CA2599393A1 - Small molecule inhibitors of stat3 and the uses thereof - Google Patents

Small molecule inhibitors of stat3 and the uses thereof Download PDF

Info

Publication number
CA2599393A1
CA2599393A1 CA002599393A CA2599393A CA2599393A1 CA 2599393 A1 CA2599393 A1 CA 2599393A1 CA 002599393 A CA002599393 A CA 002599393A CA 2599393 A CA2599393 A CA 2599393A CA 2599393 A1 CA2599393 A1 CA 2599393A1
Authority
CA
Canada
Prior art keywords
apoptosis
stat3
sta
cell
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002599393A
Other languages
English (en)
French (fr)
Inventor
Hui Song
Renxiao Wang
Shaomeng Wang
Jiayuh Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2599393A1 publication Critical patent/CA2599393A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002599393A 2005-02-25 2006-02-24 Small molecule inhibitors of stat3 and the uses thereof Abandoned CA2599393A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65659705P 2005-02-25 2005-02-25
US60/656,597 2005-02-25
PCT/US2006/006637 WO2006091837A2 (en) 2005-02-25 2006-02-24 Small molecule inhibitors of stat3 and the uses thereof

Publications (1)

Publication Number Publication Date
CA2599393A1 true CA2599393A1 (en) 2006-08-31

Family

ID=36928057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002599393A Abandoned CA2599393A1 (en) 2005-02-25 2006-02-24 Small molecule inhibitors of stat3 and the uses thereof

Country Status (7)

Country Link
US (1) US20060247318A1 (enExample)
EP (1) EP1853242A4 (enExample)
JP (1) JP2008535785A (enExample)
CN (1) CN101511179A (enExample)
AU (1) AU2006216510A1 (enExample)
CA (1) CA2599393A1 (enExample)
WO (1) WO2006091837A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2625891A1 (en) 2005-10-14 2007-04-26 Carlton D. Donald Inhibition of pax2 by defb1 induction as a therapy for cancer
US7857804B2 (en) * 2006-09-01 2010-12-28 Mccaffrey Timothy A Use of Bcl inhibitors for the prevention of fibroproliferative reclosure of dilated blood vessels and other iatrogenic fibroproliferative disorders
CA2671121C (en) * 2006-12-06 2016-06-07 University Of Central Florida Research Foundation, Inc. Stat3 inhibitor having anti-cancer activity and associated methods
CA2667364A1 (en) * 2007-01-16 2008-07-24 Musc Foundation For Research Development Compositions and methods for diagnosing, treating, and preventing prostate conditions
WO2009032338A1 (en) * 2007-09-09 2009-03-12 University Of Florida Research Foundation Apratoxin therapeutic agents: mechanism and methods of treatment
WO2009032351A1 (en) * 2007-09-09 2009-03-12 University Of Florida Research Foundation Natural product agents, derivatives, and methods of treatment
HRP20160949T1 (hr) 2007-09-10 2016-10-07 Boston Biomedical, Inc. Novi sastavi i metode za liječenje karcinoma
WO2009042677A2 (en) 2007-09-24 2009-04-02 Farjo Rafal A Stat3 inhibiting compositions and methods
US8450337B2 (en) 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
CA2793527A1 (en) 2010-03-19 2011-09-22 Boston Biomedical, Inc. Use of naphthofuran derivatives in the treatment of cancer
KR101273747B1 (ko) * 2010-09-09 2013-06-12 가톨릭대학교 산학협력단 Ｓｔａ-21을 유효성분으로 함유하는 관절염의 예방 및 치료용 조성물
CN102961374B (zh) * 2012-12-12 2015-01-14 苏州大学 一种化合物的应用以及stat3抑制剂
WO2014169078A2 (en) 2013-04-09 2014-10-16 Boston Biomedical, Inc. Methods for treating cancer
US11406707B2 (en) 2014-02-10 2022-08-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. STAT3 phosphorylation during graft-versus-host disease
CN104725480A (zh) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 一种信号传导及转录激活因子抑制多肽及其应用
CN104693280A (zh) * 2015-04-06 2015-06-10 苏州普罗达生物科技有限公司 信号传导及转录激活因子抑制多肽及其应用
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CN106822898B (zh) * 2017-02-17 2018-09-25 王晓华 靶向下调stat3基因表达在提高肺腺癌化疗敏感性方面的应用
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
CN109988125B (zh) * 2018-10-25 2022-03-18 河南省锐达医药科技有限公司 一类新型苯甲酰苯胺化合物的制备方法和在肿瘤治疗上的应用
CN113939300A (zh) 2019-04-05 2022-01-14 凯麦拉医疗公司 Stat降解剂和其用途
WO2021232067A1 (en) * 2020-05-15 2021-11-18 Glg Pharma, Llc Stats3 inhibition for treatment and prevention of human coronavirus infection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491588A (en) * 1982-03-31 1985-01-01 University Of Tennessee Research Corporation Treatment of psoriasis and seborrheic dermatitis with imidazole antibiotics
WO2000044774A2 (en) * 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy

Also Published As

Publication number Publication date
WO2006091837A3 (en) 2009-04-16
WO2006091837A2 (en) 2006-08-31
JP2008535785A (ja) 2008-09-04
EP1853242A2 (en) 2007-11-14
US20060247318A1 (en) 2006-11-02
AU2006216510A1 (en) 2006-08-31
CN101511179A (zh) 2009-08-19
EP1853242A4 (en) 2009-11-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued