JP2008535927A - ポリマー及びパッセンジャー薬のミセル組成物 - Google Patents

ポリマー及びパッセンジャー薬のミセル組成物 Download PDF

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Publication number
JP2008535927A
JP2008535927A JP2008506677A JP2008506677A JP2008535927A JP 2008535927 A JP2008535927 A JP 2008535927A JP 2008506677 A JP2008506677 A JP 2008506677A JP 2008506677 A JP2008506677 A JP 2008506677A JP 2008535927 A JP2008535927 A JP 2008535927A
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Prior art keywords
peg
geldanamycin
prodrug
drug
rapamycin
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JP2008506677A
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Japanese (ja)
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JP2008535927A5 (cg-RX-API-DMAC10.html
Inventor
エス． クウォン，グレン
エル． フォレスト，マーカス
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ウィスコンシン アルムニ リサーチ ファンデイション
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Publication of JP2008535927A publication Critical patent/JP2008535927A/ja
Publication of JP2008535927A5 publication Critical patent/JP2008535927A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008506677A 2005-04-12 2006-04-12 ポリマー及びパッセンジャー薬のミセル組成物 Pending JP2008535927A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67046005P 2005-04-12 2005-04-12
US71600005P 2005-09-09 2005-09-09
PCT/US2006/013800 WO2006110862A2 (en) 2005-04-12 2006-04-12 Micelle composition of polymer and passenger drug

Publications (2)

Publication Number Publication Date
JP2008535927A true JP2008535927A (ja) 2008-09-04
JP2008535927A5 JP2008535927A5 (cg-RX-API-DMAC10.html) 2008-12-25

Family

ID=37011968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008506677A Pending JP2008535927A (ja) 2005-04-12 2006-04-12 ポリマー及びパッセンジャー薬のミセル組成物

Country Status (7)

Country Link
US (2) US8173167B2 (cg-RX-API-DMAC10.html)
EP (1) EP1871343A2 (cg-RX-API-DMAC10.html)
JP (1) JP2008535927A (cg-RX-API-DMAC10.html)
KR (1) KR20080009196A (cg-RX-API-DMAC10.html)
AU (1) AU2006235538A1 (cg-RX-API-DMAC10.html)
CA (1) CA2603987A1 (cg-RX-API-DMAC10.html)
WO (1) WO2006110862A2 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516407A (ja) * 2009-12-30 2013-05-13 サムヤン バイオファーマシューティカルズ コーポレイション 改善された水溶解度を有するラパマイシン含有高分子ナノ粒子注射剤組成物及びその製造方法、並びに放射線療法と併用するための抗癌組成物
JP2013203680A (ja) * 2012-03-28 2013-10-07 Kobe Gakuin ビタミンｅ誘導体を含有する血中滞留性薬物キャリアー粒子

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US20100119529A1 (en) * 2006-05-12 2010-05-13 Furgeson Darin Y Elastin-like polymer delivery vehicles
DE102006038233A1 (de) * 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Markerkomposit für medizinische Implantate
US20080102127A1 (en) * 2006-10-26 2008-05-01 Gao Hai Y Hybrid lipid-polymer nanoparticulate delivery composition
US20080248097A1 (en) * 2007-02-26 2008-10-09 Kwon Glen S Polymeric micelles for combination drug delivery
WO2009006311A2 (en) * 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
WO2009009067A2 (en) * 2007-07-09 2009-01-15 Kwon Glen S Micelle encapsulation of theropeutic agents
US9422234B2 (en) * 2007-11-30 2016-08-23 The Johns Hopkins University Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer
US20090209757A1 (en) * 2008-01-10 2009-08-20 Santiago Ini Processes for the preparation and purification of paliperidone palmitate
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
US9271929B2 (en) * 2008-11-25 2016-03-01 École Polytechnique Fédérale De Lausanne (Epfl) Block copolymers and uses thereof
EP2419136A4 (en) * 2009-04-16 2013-01-02 Merck Sharp & Dohme COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
WO2010140869A2 (en) * 2009-06-05 2010-12-09 Iljin Copper Foil Co., Ltd. Complex, multilayer using the same, and device coated with the multilayer
WO2011038278A2 (en) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
WO2015161139A1 (en) 2014-04-16 2015-10-22 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
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EP2382966A1 (en) * 2010-03-12 2011-11-02 DSM IP Assets B.V. Micelle compositions and process for the preparation thereof
CN107320734A (zh) 2011-04-29 2017-11-07 西莱克塔生物科技公司 从合成纳米载体中控制释放免疫抑制剂
WO2012151544A1 (en) 2011-05-05 2012-11-08 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
CN102293736B (zh) * 2011-08-31 2013-06-05 兰州大学 紫杉醇-聚合物载药胶束制备工艺
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JP2016503012A (ja) 2012-12-12 2016-02-01 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 化合物相互作用ドメインを含む製剤及びキャリアシステム
CN103142479A (zh) * 2013-03-29 2013-06-12 中国药科大学 一种磷脂-维生素e琥珀酸聚乙二醇酯胶束的应用
CN105307641A (zh) 2013-05-03 2016-02-03 西莱克塔生物科技公司 用于降低不期望体液免疫应答的给药组合
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US9700544B2 (en) * 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
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US11633355B2 (en) 2014-12-12 2023-04-25 Clemson University Research Foundation Multi-functional particles and methods of using the same
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Publication number Priority date Publication date Assignee Title
JP2013516407A (ja) * 2009-12-30 2013-05-13 サムヤン バイオファーマシューティカルズ コーポレイション 改善された水溶解度を有するラパマイシン含有高分子ナノ粒子注射剤組成物及びその製造方法、並びに放射線療法と併用するための抗癌組成物
JP2015078247A (ja) * 2009-12-30 2015-04-23 サムヤン バイオファーマシューティカルズ コーポレイシ 放射線療法と併用して肺癌の治療に有用なラパマイシン含有高分子ナノ粒子静脈注射用抗癌組成物
US9173841B2 (en) 2009-12-30 2015-11-03 Samyang Biopharmaceuticals Corporation Polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, preparation method thereof, and anticancer composition for combined use with radiotherapy
JP2013203680A (ja) * 2012-03-28 2013-10-07 Kobe Gakuin ビタミンｅ誘導体を含有する血中滞留性薬物キャリアー粒子

Also Published As

Publication number Publication date
US9107814B2 (en) 2015-08-18
US8173167B2 (en) 2012-05-08
KR20080009196A (ko) 2008-01-25
EP1871343A2 (en) 2008-01-02
US20060251710A1 (en) 2006-11-09
CA2603987A1 (en) 2006-10-19
WO2006110862A2 (en) 2006-10-19
WO2006110862A3 (en) 2007-07-05
WO2006110862A9 (en) 2008-08-07
AU2006235538A1 (en) 2006-10-19
US20120309780A1 (en) 2012-12-06

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