JP2008535785A - Ｓｔａｔ３の小分子阻害剤およびその使用 - Google Patents

Ｓｔａｔ３の小分子阻害剤およびその使用 Download PDF

Info

Publication number
JP2008535785A
JP2008535785A JP2007557196A JP2007557196A JP2008535785A JP 2008535785 A JP2008535785 A JP 2008535785A JP 2007557196 A JP2007557196 A JP 2007557196A JP 2007557196 A JP2007557196 A JP 2007557196A JP 2008535785 A JP2008535785 A JP 2008535785A
Authority
JP
Japan
Prior art keywords
apoptosis
sta
stat3
cancer
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007557196A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008535785A5 (enExample
Inventor
フイ ソン
レンツァオ ワン
シャオメン ワン
ジアーユ リン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan-Ann Arbor
Original Assignee
University of Michigan (System)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan (System) filed Critical University of Michigan (System)
Publication of JP2008535785A publication Critical patent/JP2008535785A/ja
Publication of JP2008535785A5 publication Critical patent/JP2008535785A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007557196A 2005-02-25 2006-02-24 Ｓｔａｔ３の小分子阻害剤およびその使用 Withdrawn JP2008535785A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65659705P 2005-02-25 2005-02-25
PCT/US2006/006637 WO2006091837A2 (en) 2005-02-25 2006-02-24 Small molecule inhibitors of stat3 and the uses thereof

Publications (2)

Publication Number Publication Date
JP2008535785A true JP2008535785A (ja) 2008-09-04
JP2008535785A5 JP2008535785A5 (enExample) 2009-04-09

Family

ID=36928057

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007557196A Withdrawn JP2008535785A (ja) 2005-02-25 2006-02-24 Ｓｔａｔ３の小分子阻害剤およびその使用

Country Status (7)

Country Link
US (1) US20060247318A1 (enExample)
EP (1) EP1853242A4 (enExample)
JP (1) JP2008535785A (enExample)
CN (1) CN101511179A (enExample)
AU (1) AU2006216510A1 (enExample)
CA (1) CA2599393A1 (enExample)
WO (1) WO2006091837A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2395076A1 (en) 2005-10-14 2011-12-14 MUSC Foundation For Research Development Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
US7857804B2 (en) * 2006-09-01 2010-12-28 Mccaffrey Timothy A Use of Bcl inhibitors for the prevention of fibroproliferative reclosure of dilated blood vessels and other iatrogenic fibroproliferative disorders
DK2120958T3 (da) 2006-12-06 2013-07-01 Univ Central Florida Res Found Stat3-inhibitor med anticancer-aktivitet og associerede fremgangsmåder
ZA200902814B (en) * 2007-01-16 2010-08-25 Musc Found For Res Dev Compositions and methods for diagnosing, treating, and preventing prostate conditions
WO2009032338A1 (en) * 2007-09-09 2009-03-12 University Of Florida Research Foundation Apratoxin therapeutic agents: mechanism and methods of treatment
WO2009032351A1 (en) * 2007-09-09 2009-03-12 University Of Florida Research Foundation Natural product agents, derivatives, and methods of treatment
EP2190429B1 (en) * 2007-09-10 2016-04-20 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
US20090082470A1 (en) * 2007-09-24 2009-03-26 Rafal Farjo Stat3 inhibiting compositions and methods
US8450337B2 (en) 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
DK2547205T3 (da) 2010-03-19 2024-05-27 1Globe Biomedical Co Ltd Hidtil ukendte fremgangsmåder til målretning mod cancerstamceller
KR101273747B1 (ko) * 2010-09-09 2013-06-12 가톨릭대학교 산학협력단 Ｓｔａ-21을 유효성분으로 함유하는 관절염의 예방 및 치료용 조성물
CN102961374B (zh) * 2012-12-12 2015-01-14 苏州大学 一种化合物的应用以及stat3抑制剂
US20160030384A1 (en) 2013-04-09 2016-02-04 Boston Biomedical, Inc. 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
WO2015120436A2 (en) 2014-02-10 2015-08-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Stat3 phosphorylation during graft-versus-host disease
CN104693280A (zh) * 2015-04-06 2015-06-10 苏州普罗达生物科技有限公司 信号传导及转录激活因子抑制多肽及其应用
CN104725480A (zh) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 一种信号传导及转录激活因子抑制多肽及其应用
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CN106822898B (zh) * 2017-02-17 2018-09-25 王晓华 靶向下调stat3基因表达在提高肺腺癌化疗敏感性方面的应用
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
CN109988125B (zh) * 2018-10-25 2022-03-18 河南省锐达医药科技有限公司 一类新型苯甲酰苯胺化合物的制备方法和在肿瘤治疗上的应用
KR102980990B1 (ko) 2019-04-05 2026-06-25 카이메라 쎄라퓨틱스 인코포레이티드 Stat 분해제 및 이의 용도
US20230192786A1 (en) * 2020-05-15 2023-06-22 Glg Pharma, Llc Stat3 inhibition for treatment and prevention of human coronavirus infection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491588A (en) * 1982-03-31 1985-01-01 University Of Tennessee Research Corporation Treatment of psoriasis and seborrheic dermatitis with imidazole antibiotics
JP2003525862A (ja) * 1999-01-27 2003-09-02 ザ ユニヴァーシティー オブ サウス フロリダ ヒト癌の治療のためのｓｔａｔ３シグナル伝達の阻害

Also Published As

Publication number Publication date
WO2006091837A3 (en) 2009-04-16
AU2006216510A1 (en) 2006-08-31
CN101511179A (zh) 2009-08-19
EP1853242A4 (en) 2009-11-18
EP1853242A2 (en) 2007-11-14
WO2006091837A2 (en) 2006-08-31
US20060247318A1 (en) 2006-11-02
CA2599393A1 (en) 2006-08-31

Similar Documents

Publication Publication Date Title
JP7849747B2 (ja) Ｔ細胞疲弊を阻害するための組成物および方法
WO2006091837A2 (en) Small molecule inhibitors of stat3 and the uses thereof
JP5399904B2 (ja) Ｍｄｍ２の小分子阻害剤およびその使用
Pathak et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
KR102389552B1 (ko) Mdm2 저해제 및 이 저해제를 사용하는 치료 방법
ES2624808T3 (es) Antagonistas de MDM2 espirooxindólicos
JP2008511548A (ja) 抗アポトーシスｂｃｌ−２ファミリーメンバーの低分子阻害剤およびその使用法
Friesen et al. Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells
CN1960719B (zh) 棉酚共结晶及其应用
AU2015362670A1 (en) Small molecule inhibitors of EGFR and PI3K
JP2010529023A (ja) 疾患の処置のためのゴシポールの律動的投薬法
CN101160314A (zh) Mdm2的小分子抑制剂以及其应用
ES2657649T3 (es) Inhibidores de Mcl-1 de molécula pequeña y sus usos
Liu et al. Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor
Ding et al. Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells
JP2008533039A (ja) 抗アポトーシスＢｃｌ−２ファミリーメンバーのクロメン−４−オン阻害剤およびその使用
CN101132783B (zh) 阿朴棉子酚酮及其用途
AU2017354019A1 (en) Small molecule dual inhibitors of EGFR/PI3K and uses thereof
CN103191095B (zh) 一种stat3信号通路小分子抑制剂及其在制备抗肿瘤药物中的应用
WO2017031116A1 (en) Small molecule inhibitors of ku70/80 and uses thereof
John et al. Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment
JP2019510084A (ja) 小分子型の活性酸素種誘導剤及びミトコンドリア活性阻害剤
US20240124419A1 (en) Small molecule inhibitors of grp78 and uses thereof
WO2012078982A2 (en) Xzh-5 inhibits constitutive and interleukin-6-induced stat3 phosphorylation in human hepatocellular carcinoma cells
Jiang et al. Curcumin Alleviates Bone Cancer Pain by Inhibiting Satellite Glial Cell Activity via Janus Kinase 1/Signal Transducer and Transcription 3 Pathway Activator

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090220

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090220

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20090826