JP2008532974A5 - - Google Patents
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- Publication number
- JP2008532974A5 JP2008532974A5 JP2008500172A JP2008500172A JP2008532974A5 JP 2008532974 A5 JP2008532974 A5 JP 2008532974A5 JP 2008500172 A JP2008500172 A JP 2008500172A JP 2008500172 A JP2008500172 A JP 2008500172A JP 2008532974 A5 JP2008532974 A5 JP 2008532974A5
- Authority
- JP
- Japan
- Prior art keywords
- diabetes
- pharmaceutically acceptable
- acceptable salt
- type
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 238000004519 manufacturing process Methods 0.000 claims 13
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 206010012601 diabetes mellitus Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 5
- 229960002586 roflumilast Drugs 0.000 claims 5
- PCGSQNPMMSALEJ-UHFFFAOYSA-N roflumilast n-oxide Chemical compound ClC1=C[N+]([O-])=CC(Cl)=C1NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 PCGSQNPMMSALEJ-UHFFFAOYSA-N 0.000 claims 5
- 208000032928 Dyslipidaemia Diseases 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 238000011294 monotherapeutic Methods 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 230000001575 pathological effect Effects 0.000 claims 4
- 230000001629 suppression Effects 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 3
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 3
- 230000003143 atherosclerotic effect Effects 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 238000009097 single-agent therapy Methods 0.000 claims 2
- 201000004569 Blindness Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 201000001431 Hyperuricemia Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000011542 limb amputation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101772 | 2005-03-08 | ||
| EP05101772.1 | 2005-03-08 | ||
| PCT/EP2006/060418 WO2006094933A1 (en) | 2005-03-08 | 2006-03-03 | Roflumilast for the treatment of diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129982A Division JP5611275B2 (ja) | 2005-03-08 | 2012-06-07 | 真性糖尿病の治療のためのロフルミラスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008532974A JP2008532974A (ja) | 2008-08-21 |
| JP2008532974A5 true JP2008532974A5 (cg-RX-API-DMAC7.html) | 2009-04-30 |
| JP5091106B2 JP5091106B2 (ja) | 2012-12-05 |
Family
ID=34938922
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500172A Expired - Fee Related JP5091106B2 (ja) | 2005-03-08 | 2006-03-03 | 真性糖尿病の治療のためのロフルミラスト |
| JP2012129982A Expired - Fee Related JP5611275B2 (ja) | 2005-03-08 | 2012-06-07 | 真性糖尿病の治療のためのロフルミラスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129982A Expired - Fee Related JP5611275B2 (ja) | 2005-03-08 | 2012-06-07 | 真性糖尿病の治療のためのロフルミラスト |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8017633B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1874308A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5091106B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101302838B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN102600144A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006222060B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0609371A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2599376C (cg-RX-API-DMAC7.html) |
| EA (1) | EA015382B1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL185277A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007010560A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20074943L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ560269A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006094933A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200706294B (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE409057T1 (de) | 2002-02-11 | 2008-10-15 | Antares Pharma Inc | Intradermales injektionsgerät |
| CA2595730C (en) | 2005-01-24 | 2014-10-07 | Antares Pharma, Inc. | Prefilled needle assisted syringe jet injector |
| EP1874308A1 (en) * | 2005-03-08 | 2008-01-09 | Nycomed GmbH | Roflumilast for the treatment of diabetes mellitus |
| TW200738266A (en) * | 2005-09-29 | 2007-10-16 | Sankyo Co | Pharmaceutical agent containing insulin resistance improving agent |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
| NZ574710A (en) * | 2006-09-07 | 2012-02-24 | Nycomed Gmbh | Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus |
| EP3636301A1 (en) | 2008-03-10 | 2020-04-15 | Antares Pharma, Inc. | Injector safety device |
| CN101548972B (zh) * | 2008-04-03 | 2012-10-17 | 万特制药(海南)有限公司 | 一种含有瑞格列奈的固体药物组合物 |
| CA2732812C (en) | 2008-08-05 | 2017-10-31 | Antares Pharma, Inc. | Multiple dosage injector |
| ES2988196T3 (es) | 2009-03-20 | 2024-11-19 | Antares Pharma Inc | Sistema de inyección de agentes peligrosos |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| EP4327849A3 (en) | 2012-03-06 | 2024-04-24 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
| CN104487114A (zh) | 2012-04-06 | 2015-04-01 | 安塔雷斯药品公司 | 针头辅助喷射注射给予睾酮组合物 |
| WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| HUE066268T2 (hu) | 2013-02-11 | 2024-07-28 | Antares Pharma Inc | Csökkentett kioldóerõt igénylõ tûs befecskendezõ eszköz |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| ES2742046T3 (es) | 2013-03-11 | 2020-02-12 | Antares Pharma Inc | Inyector de dosis con sistema de piñón |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| EP3165224A1 (en) * | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| CN109328193A (zh) | 2016-04-19 | 2019-02-12 | 尤瑞卡有限公司 | 肽-低聚脲折叠体化合物及其使用方法 |
| GB202306663D0 (en) * | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174901A (en) * | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| JPS5869812A (ja) | 1981-10-22 | 1983-04-26 | Chugai Pharmaceut Co Ltd | 血糖降下剤 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| NZ225447A (en) | 1987-07-20 | 1991-12-23 | Merck & Co Inc | Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions |
| US5698711A (en) * | 1991-01-28 | 1997-12-16 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| GB9215633D0 (en) | 1992-07-23 | 1992-09-09 | Smithkline Beecham Plc | Novel treatment |
| PL307265A1 (en) | 1992-07-28 | 1995-05-15 | Rhone Poulenc Rorer Ltd | Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom |
| AU682156B2 (en) * | 1992-10-15 | 1997-09-25 | Dana-Farber Cancer Institute, Inc. | Treatment of insulin resistance in obesity linked type II diabetes using antagonists to TNF-alpha function |
| CZ290266B6 (cs) * | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| NZ291507A (en) * | 1994-08-29 | 1997-12-19 | Yamanouchi Pharma Co Ltd | 1,8-naphthyridine derivatives; medicaments |
| SI0882021T1 (en) | 1996-01-31 | 2003-10-31 | Altana Pharma Ag | New phenanthridines |
| DE19617864A1 (de) * | 1996-04-23 | 1997-10-30 | Schering Ag | Neue chirale Phenyldihydrofuranone |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| ES2222613T3 (es) | 1997-09-12 | 2005-02-01 | Pharis Biotec Gmbh | Composicion para la terapia de diabetes mellitus y de la obesidad. |
| SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| DE60019894T2 (de) | 1999-01-15 | 2006-01-12 | Altana Pharma Ag | Phenantrhridin-n-oxides mit pde-iv hemmender wirkung |
| HRP20010578A2 (en) | 1999-01-15 | 2002-08-31 | Byk Gulden Lomberg Chem Fab | Phenylphenanthridines with pde-iv inhibiting activity |
| US7323496B2 (en) | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| AU3270301A (en) | 1999-11-13 | 2001-05-30 | Icos Corporation | Combined pde3 and pde4 inhibitor therapy for the treatment of obesity |
| EP1236725B1 (en) | 1999-12-08 | 2004-03-10 | Grelan Pharmaceutical Co., Ltd. | Novel 1,8-naphthyridin-2(1h)-one derivatives |
| WO2001068621A1 (en) * | 2000-03-13 | 2001-09-20 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclohexene derivatives useful as antagonists of the motilin receptor |
| EP1270577B1 (en) * | 2000-03-23 | 2006-12-06 | Takeda Pharmaceutical Company Limited | Furoisoquinoline derivatives, process for producing the same and use thereof |
| AU2001261962B2 (en) * | 2000-05-25 | 2005-04-21 | Merck Frosst Canada Ltd | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
| HUP0303673A3 (en) | 2000-08-11 | 2010-04-28 | Ono Pharmaceutical Co | Piperidine derivatives and pharmaceutical compositions containing these derivatives as the active ingredient |
| EP1307183A2 (en) | 2000-08-11 | 2003-05-07 | Pfizer Limited | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
| YU57603A (sh) | 2001-01-22 | 2006-08-17 | Memory Pharmaceuticals Corporation | Inhibitori fosfodiesteraze 4 |
| IL156412A0 (en) * | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| CZ20031902A3 (cs) * | 2001-01-31 | 2004-07-14 | Pfizer Products Inc. | Etherové deriváty užitečné jako inhibitory isozymů PDE4 |
| EP1362044A1 (en) | 2001-02-15 | 2003-11-19 | ALTANA Pharma AG | Phthalazinone-piperidino-derivatives as pde4 inhibitors |
| HUP0600103A2 (en) * | 2001-03-02 | 2006-06-28 | Bristol Myers Squibb Co | Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| DE10150517A1 (de) | 2001-10-12 | 2003-04-17 | Merck Patent Gmbh | Verwendung von Phosphodiesterase IV-Inhibitoren |
| US20030181461A1 (en) | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| DK1511516T3 (da) * | 2002-05-28 | 2009-04-06 | Nycomed Gmbh | Topisk anvendeligt farmaceutisk præparat |
| AU2003253130A1 (en) | 2002-08-19 | 2004-03-03 | Glenmark Pharmaceuticals Limited | Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders |
| US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| WO2004098598A1 (en) | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | COMPOSITION COMPRISING ROFLUMILAST AND A TNFα ANTAGONIST |
| WO2004098596A1 (en) | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising roflumilast and il-1 trap |
| WO2004098597A1 (en) | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising roflumilast and shuil-1r ii |
| WO2004098595A1 (en) | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | COMPOSITION COMPRISING ROFLUMILAST AND A TNFα ANTAGONIST |
| NZ544040A (en) * | 2003-05-22 | 2009-03-31 | Nycomed Gmbh | Composition comprising a PDE4 inhibitor and a PDE5 inhibitor |
| WO2005020926A2 (en) * | 2003-08-28 | 2005-03-10 | Pharmacia Corporation | Treatment or prevention of vascular disorders with cox-2 inhibitors in combination with cyclic amp-specific phosphodiesterase inhibitors |
| WO2005023253A1 (en) * | 2003-09-05 | 2005-03-17 | Altana Pharma Ag | Use of pde4 inhibitors for the treatment of diabetes mellitus |
| MXPA06004499A (es) | 2003-10-21 | 2006-06-27 | Pharmacia Corp | Metodo para el tratamiento o la prevencion de inflamacion respiratoria con un inhibidor de ciclooxigenasa 2 en combinacion con un inhibidor de fosfodiesterasa 4 y sus composiciones. |
| JP2007532135A (ja) | 2004-04-13 | 2007-11-15 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 高血糖症および関連障害の処置のための、ヒトｇタンパク質共役レセプターおよびそのモジュレーター |
| EP1874308A1 (en) * | 2005-03-08 | 2008-01-09 | Nycomed GmbH | Roflumilast for the treatment of diabetes mellitus |
-
2006
- 2006-03-03 EP EP06708617A patent/EP1874308A1/en not_active Withdrawn
- 2006-03-03 CN CN2012100579547A patent/CN102600144A/zh active Pending
- 2006-03-03 JP JP2008500172A patent/JP5091106B2/ja not_active Expired - Fee Related
- 2006-03-03 KR KR1020077022434A patent/KR101302838B1/ko not_active Expired - Fee Related
- 2006-03-03 US US11/885,450 patent/US8017633B2/en not_active Expired - Fee Related
- 2006-03-03 NZ NZ560269A patent/NZ560269A/en not_active IP Right Cessation
- 2006-03-03 AU AU2006222060A patent/AU2006222060B2/en not_active Ceased
- 2006-03-03 MX MX2007010560A patent/MX2007010560A/es not_active Application Discontinuation
- 2006-03-03 CA CA2599376A patent/CA2599376C/en not_active Expired - Fee Related
- 2006-03-03 CN CN2006800072465A patent/CN101137368B/zh not_active Expired - Fee Related
- 2006-03-03 EA EA200701845A patent/EA015382B1/ru not_active IP Right Cessation
- 2006-03-03 BR BRPI0609371-0A patent/BRPI0609371A2/pt not_active IP Right Cessation
- 2006-03-03 WO PCT/EP2006/060418 patent/WO2006094933A1/en not_active Ceased
-
2007
- 2007-07-27 ZA ZA200706294A patent/ZA200706294B/xx unknown
- 2007-08-14 IL IL185277A patent/IL185277A/en not_active IP Right Cessation
- 2007-10-01 NO NO20074943A patent/NO20074943L/no not_active Application Discontinuation
-
2011
- 2011-07-11 US US13/179,895 patent/US8541456B2/en not_active Expired - Fee Related
-
2012
- 2012-06-07 JP JP2012129982A patent/JP5611275B2/ja not_active Expired - Fee Related
- 2012-07-18 IL IL221006A patent/IL221006A0/en unknown
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