JP2008535907A5 - - Google Patents
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- Publication number
- JP2008535907A5 JP2008535907A5 JP2008505998A JP2008505998A JP2008535907A5 JP 2008535907 A5 JP2008535907 A5 JP 2008535907A5 JP 2008505998 A JP2008505998 A JP 2008505998A JP 2008505998 A JP2008505998 A JP 2008505998A JP 2008535907 A5 JP2008535907 A5 JP 2008535907A5
- Authority
- JP
- Japan
- Prior art keywords
- average
- active agent
- formulation
- max
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims 58
- 238000009472 formulation Methods 0.000 claims 55
- 239000000203 mixture Substances 0.000 claims 55
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 35
- 230000036470 plasma concentration Effects 0.000 claims 27
- 208000024827 Alzheimer disease Diseases 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 17
- LZXHHNKULPHARO-UHFFFAOYSA-M (3,4-dichlorophenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].C1=C(Cl)C(Cl)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LZXHHNKULPHARO-UHFFFAOYSA-M 0.000 claims 16
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Amino-1-propanesulfonic acid Natural products NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims 16
- 239000003937 drug carrier Substances 0.000 claims 9
- 230000003920 cognitive function Effects 0.000 claims 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- 230000006999 cognitive decline Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical group CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 238000013265 extended release Methods 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000000971 hippocampal effect Effects 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 230000001991 pathophysiological effect Effects 0.000 claims 1
- 230000000541 pulsatile effect Effects 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67022405P | 2005-04-12 | 2005-04-12 | |
| PCT/IB2006/003865 WO2007069073A2 (en) | 2005-04-12 | 2006-04-12 | Pharmaceutical formulations of amyloid inhibiting compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535907A JP2008535907A (ja) | 2008-09-04 |
| JP2008535907A5 true JP2008535907A5 (https=) | 2009-05-21 |
Family
ID=38163292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505998A Pending JP2008535907A (ja) | 2005-04-12 | 2006-04-12 | アミロイド阻害化合物の薬学的製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060251714A1 (https=) |
| EP (1) | EP1890685A2 (https=) |
| JP (1) | JP2008535907A (https=) |
| KR (1) | KR20070120190A (https=) |
| CN (1) | CN101193628A (https=) |
| CA (1) | CA2611586A1 (https=) |
| WO (1) | WO2007069073A2 (https=) |
| ZA (1) | ZA200708699B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070049638A1 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
| PT2089417E (pt) | 2006-10-12 | 2015-04-14 | Bhi Ltd Partnership | Métodos, compostos, composições e veículos para administrar o ácido 3-amino-1-propanossulfónico |
| WO2010096925A1 (en) * | 2009-02-26 | 2010-09-02 | Bellus Health (International) Limited | Homotaurine-supplemented and/or enriched edible material, methods of preparation an d uses |
| CN103875786A (zh) * | 2014-02-27 | 2014-06-25 | 如皋市坝新肠衣有限公司 | 一种肠衣的生产工艺 |
| FI3347002T3 (fi) | 2015-09-10 | 2023-08-10 | Alzheon Inc | Alzheimerin taudin hoitaminen tietyssä potilaspopulaatiossa |
| CN115397849A (zh) * | 2020-02-13 | 2022-11-25 | 考格尼申治疗股份有限公司 | 减少患有认知衰退的患者中的β-淀粉样蛋白单体水平的方法 |
| US12336972B2 (en) * | 2021-01-22 | 2025-06-24 | Celagenex Research (India) Pvt. Ltd. | Synergistic nutritional compositions for treating neurocognitive disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| JPH07223970A (ja) * | 1994-02-10 | 1995-08-22 | Tanabe Seiyaku Co Ltd | 消化管内適所放出製剤 |
| EP0759303B1 (en) * | 1994-04-22 | 2002-10-16 | Yamanouchi Pharmaceutical Co. Ltd. | Colon-specific drug release system |
| EP0957749A2 (en) * | 1995-09-12 | 1999-11-24 | The General Hospital Corporation | Method for early detection of ovarian cancer |
| US20020022657A1 (en) * | 1998-02-11 | 2002-02-21 | Francine Gervais | Methods for modulating neuronal cell death |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| IL150374A0 (en) * | 1999-12-23 | 2002-12-01 | Neurochem Inc | Compounds and methods for modulating cerebral amyloid angiopathy |
| FR2832928B1 (fr) * | 2001-11-30 | 2004-02-06 | Dermo Cosmologie Lab De | Composition a base d'ester de diosgenine applicable par voie topique |
| US20050031651A1 (en) * | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| US7253306B2 (en) * | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
| US20050215562A1 (en) * | 2003-06-23 | 2005-09-29 | Patrick Tremblay | Methods for treating protein aggregation disorders |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20060079578A1 (en) * | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20050038000A1 (en) * | 2003-06-23 | 2005-02-17 | Xianqi Kong | Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases |
| US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
-
2006
- 2006-04-12 CA CA002611586A patent/CA2611586A1/en not_active Abandoned
- 2006-04-12 KR KR1020077026152A patent/KR20070120190A/ko not_active Withdrawn
- 2006-04-12 US US11/402,267 patent/US20060251714A1/en not_active Abandoned
- 2006-04-12 WO PCT/IB2006/003865 patent/WO2007069073A2/en not_active Ceased
- 2006-04-12 CN CNA2006800206830A patent/CN101193628A/zh active Pending
- 2006-04-12 US US11/402,277 patent/US20060257480A1/en not_active Abandoned
- 2006-04-12 EP EP06831844A patent/EP1890685A2/en not_active Withdrawn
- 2006-04-12 JP JP2008505998A patent/JP2008535907A/ja active Pending
-
2007
- 2007-10-11 ZA ZA200708699A patent/ZA200708699B/xx unknown
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