella mesh |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1024054A (ja) * | 1996-03-26 | 1998-01-27 | Ethicon Gmbh & Co Kg | 面移植片 |
US20020072694A1 (en) * | 2000-09-07 | 2002-06-13 | Snitkin Eva S. | Coated sling material |
JP2004525693A (ja) * | 2001-03-09 | 2004-08-26 | サイムド ライフ システムズ, インコーポレイテッド | 医療用スリング |
US20040172048A1 (en) * | 2001-03-30 | 2004-09-02 | James Browning | Surgical implant |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4633873A (en) * | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
US5582616A (en) * | 1994-08-05 | 1996-12-10 | Origin Medsystems, Inc. | Surgical helical fastener with applicator |
US5964783A (en) * | 1997-11-07 | 1999-10-12 | Arthrex, Inc. | Suture anchor with insert-molded suture |
US6306079B1 (en) * | 1999-12-07 | 2001-10-23 | Arnaldo F. Trabucco | Mesh pubovaginal sling |
US7070556B2 (en) * | 2002-03-07 | 2006-07-04 | Ams Research Corporation | Transobturator surgical articles and methods |
EP1437968B1 (en) * | 2001-10-23 | 2013-04-10 | Covidien LP | Surgical fasteners |
-
2006
- 2006-03-22 CA CA002601156A patent/CA2601156A1/en not_active Abandoned
- 2006-03-22 AU AU2006227112A patent/AU2006227112A1/en not_active Abandoned
- 2006-03-22 WO PCT/US2006/010330 patent/WO2006102374A2/en active Application Filing
- 2006-03-22 US US11/886,934 patent/US20090204129A1/en not_active Abandoned
- 2006-03-22 EP EP06739210A patent/EP1861055A4/en not_active Withdrawn
- 2006-03-22 JP JP2008503111A patent/JP2008538300A/ja not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1024054A (ja) * | 1996-03-26 | 1998-01-27 | Ethicon Gmbh & Co Kg | 面移植片 |
US20020072694A1 (en) * | 2000-09-07 | 2002-06-13 | Snitkin Eva S. | Coated sling material |
JP2004525693A (ja) * | 2001-03-09 | 2004-08-26 | サイムド ライフ システムズ, インコーポレイテッド | 医療用スリング |
US20040172048A1 (en) * | 2001-03-30 | 2004-09-02 | James Browning | Surgical implant |
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Also Published As
Publication number | Publication date |
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EP1861055A4 (en) | 2013-01-16 |
US20090204129A1 (en) | 2009-08-13 |
EP1861055A2 (en) | 2007-12-05 |
WO2006102374A3 (en) | 2009-04-02 |
WO2006102374A2 (en) | 2006-09-28 |
CA2601156A1 (en) | 2006-09-28 |
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