CN114650842A - 抗tim-3抗体 - Google Patents

抗tim-3抗体 Download PDF

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CN114650842A
CN114650842A CN202080058838.XA CN202080058838A CN114650842A CN 114650842 A CN114650842 A CN 114650842A CN 202080058838 A CN202080058838 A CN 202080058838A CN 114650842 A CN114650842 A CN 114650842A
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汤乐妍
A·舒尔克因斯
K·坦
陈俊男
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Single Cell Technology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

提供了能特异性识别含T细胞免疫球蛋白和粘蛋白结构域‑3(TIM‑3)蛋白的抗体。具体地，本公开提供了能结合人TIM‑3(SEQ ID NO:1)的抗体，其具有所公开的各抗体的重链可变(VH)区和轻链可变(VL)区序列的互补决定区(CDR)序列。还公开了包含所述抗体的药物组合物，其用于治疗癌症的方法。

Description

抗TIM-3抗体
相关申请的交叉引用
本申请要求于2019年6月21日提交的第62/864,835号美国临时申请的优先权，并通过引用将其整体纳入本文用于所有目的。
序列表的并入
本申请包含序列表，其通过EFS-Web提交并通过引用全部内容纳入本文。2020年6月22日生成的ASCII文本命名为SCT0009-401-PC_Sequence_Listing_ST25.txt，大小为402,000字节。
背景技术
含T细胞免疫球蛋白和粘蛋白结构域-3(TIM-3)，也称为甲型肝炎病毒细胞受体2(HAVCR2)，是一种I型跨膜蛋白，其作为免疫反应的关键调节剂起作用。TIM-3最初是在活化的IFN-γ产生型的T细胞(例如，1型辅助CD4+T细胞和细胞毒性CD8+T细胞)上识别的，并显示在与半乳凝素-9结合后诱导T细胞死亡或耗竭(Monney等，2002)。最近的研究表明，TIM-3表达在调节许多先天免疫细胞(例如，巨噬细胞、单核细胞、树突细胞、肥大细胞和自然杀伤细胞)的活性中也很重要(Han等，2013)。
与许多抑制性受体(例如，PD-1和CTLA-4)一样，TIM-3的表达与许多类型的慢性疾病相关，包括癌症。已在晚期黑色素瘤、非小细胞肺癌或滤泡性B细胞非霍奇金淋巴瘤患者中检测到TIM-3+T细胞。并且TIM-3+调节性T细胞的存在已被认为是肺癌进展的有效指标(Anderson，2014)。
已经识别了TIM-3的几种潜在配体：半乳凝素-9、HMGB1、脑信号蛋白-4A、CEACAM-1、ILT-4和磷脂酰丝氨酸(PtdSer或PS)。PS是一种重要的细胞膜成分，通常位于细胞膜的内叶。但随着细胞发生凋亡，PS会重新分布并暴露于外膜。在许多肿瘤细胞系中也观察到这种重新分布(Riedl等，2011)。TIM-3与PS的结合可能对吞噬作用和交叉呈递至关重要(Nakayama等，2009)。
研究显示TIM-3与抑制性受体PD-1之间的密切关系。例如，许多肿瘤特异性T细胞同时表达PD-1和TIM-3，与仅表达PD-1或TIM-3的T细胞相比，这些T细胞的功能更失调(Fourcade等，2010)。
因此，需要改进的治疗癌症的方法，例如治疗性单克隆抗体。用于这种改进的治疗方法的药物可包含特异性结合至TIM-3并逆转或部分逆转TIM-3介导的抗肿瘤免疫反应抑制的抗体或抗体片段。
发明内容
提供了识别和特异性结合人TIM-3的抗体。在一个实施方式中，本公开提供了一种结合至SEQ ID NO:1的抗体。
序列简要说明
表1
Figure BDA0003511285460000021
Figure BDA0003511285460000031
Figure BDA0003511285460000041
Figure BDA0003511285460000051
Figure BDA0003511285460000061
Figure BDA0003511285460000071
Figure BDA0003511285460000081
Figure BDA0003511285460000091
Figure BDA0003511285460000101
Figure BDA0003511285460000111
Figure BDA0003511285460000121
Figure BDA0003511285460000131
Figure BDA0003511285460000141
Figure BDA0003511285460000151
具体实施方式
本公开提供了能够结合至TIM-3的抗体。在一个实施方式中，本公开提供了一种能结合至SEQ ID NO:1的分离的抗体。
抗体
本公开提供了能特异性结合至SEQ ID NO:1的抗体。如本文所用，术语“抗体”包括能与相同抗原结合的全长免疫球蛋白和抗体片段两者。抗体可以是例如单克隆抗体、多克隆抗体、嵌合抗体、人源化抗体或单链抗体。如本文所用，术语“抗原结合片段”、“片段”和“抗体片段”可互换使用，指包含全长抗体的部分的任何片段，通常至少是其抗原结合部分或可变区。抗体片段的示例包括但不限于双抗体、单链抗体分子、多特异性抗体、Fab、Fab'、F(ab')2、Fv或scFv。
短语“治疗有效”旨在限定用于治疗疾病或病症或影响临床终点的活性成分的量。
术语“治疗上可接受的”是指适用于与患者组织接触而没有过度毒性、刺激和过敏反应的那些化合物(或盐、前药、互变异构体、两性离子形式等)，其与合理的益处/风险比相称，并且有效于其预期用途。
如本文所用，术语“治疗”、“治疗性”等是指改善疾病，以减少、改善或消除其原因、其进展、其严重性或其一种或多种症状，或以其它方式有益地改变对象的疾病。对患者的“治疗”或“治疗性”意在包括预防。治疗在本质上也可以是占先的，即它可以包括预防暴露于疾病或处于疾病风险中的对象的疾病。疾病的预防可以包括完全防止疾病，例如在预防病原体感染的情况下，或者可以包括预防疾病进展。例如，疾病的预防可能并不意味着在任何水平上完全排除与疾病相关的任何影响，而是可能意味着预防临床显著或可检测水平的疾病症状。预防疾病还可以意味着预防疾病进展到疾病的后期。
术语“对象”和“患者”在本文中可互换使用以表示包括人类在内的所有哺乳动物。对象的示例包括但不限于人、猴、狗、猫、马、牛、山羊、绵羊、猪和兔子。在一个实施方式中，对象或患者是人。
在某些实施方式中，用单独或组合的抗TIM-3抗体分子治疗的癌症包括但不限于实体瘤、血液癌症(例如白血病、淋巴瘤、骨髓瘤)和其转移性病变。在一个实施方式中，癌症是实体瘤。实体瘤的实例包括各种器官系统的恶性肿瘤，例如肉瘤和癌(例如腺癌)，例如影响肺、乳腺、淋巴、胃肠道或结肠直肠、生殖器和泌尿生殖道(例如肾、尿路上皮、膀胱细胞)、咽、CNS(例如，脑、神经或神经胶质细胞)、皮肤(例如，黑色素瘤)、头颈部(例如，头颈部鳞状细胞癌(HNCC))和胰腺。例如，黑色素瘤、结肠癌、胃癌、直肠癌、肾细胞癌、乳腺癌(例如，不表达雌激素受体、孕激素受体或Her2/neu中的一种、两种或全部的乳腺癌，例如，三阴性乳腺癌)、肝癌、肺癌(例如，非小细胞肺癌(NSCLC)(例如，具有鳞状和/或非鳞状组织学形态的NSCLC)、前列腺癌、头颈癌(例如HPV+鳞状细胞癌)、小肠癌和食道癌。血液癌症的示例包括但不限于白血病(例如，髓细胞性白血病、淋巴性白血病或慢性淋巴细胞性白血病(CLL))、淋巴瘤(例如，霍奇金淋巴瘤(HL)、非霍奇金淋巴瘤(NHL)、弥漫性大B细胞淋巴瘤(DLBCL)、T细胞淋巴瘤或套细胞淋巴瘤(MCL))和骨髓瘤，例如多发性骨髓瘤。癌症可以是早期、中期、晚期或转移性癌症。对于发现和开发本领域通常已知的针对TIM-3的抗体治疗剂，请参见美国专利号10,077,306，其通过引用全文的方式纳入本文。
本文所公开的提供的抗体可用于治疗、预防和/或诊断癌性或恶性病症(例如，癌症如黑素瘤，例如晚期黑素瘤；胰腺癌，例如晚期胰腺癌；实体瘤；乳腺癌，例如，转移性乳腺癌；肾细胞癌，例如晚期或转移性肾细胞癌(MRCC)或透明细胞肾细胞癌)。
所提供的抗体可用于诊断、治疗或监测TIM-3表达型癌症及其进展、消退或稳定；确定患者是否应接受癌症治疗；或确定对象是否患有TIM-3表达型癌症，因此可能适合用TIM-3特异性抗癌治疗剂进行治疗。在一些实施方式中，本文所述的抗体或其片段可用于各种体外分子生物学应用，例如酶联免疫吸附测定(ELISA)、Western印迹、免疫组织化学、免疫细胞化学、流式细胞术和荧光激活细胞分选(FACS)、免疫沉淀和/或酶联免疫斑点测定(ELISPOT)。在一些实施方式中，所述抗体或其片段可被包装于试剂盒或药盒中，连同或不连同本领域技术人员所知的用于进行任一上述分子生物学技术操作的其它试剂。
本公开提供了抗体SCT-Fa001，SCT-Fa002，SCT-Fa003，SCT-Fa004，SCT-Fa005，SCT-Fa006，SCT-Fa007，SCT-Fa008，SCT-Fa009，SCT-Fa010，SCT-Fa011，SCT-Fa012，SCT-Fa013，SCT-Fa014，SCT-Fa015，SCT-Fa016，SCT-Fa017，SCT-Fa018，SCT-Fa019，SCT-Fa020，SCT-Fa021，SCT-Fa022，SCT-Fa023，SCT-Fa024，SCT-Fa025，SCT-Fa026，SCT-Fa027，SCT-Fa028，SCT-Fa029，SCT-Fa030，SCT-Fa031，SCT-Fa032，SCT-Fa033，SCT-Fa034，SCT-Fa035，SCT-Fa036，SCT-Fa037，SCT-Fa038，SCT-Fa039，SCT-Fa040，SCT-Fa041，SCT-Fa042，SCT-Fa043，SCT-Fa044，SCT-Fa045，SCT-Fa046，SCT-Fa047，SCT-Fa048，SCT-Fa049，SCT-Fa050，SCT-Fa051，SCT-Fa052，SCT-Fa053，SCT-Fa054，SCT-Fa055，SCT-Fa056，SCT-Fa057，SCT-Fa058，SCT-Fa059，SCT-Fa060，SCT-Fa061，SCT-Fa062，SCT-Fa063，SCT-Fa064，SCT-Fa065，SCT-Fa066，SCT-Fa067，SCT-Fa068，SCT-Fa069，SCT-Fa070，SCT-Fa071，SCT-Fa072，SCT-Fa073，SCT-Fa074，SCT-Fa075，SCT-Fa076，SCT-Fa077，SCT-Fa078，SCT-Fa079，SCT-Fa080，SCT-Fa081，SCT-Fa082，SCT-Fa083，SCT-Fa084，SCT-Fa085，SCT-Fa086，SCT-Fa087，SCT-Fa088，SCT-Fa089，SCT-Fa090，SCT-Fa091，SCT-Fa092，SCT-Fa093，SCT-Fa094，SCT-Fa095，SCT-Fa096，SCT-Fa097，SCT-Fa098，SCT-Fa099，SCT-Fa100，SCT-Fa101，SCT-Fa102，SCT-Fa103，SCT-Fa104，SCT-Fa105，SCT-Fa106，SCT-Fa107，SCT-Fa108，SCT-Fa109，SCT-Fa110，SCT-Fa111，SCT-Fa112，SCT-Fa113，SCT-Fa114，SCT-Fa115，SCT-Fa116，SCT-Fa117，SCT-Fa118，SCT-Fa119，SCT-Fa120，SCT-Fa121，SCT-Fa122，SCT-Fa123，SCT-Fa124，SCT-Fa125，SCT-Fa126，SCT-Fa127，SCT-Fa128，SCT-Fa129，SCT-Fa130，SCT-Fa131，SCT-Fa132，SCT-Fa133，SCT-Fa134，SCT-Fa135，SCT-Fa136，SCT-Fa137，SCT-Fa138，SCT-Fa139，SCT-Fa140，SCT-Fa141，SCT-Fa142，SCT-Fa143，SCT-Fa144，SCT-Fa145，SCT-Fa146，SCT-Fa147，SCT-Fa148，SCT-Fa149，SCT-Fa150，SCT-Fa151，SCT-Fa152，SCT-Fa153，SCT-Fa154，SCT-Fa155，SCT-Fa156，SCT-Fa157，SCT-Fa158，SCT-Fa159，SCT-Fa160，SCT-Fa161，SCT-Fa162，SCT-Fa163，SCT-Fa164，SCT-Fa165，SCT-Fa166，SCT-Fa167，SCT-Fa168，SCT-Fa169，SCT-Fa170，SCT-Fa171，SCT-Fa172，SCT-Fa173，SCT-Fa174，SCT-Fa175，SCT-Fa176，SCT-Fa177，SCT-Fa178，SCT-Fa179，SCT-Fa180，SCT-Fa181，SCT-Fa182，SCT-Fa183，SCT-Fa184，SCT-Fa185，SCT-Fa186，SCT-Fa187，SCT-Fa188，SCT-Fa189，SCT-Fa190，SCT-Fa191，SCT-Fa192，SCT-Fa193，SCT-Fa194，和SCT-Fa195。这些各自为鼠单克隆抗体。
此外，本公开范围还包括重组抗TIM-3抗体，例如嵌合和人源化单克隆抗体，包括人和非人部分，其可采用标准重组DNA技术制备。这种嵌合和人源化单克隆抗体可以通过重组DNA技术产生，例如美国专利号7,112,421；Better等.(1988)Science 240:1041-1043；或Liu等.(1987)Proc.Natl.Acad.Sci.USA84:3439-3443中描述的方法。
抗体可变结构域序列
本公开的抗体可包含以下的重链可变结构域序列：SEQ ID NO:4，SEQ ID NO:5，SEQ ID NO:6，SEQ ID NO:7，SEQ ID NO:8，SEQ ID NO:9，SEQ ID NO:10，SEQ ID NO:11，SEQID NO:12，SEQ ID NO:13，SEQ ID NO:14，SEQ ID NO:14，SEQ ID NO:15，SEQ ID NO:15，SEQID NO:16，SEQ ID NO:17，SEQ ID NO:18，SEQ ID NO:19，SEQ ID NO:20，SEQ ID NO:21，SEQID NO:22，SEQ ID NO:23，SEQ ID NO:24，SEQ ID NO:25，SEQ ID NO:26，SEQ ID NO:27，SEQID NO:28，SEQ ID NO:29，SEQ ID NO:30，SEQ ID NO:31，SEQ ID NO:32，SEQ ID NO:33，SEQID NO:34，SEQ ID NO:35，SEQ ID NO:35，SEQ ID NO:36，SEQ ID NO:37，SEQ ID NO:38，SEQID NO:39，SEQ ID NO:40，SEQ ID NO:41，SEQ ID NO:42，SEQ ID NO:43，SEQ ID NO:44，SEQID NO:45，SEQ ID NO:46，SEQ ID NO:47，SEQ ID NO:48，SEQ ID NO:49，SEQ ID NO:50，SEQID NO:51，SEQ ID NO:52，SEQ ID NO:53，SEQ ID NO:54，SEQ ID NO:55，SEQ ID NO:56，SEQID NO:57，SEQ ID NO:58，SEQ ID NO:59，SEQ ID NO:60，SEQ ID NO:61，SEQ ID NO:62，SEQID NO:63，SEQ ID NO:64，SEQ ID NO:65，SEQ ID NO:66，SEQ ID NO:67，SEQ ID NO:67，SEQID NO:68，SEQ ID NO:69，SEQ ID NO:70，SEQ ID NO:71，SEQ ID NO:72，SEQ ID NO:73，SEQID NO:74，SEQ ID NO:75，SEQ ID NO:76，SEQ ID NO:77，SEQ ID NO:78，SEQ ID NO:79，SEQID NO:80，SEQ ID NO:81，SEQ ID NO:82，SEQ ID NO:83，SEQ ID NO:84，SEQ ID NO:85，SEQID NO:86，SEQ ID NO:87，SEQ ID NO:88，SEQ ID NO:89，SEQ ID NO:90，SEQ ID NO:90，SEQID NO:91，SEQ ID NO:92，SEQ ID NO:93，SEQ ID NO:94，SEQ ID NO:95，SEQ ID NO:96，SEQID NO:96，SEQ ID NO:97，SEQ ID NO:98，SEQ ID NO:99，SEQ ID NO:100，SEQ ID NO:101，SEQ ID NO:102，SEQ ID NO:103，SEQ ID NO:104，SEQ ID NO:105，SEQ ID NO:106，SEQ IDNO:107，SEQ ID NO:108，SEQ ID NO:109，SEQ ID NO:110，SEQ ID NO:111，SEQ ID NO:112，SEQ ID NO:113，SEQ ID NO:114，SEQ ID NO:115，SEQ ID NO:116，SEQ ID NO:117，SEQ IDNO:118，SEQ ID NO:119，SEQ ID NO:120，SEQ ID NO:121，SEQ ID NO:122，SEQ ID NO:123，SEQ ID NO:124，SEQ ID NO:125，SEQ ID NO:126，SEQ ID NO:127，SEQ ID NO:128，SEQ IDNO:129，SEQ ID NO:130，SEQ ID NO:131，SEQ ID NO:132，SEQ ID NO:133，SEQ ID NO:134，SEQ ID NO:135，SEQ ID NO:136，SEQ ID NO:137，SEQ ID NO:138，SEQ ID NO:139，SEQ IDNO:140，SEQ ID NO:141，SEQ ID NO:142，SEQ ID NO:143，SEQ ID NO:144，SEQ ID NO:145，SEQ ID NO:146，SEQ ID NO:147，SEQ ID NO:148，SEQ ID NO:149，SEQ ID NO:150，SEQ IDNO:151，SEQ ID NO:152，SEQ ID NO:153，SEQ ID NO:154，SEQ ID NO:155，SEQ ID NO:156，SEQ ID NO:156，SEQ ID NO:156，SEQ ID NO:157，SEQ ID NO:157，SEQ ID NO:158，SEQ IDNO:159，SEQ ID NO:160，SEQ ID NO:161，SEQ ID NO:162，SEQ ID NO:163，SEQ ID NO:164，SEQ ID NO:165，SEQ ID NO:166，SEQ ID NO:167，SEQ ID NO:168，SEQ ID NO:169，SEQ IDNO:170，SEQ ID NO:171，SEQ ID NO:171，SEQ ID NO:172，SEQ ID NO:173，SEQ ID NO:174，SEQ ID NO:175，SEQ ID NO:175，SEQ ID NO:176，SEQ ID NO:177，SEQ ID NO:178，SEQ IDNO:179，SEQ ID NO:180，SEQ ID NO:181，SEQ ID NO:182，SEQ ID NO:183，SEQ ID NO:184，SEQ ID NO:185，SEQ ID NO:186，或SEQ ID NO:186。重链可变结构域序列可基本由以下组成：SEQ ID NO:4，SEQ ID NO:5，SEQ ID NO:6，SEQ ID NO:7，SEQ ID NO:8，SEQ ID NO:9，SEQ ID NO:10，SEQ ID NO:11，SEQ ID NO:12，SEQ ID NO:13，SEQ ID NO:14，SEQ ID NO:14，SEQ ID NO:15，SEQ ID NO:15，SEQ ID NO:16，SEQ ID NO:17，SEQ ID NO:18，SEQ IDNO:19，SEQ ID NO:20，SEQ ID NO:21，SEQ ID NO:22，SEQ ID NO:23，SEQ ID NO:24，SEQ IDNO:25，SEQ ID NO:26，SEQ ID NO:27，SEQ ID NO:28，SEQ ID NO:29，SEQ ID NO:30，SEQ IDNO:31，SEQ ID NO:32，SEQ ID NO:33，SEQ ID NO:34，SEQ ID NO:35，SEQ ID NO:35，SEQ IDNO:36，SEQ ID NO:37，SEQ ID NO:38，SEQ ID NO:39，SEQ ID NO:40，SEQ ID NO:41，SEQ IDNO:42，SEQ ID NO:43，SEQ ID NO:44，SEQ ID NO:45，SEQ ID NO:46，SEQ ID NO:47，SEQ IDNO:48，SEQ ID NO:49，SEQ ID NO:50，SEQ ID NO:51，SEQ ID NO:52，SEQ ID NO:53，SEQ IDNO:54，SEQ ID NO:55，SEQ ID NO:56，SEQ ID NO:57，SEQ ID NO:58，SEQ ID NO:59，SEQ IDNO:60，SEQ ID NO:61，SEQ ID NO:62，SEQ ID NO:63，SEQ ID NO:64，SEQ ID NO:65，SEQ IDNO:66，SEQ ID NO:67，SEQ ID NO:67，SEQ ID NO:68，SEQ ID NO:69，SEQ ID NO:70，SEQ IDNO:71，SEQ ID NO:72，SEQ ID NO:73，SEQ ID NO:74，SEQ ID NO:75，SEQ ID NO:76，SEQ IDNO:77，SEQ ID NO:78，SEQ ID NO:79，SEQ ID NO:80，SEQ ID NO:81，SEQ ID NO:82，SEQ IDNO:83，SEQ ID NO:84，SEQ ID NO:85，SEQ ID NO:86，SEQ ID NO:87，SEQ ID NO:88，SEQ IDNO:89，SEQ ID NO:90，SEQ ID NO:90，SEQ ID NO:91，SEQ ID NO:92，SEQ ID NO:93，SEQ IDNO:94，SEQ ID NO:95，SEQ ID NO:96，SEQ ID NO:96，SEQ ID NO:97，SEQ ID NO:98，SEQ IDNO:99，SEQ ID NO:100，SEQ ID NO:101，SEQ ID NO:102，SEQ ID NO:103，SEQ ID NO:104，SEQ ID NO:105，SEQ ID NO:106，SEQ ID NO:107，SEQ ID NO:108，SEQ ID NO:109，SEQ IDNO:110，SEQ ID NO:111，SEQ ID NO:112，SEQ ID NO:113，SEQ ID NO:114，SEQ ID NO:115，SEQ ID NO:116，SEQ ID NO:117，SEQ ID NO:118，SEQ ID NO:119，SEQ ID NO:120，SEQ IDNO:121，SEQ ID NO:122，SEQ ID NO:123，SEQ ID NO:124，SEQ ID NO:125，SEQ ID NO:126，SEQ ID NO:127，SEQ ID NO:128，SEQ ID NO:129，SEQ ID NO:130，SEQ ID NO:131，SEQ IDNO:132，SEQ ID NO:133，SEQ ID NO:134，SEQ ID NO:135，SEQ ID NO:136，SEQ ID NO:137，SEQ ID NO:138，SEQ ID NO:139，SEQ ID NO:140，SEQ ID NO:141，SEQ ID NO:142，SEQ IDNO:143，SEQ ID NO:144，SEQ ID NO:145，SEQ ID NO:146，SEQ ID NO:147，SEQ ID NO:148，SEQ ID NO:149，SEQ ID NO:150，SEQ ID NO:151，SEQ ID NO:152，SEQ ID NO:153，SEQ IDNO:154，SEQ ID NO:155，SEQ ID NO:156，SEQ ID NO:156，SEQ ID NO:156，SEQ ID NO:157，SEQ ID NO:157，SEQ ID NO:158，SEQ ID NO:159，SEQ ID NO:160，SEQ ID NO:161，SEQ IDNO:162，SEQ ID NO:163，SEQ ID NO:164，SEQ ID NO:165，SEQ ID NO:166，SEQ ID NO:167，SEQ ID NO:168，SEQ ID NO:169，SEQ ID NO:170，SEQ ID NO:171，SEQ ID NO:171，SEQ IDNO:172，SEQ ID NO:173，SEQ ID NO:174，SEQ ID NO:175，SEQ ID NO:175，SEQ ID NO:176，SEQ ID NO:177，SEQ ID NO:178，SEQ ID NO:179，SEQ ID NO:180，SEQ ID NO:181，SEQ IDNO:182，SEQ ID NO:183，SEQ ID NO:184，SEQ ID NO:185，SEQ ID NO:186，或SEQ ID NO:186。
本公开的抗体可包含以下的轻链可变结构域序列：SEQ ID NO:187，SEQ ID NO:188，SEQ ID NO:189，SEQ ID NO:190，SEQ ID NO:191，SEQ ID NO:191，SEQ ID NO:192，SEQID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:193，SEQ ID NO:194，SEQ ID NO:194，SEQ ID NO:195，SEQ ID NO:196，SEQ ID NO:197，SEQ ID NO:198，SEQID NO:198，SEQ ID NO:199，SEQ ID NO:200，SEQ ID NO:201，SEQ ID NO:202，SEQ ID NO:203，SEQ ID NO:204，SEQ ID NO:205，SEQ ID NO:206，SEQ ID NO:207，SEQ ID NO:208，SEQID NO:209，SEQ ID NO:209，SEQ ID NO:209，SEQ ID NO:210，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:212，SEQ ID NO:213，SEQ ID NO:214，SEQ ID NO:214，SEQID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:215，SEQ ID NO:216，SEQ ID NO:217，SEQ ID NO:218，SEQ ID NO:219，SEQ ID NO:219，SEQID NO:220，SEQ ID NO:221，SEQ ID NO:222，SEQ ID NO:223，SEQ ID NO:224，SEQ ID NO:225，SEQ ID NO:226，SEQ ID NO:227，SEQ ID NO:228，SEQ ID NO:228，SEQ ID NO:229，SEQID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:230，SEQ ID NO:230，SEQ ID NO:230，SEQ ID NO:231，SEQID NO:231，SEQ ID NO:232，SEQ ID NO:232，SEQ ID NO:233，SEQ ID NO:233，SEQ ID NO:234，SEQ ID NO:235，SEQ ID NO:236，SEQ ID NO:236，SEQ ID NO:236，SEQ ID NO:237，SEQID NO:238，SEQ ID NO:239，SEQ ID NO:240，SEQ ID NO:240，SEQ ID NO:241，SEQ ID NO:242，SEQ ID NO:243，SEQ ID NO:244，SEQ ID NO:245，SEQ ID NO:246，SEQ ID NO:247，SEQID NO:248，SEQ ID NO:249，SEQ ID NO:250，SEQ ID NO:251，SEQ ID NO:252，SEQ ID NO:253，SEQ ID NO:253，SEQ ID NO:254，SEQ ID NO:255，SEQ ID NO:256，SEQ ID NO:257，SEQID NO:258，SEQ ID NO:259，SEQ ID NO:260，SEQ ID NO:261，SEQ ID NO:262，SEQ ID NO:263，SEQ ID NO:264，SEQ ID NO:265，SEQ ID NO:266，SEQ ID NO:266，SEQ ID NO:267，SEQID NO:268，SEQ ID NO:269，SEQ ID NO:270，SEQ ID NO:271，SEQ ID NO:272，SEQ ID NO:273，SEQ ID NO:274，SEQ ID NO:275，SEQ ID NO:276，SEQ ID NO:277，SEQ ID NO:278，SEQID NO:279，SEQ ID NO:280，SEQ ID NO:280，SEQ ID NO:281，SEQ ID NO:281，SEQ ID NO:282，SEQ ID NO:283，SEQ ID NO:283，SEQ ID NO:284，SEQ ID NO:285，SEQ ID NO:286，SEQID NO:287，SEQ ID NO:288，SEQ ID NO:289，SEQ ID NO:290，SEQ ID NO:291，SEQ ID NO:292，SEQ ID NO:293，SEQ ID NO:294，SEQ ID NO:295，SEQ ID NO:296，SEQ ID NO:297，SEQID NO:297，SEQ ID NO:298，SEQ ID NO:299，SEQ ID NO:300，SEQ ID NO:301，SEQ ID NO:302，SEQ ID NO:303，SEQ ID NO:304，SEQ ID NO:305，SEQ ID NO:305，SEQ ID NO:306，SEQID NO:307，SEQ ID NO:308，SEQ ID NO:309，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:311，SEQ ID NO:312，SEQ ID NO:313，SEQID NO:314，SEQ ID NO:314，SEQ ID NO:315，SEQ ID NO:316，SEQ ID NO:317，SEQ ID NO:317，SEQ ID NO:318，SEQ ID NO:319，SEQ ID NO:320，SEQ ID NO:321，SEQ ID NO:322，SEQID NO:323，SEQ ID NO:324，SEQ ID NO:325，SEQ ID NO:326，SEQ ID NO:326，SEQ ID NO:327，SEQ ID NO:328，SEQ ID NO:329，SEQ ID NO:330，SEQ ID NO:331，SEQ ID NO:332，或SEQ ID NO:332。轻链可变结构域序列可基本由以下组成：SEQ ID NO:187，SEQ ID NO:188，SEQ ID NO:189，SEQ ID NO:190，SEQ ID NO:191，SEQ ID NO:191，SEQ ID NO:192，SEQ IDNO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:193，SEQ ID NO:194，SEQ ID NO:194，SEQ ID NO:195，SEQ ID NO:196，SEQ ID NO:197，SEQ ID NO:198，SEQ IDNO:198，SEQ ID NO:199，SEQ ID NO:200，SEQ ID NO:201，SEQ ID NO:202，SEQ ID NO:203，SEQ ID NO:204，SEQ ID NO:205，SEQ ID NO:206，SEQ ID NO:207，SEQ ID NO:208，SEQ IDNO:209，SEQ ID NO:209，SEQ ID NO:209，SEQ ID NO:210，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:212，SEQ ID NO:213，SEQ ID NO:214，SEQ ID NO:214，SEQ IDNO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:215，SEQ ID NO:216，SEQ ID NO:217，SEQ ID NO:218，SEQ ID NO:219，SEQ ID NO:219，SEQ IDNO:220，SEQ ID NO:221，SEQ ID NO:222，SEQ ID NO:223，SEQ ID NO:224，SEQ ID NO:225，SEQ ID NO:226，SEQ ID NO:227，SEQ ID NO:228，SEQ ID NO:228，SEQ ID NO:229，SEQ IDNO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:230，SEQ ID NO:230，SEQ ID NO:230，SEQ ID NO:231，SEQ IDNO:231，SEQ ID NO:232，SEQ ID NO:232，SEQ ID NO:233，SEQ ID NO:233，SEQ ID NO:234，SEQ ID NO:235，SEQ ID NO:236，SEQ ID NO:236，SEQ ID NO:236，SEQ ID NO:237，SEQ IDNO:238，SEQ ID NO:239，SEQ ID NO:240，SEQ ID NO:240，SEQ ID NO:241，SEQ ID NO:242，SEQ ID NO:243，SEQ ID NO:244，SEQ ID NO:245，SEQ ID NO:246，SEQ ID NO:247，SEQ IDNO:248，SEQ ID NO:249，SEQ ID NO:250，SEQ ID NO:251，SEQ ID NO:252，SEQ ID NO:253，SEQ ID NO:253，SEQ ID NO:254，SEQ ID NO:255，SEQ ID NO:256，SEQ ID NO:257，SEQ IDNO:258，SEQ ID NO:259，SEQ ID NO:260，SEQ ID NO:261，SEQ ID NO:262，SEQ ID NO:263，SEQ ID NO:264，SEQ ID NO:265，SEQ ID NO:266，SEQ ID NO:266，SEQ ID NO:267，SEQ IDNO:268，SEQ ID NO:269，SEQ ID NO:270，SEQ ID NO:271，SEQ ID NO:272，SEQ ID NO:273，SEQ ID NO:274，SEQ ID NO:275，SEQ ID NO:276，SEQ ID NO:277，SEQ ID NO:278，SEQ IDNO:279，SEQ ID NO:280，SEQ ID NO:280，SEQ ID NO:281，SEQ ID NO:281，SEQ ID NO:282，SEQ ID NO:283，SEQ ID NO:283，SEQ ID NO:284，SEQ ID NO:285，SEQ ID NO:286，SEQ IDNO:287，SEQ ID NO:288，SEQ ID NO:289，SEQ ID NO:290，SEQ ID NO:291，SEQ ID NO:292，SEQ ID NO:293，SEQ ID NO:294，SEQ ID NO:295，SEQ ID NO:296，SEQ ID NO:297，SEQ IDNO:297，SEQ ID NO:298，SEQ ID NO:299，SEQ ID NO:300，SEQ ID NO:301，SEQ ID NO:302，SEQ ID NO:303，SEQ ID NO:304，SEQ ID NO:305，SEQ ID NO:305，SEQ ID NO:306，SEQ IDNO:307，SEQ ID NO:308，SEQ ID NO:309，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:311，SEQ ID NO:312，SEQ ID NO:313，SEQ IDNO:314，SEQ ID NO:314，SEQ ID NO:315，SEQ ID NO:316，SEQ ID NO:317，SEQ ID NO:317，SEQ ID NO:318，SEQ ID NO:319，SEQ ID NO:320，SEQ ID NO:321，SEQ ID NO:322，SEQ IDNO:323，SEQ ID NO:324，SEQ ID NO:325，SEQ ID NO:326，SEQ ID NO:326，SEQ ID NO:327，SEQ ID NO:328，SEQ ID NO:329，SEQ ID NO:330，SEQ ID NO:331，SEQ ID NO:332，或SEQID NO:332。
本公开还提供一种可变结构域序列，其包含与选自以下的序列至少80％、至少85％、至少90％，或至少95％等同(identical)的序列：SEQ ID NO:4，SEQ ID NO:5，SEQ IDNO:6，SEQ ID NO:7，SEQ ID NO:8，SEQ ID NO:9，SEQ ID NO:10，SEQ ID NO:11，SEQ ID NO:12，SEQ ID NO:13，SEQ ID NO:14，SEQ ID NO:14，SEQ ID NO:15，SEQ ID NO:15，SEQ IDNO:16，SEQ ID NO:17，SEQ ID NO:18，SEQ ID NO:19，SEQ ID NO:20，SEQ ID NO:21，SEQ IDNO:22，SEQ ID NO:23，SEQ ID NO:24，SEQ ID NO:25，SEQ ID NO:26，SEQ ID NO:27，SEQ IDNO:28，SEQ ID NO:29，SEQ ID NO:30，SEQ ID NO:31，SEQ ID NO:32，SEQ ID NO:33，SEQ IDNO:34，SEQ ID NO:35，SEQ ID NO:35，SEQ ID NO:36，SEQ ID NO:37，SEQ ID NO:38，SEQ IDNO:39，SEQ ID NO:40，SEQ ID NO:41，SEQ ID NO:42，SEQ ID NO:43，SEQ ID NO:44，SEQ IDNO:45，SEQ ID NO:46，SEQ ID NO:47，SEQ ID NO:48，SEQ ID NO:49，SEQ ID NO:50，SEQ IDNO:51，SEQ ID NO:52，SEQ ID NO:53，SEQ ID NO:54，SEQ ID NO:55，SEQ ID NO:56，SEQ IDNO:57，SEQ ID NO:58，SEQ ID NO:59，SEQ ID NO:60，SEQ ID NO:61，SEQ ID NO:62，SEQ IDNO:63，SEQ ID NO:64，SEQ ID NO:65，SEQ ID NO:66，SEQ ID NO:67，SEQ ID NO:67，SEQ IDNO:68，SEQ ID NO:69，SEQ ID NO:70，SEQ ID NO:71，SEQ ID NO:72，SEQ ID NO:73，SEQ IDNO:74，SEQ ID NO:75，SEQ ID NO:76，SEQ ID NO:77，SEQ ID NO:78，SEQ ID NO:79，SEQ IDNO:80，SEQ ID NO:81，SEQ ID NO:82，SEQ ID NO:83，SEQ ID NO:84，SEQ ID NO:85，SEQ IDNO:86，SEQ ID NO:87，SEQ ID NO:88，SEQ ID NO:89，SEQ ID NO:90，SEQ ID NO:90，SEQ IDNO:91，SEQ ID NO:92，SEQ ID NO:93，SEQ ID NO:94，SEQ ID NO:95，SEQ ID NO:96，SEQ IDNO:96，SEQ ID NO:97，SEQ ID NO:98，SEQ ID NO:99，SEQ ID NO:100，SEQ ID NO:101，SEQID NO:102，SEQ ID NO:103，SEQ ID NO:104，SEQ ID NO:105，SEQ ID NO:106，SEQ ID NO:107，SEQ ID NO:108，SEQ ID NO:109，SEQ ID NO:110，SEQ ID NO:111，SEQ ID NO:112，SEQID NO:113，SEQ ID NO:114，SEQ ID NO:115，SEQ ID NO:116，SEQ ID NO:117，SEQ ID NO:118，SEQ ID NO:119，SEQ ID NO:120，SEQ ID NO:121，SEQ ID NO:122，SEQ ID NO:123，SEQID NO:124，SEQ ID NO:125，SEQ ID NO:126，SEQ ID NO:127，SEQ ID NO:128，SEQ ID NO:129，SEQ ID NO:130，SEQ ID NO:131，SEQ ID NO:132，SEQ ID NO:133，SEQ ID NO:134，SEQID NO:135，SEQ ID NO:136，SEQ ID NO:137，SEQ ID NO:138，SEQ ID NO:139，SEQ ID NO:140，SEQ ID NO:141，SEQ ID NO:142，SEQ ID NO:143，SEQ ID NO:144，SEQ ID NO:145，SEQID NO:146，SEQ ID NO:147，SEQ ID NO:148，SEQ ID NO:149，SEQ ID NO:150，SEQ ID NO:151，SEQ ID NO:152，SEQ ID NO:153，SEQ ID NO:154，SEQ ID NO:155，SEQ ID NO:156，SEQID NO:156，SEQ ID NO:156，SEQ ID NO:157，SEQ ID NO:157，SEQ ID NO:158，SEQ ID NO:159，SEQ ID NO:160，SEQ ID NO:161，SEQ ID NO:162，SEQ ID NO:163，SEQ ID NO:164，SEQID NO:165，SEQ ID NO:166，SEQ ID NO:167，SEQ ID NO:168，SEQ ID NO:169，SEQ ID NO:170，SEQ ID NO:171，SEQ ID NO:171，SEQ ID NO:172，SEQ ID NO:173，SEQ ID NO:174，SEQID NO:175，SEQ ID NO:175，SEQ ID NO:176，SEQ ID NO:177，SEQ ID NO:178，SEQ ID NO:179，SEQ ID NO:180，SEQ ID NO:181，SEQ ID NO:182，SEQ ID NO:183，SEQ ID NO:184，SEQID NO:185，SEQ ID NO:186，或SEQ ID NO:186。本公开还提供一种可变结构域序列，其包含与选自以下的序列至少80％、至少85％、至少90％，或至少95％等同的序列：SEQ ID NO:187，SEQ ID NO:188，SEQ ID NO:189，SEQ ID NO:190，SEQ ID NO:191，SEQ ID NO:191，SEQID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:192，SEQ ID NO:193，SEQ ID NO:194，SEQ ID NO:194，SEQ ID NO:195，SEQ ID NO:196，SEQ ID NO:197，SEQID NO:198，SEQ ID NO:198，SEQ ID NO:199，SEQ ID NO:200，SEQ ID NO:201，SEQ ID NO:202，SEQ ID NO:203，SEQ ID NO:204，SEQ ID NO:205，SEQ ID NO:206，SEQ ID NO:207，SEQID NO:208，SEQ ID NO:209，SEQ ID NO:209，SEQ ID NO:209，SEQ ID NO:210，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:211，SEQ ID NO:212，SEQ ID NO:213，SEQ ID NO:214，SEQID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:214，SEQ ID NO:215，SEQ ID NO:216，SEQ ID NO:217，SEQ ID NO:218，SEQ ID NO:219，SEQID NO:219，SEQ ID NO:220，SEQ ID NO:221，SEQ ID NO:222，SEQ ID NO:223，SEQ ID NO:224，SEQ ID NO:225，SEQ ID NO:226，SEQ ID NO:227，SEQ ID NO:228，SEQ ID NO:228，SEQID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:229，SEQ ID NO:230，SEQ ID NO:230，SEQ ID NO:230，SEQID NO:231，SEQ ID NO:231，SEQ ID NO:232，SEQ ID NO:232，SEQ ID NO:233，SEQ ID NO:233，SEQ ID NO:234，SEQ ID NO:235，SEQ ID NO:236，SEQ ID NO:236，SEQ ID NO:236，SEQID NO:237，SEQ ID NO:238，SEQ ID NO:239，SEQ ID NO:240，SEQ ID NO:240，SEQ ID NO:241，SEQ ID NO:242，SEQ ID NO:243，SEQ ID NO:244，SEQ ID NO:245，SEQ ID NO:246，SEQID NO:247，SEQ ID NO:248，SEQ ID NO:249，SEQ ID NO:250，SEQ ID NO:251，SEQ ID NO:252，SEQ ID NO:253，SEQ ID NO:253，SEQ ID NO:254，SEQ ID NO:255，SEQ ID NO:256，SEQID NO:257，SEQ ID NO:258，SEQ ID NO:259，SEQ ID NO:260，SEQ ID NO:261，SEQ ID NO:262，SEQ ID NO:263，SEQ ID NO:264，SEQ ID NO:265，SEQ ID NO:266，SEQ ID NO:266，SEQID NO:267，SEQ ID NO:268，SEQ ID NO:269，SEQ ID NO:270，SEQ ID NO:271，SEQ ID NO:272，SEQ ID NO:273，SEQ ID NO:274，SEQ ID NO:275，SEQ ID NO:276，SEQ ID NO:277，SEQID NO:278，SEQ ID NO:279，SEQ ID NO:280，SEQ ID NO:280，SEQ ID NO:281，SEQ ID NO:281，SEQ ID NO:282，SEQ ID NO:283，SEQ ID NO:283，SEQ ID NO:284，SEQ ID NO:285，SEQID NO:286，SEQ ID NO:287，SEQ ID NO:288，SEQ ID NO:289，SEQ ID NO:290，SEQ ID NO:291，SEQ ID NO:292，SEQ ID NO:293，SEQ ID NO:294，SEQ ID NO:295，SEQ ID NO:296，SEQID NO:297，SEQ ID NO:297，SEQ ID NO:298，SEQ ID NO:299，SEQ ID NO:300，SEQ ID NO:301，SEQ ID NO:302，SEQ ID NO:303，SEQ ID NO:304，SEQ ID NO:305，SEQ ID NO:305，SEQID NO:306，SEQ ID NO:307，SEQ ID NO:308，SEQ ID NO:309，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:310，SEQ ID NO:311，SEQ ID NO:312，SEQID NO:313，SEQ ID NO:314，SEQ ID NO:314，SEQ ID NO:315，SEQ ID NO:316，SEQ ID NO:317，SEQ ID NO:317，SEQ ID NO:318，SEQ ID NO:319，SEQ ID NO:320，SEQ ID NO:321，SEQID NO:322，SEQ ID NO:323，SEQ ID NO:324，SEQ ID NO:325，SEQ ID NO:326，SEQ ID NO:326，SEQ ID NO:327，SEQ ID NO:328，SEQ ID NO:329，SEQ ID NO:330，SEQ ID NO:331，SEQID NO:332，或SEQ ID NO:332。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:4至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:317至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:5至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:211至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:6至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:302至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:7至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:223至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:8至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:260至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:9至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:325至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:10至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:305至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:11至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:319至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:12至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:241至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:13至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:306至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:14至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:315至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:14至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:316至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:15至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:312至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:15至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:314至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:16至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:314至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:17至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:288至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:18至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:313至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:19至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:298至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:20至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:307至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:21至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:246至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:22至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:261至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:23至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:330至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:24至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:237至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:25至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:238至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:26至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:236至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:27至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:236至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:28至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:231至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:29至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:232至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:30至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:224至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:31至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:235至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:32至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:240至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:33至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:220至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:34至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:221至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:35至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:240至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:35至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:317至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:36至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:277至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:37至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:239至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:38至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:236至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:39至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:228至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:40至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:228至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:41至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:231至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:42至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:232至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:43至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:233至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:44至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:233至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:45至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:269至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:46至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:305至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:47至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:284至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:48至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:283至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:49至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:283至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:50至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:318至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:51至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:262至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:52至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:206至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:53至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:205至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:54至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:204至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:55至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:202至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:56至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:263至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:57至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:310至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:58至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:320至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:59至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:259至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:60至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:287至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:61至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:203至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:62至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:310至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:63至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:311至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:64至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:265至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:65至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:310至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:66至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:308至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:67至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:290至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:67至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:310至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:68至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:309至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:69至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:310至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:70至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:264至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:71至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:300至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:72至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:324至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:73至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:326至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:74至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:326至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:75至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:243至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:76至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:217至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:77至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:78至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:211至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:79至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:80至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:81至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:82至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:213至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:83至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:215至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:84至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:332至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:85至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:328至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:86至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:331至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:87至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:329至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:88至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:332至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:89至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:198至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:90至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:197至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:90至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:198至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:91至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:92至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:299至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:93至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:285至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:94至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:267至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:95至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:222至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:96至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:227至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:96至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:97至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:98至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:99至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:100至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:101至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:230至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:102至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:225至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:103至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:234至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:104至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:105至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:230至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:106至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:230至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:107至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:229至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:108至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:282至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:109至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:110至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:212至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:111至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:268至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:112至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:266至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:113至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:280至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:114至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:266至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:115至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:187至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:116至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:280至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:117至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:281至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:118至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:278至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:119至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:250至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:120至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:253至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:121至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:249至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:122至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:256至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:123至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:252至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:124至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:257至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:125至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:219至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:126至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:219至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:127至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:251至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:128至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:245至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:129至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:254至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:130至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:244至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:131至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:272至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:132至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:271至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:133至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:289至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:134至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:301至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:135至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:292至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:136至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:195至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:137至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:291至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:138至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:304至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:139至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:296至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:140至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:294至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:141至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:255至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:142至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:143至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:211至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:144至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:214至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:145至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:218至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:146至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:216至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:147至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:286至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:148至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:295至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:149至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:190至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:150至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:193至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:151至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:194至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:152至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:297至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:153至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:194至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:154至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:297至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:155至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:192至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:156至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:188至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:156至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:189至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:156至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:327至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:157至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:192至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:157至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:242至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:158至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:192至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:159至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:191至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:160至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:191至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:161至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:192至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:162至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:192至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:163至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:248至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:164至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:270至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:165至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:273至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:166至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:281至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:167至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:322至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:168至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:209至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:169至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:321至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:170至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:279至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ IDNO:171至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ IDNO:303至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:171至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:323至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:172至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:207至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:173至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:200至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:174至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:247至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:175至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:199至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:175至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:210至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:176至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:196至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:177至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:201至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:178至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:274至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:179至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:209至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:180至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:209至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQID NO:181至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQID NO:208至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:182至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:253至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:183至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:276至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:184至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:275至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:185至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:293至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:186至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:226至少80％、至少85％、至少90％或至少95％等同。本公开还提供一种抗体，其包含重链可变结构域序列和轻链可变结构域序列，所述重链可变结构域序列与SEQ ID NO:186至少80％、至少85％、至少90％或至少95％等同，所述轻链可变结构域序列与SEQ ID NO:258至少80％、至少85％、至少90％或至少95％等同。
表1提供了本文所述的TIM-3特异性抗体的总结：
药物组合物
包含本公开的抗体或抗体片段的药物组合物也被考虑并可用于本文公开的方法中。药物组合物可以包含一种或多种本文所述的抗体或抗体片段以及药学上可接受的运载体或赋形剂。尽管运载体或赋形剂可以促进给药，但其本身不应诱导对接受组合物的对象或个体有害的抗体的产生；它也不应有毒。合适的运载体可以是大的、缓慢代谢的大分子，例如蛋白质、多肽、脂质体、多糖、聚乳酸、聚乙醇酸、聚合氨基酸、氨基酸共聚物和无活性病毒颗粒，并且是本领域技术人员已知的。
本文所述的抗体或抗原结合片段，或本文公开的药物组合物，可以通过任何数量的途径施用，包括但不限于口服、静脉内、肌肉内、动脉内、髓内、腹膜内、鞘内、脑室内、透皮、经皮、局部、皮下、鼻内、肠内、舌下、阴道内或直肠途径。通常，治疗组合物可以制备为液体溶液或悬浮液形式的可注射剂。也可以制备适合在注射前溶解或悬浮在液体载剂中的固体形式。
在一个实施方式中，抗体或其抗原结合片段或药物组合物静脉内给予。在另一个实施方式中，抗体或其抗原结合片段或药物组合物通过静脉输注给予。
组合物的直接递送通常通过皮下注射、腹膜内注射、静脉内注射或肌内注射来实现，或递送至组织的间质空间。也可以将组合物给予到病灶中。剂量治疗可以是单剂量方案或多剂量方案。已知的基于抗体的药物提供与给药频率有关的指导，例如，是否应该每天、每周、每月等递送药物。频率和剂量也可能取决于症状的严重程度。
应理解，组合物中的活性成分将是抗体分子、抗体片段或其变体和衍生物。因此，它很容易在胃肠道中降解。因此，如果组合物要通过使用胃肠道的途径给药，则组合物将需要包含保护抗体免于降解但一旦抗体从胃肠道吸收就释放抗体的物质(agent)。
本发明的方法可以单独使用如上所述的抗体或其抗原结合片段或将其与其它药学活性化合物组合来治疗例如上文公开的那些病症。可以同时(以相同剂型或以单独剂型)或依次给予其它药学活性化合物。因此，在一个实施方式中，本发明包括通过向对象给予治疗有效量的本发明的抗体或其抗原结合片段和一种或多种其它药学活性化合物来治疗病症的方法。
在一些实施方式中，本发明的抗体或其抗原结合片段与现有的TIM-3相关疾病疗法组合使用。
实施例
提出以下实施例是为了向本领域普通技术人员提供如何实施和使用本公开的完整描述，并不旨在限制本发明人认为其公开的范围，也不旨在表示以下实验是全部或唯一可以进行的实验。虽然已努力保证所用数值(如量、温度等)的准确性，但应允许一些实验误差和偏差。除非另有说明，份数是重量份数，分子量是重均分子量，温度是摄氏度，压力是大气压或接近大气压。
实施例1：鼠抗人TIM-3抗体的分离
免疫和单细胞悬液生成
采用重组人TIM-3(带His标记，目录号：TM3-H5229，百普赛斯生物科技股份有限公司(ACROBiosystems)，中国北京，SEQ ID NO:2)来免疫C57/BL6幼鼠，各自使用SigmaAdjuvant
Figure BDA0003511285460000491
(西格玛奥德里奇公司(Sigma-Aldrich)，密苏里州圣路易斯)中的80μg蛋白质，持续35天的时间段，采用抗体解决方案公司(Antibody Solutions)(加利福尼亚州森尼维耳市)的快速免疫方案。在第35天收获淋巴结。产生淋巴结的单细胞悬液，悬液通过70μm网孔(BD生物科技公司(BD Bioscience))过滤以去除团块。
浆细胞分离、抗体捕获和抗原询检(interrogation)
使用基于CD138的细胞表面表达的试剂盒(美天旎(Miltenyi)，加利福尼亚州奥伯恩)，富集过滤的淋巴细胞悬浮液中主动分泌IgG的浆细胞。使用美国专利号9,328,172中描述的方法，将新鲜富集的浆细胞沉积在PDMS装置上，以允许单细胞沉降在装置上的微孔中。从各浆细胞分泌的抗体在衍生化的显微镜载玻片上被捕获。通过用不同浓度的用人Fc加标的荧光标记的TIM-3蛋白(百普赛斯生物科技股份有限公司(ACROBiosystems)，中国北京，目录号：TM3-H5258，SEQ ID NO:3)询检抗体捕获载玻片来识别抗原特异性抗体分泌细胞。使用试剂盒(阿纳斯派公司(AnaSpec)，加利福尼亚州费力蒙，AS-72046，AnaTagTMHiLyteTMFluor555微量蛋白标记试剂盒*超便捷*)进行标记。
mRNA捕获
抗体捕获后，培养基被除去并用裂解缓冲液替换，随后用定制的寡核苷酸微阵列(安捷伦公司(Agilent)，加利福尼亚州圣克拉拉)迅速封闭微孔的顶部。该操作先前在美国专利号9,328,172中有所描述。制备定制的寡核苷酸微阵列，从而使各特征(feature)不仅包含指定其坐标的独特标签，而且还包含用于鼠IgG重链、鼠Igκ轻链的所有亚类(1、2a、2b和3)的捕获探针。
cDNA合成、PCR扩增和下一代测序
定制微阵列上捕获的mRNA被进一步处理以合成各mRNA的cDNA，所述mRNA最初在各特征上纳入独特标签。然后使用Taq聚合酶(普洛麦格公司(Promega)，威斯康星州麦迪逊)和合适的引物组扩增cDNA，以允许扩增以下基因：IgG重链亚类的可变结构域和Igκ轻链的可变结构域。虽然现在从细胞中被释放出来，但各基因的这些片段当前都用来自定制寡核苷酸微阵列的独特标签标记，表明它们的起初位置。对扩增子进行进一步操作，使其两端附有合适的序列，以能够在赛麦提有限责任公司(SeqMatic LLC)(加利福尼亚州费力蒙)的Illumina MiSeq仪器上使用2x250 bp化学进行测序。
图像和DNA序列的生物信息学分析
处理来自MiSeq的测序读数，并且识别各读数中的嵌入标签并将其转换为坐标。绘制坐标以产生回收的mRNA的合成图。大多数坐标形成簇，为回收的mRNA序列指定原始细胞的位置。接下来，根据与由合适荧光标记二抗可视化的抗体点的位置相匹配的簇，识别和整理存在于各读数中的具有坐标的CDR3基序。对于给定的抗体点，等同或几乎等同的CDR3被组织起来并形成一致的VH和VL序列对。包含识别的CDR3的VH或VL序列的剩余部分被识别，并且相关的测序读数被组装成VH和VL的全长cDNA序列。这对全长cDNA与和各抗原特异性抗体点相关联的亲和性测量值相关。
实施例2：抗TIM-3抗体的分子重建和重组表达
服务提供者根据已知技术使用配对的VH和VL抗TIM-3抗体序列的选择子集来合成相应的基因片段。将得到的基因片段克隆到合适的质粒载体中并转染到适当的哺乳动物宿主中，例如HEK293，用于重组表达以产生全IgG形式的抗体制剂。通过在OD280测量以评估产生的量和通过在PAGE上的凝胶电泳以评估所产生的抗体链的大小来表征抗体制剂。
实施例3：重组抗TIM-3抗体的表征
重组表达的抗体用于使用报告细胞测定来评估它们通过磷脂酰丝氨酸轴阻断TIM-3信号转导的能力。这种作为试剂盒的测定是市售可得的(货号JA2211，普洛麦格，威斯康星州麦迪逊)。该试剂盒包含通过遗传工程以表达人TIM-3的TIM-3效应细胞和由T细胞活化途径依赖性反应元件驱动的NanoLuc荧光素酶报告基因。相应的靶细胞，MHCII阳性人细胞系也包括在内。设置完成后，产生的发光信号由发光计(CS1978C14，普洛麦格，威斯康星州麦迪逊)检测，且结果(包括EC50值)将用于与具有已知TIM-3生物活性的基准抗体进行比较(图1)。作为剂量依赖性阻断TIM-3信号转导的结果，阻断性抗体将显示减少的发光。
从上述抗体活动(antibody campaign)中回收的抗体在本文中列出。本文所述的抗TIM-3抗体的CDR序列和VH和VL序列分别描述于表2和表3中。
表2
Figure BDA0003511285460000521
Figure BDA0003511285460000531
Figure BDA0003511285460000541
Figure BDA0003511285460000551
Figure BDA0003511285460000561
Figure BDA0003511285460000571
Figure BDA0003511285460000581
表3
Figure BDA0003511285460000582
Figure BDA0003511285460000591
Figure BDA0003511285460000601
Figure BDA0003511285460000611
Figure BDA0003511285460000621
Figure BDA0003511285460000631
Figure BDA0003511285460000641
Figure BDA0003511285460000651
Figure BDA0003511285460000661
Figure BDA0003511285460000671
Figure BDA0003511285460000681
Figure BDA0003511285460000691
Figure BDA0003511285460000701
前述内容仅说明本公开的原理。应理解，本领域技术人员能够设计各种安排，虽然本文没有明确描述或显示这些安排，但它们均体现本公开的原理并包含在本发明构思和范围内。而且，本文所述的所有实施例和条件语言主要旨在辅助读者理解本公开的原理和本公开对发展现有技术作出的贡献，且不对这些具体引用的实施例和条件构成限制。而且，本文有关本公开原理、方面、实施方式以及具体实施例的所有陈述都应包括其结构和功能等同形式。此外，这些等同物应包括目前已知的等同形式和将来开发的等同形式，即新开发的具有相同功能的任何元件，无论其是何种结构。因此，本公开的范围不应仅限于本文所示和所述的示范性实施方式。适当的是，本公开的范围和构思由所附权利要求书限定。
引用的参考文献
其它参考文献
Anderson,A.C.(2014).Tim-3：癌症免疫治疗领域的新兴目标(Tim-3:anemerging target in the cancer immunotherapy landscape).Cancer Immunol.Res.2,393–398.
Fourcade,J.,Sun,Z.,Benallaoua,M.,Guillaume,P.,Luescher,I.F.,Sander,C.,Kirkwood,J.M.,Kuchroo,V.,和Zarour,H.M.(2010).Tim-3和PD-1表达的上调与黑色素瘤患者的肿瘤抗原特异性CD8+T细胞功能障碍有关(Upregulation of Tim-3and PD-1expression is associated with tumor antigen-specific CD8+T cell dysfunctionin melanoma patients).J.Exp.Med.207,2175–2186.
Han,G.,Chen,G.,Shen,B.,和Li,Y.(2013).Tim-3：先天免疫细胞的激活标志物和激活限制物(Tim-3:an activation marker and activation limiter of innate immunecells).Front.Immunol.4,449.
Monney,L.,Sabatos,C.A.,Gaglia,J.L.,Ryu,A.,Waldner,H.,Chernova,T.,Manning,S.,Greenfield,E.A.,Coyle,A.J.,Sobel,R.A.等(2002).Th1特异性细胞表面蛋白Tim-3调节巨噬细胞活化和自身免疫性疾病的严重程度(Th1-specific cell surfaceprotein Tim-3regulates macrophage activation and severity of an autoimmunedisease).Nature 415,536–541.
Nakayama,M.,Akiba,H.,Takeda,K.,Kojima,Y.,Hashiguchi,M.,Azuma,M.,Yagita,H.,和Okumura,K.(2009).Tim-3介导凋亡细胞的吞噬作用和交叉呈递(Tim-3mediates phagocytosis of apoptotic cells and cross-presentation).Blood 113,3821–3830.
Riedl,S.,Rinner,B.,Asslaber,M.,Schaider,H.,Walzer,S.,Novak,A.,Lohner,K.,和Zweytick,D.(2011).寻找新的靶点——治疗效果不佳非凋亡性肿瘤细胞和恶性肿瘤转移灶暴露的磷脂酰丝氨酸(In search of a novel target—Phosphatidylserineexposed by non-apoptotic tumor cells and metastases of malignancies with poortreatment efficacy).Biochim.Biophys.Acta BBA-Biomembr.1808,2638–2645.
序列表
<110> 单细胞技术股份有限公司(Single Cell Technology, Inc.)
TANG, Leyan
A·舒尔克因斯(SCHULKINS, Allison)
K·坦(THAN, Kimberly)
CHEN, Chun-Nan
<120> 抗TIM-3抗体
<130> SCT0009-401-PC
<150> 62/864,835
<151> 2019-06-21
<160> 722
<170> PatentIn version 3.5
<210> 1
<211> 301
<212> PRT
<213> 智人(Homo sapiens)
<400> 1
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
1 5 10 15
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
20 25 30
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
35 40 45
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
50 55 60
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65 70 75 80
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
85 90 95
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
100 105 110
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
115 120 125
Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe
130 135 140
Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala
145 150 155 160
Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile
165 170 175
Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu
180 185 190
Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly
195 200 205
Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe
210 215 220
Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile
225 230 235 240
Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu
245 250 255
Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr
260 265 270
Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln
275 280 285
Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro
290 295 300
<210> 2
<211> 197
<212> PRT
<213> 人工序列
<220>
<223> 带His标签的人TIM-3蛋白质序列
<400> 2
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
1 5 10 15
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
20 25 30
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
35 40 45
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
50 55 60
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65 70 75 80
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
85 90 95
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
100 105 110
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
115 120 125
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
130 135 140
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145 150 155 160
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
165 170 175
Thr Ile Arg Gly Gly Gly Ser Gly Gly Gly Ser His His His His His
180 185 190
His His His His His
195
<210> 3
<211> 416
<212> PRT
<213> 人工序列
<220>
<223> 带人Fc标签的人TIM-3蛋白质序列
<400> 3
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
1 5 10 15
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
20 25 30
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
35 40 45
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
50 55 60
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65 70 75 80
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
85 90 95
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
100 105 110
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
115 120 125
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
130 135 140
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145 150 155 160
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
165 170 175
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Ser Asp Lys Thr
180 185 190
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
195 200 205
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
210 215 220
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225 230 235 240
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
245 250 255
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
260 265 270
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
275 280 285
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
290 295 300
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305 310 315 320
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
325 330 335
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
340 345 350
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
355 360 365
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
370 375 380
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385 390 395 400
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
405 410 415
<210> 4
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 4
Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asn Ser Phe Thr Asp Tyr
20 25 30
Asn Leu Asn Trp Val Lys Gln Ser His Gly Lys Ser Phe Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Val Lys Ala Ala Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Asn Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser
100 105 110
Ala
<210> 5
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 5
Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Asn Asn Pro Lys Tyr Gly Thr Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Phe Asp Val
100 105 110
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 6
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 6
Glu Gly Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Lys Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Lys His Ser Lys His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Ser Tyr Asp Tyr Ile Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 7
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 7
Glu Val His Leu Gln Gln Ser Gly Ala Glu Phe Met Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Gly His
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asp Gly Ala Thr Lys Phe Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 8
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 8
Glu Val His Leu Gln Gln Ser Val Ala Glu Val Val Arg Pro Gly Ala
1 5 10 15
Ser Val Asn Leu Ser Cys Thr Val Ser Gly Phe Asn Asn Lys Asn Thr
20 25 30
Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asp Pro Ala Asn Gly Asn Val Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Ser Arg Leu Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 9
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 9
Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Asp Trp Ile
35 40 45
Ala Tyr Ile Ser Ser Gly Ser Ile Ser Ser Asp Ser Ser Thr Ile Tyr
50 55 60
Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
65 70 75 80
Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr
85 90 95
Ala Met Tyr Tyr Cys Ala Arg His Asp Trp Arg Gly Leu Tyr Gly Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 10
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 10
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val His Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Gly Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Gly Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Tyr Tyr Ala Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 11
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 11
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Leu Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Gly Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Gly Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Tyr Tyr Ala Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 12
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 12
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Ile Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Tyr Asp Gly Ser Arg Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Asn Ile Tyr Tyr Tyr Gly Gly Ser Ser Tyr Gly Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 13
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 13
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 14
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 14
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 15
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 15
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Gly Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 16
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 16
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Glu Lys Ser Ile Leu Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 17
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 17
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 18
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 18
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 19
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 19
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Ser Ser Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Tyr Tyr Ala Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 20
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 20
Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Phe Asp Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr Trp Gly Gln Gly Ser Ala
100 105 110
Leu Thr Val Ser Ser
115
<210> 21
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 21
Glu Val Gln Leu His Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 22
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 22
Glu Val Gln Leu His Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Glu Tyr Thr Phe Ala Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Ala Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Asp Phe Tyr Gly Asn Ser Tyr Val Gly Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 23
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 23
Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Ile His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Lys Asp Gly Asn Thr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 24
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 24
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Asp Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Leu His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asp Gly Glu Thr Lys Tyr Gly Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ser Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 25
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 25
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Asp Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Ser Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Asp Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Leu Thr Val Ser Ser
115
<210> 26
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 26
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Phe
20 25 30
Tyr Met His Trp Val His Gln Arg Thr Glu Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Lys Thr Lys Phe Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 27
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 27
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Phe
20 25 30
Tyr Met His Trp Val His Gln Arg Thr Glu Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Lys Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 28
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 28
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Thr Asp Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Gly Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 29
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 29
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Asp His Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Gly Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 30
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 30
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Asp Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Lys Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe
65 70 75 80
Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 31
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 31
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Ser
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Pro
100 105 110
Leu Thr Val Ser Ser
115
<210> 32
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 32
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Val Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe
65 70 75 80
Leu His Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 33
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 33
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Ala Thr Ser Ser Asn Thr Pro Tyr
65 70 75 80
Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 34
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 34
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Ala Thr Ser Ser Asn Thr Pro Tyr
65 70 75 80
Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 35
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 35
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Asp Phe Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Val Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Phe
65 70 75 80
Leu His Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 36
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 36
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Pro Ser Asp Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Val Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 37
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 37
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Asp Lys Ile Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 38
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 38
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asn Asp Lys Ile Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 39
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 39
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Phe Thr Ala Ser Asp Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Val Tyr Phe Cys
85 90 95
Thr Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Asp Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 40
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 40
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Phe Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Thr Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 41
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 41
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Tyr Thr Ser Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Thr Asp Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Ile Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Gly Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 42
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 42
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Tyr Thr Ser Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Thr Asp Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Gly Glu Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Gly Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 43
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 43
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Asp Glu Ile Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Ser
65 70 75 80
Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 44
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 44
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asn Asp Glu Ile Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Asn Thr Ala Ser
65 70 75 80
Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 45
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 45
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ser Ser Gly Phe Asn Ile Lys Asp Tyr
20 25 30
Tyr Leu His Trp Val Met Gln Arg Thr Glu His Gly Leu Asn Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Asp Ala Glu Thr Lys Tyr Ala Pro Gln Phe
50 55 60
Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Asp Phe Gly Tyr Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 46
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 46
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Ala Trp Ile
35 40 45
Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe
50 55 60
Lys Asn Lys Ala Thr Leu Thr Val Asp Asp Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Asp Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asp Tyr Gly Ser Arg Glu Trp Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 47
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 47
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Leu Asn Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe
50 55 60
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Gly Leu Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 48
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Asp Ile Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Gly Leu Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 49
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 49
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Asp Ile Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Glu Gly Leu Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
100 105 110
Ser
<210> 50
<211> 114
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 50
Glu Val Gln Leu Gln Gln Ser Gly Pro Met Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Ala Phe
20 25 30
Tyr Met Ser Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Val Asn Pro Tyr Asn Gly Gly Ala Gly Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Leu Leu Trp Glu Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 51
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 51
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Glu Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Ala Thr Tyr Asn Gln Arg Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Asp Phe Tyr Gly Asn Arg Tyr Val Gly Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 52
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 52
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Tyr Asn Ser Ala Ser Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys
85 90 95
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 53
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 53
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Tyr Asn Ser Ala Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys
85 90 95
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 54
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 54
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Tyr Asn Ser Ala Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Val Asn Ser Leu Thr Ser Glu Asp Ser Leu Val Tyr Tyr Cys
85 90 95
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 55
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 55
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Ser Pro Tyr Asn Gly Gly Thr Ser Gln Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asp Tyr Gly Ser Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 56
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 56
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Ala Thr Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Asp Phe Tyr Asp Asn Ala Tyr Val Gly Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 57
<211> 122
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 57
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Asp Tyr Asp Val Asn Tyr Ser Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 58
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 58
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Val Ser Glu Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Val Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Asp Phe His Gly Asn Ser Tyr Val Gly Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 59
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 59
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Tyr Asn Ser Gly Ile Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Asp Thr Ala Tyr
65 70 75 80
Met Asp Leu Asn Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys
85 90 95
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 60
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 60
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Leu Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Thr Tyr Asn Pro Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Asp Tyr Phe Asp Asn Lys Tyr Val Gly Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 61
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 61
Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
His Met Asn Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile
35 40 45
Gly Ile Ile Asn Pro Tyr Asn Ser Ala Thr Thr Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys
85 90 95
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 62
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 62
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Pro Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 63
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 63
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Arg Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Phe Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 64
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 64
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Phe Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 65
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 65
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ile Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 66
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 66
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Ala Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 67
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 67
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 68
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 68
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Gln Asp Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Phe Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 69
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 69
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Phe Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Ile
50 55 60
Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Thr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Asn Asp Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 70
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 70
Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Phe
20 25 30
Tyr Met His Trp Val His Gln Arg Thr Glu Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Glu Asp Gly Lys Thr Lys Tyr Ala Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 71
<211> 124
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys
85 90 95
Thr Arg His Glu Ile Thr Thr Val Leu Ser Thr Asp Tyr Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 72
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Asp Trp Ile
35 40 45
Ala Tyr Ile Ser Ser Gly Ser Ile Ser Ser Gly Ser Ser Thr Ile Tyr
50 55 60
Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
65 70 75 80
Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr
85 90 95
Ala Met Tyr Tyr Cys Ala Arg His Asp Trp Arg Gly Leu Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 73
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met His Trp Val Pro Gln Ala Pro Glu Lys Gly Leu Asp Trp Ile
35 40 45
Ala Tyr Ile Ser Gly Gly Ser Ile Ser Ser Gly Ser Ser Thr Ile Tyr
50 55 60
Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
65 70 75 80
Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr
85 90 95
Ala Met Tyr Tyr Cys Ala Arg His Asp Trp Arg Gly Leu Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 74
<211> 125
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Asp Trp Ile
35 40 45
Ala Tyr Ile Ser Gly Gly Ser Ile Ser Ser Gly Ser Ser Thr Ile Tyr
50 55 60
Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
65 70 75 80
Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr
85 90 95
Ala Met Tyr Tyr Cys Ala Arg His Asp Trp Arg Gly Leu Tyr Ala Met
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120 125
<210> 75
<211> 114
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 75
Glu Val Gln Val Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Arg Gly Leu Ser Cys Glu Gly Ser Gly Phe Thr Phe Ser Gly Phe
20 25 30
Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Thr Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Ser Asp Gly Ser Thr Ile His Tyr Gly Pro Ser Met
50 55 60
Lys Asp Arg Phe Thr Ile Phe Arg Asp Asn Asp Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Asn Val Arg Ser Glu Asp Thr Ala Lys Tyr Phe Cys
85 90 95
Met Ser Leu Leu Leu Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val
100 105 110
Ser Ser
<210> 76
<211> 122
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 76
Glu Val Arg Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Tyr Asp Gly Thr Asn Thr Tyr Tyr Leu Asp Ser Leu
50 55 60
Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Ser Gly Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Gly Arg Gly Ile Tyr Tyr Tyr Gly Arg Ser His Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 77
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 77
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 78
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 78
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr His Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 79
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 79
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln His Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 80
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 80
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 81
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 81
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 82
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 82
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Lys Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 83
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 83
Gln Gly Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ala Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 84
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 84
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ser Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Gly Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 85
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 85
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ala Tyr Asp Tyr Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 86
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 86
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ala Tyr Asp Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 87
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 87
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ala Tyr Asp Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 88
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 88
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ser Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Gly Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 89
<211> 116
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 89
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Met Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Arg Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
Ala Arg Ala Gln His Tyr Phe Asp Trp Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 90
<211> 116
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 90
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Met Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Thr Tyr
20 25 30
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Ser Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
Ala Arg Ala Gln His Tyr Phe Asp Trp Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 91
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 91
Gln Val His Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 92
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 92
Gln Val Leu Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Asp Ile Ser Thr His Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Ser Ser Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 93
<211> 115
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 93
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Ser
20 25 30
Val Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Ile Ile Trp Ala Gly Gly Asp Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Asn Leu Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
Val Ser Ser
115
<210> 94
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 94
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Ile Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Gly Ala Asn Thr Tyr Tyr Asn Asp Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ile Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Ala Asn Trp Ala Phe Ala Ser Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 95
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 95
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp His
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 96
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 96
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 97
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 97
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ile Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Phe Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 98
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 98
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ile Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 99
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 99
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Asn Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Asn Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Val Arg Val Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 100
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 100
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Leu Tyr Asn Ala Lys Phe
50 55 60
Glu Gly Lys Ala Thr Leu Thr Ala Glu Arg Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Val Arg Val Tyr Tyr Tyr Ala Met Asp Phe
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 101
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 101
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Cys Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Thr Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 102
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 102
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Asn Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 103
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 103
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Val Arg Val Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 104
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 104
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 105
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 105
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Thr Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 106
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 106
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Thr Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Val Thr Ser Val Thr Val Ser Ser
115 120
<210> 107
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 107
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 108
<211> 115
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 108
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr
20 25 30
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Ile Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65 70 75 80
Lys Leu Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Thr Ala Asn Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
Val Ser Ser
115
<210> 109
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 109
Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Ile Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Met Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Gly Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 110
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 110
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Glu Ala Ser Gly Asn Thr Phe Thr Ser Tyr
20 25 30
Trp Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ile Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Tyr Ser Ser Pro Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 111
<211> 116
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 111
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Met Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Trp Phe Phe Asp Ile Trp Gly Thr Gly Thr Thr Val
100 105 110
Thr Val Ser Ser
115
<210> 112
<211> 116
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 112
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Cys Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Met Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Trp Phe Phe Asp Ile Trp Gly Thr Gly Thr Thr Val
100 105 110
Thr Val Ser Ser
115
<210> 113
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 113
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Ser Ser
20 25 30
Trp Met Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Ile His Arg Gly Phe Tyr Phe Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 114
<211> 116
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 114
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Met Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Trp Phe Phe Asp Ile Trp Gly Thr Gly Thr Thr Val
100 105 110
Thr Val Ser Ser
115
<210> 115
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 115
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Asn Ser Gly Asp Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Ile Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 116
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 116
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Ser Ser
20 25 30
Trp Met Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Ile His Arg Gly Phe Tyr Phe Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 117
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 117
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Ser Tyr
20 25 30
Trp Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Asn Gln Lys Tyr
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Ile Ser His Tyr Ser Gly Ser Ser Pro Glu Thr Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 118
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 118
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser His
20 25 30
Trp Met Tyr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asp Tyr Ser Gln Glu Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Trp Ser Tyr Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 119
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 119
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Thr Phe
20 25 30
Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 120
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 120
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 121
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 121
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp His Trp Gly
100 105 110
Arg Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 122
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 122
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Gly Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 123
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 123
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 124
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 124
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Gly Tyr Ser Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 125
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 125
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 126
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 126
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 127
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 127
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp His Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 128
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 128
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Arg Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Lys Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 129
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 129
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Arg Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Gly Tyr Thr Asn Tyr Asn His Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 130
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 130
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Ser Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ser Asn Asn Asn Gln Asn Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 131
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 131
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Asn Tyr
20 25 30
Trp Ile Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Ala Trp Ile
35 40 45
Gly Asp Ile Tyr Pro Ser Asp Asn Lys Thr His Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
100 105 110
Ser
<210> 132
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 132
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Ser Tyr
20 25 30
Trp Ile Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asp Ile Tyr Pro Ser Asp Ser Lys Thr His Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
100 105 110
Ser
<210> 133
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 133
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asn Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser His Thr Ser Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Thr Ser
65 70 75 80
Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 134
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 134
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr
20 25 30
Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Asp Asn Asn Thr His Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Ala Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 135
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 135
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Ser Ser Ser Thr Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 136
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 136
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Asp Ser Ser Thr Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 137
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 137
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Ser Ser Ser Thr Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 138
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 138
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Asp Pro Ser Asp Ser Asn Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ser Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 139
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 139
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ile Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Thr Ser Asn Thr Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 140
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 140
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Ser Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Asp Thr Asn Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Arg Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 141
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 141
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Thr Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Arg Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ala Leu Thr Val Ser Ser
115 120
<210> 142
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 142
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Met Gln Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Ala Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Phe Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 143
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 143
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Val Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 144
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 144
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Cys Cys
85 90 95
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 145
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 145
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Gly Ala Tyr Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 146
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 146
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr Asp Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Phe
65 70 75 80
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Val Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 147
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 147
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Ser His
20 25 30
Trp Met Tyr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asp Tyr Ser Gln Glu Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Trp Ser Tyr Tyr Tyr Gly Thr Arg Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 148
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 148
Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Ser Asp Asn Asn Thr His Tyr Asn Gln Lys Phe
50 55 60
Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys
85 90 95
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Phe Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 149
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 149
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Cys Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Asn Gly Gly Pro Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 150
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 150
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 151
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 151
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 152
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 152
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 153
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 153
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 154
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 154
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Ile Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 155
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 155
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Thr Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 156
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 156
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Tyr Gly Gly Pro Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 157
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 157
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Tyr Gly Gly Ser Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 158
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 158
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 159
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 159
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Val Ser Tyr
20 25 30
Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Asn Gly Gly Ser Asn Tyr Asn Glu Arg Phe
50 55 60
Arg Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 160
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 160
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Val Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Asn Gly Gly Ser Asn Tyr Asn Glu Arg Phe
50 55 60
Arg Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 161
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 161
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Thr Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 162
<211> 117
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 162
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Asn Ser Gly Thr Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 163
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 163
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ile Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 164
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 164
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Ser Tyr
20 25 30
Gly Leu Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Ala Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Ala Val Val Ala Gly Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ala Leu Thr Val Ser Ser
115 120
<210> 165
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 165
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Ala Ile Val Ala Gly Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 166
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 166
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Tyr Gly Ser Ser Ser Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 167
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 167
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Arg Pro Gly Ala
1 5 10 15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Asp Tyr
20 25 30
Glu Met Tyr Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Glu Val Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
100 105 110
<210> 168
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 168
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Gly Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Asp
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Trp Gly Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 169
<211> 115
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 169
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Val Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys
85 90 95
Thr Ser Asn Gly Tyr Pro Glu His Trp Gly Gln Gly Thr Thr Leu Thr
100 105 110
Val Ser Ser
115
<210> 170
<211> 122
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 170
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe
20 25 30
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ile Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Gly Ile Tyr Tyr Gly Asn Tyr Gly Ser Ala Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 171
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 171
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Glu Met Tyr Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asp Pro Glu Thr Gly Gly Thr Ala His Asp Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Trp Ala Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
100 105 110
<210> 172
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 172
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Asn Gly Gly Thr Thr Tyr Asn Glu Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys
85 90 95
Ala Arg Thr Ala Tyr Gly Ser Pro Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 173
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 173
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Ala Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Ser Gly Ala Thr Thr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Arg Ala Thr Leu Thr Ala Asp Met Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys
85 90 95
Ala Arg Thr Ala Tyr Gly Ser Pro Leu Asp Cys Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 174
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 174
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Ser Gly Ala Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Arg Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Arg Thr Thr Val Val Ala Pro Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 175
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 175
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Ser Pro Gly Ser Gly Ala Thr Thr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Ala Tyr Gly Ser Pro Leu Asp Phe Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 176
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 176
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Ser Pro Gly Ser Gly Gly Thr Thr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Ala Tyr Gly His Val Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 177
<211> 118
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 177
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Arg Val Ser Cys Thr Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Ser Pro Gly Ser Gly Gly Thr Thr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Ala Tyr Gly His Val Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 178
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 178
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Ser Asn
20 25 30
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Ile Tyr Tyr Asn Glu Lys Val
50 55 60
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Ala Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Thr Val Val Ala Gly Gly Phe Asp Phe Trp Gly Gln
100 105 110
Gly Thr Val Leu Thr Val Ser Ser
115 120
<210> 179
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 179
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Ile His Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Asp
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Trp Gly Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 180
<211> 119
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 180
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Asp
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Trp Gly Asn Trp Tyr Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 181
<211> 122
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 181
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Ile His Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
35 40 45
Glu Trp Ile Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn
50 55 60
Glu Lys Phe Lys Val Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser
65 70 75 80
Thr Ala Asp Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
85 90 95
Tyr Tyr Cys Ala Arg Glu Ala Trp Gly Asn Trp Tyr Phe Asp Val Trp
100 105 110
Gly Thr Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 182
<211> 121
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 182
Gln Val Gln Leu Arg Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 183
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 183
Gln Val Gln Leu Arg Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ser Phe
20 25 30
Gly Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Ile Tyr His Asn Glu Lys Leu
50 55 60
Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Ala Val Val Ala Gly Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 184
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 184
Gln Val Gln Leu Arg Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Ile Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Ala Val Val Ala Gly Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 185
<211> 120
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 185
Gln Val Gln Leu Arg Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Ile Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Thr Ala Val Val Ala Gly Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 186
<211> 123
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 186
Gln Val Gln Leu Arg Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Val Asn
65 70 75 80
Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 187
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 187
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Phe Gln Lys Thr Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 188
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 188
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Ile
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 189
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 189
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Leu
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 190
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 190
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 191
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 191
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Leu
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 192
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 192
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 193
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 193
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Tyr Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 194
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 194
Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Ile Ser Thr Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 195
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 195
Asp Phe Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 196
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 196
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Lys Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 197
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 197
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asp Arg Tyr
20 25 30
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Thr Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 198
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 198
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asp Ser Tyr
20 25 30
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Thr Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 199
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 199
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Val Asn Arg Leu Val Asp Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Gln Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 200
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 200
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr
20 25 30
Leu Ser Trp Leu Gln Gln Lys Ala Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Glu Asn Arg Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 201
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 201
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Lys Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 202
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 202
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Asn Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 203
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 203
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Leu Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Gly Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 204
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 204
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Leu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 205
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 205
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 206
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 206
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Thr Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 207
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 207
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Arg Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr
20 25 30
Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 208
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 208
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser
20 25 30
Ile His Trp Phe Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65 70 75 80
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 209
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 209
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser
20 25 30
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65 70 75 80
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 210
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 210
Asp Ile Leu Leu Thr Gln Ser Pro Asp Ile Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser
20 25 30
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Ser Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65 70 75 80
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 211
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 211
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Arg Val Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Leu Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Val Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 212
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 212
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Ile Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Ser Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ile Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 213
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 213
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ile Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 214
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 214
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Val Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 215
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 215
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Val Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn
100 105
<210> 216
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 216
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Ser Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Glu Tyr Tyr Cys Val Gln Tyr Val Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 217
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 217
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Asn Asn Asn
20 25 30
Val Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Tyr Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Asp Gln Phe Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 218
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 218
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly
1 5 10 15
Asp Thr Val Thr Ile Ile Cys His Ala Ser Gln Asp Ile Arg Ser Asn
20 25 30
Ile Gly Trp Leu Arg Gln Lys Pro Gly Thr Ser Phe Lys Gly Leu Ile
35 40 45
Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Val Gln Phe Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 219
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 219
Asp Ile Gln Leu Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 220
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 220
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Ile Thr Ile Asn Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 221
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 221
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Ile Thr Ile Asn Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 222
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 222
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Asn Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 223
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 223
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Ser Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ile Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Ser Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 224
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 224
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 225
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 225
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asp Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 226
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 226
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Leu Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 227
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 227
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Ala Leu Lys
100 105
<210> 228
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 228
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys
100 105
<210> 229
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 229
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 230
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 230
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys
100 105
<210> 231
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 231
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile
100 105
<210> 232
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 232
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 233
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 233
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Ile Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Gln Leu Glu Ile Lys
100 105
<210> 234
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 234
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Thr Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 235
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 235
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Thr Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Lys Met His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Asn Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 236
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 236
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Thr Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Asn Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 237
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 237
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Thr Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ala Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 238
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 238
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Thr Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ala Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 239
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 239
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Ile Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Asn Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 240
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 240
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Thr Val Thr Ile Thr Cys His Ala Ser Gln Thr Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 241
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 241
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Asn Ala Glu Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 242
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 242
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
20 25 30
Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
50 55 60
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 243
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 243
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
20 25 30
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
Ser Arg Ala Ser Ser Leu Asp Phe Gly Val Pro Lys Arg Phe Arg Gly
50 55 60
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 244
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 244
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ala Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 245
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 245
Asp Ile Gln Met Thr Gln Thr Ala Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ala Leu Pro Trp
85 90 95
Thr Phe Ser Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 246
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 246
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Glu Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln
65 70 75 80
Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Met Leu Pro Leu
85 90 95
Thr Phe Asp Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 247
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 247
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Arg
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 248
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 248
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Glu Lys Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 249
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 249
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Ala Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 250
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 250
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Ile Tyr Phe Cys Gln Gln Ala Asn Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 251
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 251
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Asn Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 252
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 252
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys
100 105
<210> 253
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 253
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu Pro Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Lys Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 254
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 254
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Arg Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 255
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 255
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Ala Gln
65 70 75 80
Gly Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Ser Thr Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys
100 105
<210> 256
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 256
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 257
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 257
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ser Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Ser Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Asn Ala Leu Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 258
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 258
Asp Ile Gln Val Thr Gln Ser Ser Pro Phe Leu Ser Val Ser Leu Gly
1 5 10 15
Gly Arg Val Ile Ile Ser Cys Lys Ala Ser Asp His Ile Asn Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Ile Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Thr
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asn Thr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 259
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 259
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Glu Thr Leu Ile
35 40 45
Tyr Arg Thr Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 260
<211> 111
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 260
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr
20 25 30
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Tyr
65 70 75 80
Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
85 90 95
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 261
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 261
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Thr Asp
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Ser Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Ile Tyr Phe Cys Gln Gln Ser His Thr Trp Pro Gln
85 90 95
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 262
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 262
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Ile Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Gln
85 90 95
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 263
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 263
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asn Asn
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Gln
85 90 95
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 264
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 264
Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Arg Pro Arg Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile
100 105
<210> 265
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 265
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 266
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 266
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ala Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Phe Asn Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Asn Leu Glu Ile Lys
100 105
<210> 267
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 267
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Gly Val Ser Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Glu Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Thr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 268
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 268
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asn Arg Val Ser Ile Thr Cys Lys Val Ser Gln Asp Val Ser Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ala Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Phe Asn Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Asn Leu Glu Ile Lys
100 105
<210> 269
<211> 106
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 269
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Arg
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln
100 105
<210> 270
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 270
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser
20 25 30
Arg Thr Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Leu Ser Gly Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Thr Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 271
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 271
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Lys Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Asp Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 272
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 272
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Lys Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 273
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 273
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Ile Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Thr Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 274
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 274
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Thr Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Thr Tyr Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile
100 105 110
Lys
<210> 275
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 275
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Thr Gly
1 5 10 15
Glu Lys Val Thr Val Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Ile Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 276
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 276
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Thr Gly
1 5 10 15
Glu Lys Val Thr Val Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Ile Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ser Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 277
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 277
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 278
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 278
Asp Val Leu Met Thr Gln Ala Pro Pro Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Cys Gln Gly
85 90 95
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 279
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 279
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Ala Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 280
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 280
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 281
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 281
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 282
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 282
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 283
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 283
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Thr Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Ile Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 284
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 284
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Asn Leu Leu Ile Tyr Lys Val Ala Asn Arg Leu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 285
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 285
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Thr Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 286
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 286
Asp Val Leu Met Thr Gln Thr Pro Pro Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Cys Gln Gly
85 90 95
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 287
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 287
Asp Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Thr Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Gln
85 90 95
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 288
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 288
Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 289
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 289
Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Leu Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 290
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 290
Asp Val Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Phe Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Phe Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 291
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 291
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 292
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 292
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 293
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 293
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Thr Gly
1 5 10 15
Glu Arg Val Thr Val Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Ile Gln Lys Asn Ser Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 294
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 294
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Gly Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Ser Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Thr
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 295
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 295
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp His Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Asp Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 296
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 296
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Thr Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 297
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 297
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Ile Ser Thr Arg Phe Ser Gly Val Leu
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 298
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 298
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Thr Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Leu Thr Phe Gly Ala Gly Ser Lys Leu Glu Leu Lys
100 105 110
<210> 299
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 299
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Gly
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr
85 90 95
Ile His Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 300
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 300
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Ile Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ile Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Arg
100 105 110
<210> 301
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 301
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asn Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 302
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 302
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 303
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 303
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 304
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 304
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 305
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 305
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 306
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 306
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
20 25 30
Asn Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Ala Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 307
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 307
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Ile Thr Ile Gly
1 5 10 15
Gln Pro Ala Ala Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ala
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 308
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 308
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Ala Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Phe Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Phe Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 309
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 309
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Phe Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Phe Phe Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 310
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 310
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Phe Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Phe Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 311
<211> 113
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 311
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Phe Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 312
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 312
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Gly Trp Leu Phe Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 313
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 313
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 314
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 314
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 315
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 315
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Ser Trp Leu Phe Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 316
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 316
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Asn Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Thr Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 317
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 317
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
1 5 10 15
Gln Pro Val Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Gln Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
Thr Leu Phe Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys
100 105 110
<210> 318
<211> 111
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 318
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly
85 90 95
Thr His Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 319
<211> 112
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 319
Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 320
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 320
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
1 5 10 15
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asp
20 25 30
Leu His Trp Tyr Gln Gln Lys Ser His Asp Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr
65 70 75 80
Glu Asp Phe Gly Ile Tyr Phe Cys Gln Gln Ser His Ser Trp Pro Gln
85 90 95
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 321
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 321
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Gly Val Ser Ser Thr
20 25 30
Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 322
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 322
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Val Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His His Tyr His Arg Ser Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 323
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 323
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Val Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His His Tyr Asn Arg Ser Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 324
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 324
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Lys Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Ser Ser Ser Tyr Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 325
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 325
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Lys Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 326
<211> 108
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 326
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Lys Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Ser Tyr Phe Cys Leu Gln Trp Ser Ser Tyr Pro
85 90 95
Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 327
<211> 106
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 327
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 328
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 328
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Met Asn Asn Gly
20 25 30
Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Ser Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ala Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 329
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 329
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser His Gly
20 25 30
Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Ser Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 330
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 330
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 331
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 331
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Tyr Gly
20 25 30
Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Ser Tyr Ser Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 332
<211> 107
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 332
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Pro Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Asn
20 25 30
Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Arg Tyr Gly Thr Asp Phe Ser Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 333
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 333
Gly Asn Ser Phe Thr Asp Tyr Asn
1 5
<210> 334
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 334
Ile Asn Pro Asn Tyr Gly Thr Thr
1 5
<210> 335
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 335
Ala Arg Glu Gly Asn Gly
1 5
<210> 336
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 336
Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr
1 5 10
<210> 337
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 337
Leu Val Ser
1
<210> 338
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 338
Trp Gln Gly Thr Leu Phe Pro Trp Thr
1 5
<210> 339
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 339
Gly Tyr Ser Phe Thr Asp Tyr Asn
1 5
<210> 340
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 340
Asn Asn Pro Lys Tyr Gly Thr Thr
1 5
<210> 341
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 341
Ala Arg Arg Gly Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Phe Asp Val
1 5 10 15
<210> 342
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 342
Gln Asp Ile Arg Ser Asn
1 5
<210> 343
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 343
His Gly Thr
1
<210> 344
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 344
Val Gln Tyr Val Gln Phe Pro Arg Thr
1 5
<210> 345
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 345
Gly Phe Thr Phe Ser Asp Ala Trp
1 5
<210> 346
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 346
Ile Arg Asn Lys Ala Asn Lys His
1 5
<210> 347
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 347
Ser Tyr Asp Tyr Ile Phe Ala Tyr
1 5
<210> 348
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 348
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 349
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 349
Lys Val Ser
1
<210> 350
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 350
Ser Gln Ser Thr His Val Pro Trp Thr
1 5
<210> 351
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 351
Gly Phe Asn Ile Lys Gly His Tyr
1 5
<210> 352
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 352
Ile Asp Pro Asp Asp Gly Ala Thr
1 5
<210> 353
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 353
Thr Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr
1 5 10
<210> 354
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 354
Gln Asn Ile Asn Val Trp
1 5
<210> 355
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 355
Lys Ala Ser
1
<210> 356
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 356
Gln Gln Gly Gln Asn Tyr Pro Tyr Thr
1 5
<210> 357
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 357
Gly Phe Asn Asn Lys Asn Thr Tyr
1 5
<210> 358
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 358
Ile Asp Pro Ala Asn Gly Asn Val
1 5
<210> 359
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 359
Ala Arg Gly Ser Ser Arg Leu Tyr Tyr Ala Leu Asp Tyr
1 5 10
<210> 360
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 360
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe
1 5 10
<210> 361
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 361
Arg Ala Ser
1
<210> 362
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 362
Gln Gln Ser Asn Glu Asp Pro Tyr Thr
1 5
<210> 363
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 363
Gly Phe Thr Phe Ser Asp Tyr Gly
1 5
<210> 364
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 364
Ile Ser Ser Gly Ser Ile Ser Ser
1 5
<210> 365
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 365
Ala Arg His Asp Trp Arg Gly Leu Tyr Gly Met Asp Tyr
1 5 10
<210> 366
<211> 7
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 366
Ser Ser Val Ser Ser Ser Tyr
1 5
<210> 367
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 367
Ser Thr Ser
1
<210> 368
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 368
His Gln Trp Ser Ser Tyr Pro Pro Thr
1 5
<210> 369
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 369
Gly Phe Thr Phe Ser Asp Tyr Tyr
1 5
<210> 370
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 370
Ile Asn Phe Asp Gly Ser Gly Thr
1 5
<210> 371
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 371
Ala Arg Leu Tyr Asp Gly Tyr Tyr Ala Tyr
1 5 10
<210> 372
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 372
Ser Gln Ser Thr His Val Pro Leu Thr
1 5
<210> 373
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 373
Ile Asn Tyr Asp Gly Ser Arg Thr
1 5
<210> 374
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 374
Ala Arg Asn Ile Tyr Tyr Tyr Gly Gly Ser Ser Tyr Gly Met Asp Tyr
1 5 10 15
<210> 375
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 375
Gly Asn Ile His Asn Tyr
1 5
<210> 376
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 376
Asn Ala Glu
1
<210> 377
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 377
Gln His Phe Trp Ser Thr Pro Leu Thr
1 5
<210> 378
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 378
Ala Arg Leu Tyr Asp Gly Ser Leu Asp Tyr
1 5 10
<210> 379
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 379
Gln Ser Leu Leu Tyr Thr Asn Gly Lys Thr Tyr
1 5 10
<210> 380
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 380
Val Gln Gly Thr His Phe Pro Leu Thr
1 5
<210> 381
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 381
Ala Arg Leu Tyr Asp Gly Ser His Asp Tyr
1 5 10
<210> 382
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 382
Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr
1 5 10
<210> 383
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 383
Val Gln Gly Thr His Phe Pro Gln Thr
1 5
<210> 384
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 384
Ile Asn Phe Asp Gly Ser Ser Ser
1 5
<210> 385
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 385
Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 386
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 386
Val Gln Ala Thr His Phe Pro Leu Thr
1 5
<210> 387
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 387
Gly Tyr Thr Phe Thr Asp Tyr Asn
1 5
<210> 388
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 388
Ile Asn Pro Asn Asn Gly Gly Ile
1 5
<210> 389
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 389
Val Gly Ser Leu Asp Tyr
1 5
<210> 390
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 390
Gln Asp Ile Asn Asn Tyr
1 5
<210> 391
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 391
Tyr Thr Ser
1
<210> 392
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 392
Gln Gln Gly Tyr Met Leu Pro Leu Thr
1 5
<210> 393
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 393
Glu Tyr Thr Phe Ala Asp Tyr Tyr
1 5
<210> 394
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 394
Ile Asn Pro Tyr Asn Gly Gly Ala
1 5
<210> 395
<211> 18
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 395
Ala Arg Asp Ala Asp Phe Tyr Gly Asn Ser Tyr Val Gly Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 396
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 396
Gln Ser Ile Asn Thr Asp
1 5
<210> 397
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 397
Tyr Ala Ser
1
<210> 398
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 398
Gln Gln Ser His Thr Trp Pro Gln Tyr Thr
1 5 10
<210> 399
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 399
Gly Tyr Thr Phe Thr Ser Tyr Trp
1 5
<210> 400
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 400
Ile Asp Pro Asn Ser Gly Gly Thr
1 5
<210> 401
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 401
Thr Lys Asp Gly Asn Thr Pro Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 402
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 402
Gln Ser Val Ser Asn Ala
1 5
<210> 403
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 403
Gln Gln Asp Tyr Ser Ser Pro Leu Thr
1 5
<210> 404
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 404
Asp Phe Asn Ile Lys Asp Tyr Tyr
1 5
<210> 405
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 405
Ile Asp Pro Asp Asp Gly Glu Thr
1 5
<210> 406
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 406
Ser Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr
1 5 10
<210> 407
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 407
Ile Asp Pro Glu Asp Asp Glu Thr
1 5
<210> 408
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 408
Ala Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr
1 5 10
<210> 409
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 409
Gly Phe Asn Ile Lys Asp Phe Tyr
1 5
<210> 410
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 410
Ile Asp Pro Glu Asp Gly Lys Thr
1 5
<210> 411
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 411
Ala Arg Ser Asn Pro Tyr Phe Phe Asp Tyr
1 5 10
<210> 412
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 412
Gln Thr Ile Asn Val Trp
1 5
<210> 413
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 413
His Gln Gly Gln Ser Tyr Pro Tyr Thr
1 5
<210> 414
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 414
Gly Phe Asn Ile Lys Asp Tyr Tyr
1 5
<210> 415
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 415
Ile Asp Pro Asp Asn Gly Glu Thr
1 5
<210> 416
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 416
Ala Arg Ser Ser Pro Tyr Tyr Phe Asp Tyr
1 5 10
<210> 417
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 417
Gln Gln Gly Gln Asn Phe Pro Tyr Thr
1 5
<210> 418
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 418
Gln Gln Gly Gln Ser Tyr Pro Tyr Thr
1 5
<210> 419
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 419
Ile Asp Pro Glu Asp Gly Glu Thr
1 5
<210> 420
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 420
Gly Arg Ser Asn Pro Tyr Tyr Phe Asp Tyr
1 5 10
<210> 421
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 421
Gln Asn Val Gly Thr Asn
1 5
<210> 422
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 422
Ser Ala Ser
1
<210> 423
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 423
Gln Gln Tyr Asn Thr Tyr Pro Leu Thr
1 5
<210> 424
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 424
Ile Asp Pro Asp Asn Asp Lys Ile
1 5
<210> 425
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 425
Gln Thr Ile Asn Ile Trp
1 5
<210> 426
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 426
Ile Asp Pro Glu Asn Asp Lys Ile
1 5
<210> 427
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 427
Ile Asp Pro Asp Asn Asp Glu Ile
1 5
<210> 428
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 428
Gln Gln Gly Gln Asn Ile Pro Tyr Thr
1 5
<210> 429
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 429
Ile Asp Pro Asp Asp Ala Glu Thr
1 5
<210> 430
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 430
Thr Arg Asp Phe Gly Tyr Thr Asp Tyr Phe Asp Tyr
1 5 10
<210> 431
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 431
Gln Asp Val Ser Thr Ala
1 5
<210> 432
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 432
Gln Gln His Tyr Ser Thr Pro Thr
1 5
<210> 433
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 433
Ile Tyr Pro Tyr Asn Gly Gly Thr
1 5
<210> 434
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 434
Ala Arg Glu Asp Tyr Gly Ser Arg Glu Trp Phe Ala Tyr
1 5 10
<210> 435
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 435
Gly Tyr Thr Phe Thr Asp Tyr Tyr
1 5
<210> 436
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 436
Ile Asn Leu Asn Asn Gly Gly Thr
1 5
<210> 437
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 437
Glu Gly Leu Gly Gly Tyr
1 5
<210> 438
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 438
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 439
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 439
Lys Val Ala
1
<210> 440
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 440
Phe Gln Gly Ser His Val Pro Phe Thr
1 5
<210> 441
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 441
Gly Tyr Thr Leu Thr Asp Tyr Tyr
1 5
<210> 442
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 442
Ile Asn Pro Asn Asn Gly Asp Ile
1 5
<210> 443
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 443
Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 444
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 444
Gly Asn Thr Phe Thr Ala Phe Tyr
1 5
<210> 445
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 445
Val Asn Pro Tyr Asn Gly Gly Ala
1 5
<210> 446
<211> 7
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 446
Leu Leu Trp Glu Phe Ala His
1 5
<210> 447
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 447
Trp Gln Gly Thr His Ser Trp Thr
1 5
<210> 448
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 448
Glu Tyr Thr Phe Thr Asp Tyr Tyr
1 5
<210> 449
<211> 18
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 449
Ala Arg Asp Val Asp Phe Tyr Gly Asn Arg Tyr Val Gly Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 450
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 450
Gln Ser Ile Ser Asn Asn
1 5
<210> 451
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 451
Gln Gln Ser Asn Ser Trp Pro Gln Tyr Thr
1 5 10
<210> 452
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 452
Gly Tyr Ser Phe Thr Gly Tyr His
1 5
<210> 453
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 453
Ile Asn Pro Tyr Asn Ser Ala Ser
1 5
<210> 454
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 454
Val Arg Gly Ala Tyr Gly Asn Pro Leu Asp Tyr
1 5 10
<210> 455
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 455
Gln Asp Ile Asn Ser Tyr
1 5
<210> 456
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 456
Arg Thr Asn
1
<210> 457
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 457
Leu Gln Tyr Asp Glu Tyr Pro Tyr Thr
1 5
<210> 458
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 458
Ile Asn Pro Tyr Asn Ser Ala Thr
1 5
<210> 459
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 459
Arg Ala Asn
1
<210> 460
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 460
Gly Tyr Thr Phe Thr Asp Tyr His
1 5
<210> 461
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 461
Ile Ser Pro Tyr Asn Gly Gly Thr
1 5
<210> 462
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 462
Ala Arg Ser Asp Tyr Gly Ser Pro Leu Asp Tyr
1 5 10
<210> 463
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 463
Leu Gln Tyr Asp Glu Phe Pro Tyr Thr
1 5
<210> 464
<211> 18
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 464
Ala Arg Asp Val Asp Phe Tyr Asp Asn Ala Tyr Val Gly Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 465
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 465
Gln Thr Ile Ser Asn Asn
1 5
<210> 466
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 466
Ile Asn Pro Tyr Asn Gly Gly Thr
1 5
<210> 467
<211> 15
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 467
Ala Arg Gly Gly Asp Tyr Asp Val Asn Tyr Ser Ala Met Asp Tyr
1 5 10 15
<210> 468
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 468
Trp Gln Gly Thr His Phe Pro Thr Trp Thr
1 5 10
<210> 469
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 469
Ile Asn Pro Tyr Asn Gly Gly Val
1 5
<210> 470
<211> 18
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 470
Ala Arg Asp Ala Asp Phe His Gly Asn Ser Tyr Val Gly Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 471
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 471
Gln Ser Ile Ser Asn Asp
1 5
<210> 472
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 472
Gln Gln Ser His Ser Trp Pro Gln Tyr Thr
1 5 10
<210> 473
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 473
Ile Asn Pro Tyr Asn Ser Gly Ile
1 5
<210> 474
<211> 18
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 474
Ala Arg Asp Val Asp Tyr Phe Asp Asn Lys Tyr Val Gly Tyr Ala Met
1 5 10 15
Asp Tyr
<210> 475
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 475
Gly Tyr Thr Phe Thr Arg Tyr Trp
1 5
<210> 476
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 476
Ile Tyr Pro Gly Asn Ser Asp Thr
1 5
<210> 477
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 477
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Tyr
1 5 10
<210> 478
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 478
Gly Tyr Thr Phe Ile Arg Tyr Trp
1 5
<210> 479
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 479
Thr Phe Tyr Tyr Gly Asn Tyr Val Asn Phe
1 5 10
<210> 480
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 480
Thr Phe Phe Tyr Gly Asn Tyr Val Asn Tyr
1 5 10
<210> 481
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 481
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr
1 5 10
<210> 482
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 482
Trp Ala Ser
1
<210> 483
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 483
Gln Gln Tyr Tyr Ser Tyr Pro Arg Thr
1 5
<210> 484
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 484
Gln Ser Leu Leu Ala Ser Asp Gly Lys Thr Tyr
1 5 10
<210> 485
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 485
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 486
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 486
Ile Ser Ser Gly Gly Ser Tyr Thr
1 5
<210> 487
<211> 17
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 487
Thr Arg His Glu Ile Thr Thr Val Leu Ser Thr Asp Tyr Ala Met Asp
1 5 10 15
Tyr
<210> 488
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 488
Gln Ser Leu Val His Ser Ile Gly Asn Thr Tyr
1 5 10
<210> 489
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 489
Ser Gln Ser Thr His Ile Pro Trp Thr
1 5
<210> 490
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 490
Ala Arg His Asp Trp Arg Gly Leu Tyr Ala Met Asp Tyr
1 5 10
<210> 491
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 491
His Gln Ser Ser Ser Tyr Pro Pro Thr
1 5
<210> 492
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 492
Ile Ser Gly Gly Ser Ile Ser Ser
1 5
<210> 493
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 493
Leu Gln Trp Ser Ser Tyr Pro Pro Thr
1 5
<210> 494
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 494
Gly Phe Thr Phe Ser Gly Phe Trp
1 5
<210> 495
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 495
Ile Asn Ser Asp Gly Ser Thr Ile
1 5
<210> 496
<211> 7
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 496
Met Ser Leu Leu Leu Asn Val
1 5
<210> 497
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 497
Gln Glu Ile Ser Gly Tyr
1 5
<210> 498
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 498
Leu Gln Tyr Ala Asn Tyr Pro Leu Thr
1 5
<210> 499
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 499
Ile Asn Tyr Asp Gly Thr Asn Thr
1 5
<210> 500
<211> 15
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 500
Gly Arg Gly Ile Tyr Tyr Tyr Gly Arg Ser His Ala Met Asp Tyr
1 5 10 15
<210> 501
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 501
Gln Gly Ile Asn Asn Asn
1 5
<210> 502
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 502
Val Gln Tyr Asp Gln Phe Pro Pro Thr
1 5
<210> 503
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 503
Ile Asp Pro Ser Asp Asn Tyr Thr
1 5
<210> 504
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 504
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 505
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 505
Ala Lys Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 506
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 506
Val Gln Tyr Ile Gln Phe Pro Arg Thr
1 5
<210> 507
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 507
Ile Tyr Pro Gly Ser Asp Asn Thr
1 5
<210> 508
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 508
Ala Arg Ser Gly Asn Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 509
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 509
Gln Ser Val Ser Asn Asn
1 5
<210> 510
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 510
Gln Gln Asp Tyr Ser Ser Pro Tyr Thr
1 5
<210> 511
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 511
Ile Tyr Pro Gly Ser Gly Asn Thr
1 5
<210> 512
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 512
Ala Arg Ala Tyr Asp Tyr Gly Phe Pro Tyr
1 5 10
<210> 513
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 513
Gln Ser Met Asn Asn Gly
1 5
<210> 514
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 514
Ala Arg Ala Tyr Asp Tyr Gly Phe Ala Tyr
1 5 10
<210> 515
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 515
Gln Ser Val Ser Tyr Gly
1 5
<210> 516
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 516
Tyr Ser Ser
1
<210> 517
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 517
Gln Ser Val Ser His Gly
1 5
<210> 518
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 518
Gly Tyr Ile Phe Arg Thr Tyr Gly
1 5
<210> 519
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 519
Ile Asn Thr Tyr Ser Gly Glu Pro
1 5
<210> 520
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 520
Ala Arg Ala Gln His Tyr Phe Asp Trp
1 5
<210> 521
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 521
Gln Asp Ile Asp Ser Tyr
1 5
<210> 522
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 522
Arg Ala Thr
1
<210> 523
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 523
Gly Tyr Thr Phe Arg Thr Tyr Gly
1 5
<210> 524
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 524
Gln Asp Ile Asp Arg Tyr
1 5
<210> 525
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 525
Ile Tyr Pro Gly Asn Gly Asn Thr
1 5
<210> 526
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 526
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10 15
<210> 527
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 527
Gln Gln Gly Gln Ser Tyr Pro Leu Thr
1 5
<210> 528
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 528
Gly Tyr Thr Phe Thr Asn Phe Trp
1 5
<210> 529
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 529
Ile Asp Pro Ser Asp Ile Ser Thr
1 5
<210> 530
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 530
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr
1 5 10
<210> 531
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 531
Gln Ser Leu Val His Gly Asn Gly Asn Thr Tyr
1 5 10
<210> 532
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 532
Thr Val Ser
1
<210> 533
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 533
Ser Gln Thr Ile His Ala Pro Trp Thr
1 5
<210> 534
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 534
Gly Phe Ser Leu Thr Ser Ser Val
1 5
<210> 535
<211> 7
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 535
Ile Trp Ala Gly Gly Asp Thr
1 5
<210> 536
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 536
Ala Arg Asn Leu Asn Ala Met Asp Tyr
1 5
<210> 537
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 537
Phe Gln Gly Ser His Val Pro Trp Thr
1 5
<210> 538
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 538
Gly Tyr Thr Phe Thr Asp Phe Tyr
1 5
<210> 539
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 539
Ile Tyr Pro Gly Gly Ala Asn Thr
1 5
<210> 540
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 540
Ala Arg Gly Ala Asn Trp Ala Phe Ala Ser
1 5 10
<210> 541
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 541
Gln Gly Val Ser Thr Ala
1 5
<210> 542
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 542
Gln Gln Tyr Tyr Asn Thr Pro Tyr Thr
1 5
<210> 543
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 543
Gly Tyr Ile Leu Thr Asp Tyr Tyr
1 5
<210> 544
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 544
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Tyr Ala Met Asp His
1 5 10 15
<210> 545
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 545
Gly Tyr Thr Leu Ile Asp Tyr Tyr
1 5
<210> 546
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 546
Ala Arg Gly Gly Ser Ser Asp Arg Ile Tyr Tyr Phe Ala Met Asp Tyr
1 5 10 15
<210> 547
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 547
Gly Tyr Thr Leu Asn Asp Tyr Tyr
1 5
<210> 548
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 548
Ile Tyr Pro Gly Asn Asn Asn Thr
1 5
<210> 549
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 549
Ala Arg Gly Gly Ser Ser Val Arg Val Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10 15
<210> 550
<211> 16
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 550
Ala Arg Gly Gly Ser Ser Val Arg Val Tyr Tyr Tyr Ala Met Asp Phe
1 5 10 15
<210> 551
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 551
Gly Phe Ser Leu Ile Ser Tyr Gly
1 5
<210> 552
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 552
Ile Trp Ser Gly Gly Asn Thr Asp
1 5
<210> 553
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 553
Ala Arg Thr Ala Asn Ala Leu Asp Tyr
1 5
<210> 554
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 554
Gly Tyr Thr Phe Thr Asn Tyr Trp
1 5
<210> 555
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 555
Ala Gly Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 556
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 556
Gly Asn Thr Phe Thr Ser Tyr Trp
1 5
<210> 557
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 557
Ile Asp Pro Ser Asp Ser Tyr Ile
1 5
<210> 558
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 558
Ala Arg Glu Gly Ala Tyr Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 559
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 559
His Gly Ser
1
<210> 560
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 560
Ile Asp Pro Asp Ser Gly Gly Thr
1 5
<210> 561
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 561
Ala Arg Tyr Tyr Trp Phe Phe Asp Ile
1 5
<210> 562
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 562
Gln Gln His Phe Asn Thr Pro Phe Thr
1 5
<210> 563
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 563
Cys Tyr Thr Phe Ile Ser Tyr Trp
1 5
<210> 564
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 564
Gln Asp Val Gly Ala Ala
1 5
<210> 565
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 565
Gly Tyr Ser Phe Ile Ser Ser Trp
1 5
<210> 566
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 566
Ile His Pro Ser Asp Ser Asp Thr
1 5
<210> 567
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 567
Ala Ile Ile His Arg Gly Phe Tyr Phe Ala Met Asp Tyr
1 5 10
<210> 568
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 568
Gly Tyr Thr Phe Ile Ser Tyr Trp
1 5
<210> 569
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 569
Ile Asp Pro Asn Ser Gly Asp Thr
1 5
<210> 570
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 570
Ala Arg Trp Gly Trp Asp Ala Phe Ala Tyr
1 5 10
<210> 571
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 571
Gln Ser Leu Glu Asn Ser Asp Gly Asn Thr Tyr
1 5 10
<210> 572
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 572
Arg Val Ser
1
<210> 573
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 573
Leu Gln Val Thr His Val Pro Pro Thr
1 5
<210> 574
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 574
Gly Tyr Ser Phe Ile Ser Tyr Trp
1 5
<210> 575
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 575
Thr Ile Ser His Tyr Ser Gly Ser Ser Pro Glu Thr Tyr
1 5 10
<210> 576
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 576
Phe Gln Gly Ser His Val Pro Tyr Thr
1 5
<210> 577
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 577
Gly Tyr Thr Phe Ile Ser His Trp
1 5
<210> 578
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 578
Ala Ile Trp Ser Tyr Tyr Tyr Gly Ser Arg Leu Asp Tyr
1 5 10
<210> 579
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 579
Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 580
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 580
Gln Gly Ser His Val Pro Tyr Thr
1 5
<210> 581
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 581
Gly Tyr Thr Phe Thr Thr Phe Trp
1 5
<210> 582
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 582
Ile Asp Pro Ser Asp Ser Tyr Thr
1 5
<210> 583
<211> 14
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 583
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp Tyr
1 5 10
<210> 584
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 584
Gln Asp Ile Ser Asn Tyr
1 5
<210> 585
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 585
Gln Gln Ala Asn Ala Leu Pro Trp Thr
1 5
<210> 586
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 586
Gly Tyr Thr Phe Asn Thr Tyr Trp
1 5
<210> 587
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 587
Gln Gln Ala Lys Ala Leu Pro Trp Thr
1 5
<210> 588
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 588
Gly Tyr Thr Phe Ser Thr Tyr Trp
1 5
<210> 589
<211> 14
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 589
Ala Arg Asn Tyr Gly Ser Asn Tyr Val Gly Tyr Phe Asp His
1 5 10
<210> 590
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 590
Gln Gln Gly Asn Ala Leu Pro Trp Thr
1 5
<210> 591
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 591
Gln Gly Ile Ser Asn Tyr
1 5
<210> 592
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 592
Gln Gln Gly Asn Ser Leu Pro Trp Thr
1 5
<210> 593
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 593
Ile Asp Pro Ser Asp Ser Tyr Ser
1 5
<210> 594
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 594
Gln Gln Gly Asn Thr Leu Pro Trp Thr
1 5
<210> 595
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 595
Gly Tyr Thr Phe Thr Thr Tyr Trp
1 5
<210> 596
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 596
Ile Asp Pro Ser Asp Gly Tyr Ser
1 5
<210> 597
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 597
Gln Gln Gly Lys Ala Leu Pro Trp Thr
1 5
<210> 598
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 598
Ile Asp Pro Ser Asp Gly Tyr Thr
1 5
<210> 599
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 599
Gln Asp Ile Thr Asn Tyr
1 5
<210> 600
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 600
His Thr Ser
1
<210> 601
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 601
Gly Tyr Asn Phe Thr Asn Tyr Trp
1 5
<210> 602
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 602
Ile Tyr Pro Ser Asp Asn Lys Thr
1 5
<210> 603
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 603
Ala Ala Ser Met Asp Tyr
1 5
<210> 604
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 604
Gln Ser Leu Leu Asn Ser Lys Asn Gln Lys Asn Phe
1 5 10
<210> 605
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 605
Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr
1 5
<210> 606
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 606
Gly Tyr Asn Phe Thr Ser Tyr Trp
1 5
<210> 607
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 607
Ile Tyr Pro Ser Asp Ser Lys Thr
1 5
<210> 608
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 608
Ala Thr Ser Met Asp Tyr
1 5
<210> 609
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 609
Gln Asn Asp Tyr Asp Tyr Pro Tyr Thr
1 5
<210> 610
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 610
Gly Tyr Thr Phe Ile Asn Tyr Trp
1 5
<210> 611
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 611
Ile Asp Pro Ser His Thr Ser Thr
1 5
<210> 612
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 612
Ser Gln Thr Thr His Val Pro Trp Thr
1 5
<210> 613
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 613
Gly Tyr Thr Phe Ser Arg Tyr Trp
1 5
<210> 614
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 614
Ile Asp Pro Ser Asp Asn Asn Thr
1 5
<210> 615
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 615
Ile Asp Pro Ser Ser Ser Ser Thr
1 5
<210> 616
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 616
Gln Ser Leu Val His Ser Asn Gly Ile Thr Tyr
1 5 10
<210> 617
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 617
Ile Asp Pro Ser Asp Ser Ser Thr
1 5
<210> 618
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 618
Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 619
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 619
Ile Asp Pro Ser Asp Ser Asn Thr
1 5
<210> 620
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 620
Ser Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Tyr
1 5 10
<210> 621
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 621
Gly Tyr Ser Phe Thr Ile Tyr Trp
1 5
<210> 622
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 622
Ile Asp Pro Ser Thr Ser Asn Thr
1 5
<210> 623
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 623
Gln Arg Leu Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 624
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 624
Ile Asp Pro Ser Asp Thr Asn Thr
1 5
<210> 625
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 625
Ile Asp Pro Ser Asp Ser Tyr Arg
1 5
<210> 626
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 626
Gln Gln Ala Ser Thr Leu Pro Trp Thr
1 5
<210> 627
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 627
Ala Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Phe
1 5 10
<210> 628
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 628
Ala Lys Glu Gly Ala Tyr Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 629
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 629
Val Arg Glu Gly Ala Phe Ser Ser Pro Phe Ala Tyr
1 5 10
<210> 630
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 630
Gly Tyr Ser Phe Ile Ser His Trp
1 5
<210> 631
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 631
Ala Ile Trp Ser Tyr Tyr Tyr Gly Thr Arg Leu Asp Tyr
1 5 10
<210> 632
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 632
Ala Arg Asn Asp Tyr Asp Gly Gly Tyr Phe Asp Phe
1 5 10
<210> 633
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 633
Gln Ser Leu Val His Ser Asn Gly His Thr Tyr
1 5 10
<210> 634
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 634
Gly Tyr Thr Phe Ile Ser Tyr Cys
1 5
<210> 635
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 635
Ile Asp Pro Asn Asn Gly Gly Pro
1 5
<210> 636
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 636
Ala Arg Trp Gly Trp Asp Gly Phe Ala Tyr
1 5 10
<210> 637
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 637
Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 638
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 638
Leu Gln Val Thr His Val Pro Tyr Thr
1 5
<210> 639
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 639
Ile Asp Pro Asn Asn Gly Gly Thr
1 5
<210> 640
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 640
Gln Ser Leu Glu Asn Ser Tyr Gly Asn Thr Tyr
1 5 10
<210> 641
<211> 10
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 641
Thr Arg Trp Gly Trp Asp Gly Phe Ala Tyr
1 5 10
<210> 642
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 642
Arg Ile Ser
1
<210> 643
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 643
Ile Asp Pro Asn Ser Gly Ile Thr
1 5
<210> 644
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 644
Ile Asp Pro Asn Ser Gly Thr Thr
1 5
<210> 645
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 645
Ile Asp Pro Asn Tyr Gly Gly Pro
1 5
<210> 646
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 646
Leu Gln Ile Thr His Val Pro Tyr Thr
1 5
<210> 647
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 647
Leu Gln Leu Thr His Val Pro Tyr Thr
1 5
<210> 648
<211> 5
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 648
Ser Ser Val Ser Tyr
1 5
<210> 649
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 649
Leu Thr Ser
1
<210> 650
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 650
Gln Gln Trp Ser Ser Asn Pro Phe Thr
1 5
<210> 651
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 651
Ile Asp Pro Asn Tyr Gly Gly Ser
1 5
<210> 652
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 652
Gln Asp Ile Gly Ser Ser
1 5
<210> 653
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 653
Ala Thr Ser
1
<210> 654
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 654
Leu Gln Tyr Ala Ser Ser Pro Phe Thr
1 5
<210> 655
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 655
Ile Asn Pro Asn Asn Gly Gly Thr
1 5
<210> 656
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 656
Gly Tyr Thr Phe Val Ser Tyr Trp
1 5
<210> 657
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 657
Ile Asp Pro Asn Asn Gly Gly Ser
1 5
<210> 658
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 658
Ile Asp Pro Ser Asp Ser Tyr Ala
1 5
<210> 659
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 659
Gln Gln Glu Lys Thr Leu Pro Trp Thr
1 5
<210> 660
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 660
Gly Tyr Thr Phe Arg Ser Tyr Gly
1 5
<210> 661
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 661
Ile Tyr Pro Arg Ser Gly Asn Thr
1 5
<210> 662
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 662
Ala Arg Ser Thr Ala Val Val Ala Gly Gly Phe Asp Tyr
1 5 10
<210> 663
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 663
Gln Ser Leu Phe Asn Ser Arg Thr Gln Lys Asn Ser
1 5 10
<210> 664
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 664
Gln Asn Asp Tyr Thr Tyr Pro Trp Thr
1 5
<210> 665
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 665
Gly Tyr Thr Phe Thr Asn Tyr Gly
1 5
<210> 666
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 666
Ile Tyr Pro Arg Ser Gly Asn Ser
1 5
<210> 667
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 667
Ala Arg Ser Thr Ala Ile Val Ala Gly Gly Phe Asp Tyr
1 5 10
<210> 668
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 668
Gln Ser Leu Leu Asn Ser Arg Ile Gln Lys Asn Ser
1 5 10
<210> 669
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 669
Gly Tyr Thr Phe Thr Ser Tyr Gly
1 5
<210> 670
<211> 14
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 670
Ala Arg Ser Thr Tyr Gly Ser Ser Ser Tyr Ala Met Asp Tyr
1 5 10
<210> 671
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 671
Gly Tyr Thr Phe Pro Asp Tyr Glu
1 5
<210> 672
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 672
Ile Asp Pro Glu Thr Gly Gly Thr
1 5
<210> 673
<211> 5
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 673
Thr Arg Trp Ala Tyr
1 5
<210> 674
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 674
His His Tyr His Arg Ser Pro Pro Thr
1 5
<210> 675
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 675
Gly Tyr Ser Ile Thr Gly Tyr Tyr
1 5
<210> 676
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 676
Ile Tyr Pro Gly Ser Gly Ser Ile
1 5
<210> 677
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 677
Ala Arg Glu Ala Trp Gly Asn Trp Tyr Phe Asp Val
1 5 10
<210> 678
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 678
Gln Ser Ile Gly Thr Ser
1 5
<210> 679
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 679
Gln Gln Ser Asn Ser Trp Pro Tyr Thr
1 5
<210> 680
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 680
Gly Tyr Thr Phe Ser Asp Tyr Glu
1 5
<210> 681
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 681
Ile Asp Pro Glu Thr Gly Asp Thr
1 5
<210> 682
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 682
Thr Ser Asn Gly Tyr Pro Glu His
1 5
<210> 683
<211> 7
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 683
Ser Gly Val Ser Ser Thr Tyr
1 5
<210> 684
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 684
His Gln Tyr His Arg Ser Pro Leu Thr
1 5
<210> 685
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 685
Gly Tyr Thr Phe Thr Asp Phe Glu
1 5
<210> 686
<211> 15
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 686
Thr Arg Gly Ile Tyr Tyr Gly Asn Tyr Gly Ser Ala Met Asp Tyr
1 5 10 15
<210> 687
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 687
Phe Gln Gly Ser His Ala Pro Leu Thr
1 5
<210> 688
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 688
Gly Tyr Thr Phe Thr Asp Tyr Glu
1 5
<210> 689
<211> 5
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 689
Thr Arg Trp Ala Phe
1 5
<210> 690
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 690
Ser Gln Ser Thr His Val Pro Tyr Thr
1 5
<210> 691
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 691
His His Tyr Asn Arg Ser Pro Pro Thr
1 5
<210> 692
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 692
Gly Tyr Ala Phe Ser Asn Tyr Leu
1 5
<210> 693
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 693
Ile Asn Pro Gly Asn Gly Gly Thr
1 5
<210> 694
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 694
Ala Arg Thr Ala Tyr Gly Ser Pro Leu Asp Tyr
1 5 10
<210> 695
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 695
Gln Asp Ile Asn Arg Tyr
1 5
<210> 696
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 696
Gly Tyr Ala Phe Thr Asn Tyr Leu
1 5
<210> 697
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 697
Ile Asn Pro Gly Ser Gly Ala Thr
1 5
<210> 698
<211> 0
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 698
000
<210> 699
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 699
Arg Glu Asn
1
<210> 700
<211> 14
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 700
Ala Arg Arg Thr Thr Val Val Ala Pro Tyr Ala Met Asp Tyr
1 5 10
<210> 701
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 701
Gln Gln Gly Asn Thr Leu Pro Arg Thr
1 5
<210> 702
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 702
Ile Ser Pro Gly Ser Gly Ala Thr
1 5
<210> 703
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 703
Ala Arg Ser Ala Tyr Gly Ser Pro Leu Asp Phe
1 5 10
<210> 704
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 704
Arg Val Asn
1
<210> 705
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 705
Gln Gln Tyr Asp Glu Phe Pro Tyr Thr
1 5
<210> 706
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 706
Gln Asn Ile Gly Thr Ser
1 5
<210> 707
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 707
Gln Gln Ser Asn Asn Trp Pro Phe Thr
1 5
<210> 708
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 708
Ile Ser Pro Gly Ser Gly Gly Thr
1 5
<210> 709
<211> 11
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 709
Ala Arg Ser Ala Tyr Gly His Val Phe Asp Tyr
1 5 10
<210> 710
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 710
Gly Tyr Thr Phe Arg Ser Asn Gly
1 5
<210> 711
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 711
Ile Tyr Pro Arg Ser Gly Asn Ile
1 5
<210> 712
<211> 13
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 712
Ala Arg Ser Thr Thr Val Val Ala Gly Gly Phe Asp Phe
1 5 10
<210> 713
<211> 12
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 713
Gln Ser Leu Leu Asn Ser Arg Thr Gln Lys Asn Ser
1 5 10
<210> 714
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 714
Gly Tyr Ser Phe Thr Gly Tyr Tyr
1 5
<210> 715
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 715
Gly Tyr Ser Phe Thr Gly Tyr Tyr Ile
1 5
<210> 716
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 716
Ile Gly Trp Ile Tyr Pro Gly Ser
1 5
<210> 717
<211> 8
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 717
Gly Tyr Thr Phe Thr Ser Phe Gly
1 5
<210> 718
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 718
Trp Ser Ser
1
<210> 719
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 719
Gln Asn Asp Tyr Asn Tyr Pro Trp Thr
1 5
<210> 720
<211> 6
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 720
Asp His Ile Asn Asn Trp
1 5
<210> 721
<211> 3
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 721
Gly Ala Ile
1
<210> 722
<211> 9
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 722
Gln Gln Tyr Trp Asn Thr Pro Tyr Thr
1 5

Claims (11)

1.一种能结合人TIM-3(SEQ ID NO:1)的抗体，其包含：
a)具有SEQ ID NO:369的氨基酸序列的HCDR1，具有SEQ ID NO:373的氨基酸序列的HCDR2，具有SEQ ID NO:374的氨基酸序列的HCDR3，具有SEQ ID NO:375的氨基酸序列的LCDR1、具有SEQ ID NO:376的氨基酸序列的LCDR2，和具有SEQ ID NO:377的氨基酸序列的LCDR3；或
b)具有SEQ ID NO:363的氨基酸序列的HCDR1，具有SEQ ID NO:492的氨基酸序列的HCDR2，具有SEQ ID NO:490的氨基酸序列的HCDR3，具有SEQ ID NO:366的氨基酸序列的LCDR1、具有SEQ ID NO:367的氨基酸序列的LCDR2，和具有SEQ ID NO:493的氨基酸序列的LCDR3。
2.如权利要求1所述的抗体，其中，所述HCDR1具有SEQ ID NO:369的氨基酸序列，所述HCDR2具有SEQ ID NO:373的氨基酸序列，所述HCDR3具有SEQ IDNO:374的氨基酸序列，所述LCDR1具有SEQ ID NO:375的氨基酸序列，所述LCDR2具有SEQ ID NO:376的氨基酸序列，且所述LCDR3具有SEQ ID NO:377的氨基酸序列。
3.如权利要求1所述的抗体，其中，所述HCDR1具有SEQ ID NO:363的氨基酸序列，所述HCDR2具有SEQ ID NO:492的氨基酸序列，所述HCDR3具有SEQ IDNO:490的氨基酸序列，所述LCDR1具有SEQ ID NO:366的氨基酸序列，所述LCDR2具有SEQ ID NO:367的氨基酸序列，且所述LCDR3具有SEQ ID NO:493的氨基酸序列。
4.一种能结合人TIGIT(SEQ ID NO:1)的抗体，其包含：
a)具有SEQ ID NO:12的氨基酸序列的VH，和具有SEQ ID NO:241的氨基酸序列的VL；或
b)具有SEQ ID NO:74的氨基酸序列的VH，和具有SEQ ID NO:326的氨基酸序列的VL。
5.如权利要求4所述的抗体，其中，所述VH具有SEQ ID NO:12的氨基酸序列，且所述VL具有SEQ ID NO:241的氨基酸序列。
6.如权利要求4所述的抗体，其中，所述VH具有SEQ ID NO:74的氨基酸序列，且所述VL具有SEQ ID NO:326的氨基酸序列。
7.一种能结合人TIM-3(SEQ ID NO:1)的抗体，其包含：
a)包含SEQ ID NO:12的氨基酸序列的重链，和包含SEQ ID NO:241的氨基酸序列的轻链；或
b)包含SEQ ID NO:74的氨基酸序列的重链，和包含SEQ ID NO:326的氨基酸序列的轻链；或
8.如权利要求7所述的抗体，其中，所述重链包含SEQ ID NO:12的氨基酸序列，且所述轻链包含SEQ ID NO:241的氨基酸序列。
9.如权利要求7所述的抗体，其中，所述重链包含SEQ ID NO:74的氨基酸序列，且所述轻链包含SEQ ID NO:326的氨基酸序列。
10.一种药物组合物，其包含如权利要求1-9中任一项所述的抗体。
11.一种试剂盒或药盒，其包含如权利要求1-10中任一项所述的抗体。
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JOP20200096A1 (ar) * 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
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