BRPI0609371A2 - usos de roflumilast na produção de composições farmacêuticas para o tratamento de diabetes mellitus - Google Patents
usos de roflumilast na produção de composições farmacêuticas para o tratamento de diabetes mellitus Download PDFInfo
- Publication number
- BRPI0609371A2 BRPI0609371A2 BRPI0609371-0A BRPI0609371A BRPI0609371A2 BR PI0609371 A2 BRPI0609371 A2 BR PI0609371A2 BR PI0609371 A BRPI0609371 A BR PI0609371A BR PI0609371 A2 BRPI0609371 A2 BR PI0609371A2
- Authority
- BR
- Brazil
- Prior art keywords
- type
- pharmaceutically acceptable
- diabetes mellitus
- acceptable salt
- treatment
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 107
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 72
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 229960002586 roflumilast Drugs 0.000 title claims abstract description 57
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 53
- 150000003839 salts Chemical class 0.000 claims description 304
- 150000001875 compounds Chemical class 0.000 claims description 271
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 209
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 190
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 86
- 238000000034 method Methods 0.000 claims description 79
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- 239000013066 combination product Substances 0.000 claims description 52
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- PCGSQNPMMSALEJ-UHFFFAOYSA-N roflumilast n-oxide Chemical compound ClC1=C[N+]([O-])=CC(Cl)=C1NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 PCGSQNPMMSALEJ-UHFFFAOYSA-N 0.000 claims description 51
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- 239000008103 glucose Substances 0.000 claims description 29
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 28
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP05101772 | 2005-03-08 | ||
| EP05101772.1 | 2005-03-08 | ||
| PCT/EP2006/060418 WO2006094933A1 (en) | 2005-03-08 | 2006-03-03 | Roflumilast for the treatment of diabetes mellitus |
Publications (1)
| Publication Number | Publication Date |
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| BRPI0609371A2 true BRPI0609371A2 (pt) | 2010-03-30 |
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| BRPI0609371-0A BRPI0609371A2 (pt) | 2005-03-08 | 2006-03-03 | usos de roflumilast na produção de composições farmacêuticas para o tratamento de diabetes mellitus |
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| ATE409057T1 (de) | 2002-02-11 | 2008-10-15 | Antares Pharma Inc | Intradermales injektionsgerät |
| CA2595730C (en) | 2005-01-24 | 2014-10-07 | Antares Pharma, Inc. | Prefilled needle assisted syringe jet injector |
| EP1874308A1 (en) * | 2005-03-08 | 2008-01-09 | Nycomed GmbH | Roflumilast for the treatment of diabetes mellitus |
| TW200738266A (en) * | 2005-09-29 | 2007-10-16 | Sankyo Co | Pharmaceutical agent containing insulin resistance improving agent |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
| NZ574710A (en) * | 2006-09-07 | 2012-02-24 | Nycomed Gmbh | Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus |
| EP3636301A1 (en) | 2008-03-10 | 2020-04-15 | Antares Pharma, Inc. | Injector safety device |
| CN101548972B (zh) * | 2008-04-03 | 2012-10-17 | 万特制药(海南)有限公司 | 一种含有瑞格列奈的固体药物组合物 |
| CA2732812C (en) | 2008-08-05 | 2017-10-31 | Antares Pharma, Inc. | Multiple dosage injector |
| ES2988196T3 (es) | 2009-03-20 | 2024-11-19 | Antares Pharma Inc | Sistema de inyección de agentes peligrosos |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| EP4327849A3 (en) | 2012-03-06 | 2024-04-24 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
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-
2006
- 2006-03-03 EP EP06708617A patent/EP1874308A1/en not_active Withdrawn
- 2006-03-03 CN CN2012100579547A patent/CN102600144A/zh active Pending
- 2006-03-03 JP JP2008500172A patent/JP5091106B2/ja not_active Expired - Fee Related
- 2006-03-03 KR KR1020077022434A patent/KR101302838B1/ko not_active Expired - Fee Related
- 2006-03-03 US US11/885,450 patent/US8017633B2/en not_active Expired - Fee Related
- 2006-03-03 NZ NZ560269A patent/NZ560269A/en not_active IP Right Cessation
- 2006-03-03 AU AU2006222060A patent/AU2006222060B2/en not_active Ceased
- 2006-03-03 MX MX2007010560A patent/MX2007010560A/es not_active Application Discontinuation
- 2006-03-03 CA CA2599376A patent/CA2599376C/en not_active Expired - Fee Related
- 2006-03-03 CN CN2006800072465A patent/CN101137368B/zh not_active Expired - Fee Related
- 2006-03-03 EA EA200701845A patent/EA015382B1/ru not_active IP Right Cessation
- 2006-03-03 BR BRPI0609371-0A patent/BRPI0609371A2/pt not_active IP Right Cessation
- 2006-03-03 WO PCT/EP2006/060418 patent/WO2006094933A1/en not_active Ceased
-
2007
- 2007-07-27 ZA ZA200706294A patent/ZA200706294B/xx unknown
- 2007-08-14 IL IL185277A patent/IL185277A/en not_active IP Right Cessation
- 2007-10-01 NO NO20074943A patent/NO20074943L/no not_active Application Discontinuation
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2011
- 2011-07-11 US US13/179,895 patent/US8541456B2/en not_active Expired - Fee Related
-
2012
- 2012-06-07 JP JP2012129982A patent/JP5611275B2/ja not_active Expired - Fee Related
- 2012-07-18 IL IL221006A patent/IL221006A0/en unknown
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|---|---|
| US20080214625A1 (en) | 2008-09-04 |
| CN102600144A (zh) | 2012-07-25 |
| CN101137368B (zh) | 2012-05-16 |
| WO2006094933A1 (en) | 2006-09-14 |
| CA2599376C (en) | 2014-05-13 |
| US8541456B2 (en) | 2013-09-24 |
| AU2006222060A1 (en) | 2006-09-14 |
| NO20074943L (no) | 2007-10-01 |
| US8017633B2 (en) | 2011-09-13 |
| EP1874308A1 (en) | 2008-01-09 |
| MX2007010560A (es) | 2008-02-21 |
| CN101137368A (zh) | 2008-03-05 |
| JP5611275B2 (ja) | 2014-10-22 |
| KR20070111539A (ko) | 2007-11-21 |
| JP2008532974A (ja) | 2008-08-21 |
| JP2012188448A (ja) | 2012-10-04 |
| IL185277A (en) | 2013-08-29 |
| AU2006222060B2 (en) | 2011-09-01 |
| EA200701845A1 (ru) | 2008-02-28 |
| IL185277A0 (en) | 2008-02-09 |
| IL221006A0 (en) | 2012-08-30 |
| JP5091106B2 (ja) | 2012-12-05 |
| KR101302838B1 (ko) | 2013-09-03 |
| US20110269750A1 (en) | 2011-11-03 |
| NZ560269A (en) | 2010-12-24 |
| ZA200706294B (en) | 2008-09-25 |
| CA2599376A1 (en) | 2006-09-14 |
| EA015382B1 (ru) | 2011-08-30 |
| HK1116077A1 (en) | 2008-12-19 |
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