JP2008534503A5 - - Google Patents
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- Publication number
- JP2008534503A5 JP2008534503A5 JP2008503069A JP2008503069A JP2008534503A5 JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5 JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- use according
- disorder
- clomiphene
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
- 208000035475 disorder Diseases 0.000 claims 16
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 9
- 201000003585 eunuchism Diseases 0.000 claims 8
- 208000037106 male hypogonadism Diseases 0.000 claims 8
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 230000037182 bone density Effects 0.000 claims 2
- 229960003608 clomifene Drugs 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 208000006132 lipodystrophy Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036765 blood level Effects 0.000 claims 1
- 230000036314 physical performance Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000035936 sexual power Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66429005P | 2005-03-22 | 2005-03-22 | |
| US60/664,290 | 2005-03-22 | ||
| PCT/US2006/010022 WO2006102232A2 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Division JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534503A JP2008534503A (ja) | 2008-08-28 |
| JP2008534503A5 true JP2008534503A5 (https=) | 2009-03-12 |
| JP5785680B2 JP5785680B2 (ja) | 2015-09-30 |
Family
ID=37024477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503069A Expired - Fee Related JP5785680B2 (ja) | 2005-03-22 | 2006-03-17 | トランス−クロミフェン用の投与レジメン |
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8247456B2 (https=) |
| EP (2) | EP1865938A4 (https=) |
| JP (3) | JP5785680B2 (https=) |
| KR (1) | KR20070114187A (https=) |
| CN (1) | CN101163467B (https=) |
| AU (1) | AU2006227243B2 (https=) |
| BR (1) | BRPI0609389A2 (https=) |
| CA (2) | CA3071412A1 (https=) |
| MX (1) | MX2007010659A (https=) |
| NZ (1) | NZ560551A (https=) |
| PL (1) | PL383444A1 (https=) |
| RU (1) | RU2413508C2 (https=) |
| WO (1) | WO2006102232A2 (https=) |
| ZA (1) | ZA200707774B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002318225B2 (en) | 2001-07-09 | 2007-12-13 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| BRPI0609389A2 (pt) | 2005-03-22 | 2010-03-30 | Repros Therapeutics Inc | tablete, composição e respectivos usos |
| RU2467020C2 (ru) | 2006-10-31 | 2012-11-20 | Басф Се | Регулирование в способе получения абсорбирующих воду полимерных частиц в нагретой газовой фазе |
| BRPI0818637A2 (pt) * | 2007-10-16 | 2015-04-07 | Repros Therapeutics Inc | Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático |
| TW201500041A (zh) * | 2008-11-07 | 2015-01-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| WO2013020215A1 (en) * | 2011-08-09 | 2013-02-14 | Adams Kenneth W | Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males |
| AU2013221478B2 (en) * | 2012-02-14 | 2017-06-01 | Repros Therapeutics Inc. | Selective estrogen receptor modulators with short half-lives and uses thereof |
| JP2015508825A (ja) * | 2012-02-29 | 2015-03-23 | レプロス セラピューティクス インコーポレイティド | アンドロゲン欠乏症を治療するための併用療法 |
| CA2872644A1 (en) | 2012-05-31 | 2013-12-05 | Allergan Pharmaceuticals International Limited | Formulations and methods for vaginal delivery of antiprogestins |
| US9545411B2 (en) | 2012-11-02 | 2017-01-17 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| HK1216502A1 (zh) * | 2012-11-02 | 2016-11-18 | Repros Therapeutics Inc. | 用於癌症治療的反式-克羅米芬 |
| MX376689B (es) | 2013-06-05 | 2025-03-07 | Repros Therapeutics Inc | Trans-clomifeno y sus analogos como agentes que aumentan la densidad mineral osea. |
| RU2018133603A (ru) * | 2016-02-25 | 2020-03-25 | Эспен Парк Фармасьютикалз, Инк. | Пероральная дозированная форма двух изомеров кломифена и способ ее использования для лечения вторичного гипогонадизма и минимизации побочных эффектов лекарственного препарата у мужчин |
| EP3368506B1 (en) | 2016-04-22 | 2023-09-06 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061733A (en) * | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| ATE36312T1 (de) | 1985-06-08 | 1988-08-15 | Asta Pharma Ag | Neue derivate des 1,1,2,2-tetramethyl-1,2-bis-(2fluor-4-hydroxyphenyl)-ethans. |
| US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) * | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| EP0802787A4 (en) | 1994-06-17 | 1998-09-02 | Univ Nebraska | VECTOR FOR DELIVERY OF BIO-EFFECTIVE SUBSTANCES WITH GELLIFICATION -i (IN SITU) AND METHOD OF USE |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| DE69617245T2 (de) * | 1995-08-17 | 2002-07-25 | Csir, Pretoria | Produkte mit gesteuerter freisetzung |
| US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) * | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| CA2269806C (en) * | 1996-10-28 | 2006-01-24 | Bernhard H. Van Lengerich | Embedding and encapsulation of controlled release particles |
| BR9809064A (pt) * | 1997-04-03 | 2002-01-02 | Guilford Pharm Inc | Polìmeros biodegradáveis de poliéster de tereftalato-polifosfato, composições, artigos e métodos para fazer e usar os mesmos |
| US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| RU2200732C2 (ru) * | 1997-08-12 | 2003-03-20 | Глэксо Вэллкам Инк. | Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания |
| US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| TR200100309T2 (tr) | 1998-07-30 | 2001-05-21 | Stoller Enterprises, Inc | Bitkilerin salisilik asit ve organik aminler ile muamelesi. |
| WO2000007996A2 (en) * | 1998-08-07 | 2000-02-17 | Chiron Corporation | Pyrazoles as estrogen receptor modulators |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6583129B1 (en) * | 1999-06-11 | 2003-06-24 | Watson Pharmaceuticals, Inc. | Administration of non-oral androgenic steroids to women |
| CA2321321A1 (en) * | 1999-09-30 | 2001-03-30 | Isotis B.V. | Polymers loaded with bioactive agents |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| AU3104301A (en) * | 2000-01-20 | 2001-07-31 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| US7067557B2 (en) | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| WO2001091744A1 (en) * | 2000-05-26 | 2001-12-06 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| JP2004507465A (ja) * | 2000-08-11 | 2004-03-11 | ワイス | エストロゲン受容体陽性癌腫の治療方法 |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| WO2002055020A2 (en) * | 2000-12-11 | 2002-07-18 | Testocreme Llc | Topical testosterone formulations and associated methods |
| CN100377369C (zh) * | 2001-07-04 | 2008-03-26 | 日亚化学工业株式会社 | 氮化物半导体元件 |
| US7173064B2 (en) * | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
| AU2002318225B2 (en) * | 2001-07-09 | 2007-12-13 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| US6645974B2 (en) * | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| EP1429779A2 (en) * | 2001-09-21 | 2004-06-23 | Merck & Co., Inc. | Androstanes as androgen receptor modulators |
| US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US7105679B2 (en) * | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| JP4312522B2 (ja) | 2003-06-30 | 2009-08-12 | 株式会社リコー | 現像剤補給方法、現像剤補給装置、及び、画像形成装置 |
| US20080242726A1 (en) * | 2004-07-14 | 2008-10-02 | Podolski Joseph S | Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol |
| NZ556499A (en) * | 2005-02-04 | 2011-02-25 | Repros Therapeutics Inc | Methods and materials with trans-clomiphene for the treatment of male infertility |
| EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| BRPI0609389A2 (pt) | 2005-03-22 | 2010-03-30 | Repros Therapeutics Inc | tablete, composição e respectivos usos |
| CA2617905A1 (en) | 2005-08-05 | 2007-02-15 | Repros Therapeutics Inc. | Methods and compositions for treating female infertility using clomiphene |
| EP1829534A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
| BRPI0818637A2 (pt) | 2007-10-16 | 2015-04-07 | Repros Therapeutics Inc | Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático |
-
2006
- 2006-03-17 BR BRPI0609389-2A patent/BRPI0609389A2/pt active Search and Examination
- 2006-03-17 CN CN2006800089841A patent/CN101163467B/zh not_active Expired - Fee Related
- 2006-03-17 EP EP06738985A patent/EP1865938A4/en not_active Ceased
- 2006-03-17 AU AU2006227243A patent/AU2006227243B2/en not_active Ceased
- 2006-03-17 MX MX2007010659A patent/MX2007010659A/es active IP Right Grant
- 2006-03-17 PL PL383444A patent/PL383444A1/pl unknown
- 2006-03-17 WO PCT/US2006/010022 patent/WO2006102232A2/en not_active Ceased
- 2006-03-17 US US11/815,542 patent/US8247456B2/en not_active Expired - Fee Related
- 2006-03-17 JP JP2008503069A patent/JP5785680B2/ja not_active Expired - Fee Related
- 2006-03-17 NZ NZ560551A patent/NZ560551A/en not_active IP Right Cessation
- 2006-03-17 KR KR1020077021707A patent/KR20070114187A/ko not_active Ceased
- 2006-03-17 RU RU2007138867/15A patent/RU2413508C2/ru active
- 2006-03-17 CA CA3071412A patent/CA3071412A1/en not_active Abandoned
- 2006-03-17 CA CA002597700A patent/CA2597700A1/en not_active Abandoned
- 2006-03-17 EP EP11153365A patent/EP2392322A3/en not_active Withdrawn
-
2007
- 2007-09-11 ZA ZA200707774A patent/ZA200707774B/xx unknown
-
2012
- 2012-08-20 US US13/590,045 patent/US8519004B2/en not_active Expired - Fee Related
-
2014
- 2014-12-05 JP JP2014246454A patent/JP6270281B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-17 JP JP2017221743A patent/JP2018024712A/ja active Pending
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