JP2008537546A5 - - Google Patents
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- Publication number
- JP2008537546A5 JP2008537546A5 JP2008502334A JP2008502334A JP2008537546A5 JP 2008537546 A5 JP2008537546 A5 JP 2008537546A5 JP 2008502334 A JP2008502334 A JP 2008502334A JP 2008502334 A JP2008502334 A JP 2008502334A JP 2008537546 A5 JP2008537546 A5 JP 2008537546A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- tumor
- associated antigen
- antibody
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 108
- 108020004707 nucleic acids Proteins 0.000 claims 97
- 102000039446 nucleic acids Human genes 0.000 claims 97
- 206010028980 Neoplasm Diseases 0.000 claims 60
- 239000000427 antigen Substances 0.000 claims 54
- 102000036639 antigens Human genes 0.000 claims 54
- 108091007433 antigens Proteins 0.000 claims 54
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 230000000295 complement effect Effects 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 238000001514 detection method Methods 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 230000002159 abnormal effect Effects 0.000 claims 4
- 239000000032 diagnostic agent Substances 0.000 claims 4
- 229940039227 diagnostic agent Drugs 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 231100000433 cytotoxic Toxicity 0.000 claims 3
- 230000001472 cytotoxic effect Effects 0.000 claims 3
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000008275 breast carcinoma Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000004581 coalescence Methods 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000001875 tumorinhibitory effect Effects 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005013846.2 | 2005-03-24 | ||
| DE102005013846A DE102005013846A1 (de) | 2005-03-24 | 2005-03-24 | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| PCT/EP2006/002695 WO2006100089A2 (de) | 2005-03-24 | 2006-03-23 | Identifizierung von oberflächen-assoziierten antigenen für die tumordiagnose und -therapie |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012083549A Division JP5731436B2 (ja) | 2005-03-24 | 2012-04-02 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2012258431A Division JP5779167B2 (ja) | 2005-03-24 | 2012-11-27 | 腫瘍診断と治療のための表面関連抗原の同定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537546A JP2008537546A (ja) | 2008-09-18 |
| JP2008537546A5 true JP2008537546A5 (enExample) | 2009-04-30 |
| JP5253999B2 JP5253999B2 (ja) | 2013-07-31 |
Family
ID=36613498
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502334A Active JP5253999B2 (ja) | 2005-03-24 | 2006-03-23 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2012083549A Active JP5731436B2 (ja) | 2005-03-24 | 2012-04-02 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2012258431A Active JP5779167B2 (ja) | 2005-03-24 | 2012-11-27 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2014005640A Active JP5922159B2 (ja) | 2005-03-24 | 2014-01-16 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2016032631A Active JP6174177B2 (ja) | 2005-03-24 | 2016-02-24 | 腫瘍診断と治療のための表面関連抗原の同定 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012083549A Active JP5731436B2 (ja) | 2005-03-24 | 2012-04-02 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2012258431A Active JP5779167B2 (ja) | 2005-03-24 | 2012-11-27 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2014005640A Active JP5922159B2 (ja) | 2005-03-24 | 2014-01-16 | 腫瘍診断と治療のための表面関連抗原の同定 |
| JP2016032631A Active JP6174177B2 (ja) | 2005-03-24 | 2016-02-24 | 腫瘍診断と治療のための表面関連抗原の同定 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9090940B2 (enExample) |
| EP (5) | EP1861118B1 (enExample) |
| JP (5) | JP5253999B2 (enExample) |
| DE (1) | DE102005013846A1 (enExample) |
| ES (1) | ES2537319T3 (enExample) |
| WO (1) | WO2006100089A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005013846A1 (de) | 2005-03-24 | 2006-10-05 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| DE102006060824B4 (de) * | 2006-12-21 | 2011-06-01 | Johannes-Gutenberg-Universität Mainz | Nachweis von individuellen T-Zell-Reaktionsmustern gegen Tumor-assoziierte Antigene (TAA) in Tumorpatienten als Basis für die individuelle therapeutische Vakzinierung von Patienten |
| EP2060583A1 (en) * | 2007-10-23 | 2009-05-20 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
| EP2249159A1 (en) * | 2009-04-29 | 2010-11-10 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
| DK3192520T3 (da) | 2009-07-29 | 2019-05-27 | Kai Pharmaceuticals Inc | Terapeutiske midler til reducering af niveauerne af parathyreoideahormon |
| US8486657B2 (en) * | 2010-03-22 | 2013-07-16 | Xiaohong Cai | Anti-preproprotein and anti-preprotein antibodies as immunohistochemical markers |
| TW201302800A (zh) * | 2011-06-10 | 2013-01-16 | Oncotherapy Science Inc | Ｓｅｍａ５ｂ胜肽及含其之疫苗 |
| AU2013356143A1 (en) * | 2012-12-04 | 2015-06-04 | Oncotherapy Science, Inc. | SEMA5B peptides and vaccines containing the same |
| US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| WO2017141243A1 (en) | 2016-02-18 | 2017-08-24 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| KR20170117450A (ko) | 2015-02-18 | 2017-10-23 | 엔리벡스 테라퓨틱스 리미티드 | 암 치료를 위한 면역 요법 및 사이토카인 조절 요법의 조합 |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520564D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| EP4299136A3 (en) | 2015-12-16 | 2024-02-14 | Gritstone bio, Inc. | Neoantigen identification, manufacture, and use |
| WO2017123808A1 (en) | 2016-01-15 | 2017-07-20 | The J. David Gladstone Institutes | Methods of treating disease by metabolic control of t-cell differentiation |
| AU2018297578C1 (en) * | 2017-07-07 | 2022-06-09 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers |
| EP3694532B1 (en) | 2017-10-10 | 2025-02-26 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| IL274799B2 (en) | 2017-11-22 | 2025-05-01 | Gritstone Bio Inc | Reducing junction epitope presentation for neoantigens |
| WO2022256620A1 (en) * | 2021-06-03 | 2022-12-08 | The Broad Institute, Inc. | Novel targets for enhancing anti-tumor immunity |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2191A (en) | 1841-07-23 | Constructing the surgical instrument denominated the | ||
| GB9019812D0 (en) | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| WO1997026328A1 (en) | 1996-01-17 | 1997-07-24 | Imperial College Innovations Limited | Immunotherapy using cytotoxic t lymphocytes (ctl) |
| EP0971950A2 (en) | 1997-02-24 | 2000-01-19 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| AU7549498A (en) * | 1997-06-03 | 1998-12-21 | Protegene Inc. | Human proteins having transmembrane domains and dnas encoding these prot eins |
| JP2002539767A (ja) * | 1998-12-22 | 2002-11-26 | ジェンセット | シグナルペプチドを含む相補的ｄｎａのコードタンパク質 |
| US20030204075A9 (en) * | 1999-08-09 | 2003-10-30 | The Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| AU2001288237A1 (en) * | 2000-08-07 | 2002-02-18 | Curagen Corporation | Proteins and nucleic acids encoding g-protein coupled receptors |
| USH2191H1 (en) | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| AU2002255478A1 (en) * | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| JP2005527180A (ja) * | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
| US7171311B2 (en) * | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
| DK1410011T3 (da) * | 2001-06-18 | 2011-07-18 | Netherlands Cancer Inst | Diagnose og prognose for brystcancerpatienter |
| US20040076955A1 (en) | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
| DE10211088A1 (de) * | 2002-03-13 | 2003-09-25 | Ugur Sahin | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE10254601A1 (de) * | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| AU2003263660A1 (en) | 2003-08-29 | 2005-03-16 | Pantarhei Bioscience B.V. | Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood |
| DE10344799A1 (de) * | 2003-09-26 | 2005-04-14 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| DE102005013846A1 (de) | 2005-03-24 | 2006-10-05 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
-
2005
- 2005-03-24 DE DE102005013846A patent/DE102005013846A1/de not_active Ceased
-
2006
- 2006-03-23 ES ES06723678.6T patent/ES2537319T3/es active Active
- 2006-03-23 WO PCT/EP2006/002695 patent/WO2006100089A2/de not_active Ceased
- 2006-03-23 EP EP06723678.6A patent/EP1861118B1/de active Active
- 2006-03-23 EP EP20100010912 patent/EP2327417B1/de active Active
- 2006-03-23 EP EP10010913A patent/EP2311487A3/de not_active Withdrawn
- 2006-03-23 EP EP10010915A patent/EP2314310A3/de not_active Withdrawn
- 2006-03-23 EP EP10010914A patent/EP2314309A3/de not_active Withdrawn
- 2006-03-23 JP JP2008502334A patent/JP5253999B2/ja active Active
- 2006-03-23 US US11/886,758 patent/US9090940B2/en active Active
-
2012
- 2012-04-02 JP JP2012083549A patent/JP5731436B2/ja active Active
- 2012-11-27 JP JP2012258431A patent/JP5779167B2/ja active Active
-
2013
- 2013-04-17 US US13/864,411 patent/US9194004B2/en active Active
-
2014
- 2014-01-16 JP JP2014005640A patent/JP5922159B2/ja active Active
-
2015
- 2015-06-19 US US14/744,845 patent/US10036753B2/en active Active
-
2016
- 2016-02-24 JP JP2016032631A patent/JP6174177B2/ja active Active
- 2016-03-07 US US14/887,979 patent/US10302647B2/en active Active
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