JP2008536815A - チオエーテル架橋を含む巨大分子 - Google Patents

チオエーテル架橋を含む巨大分子 Download PDF

Info

Publication number
JP2008536815A
JP2008536815A JP2008501999A JP2008501999A JP2008536815A JP 2008536815 A JP2008536815 A JP 2008536815A JP 2008501999 A JP2008501999 A JP 2008501999A JP 2008501999 A JP2008501999 A JP 2008501999A JP 2008536815 A JP2008536815 A JP 2008536815A
Authority
JP
Japan
Prior art keywords
antibody
composition
antibodies
thioether
thioether bridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2008501999A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008536815A5 (enExample
Inventor
アイ． トウス グイルレルモ
スチェネルマン マルク
ウェイ ジピング
Original Assignee
メディミューン，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディミューン，エルエルシー filed Critical メディミューン，エルエルシー
Publication of JP2008536815A publication Critical patent/JP2008536815A/ja
Publication of JP2008536815A5 publication Critical patent/JP2008536815A5/ja
Abandoned legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008501999A 2005-03-14 2006-03-14 チオエーテル架橋を含む巨大分子 Abandoned JP2008536815A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66172405P 2005-03-14 2005-03-14
US69913805P 2005-07-13 2005-07-13
PCT/US2006/009311 WO2006099481A2 (en) 2005-03-14 2006-03-14 Macromolecules comprising a thioether cross-link

Publications (2)

Publication Number Publication Date
JP2008536815A true JP2008536815A (ja) 2008-09-11
JP2008536815A5 JP2008536815A5 (enExample) 2009-05-21

Family

ID=36992404

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008501999A Abandoned JP2008536815A (ja) 2005-03-14 2006-03-14 チオエーテル架橋を含む巨大分子

Country Status (6)

Country Link
US (2) US7786273B2 (enExample)
EP (1) EP1858911A4 (enExample)
JP (1) JP2008536815A (enExample)
AU (1) AU2006223002A1 (enExample)
CA (1) CA2600844A1 (enExample)
WO (1) WO2006099481A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019509483A (ja) * 2016-02-25 2019-04-04 ザ バインディング サイト グループ リミティド 質量分析キット

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG170799A1 (en) * 2006-03-28 2011-05-30 Biogen Idec Inc Anti-igf-ir antibodies and uses thereof
CN101842116A (zh) * 2007-08-28 2010-09-22 比奥根艾迪克Ma公司 结合igf-1r多个表位的组合物
CN101842117A (zh) * 2007-08-28 2010-09-22 比奥根艾迪克Ma公司 抗igf-1r抗体及其用途
BRPI0816094A2 (pt) 2007-08-30 2015-03-03 Daiichi Sankyo Co Ltd Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo.
KR20180102215A (ko) 2007-11-27 2018-09-14 더 유니버시티 오브 브리티쉬 콜롬비아 관절염의 진단과 치료를 위한 14-3-3 에타 항체 및 이의 용도
WO2009126304A1 (en) * 2008-04-11 2009-10-15 Biogen Idec Ma Inc. Therapeutic combinations of anti-igf-1r antibodies and other compounds
CN104854125A (zh) * 2012-11-05 2015-08-19 米迪缪尼有限公司 在不存在全能核酸酶的情况下分离synagis*的方法
EP3212510B1 (en) * 2014-10-31 2020-12-09 Medlmmune, LLC Manufacturing method of a degassed composition
AU2017222402B2 (en) * 2016-02-25 2024-02-01 The Binding Site Group Limited Antibodies
EP3974447A3 (en) 2016-10-21 2022-09-07 Adimab, LLC Anti-respiratory syncytial virus antibodies, and methods of their generation and use
US11479600B2 (en) 2016-10-21 2022-10-25 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201903287PA (en) 2016-10-21 2019-05-30 Adimab Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
GB201708262D0 (en) 2017-05-23 2017-07-05 Binding Site Group Ltd Assay for plasma cell associated disease
CN108017717B (zh) * 2018-01-24 2019-08-16 首都医科大学宣武医院 一种用于体外高效定向扩增的嵌合抗原受体及其应用
GB202007047D0 (en) 2020-05-13 2020-06-24 Binding Site Group Ltd Mass spectrometry controls
EP4295158A1 (en) * 2021-02-19 2023-12-27 Waters Technologies Corporation Methods for peptide mapping of adeno-associated virus (aav) proteins
WO2025104604A1 (en) 2023-11-14 2025-05-22 Janssen Pharmaceuticals, Inc. Anti-respiratory syncytial virus antibodies and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003493A1 (en) * 1989-08-29 1991-03-21 The University Of Southampton Bi-or trispecific (fab)3 or (fab)4 conjugates
US5091542A (en) 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
JP3407260B2 (ja) * 1991-08-09 2003-05-19 コルベツク，ヴインフリート ランチオニン架橋ペプチド
US6897044B1 (en) 1999-01-28 2005-05-24 Biogen Idec, Inc. Production of tetravalent antibodies
CA2370043A1 (en) * 1999-04-23 2000-11-02 Mitsubishi Chemical Corporation Liposome bonded with antibody and polyalkylene glycol
US20060123504A1 (en) * 2004-12-07 2006-06-08 Avigenics, Inc. Methods of producing polyclonal antibodies
US20060286548A1 (en) * 2005-06-16 2006-12-21 Gregory Liposky Method of making recombinant human antibodies for use in biosensor technology

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019509483A (ja) * 2016-02-25 2019-04-04 ザ バインディング サイト グループ リミティド 質量分析キット

Also Published As

Publication number Publication date
WO2006099481A3 (en) 2007-04-19
CA2600844A1 (en) 2006-09-21
US20060216284A1 (en) 2006-09-28
US7786273B2 (en) 2010-08-31
EP1858911A2 (en) 2007-11-28
EP1858911A4 (en) 2009-12-16
US20090030187A1 (en) 2009-01-29
AU2006223002A1 (en) 2006-09-21
WO2006099481A2 (en) 2006-09-21

Similar Documents

Publication Publication Date Title
JP2008536815A (ja) チオエーテル架橋を含む巨大分子
US10556959B2 (en) Anti-CD39 antibodies and uses thereof
CA3071750C (en) Antibodies that bind il-4 and/or il-13 and their uses
US10759844B2 (en) Disulfide stabilised antibodies and fragments thereof
JP5623690B2 (ja) 抗体
JP2008546805A (ja) 最適な凝集および断片化プロフィールを有する抗体製剤
US20090297514A1 (en) Humanization of antibodies
EP2484696A1 (en) Antagonistic human light-specific human monoclonal antibodies
JP2013013425A (ja) 抗体のフレームワーク・シャッフル
JP2022549351A (ja) ヘテロ二量体タンパク質
AU2012241127A1 (en) Macromolecules comprising a thioether cross-link
HK40058161A (en) Antibodies that bind il-4 and/or il-13 and their uses
AU2012207043A1 (en) Antibody formulations having optimized aggregation and fragment profiles
HK1183498B (en) Antibodies that bind il-4 and/or il-13 and their uses
HK1147765A (en) Antibodies that bind il-4 and/or il-13 and their uses
HK1147765B (en) Antibodies that bind il-4 and/or il-13 and their uses
HK1183883B (en) Antibodies that bind il-4 and/or il-13 and their uses
HK1241902A1 (en) Antibodies that bind il-4 and/or il-13 and their uses

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090304

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090304

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090325

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20100218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100218